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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | A gene for hereditary pancreatitis maps to chromosome 7q35显示文摘 | DC Whitcomb RA Preston CE Aston MJ Sossenheimer PS Barua Y Zhang A Wong- Chong GJ White PG Wood LK Gates C Ulrich SP Martin JC Post GD Ehrlich | 1996 | Gastroenterology1996，，6： | 2 |
| 3 | Shipboard Systems Deploy Automated Protection显示文摘 | Butler K L Sarma N D R Whitcomb C A | 1998 | IEEE Computer Applications in Power1998，11，2： | 1 |
| 4 | lAP Guidelines for the Surgical Management of Acute Pancreatitis显示文摘 | Uhl W Warshaw A Imrie C Bassi C McKay C J Lankisch PG Carter R Di Magno E Banks PA Whitcomb DC | 2002 | Panereatology2002，2，6： | 1 |
| 5 | Performance characteristics of a cascaded two-level converter显示文摘 | Corzine K A Sudhoff S D Whitcomb C A | 1999 | IEEE Transactions on Energy Conversion1999，14，3： | 1 |
| 6 | Optimal current control stratagies for suffaco-monnted permanent-magnet synchronous machine drives显示文摘 | CHAPMAN P L SUDHOFF S D WHITCOMB C A | 1999 | IEEE Trans on Energy Convention1999，14，4： | 1 |
| 7 | 查看详情显示文摘 | Alexander C Andersson H S Andersson L I Ansell R J Kirsch N Nicholls I A O'Mahony J Whitcombe M J | | 0，，： | 1 |
| 8 | Molecular imprinting science and technology:a survey of the literature for the years up to and including 2003显示文摘 | ALEXANDER C ANDERSSON H S ANDERSSON L I ANSELL R J KIRSCH N NICHOLLS I A OMAHONY J WHITCOMBE M J | 2006 | J Mol Recognit2006，19，2： | 1 |
| 9 | A gene for hereditary pancreatitis maps to chromosome 7q35显示文摘 | DC Whitcomb RA Preston CE Aston MJ Sossenheimer PS Barua Y Zhang A Wong- Chong GJ White PG Wood LK Gates C Ulrich SP Martin JC Post GD Ehrlich | 1996 | Gastroenterology1996，，6： | 1 |
| 10 | A gene for hereditary pancreatitis maps to chromosome 7q35显示文摘 | DC Whitcomb RA Preston CE Aston MJ Sossenheimer PS Barua Y Zhang A Wong- Chong GJ White PG Wood LK Gates C Ulrich SP Martin JC Post GD Ehrlich | 1996 | Gastroenterology1996，，6： | 1 |
| 11 | Predators of Solenopsis invicta queens prior to successful colony estab-lishment显示文摘 | Whitcomb W H Bhatkar A Nickerson J C | 1973 | Environ Entomol1973，2，： | 1 |
| 12 | Naval ship design philosophy implementation 显示文摘 | Whitcomb L C A | 1998 | Naval Engineers Journal1998，，1： | 1 |
| 13 | Predators of Solenopsis invicta queens prior to colony establishment显示文摘 | WHITCOMB W H BHATKAR A NICKERSON J C | 1973 | Environmental Entomology1973，2，： | 1 |
| 14 | Performance Characteristicsof a Cascaded Two-Level Converter显示文摘 | Corzine K A Sudhoff S D Whitcomb C A | 1999 | IEEE Transactions on Energy Con-version1999，14，3： | 1 |
| 15 | Naval ship design philosophy implementation显示文摘 | Whitcomb C A | 1998 | Naval Engineers Journal1998，110，1： | 1 |
| 16 | Cigarette smoking as a risk factor for pancreatic cancer in patients with hereditary pancreatitis显示文摘 | LOWENFELS A B MAISONNEUVE P WHITCOMB D C | 2001 | JAMA2001，286，2： | 1 |
| 17 | Genetic polymorphisms in alcoholic pancreatitis显示文摘 | Hanck C Schneider A Whitcomb DC | 2003 | Best Pract Res Clin Gastroenterol2003，17，： | 1 |
| 18 | Shipboard systems deploy automated protection 显示文摘 | BUTLER K L SARMA N D R WHITCOMB C A | 1998 | IEEE Computer Applications in Power1998，11，2： | 1 |
| 19 | Shipboard systems deploy automated protection 显示文摘 | BUTLER K L SARMA N D R WHITCOMB C A | 1998 | IEEE Computer Applications in Power1998，11，2： | 1 |
| 20 | Complement receptor 3 deficiency influences lesion progression during Leishmania major infection in BALB/c mice显示文摘 | Carter C R Whitcomb J P Campbell J A | 2009 | Infect lmmun2009，77，12： | 1 |
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