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| 1 | Improved guided bone regeneration by combined application of unmodified, fresh autologous adipose derived regenerative cells and plasma rich in growth factors:A first-in-human case report and literature review显示文摘BACKGROUND Novel strategies are needed for improving guided bone regeneration(GBR) in oral surgery prior to implant placement, particularly in maxillary sinus augmentation(GBR-MSA) and in lateral alveolar ridge augmentation(LRA). This study tested the hypothesis that the combination of freshly isolated, unmodified autologous adipose-derived regenerative cells(UA-ADRCs), fraction 2 of plasma rich in growth factors(PRGF-2) and an osteoinductive scaffold(OIS)(UAADRC/PRGF-2/OIS) is superior to the combination of PRGF-2 and the same OIS alone(PRGF-2/OIS) in GBR-MSA/LRA.CASE SUMMARY A 79-year-old patient was treated with a bilateral external sinus lift procedure as well as a bilateral lateral alveolar ridge augmentation. GBR-MSA/LRA was performed with UA-ADRC/PRGF-2/OIS on the right side, and with PRGF-2/OIS on the left side. Biopsies were collected at 6 wk and 34 wk after GBRMSA/LRA. At the latter time point implants were placed. Radiographs(32 mo follow-up time) demonstrated excellent bone healing. No radiological or histological signs of inflammation were observed. Detailed histologic,histomorphometric, and immunohistochemical analysis of the biopsies evidenced that UA-ADRC/PRGF-2/OIS resulted in better and faster bone regeneration than PRGF-2/OIS.CONCLUSION GBR-MSA with UA-ADRCs, PRGF-2, and an OIS shows effectiveness without adverse effects. | ?nder Solakoglu Werner G?tz Maren C Kiessling Christopher Alt Christoph Schmitz Eckhard U Alt | 2019 | World Journal of Stem Cells2019，11，2： | 3 |
| 2 | Intravenous transfusion of endothelial progeni- tor cells reduces neointima formation after vaseular injury显示文摘 | Werner N Junk S Lads U | 2003 | Cite Res2003，93，2： | 1 |
| 3 | The effect of metallization on the ohmic contact resistivity to heavily B-doped polycrystalline diamond films显示文摘 | WERNER M DORSCH O BAERWIND H U | 1995 | IEEE Trans Electron Devices1995，42，7： | 1 |
| 4 | TNF-alpha inhibi- tors restrict T cell activation and cycling via Notch-1 sig- nalling in inflammatory bowel disease 显示文摘 | Werner L Berndt U Paclik D | 2012 | Gut2012，61，： | 1 |
| 5 | Intravenous transfusion of endothelial progenitor cells reduced neointima formation after vascular injury显示文摘 | Werner N Junk S Laufs U | 2003 | Circ Res2003，93，2： | 1 |
| 6 | Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis显示文摘 | Laufs U Werner N Link A | 2004 | Circulation2004，109，： | 1 |
| 7 | Bone marrow-derived progenitor cells modulate vascular reendothelialization and neointimal formation:effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition显示文摘 | WERNER N PRILLER J LAUFS U | 2002 | Arterioscler Thromb Vasc Biol2002，22，10： | 1 |
| 8 | Intravenoustransfusion of endothelial progenitor cells reduces neointima formation after vascular injury 显示文摘 | Werner N Junk S Laufs U | 2003 | Circ Res2003，93，2： | 1 |
| 9 | Intravenous transfusion of endothelial progenitor cells reduces neointima formation after vascular injury 显示文摘 | Werner N Junk S Laufs U | 2003 | Circ Res2003，93，2： | 1 |
| 10 | Pre- dictors of clinical response to gluten - free diet in patients diag- nosed with din'hea- predominant irritable bowel syndrome 显示文摘 | WAHNSCHAFFE U SCHULZKE J D WERNER T | 2007 | Clin Gastroenterol Hepatol2007，5，7： | 1 |
| 11 | Simultaneous occurrence of an open Gartner-duct cyst, a homolateral aplasia of the kidney and a double uterus as a typical syndrome of abnormalities 显示文摘 | Herlyn U Werner H | 1971 | Geburtshilfe Frauenheilkd1971，31，4： | 1 |
| 12 | Integrated assessment of agricultural production practices to enhance sustainable development in agricultural landscapes显示文摘 | Sattler C Nagel U J Werner A | 2010 | Ecological Indicators2010，10，1： | 1 |
| 13 | Intravenous transfusion of endothelial progenitor cells reduces neointima formation after vascular injury显示文摘 | Werner N Junk S Laufs U | 2003 | Circ Res2003，93，2： | 1 |
| 14 | Crystal Structure and Morphology of Melt Crystallized Poly (propylene-stat-ethylene) Fractions 显示文摘 | Laihonen S Gedde U W Werner P E | 1997 | Polymer1997，38，2： | 1 |
| 15 | Drying characteristics of copra and quality of copra and coconut oil显示文摘 | Roberto C Guarte Werner M(U)hlbauer Manfred Kellert | 1996 | Postharvost Biology and Technology1996，9，： | 1 |
| 16 | Rap-id method for detection of minimal bactericidal concentration ofantibiotics显示文摘 | WERNER B R BADE-SCHUMANN U KREBS A | 2009 | J Microbiol Methods2009，77，1： | 1 |
| 17 | Physical training increases endothelial progenitor cells,inhibits neointima formation,and enhances angiogenesis显示文摘 | Laufs U Werner N Link A | 2004 | Circulation2004，109，2： | 1 |
| 18 | First-principles theory for the H + CH4→H2+ CH3 Reaction显示文摘 | Wu T Werner H J Manthe U | 2004 | Science2004，306，5705： | 1 |
| 19 | Physical training in creases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis显示文摘 | Laufs U Werner N Link A | 2004 | Circulation2004，109，3： | 1 |
| 20 | Bone marrow-derived progenitor cells modulate vascular reendothelialization and neointimal formation:effect of 3-hydroxy-3-methylglutaryl coenzyme a reducatase inhibition显示文摘 | Werner N Priller J Laufs U | 2002 | Arterioscler Thromb Vasc Biol2002，22，10： | 1 |
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