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| 1 | Prevalence and clinical characteristics associated with left atrial thrombus detection: Apixaban显示文摘BACKGROUND The prevalence of left atrial appendage(LAA) thrombus detection by transesophageal echocardiogram(TEE) in patients with non-valvular atrial fibrillation(AF) anticoagulated with apixaban is not well defined and identification of additional risk factors may help guide the selection process for pre-procedural TEE. The purpose of our study was to retrospectively analyze the prevalence of LAA thrombus detection by TEE in patients continuously anticoagulated with apixaban for ≥ 4 wk and evaluate for any cardiac risk factors or echocardiographic characteristics which may serve as predictors of thrombus formation.AIM To retrospectively analyze the prevalence of LAA thrombus detection by TEE in patients continuously anticoagulated with apixaban.METHODS Clinical and echocardiographic data for 820 consecutive patients with AF undergoing TEE at Augusta University Medical Center over a four-year period were retrospectively analyzed. All patients(apixaban: 226) with non-valvular AF and documented compliance with apixaban for ≥ 4 wk prior to index TEE were included.RESULTS Following ≥ 4 wk of continuous anticoagulation with apixaban, the prevalence ofLAA thrombus and LAA thrombus/dense spontaneous echocardiographic contrast was 3.1% and 6.6%, respectively. Persistent AF, left ventricular ejection fraction < 30%, severe LA dilation, and reduced LAA velocity were associated with thrombus formation. Following multivariate logistic regression, persistent AF(OR: 7.427; 95%CI: 1.02 to 53.92; P = 0.0474), and reduced LAA velocity(OR:1.086; 95%CI: 1.010 to 1.187; P = 0.0489) were identified as independent predictors of LAA thrombus. No Thrombi were detected in patients with a CHA2 DS2-VASc score ≤ 1.CONCLUSION Among patients with non-valvular AF and ≥ 4 wk of anticoagulation with apixaban, the prevalence of LAA thrombus detected by TEE was 3.1%. This suggests that continuous therapy with apixaban does not completely eliminate the risk of LAA thrombus and that TEE prior to cardioversion or catheter ablation may be of benefit in patients with multiple risk factors. | Hoyle L Whiteside Arun Nagabandi Kristen Brown Deepak N Ayyala Gyanendra K Sharma | 2019 | World Journal of Cardiology2019，11，2： | 2 |
| 2 | Functional and pheno- typic characteristics of CD4 ICD25 high Foxp3+ Treg clones obtained from peripheral blood of patients with cancer显示文摘 | Strauss L Bergrnann C Whiteside TL | 2007 | Int J Cancer2007，，： | 1 |
| 3 | Control of NF-kappa activity by the I kappa Bβinhibitor显示文摘 | WEIL R WHITESIDE S T ISRAL A | 1997 | Immunobiology1997，198，123： | 1 |
| 4 | The role of death receptor ligands in shaping tumor microenvironment显示文摘 | Whiteside T L | 2007 | Immunol Invest2007，36，1： | 1 |
| 5 | Anatomic consideration of nerve supply to the vastus medialis in knee surgery 显示文摘 | Jojima H Whiteside L A Ogata K | 2004 | Clin Orth Relat Res2004，，423： | 1 |
| 6 | Selectivesurvival of naturally occurring human CD4+ CD25 +Foxp3 + regulatory T cells cultured with rapamycin 显示文摘 | Strauss L Whiteside TL Knights A | 2007 | JImmunol2007，178，1： | 1 |
| 7 | Fabrication of submicrometer features on curved substrates by microcontact printing 显示文摘 | WILBUR J L WHITESIDES G M | 1995 | Science1995，269，： | 1 |
| 8 | Nutritional pathways of the intervertebral disc: An experimental study using hydrogen washout technique显示文摘 | OGATA K WHITESIDE L A | 1981 | Spine(Phila Pa 1976)1981，6，3： | 1 |
| 9 | Selective survival of naturally occurring human CD4^+CD25^+ FoxP3+ regulatory T cells cultured with rapamycin显示文摘 | Strauss L Whiteside TL Knights A | 2007 | J Immunol2007，178，1： | 1 |
| 10 | Risk factors for prolapse recurrence after vaginal repair显示文摘 | Whiteside J L Weber A M Meyn L A | 2004 | Am J Obstet Gynecol2004，191，5： | 1 |
| 11 | The role of Fas/FasL in immunosuppression induced by human tumors显示文摘 | Rabinowich H | 1998 | Cancer Immunol Immunother1998，46，4： | 1 |
| 12 | A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2 - selective agonist, GW405833 显示文摘 | Whiteside G T Gottshall S L Boulet J M | 2005 | Eur J Pharmacol2005，528，13： | 1 |
| 13 | Effect of rotigotine on sleep and quality of life in Parkinson's disease patients:post hoc analysis of RECOVER patients who were symptomatic at baseline显示文摘 | Ghys L Surmann E Whitesides J | 2011 | Expert Opin Pharmacother2011，12，： | 1 |
| 14 | Enzymatic treatment of flax at the roving stage for production of wet-spun yarn 显示文摘 | SHARMA H S S WHITESIDE L KERNAGHAN K | 2005 | Enzyme and Microbial Technology2005，37，4： | 1 |
| 15 | Surgical technique: Transfer of the anterior portion of the gluteus maximus muscle for abductor deficiency of the hip 显示文摘 | WHITESIDE L A | 2012 | Clin Orthop Relat Res2012，470，2： | 1 |
| 16 | Bone landmarks are more reliable than tensioned gaps in TKA component alignment显示文摘 | Hanada H Whiteside L A Steiger J | 2007 | Clin Orthop Relat Res2007，，462： | 1 |
| 17 | Adsorption of proteins onto surfaces containing end-attached oligo ( ethylene oxide) : A model system using selbassembled monolayers显示文摘 | Prime K L Whitesides G M | 1993 | J Am Chem Soc1993，115，10： | 1 |
| 18 | The tumor microenvironment and its role in promoting tumor growth显示文摘 | Whiteside T L | 2008 | Oncogene2008，27，45： | 1 |
| 19 | Expression of ICOS on human melanoma-infiltrating CD4(+)CD25highFoxp3(+) T regulatory cells:implications and impact on tumor-mediated immune suppression显示文摘 | Strauss L Bergmann C Szczepanski M J Lang S Kirkwood J M Whiteside T L | 2008 | J Immunol2008，180，： | 1 |
| 20 | Selective survival of naturally occurring human CD4^++ CD25^+ Foxp3^ + regulatory T cells cultured with rapamycin显示文摘 | Strauss L Whiteside TL Knights A | 2007 | J Immunol2007，178，1： | 1 |
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