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| 1 | Factors associated with 5-year survival of combined hepatocellular and cholangiocarcinoma显示文摘BACKGROUND Combined hepatocellular and cholangiocarcinoma(HCC/CC)is a rare primary hepatic malignancy which carries a poor prognosis due to its aggressive nature.Few centers have enough cases to draw definitive conclusions and there is limited understanding of prognosis.Given the rarity of HCC/CC,an analysis of large national cancer database was needed to obtain larger number of HCC/CC cases.AIM To identify associated factors for 5-year survival of HCC/CC.METHODS We conducted a retrospective study of The Surveillance,Epidemiology,and End Results(SEER)database obtained from SEER*Stat 8.3.6 software.Previously defined histology code 8180 for the International Classification of Disease for Oncology,3rd edition was used to identify HCC/CC cases from 2004 to 2015.We collected demographics,American Joint Committee on Cancer(AJCC)stage,treatment,tumor size,and survival data.These data were converted to categorical variables.The Shapiro-Wilk normality test was used to assess normal distribution.Mann-Whitney U test was used to compare continuous variables without normal distribution,and t-test was used to compare continuous variables with a normal distribution.The Kaplan-Meier survival curve analyzed 5-year survival.Univariate and multivariate logistic regression model was used to analyze factors associated with 5-year survival.Multivariate Cox proportional hazard regression was done on 5-year survival.We defined P<0.05 was statistically significant.RESULTS We identified 497 patients with the following characteristics:Mean age 62.4 years(SD:11.3),149(30.0%)were female,racial distribution was:276(55.5%)white,53(10.7%)black,84(16.9%)Asian and Pacific Islander(API),77(15.5%)Hispanic,and 7(1.4%)others or unknown.Stage I/II disease occurred in 41.5%and tumor size<50 mm was seen in 35.6%of patients.Twenty-four(4.8%)received locoregional therapy(LRT),119(23.9%)underwent resection,and 50(10.1%)underwent liver transplantation.The overall median survival was 6 mo[Interquartile range(IQR):1-22].After multivariate logistic regression,tumor size<50 mm[Odds ratios(OR):2.415,P=0.05],resection(OR:12.849,P<0.01),and transplant(OR:27.129,P<0.01)showed significance for 5-year survival.Age>60,sex,race,AJCC stages,metastasis,and LRT were not significant.However,API vs white showed significant OR of 2.793(CI:1.120-6.967).Cox proportional hazard regression showed AJCC stages,tumor size<50 mm,LRT,resection,and transplant showed significant hazard ratio.CONCLUSION HCC/CC patients with tumor size<50 mm,resection,and transplant were associated with an increase in 5-year survival.API showed advantageous OR and hazard ratios over white,black. | Tomoki Sempokuya Eric A Wien Robert J Pattison Jihyun Ma Linda L Wong | 2020 | World Journal of Hepatology2020，12，11： | 2 |
| 2 | Local and regional-scale responses of ant diversity to a semiarid biome transition zone 显示文摘 | Bestelmeyer B T Wiens J A | 2001 | Ecography2001，24，： | 1 |
| 3 | Spatial scaling in ecology显示文摘 | | 1989 | Functional Ecology1989，3，： | 1 |
| 4 | Niches, models, and climate change: assessing the assump- tions and uncertainties 显示文摘 | Wiens J A Stralberg D Jongsomjit D | 2009 | Proceedings of the Nation- al Academy of Sciences of the United States of Ameri- ca2009，106，19： | 1 |
| 5 | EcologicalMechanisms and Landscape Ecology 显示文摘 | Wiens J A Stenseth N C Home N | 1993 | Oikos1993，66，3： | 1 |
| 6 | Constraints on neon and argon isotopic fractionation in solar wind 显示文摘 | Meshik A Mabry J Hohenberg C Marrocchi Y Pravdivtseva 0 Burnett D Olinger C Wiens R Reisenfeld D Alton J McNamara K Stansbery E Jurewicz A J G | 2007 | Science2007，318，5849： | 1 |
| 7 | Spatial scaling in ecology显示文摘 | Wiens J A | 1989 | Functional Ecology1989，3，： | 1 |
| 8 | On the use of 'grain' and 'grain size' in ecology 显示文摘 | Wiens J A | 1990 | Functional Ecology1990，4，5： | 1 |
| 9 | Animal movements and population dynamics in heterogeneous landscapes 显示文摘 | JOHNSON A R WIENS J A MILNE B T | 1992 | laudscape Ecology1992，7，： | 1 |
| 10 | A systematic review and meta-analysis of the efficacy and safety of etanercept for treating rheumatoid arthritis 显示文摘 | Wiens A Cotter C J Pontarolo R | 2009 | Scand J Immunol2009，70，： | 1 |
| 11 | The effects of land use on the structure of ground-foraging ant communities in the Argentine Chaco 显示文摘 | BESTELMEYER B T WIENS J A | 1996 | Ecological Applications1996，6，4： | 1 |
| 12 | Interactions between the fractal geometry of landscapes and allometric herbivory显示文摘 | Milne B T Turner M G Wiens J A | 1992 | Theoret Pop Biol1992，41，： | 1 |
| 13 | A meta-analysis of the efficacy and safety of using infliximab for the treatment of rheumatoid arthritis 显示文摘 | Wiens A Correr C J Venson R | 2009 | Clin Rheumatol2009，28，： | 1 |
| 14 | Spatial scaling in ecology 显示文摘 | Wiens J A | 1993 | Functional E-cology1993，，3： | 1 |
| 15 | A scaling rule for landscape patches and how it applies to conserving soil resources in Savanna显示文摘 | Ludwig J A Wiens J A Tongway D J | 2000 | Ecosystems2000，，3： | 1 |
| 16 | Muhiple scales of patchiness and patch structure: a hierarchical framework for the study of heterogeneity显示文摘 | Kotliar N Wiens J A | 1990 | Oikvs1990，59，： | 1 |
| 17 | Spatial scaling in ecology 显示文摘 | WIENS J A | 1989 | Functional Ecology1989，3，4： | 1 |
| 18 | Animal Movements and Pop Population Dynamics in Heterogeneous Landscapes 显示文摘 | Johnson A R Wiens J A Milne B T | 1992 | Landscape Ecology1992，，7： | 1 |
| 19 | Phylogenetic origins of local- seale diversity patterns and the causes of Amazonian megadiversity显示文摘 | Wiens J J Pyron R A Moen D S | 2011 | Ecology Letters2011，14，7： | 1 |
| 20 | Analyzing the effects of accidental environmental impacts: approaches and assumptions显示文摘 | WIENS J A PARKER K R | 1995 | Ecological Applications1995，5，4： | 1 |
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