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| 1 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 2 | Genetic mapping offloral traits associated with reproductive isolation in rnonkeyfolw-ers ( Mimulus ) 显示文摘 | Bradshaw H D Wilbert S M Otto K G | 1995 | Nature1995，376，： | 1 |
| 3 | Genetic strategies for enhancing phytoremediation 显示文摘 | STOMP A M HAN K H WILBERT S | 1994 | Ann NY Acad Sci1994，721，： | 1 |
| 4 | Cardiacamyloidosis approaches to diagnosis and management 显示文摘 | Desai H Wilbert S Stephen J | 2010 | Cardiol Rev2010，18，1： | 1 |
| 5 | Genetic stra- tegies for enhancing phytoremediation显示文摘 | Stomp A M Han K H Wilbert S | 1994 | Ann N Y Acad Sci1994，721，： | 1 |
| 6 | Cardiac amyloidosis approaches to diagnosis and management显示文摘 | DESAI H WILBERT S STEPHEN J | 2010 | Cardiol Rev2010，18，： | 1 |
| 7 | A Method for Assessing Thermal Comfort of Shoes Using a 'Sweating'Foot 显示文摘 | Ed H M Schols Wilbert A J van den Eijnde Ronald Heus | 2004 | European journal of applied physiology2004，92，6： | 1 |
| 8 | Systematic genetic nomencla- ture for type VII secretion systems 显示文摘 | Wilbert B Edith H Daria B | 2009 | PLoS Pathogens2009，5，10： | 1 |
| 9 | Toxicogenomics Concepts and Applications to Study Hepatic Effects of Food Additives and Chemicals显示文摘 | ROB S WILBERT H ANNE K | 2005 | Toxicology and Applied Pharmacology2005，207，： | 1 |
| 10 | Genetic improvement of tree species for remediation of hazardous wastes显示文摘 | Stomp A M Han K H Wilbert S Gordon M P | | 0，，： | 1 |
| 11 | Cardiaeamyloidosis approaches to diagnosis and management 显示文摘 | Desai H Wilbert S Stephen J | 2010 | Cardiol Rev2010，18，1： | 1 |
| 12 | Quantification of jasmonic acid, methyl jasmonate, and salicylic acid in plants by capillary liquid chromatography electrospray tandem mass spectrometry显示文摘 | Sibylle M Wilbert Lowell H Ericsson Milton P Gordon | 1998 | Analytical Biochemistry1998，257，2： | 1 |
| 13 | Effect of oltipraz, atocopherol, β-carotene and phenethylisothiocyanate on rat oesophageal, gastric, colonic and hepatic glutathione, glutathione S-transferase and peroxidase显示文摘 | STHER M M WILBERT H M P JAN B M | 1996 | Carcinogenesis1996，17，7： | 1 |
| 14 | Clinical nature and prognosis of local recurrent rectal cancer after total mesorectal excision with or without preoperative radiotherapy 显示文摘 | Mandy van den B Anne M S Wilbert B van den H | 2004 | Clin Oncol2004，22，19： | 1 |
| 15 | A meta-analysis of 1-year outcomes of transcatheter versus surgical aortic valve replacement in low-risk patients with severe aortic stenosis显示文摘Background Transcatheter aortic valve replacement(TAVR)for the treatment symptomatic severe aortic stenosis(AS)is indicated in patients with intermediate or higher surgical risk.Latest trials showed TAVR,and surgical aortic valve replacement(SAVR)perform similarly at 1-year for the composite outcomes of mortality,stroke and rehospitalization.We performed a comprehensive meta-analysis to compare individual outcomes at 1-year for TAVR compared to SAVR in low-risk patients.Methods Pub Med,Embase,and Cochrane central were searched for all the randomized controlled trials(RCTs)that reported 1-year comparative outcomes of TAVR and surgical aortic valve replacement(SAVR).Our conclusions are based upon the random-effects model using Der Simonian-Laird estimator.Results Data from 4 trials and 2887 randomized patients showed that TAVR had lower rates of all-cause mortality,cardiovascular mortality,and atrial fibrillation compared to SAVR at 1-year follow-up(P<0.05 for all).Also,TAVR was also associated with a significantly higher risk of permanent pacemaker implantation and moderate-severe paravalvular leak(P<0.05).Conclusions The latest randomised trial data demonstrates that in short-term,TAVR is safe and effective in reducing all-cause mortality or stroke.Longer follow-up of RCTs is needed to determine the durability of clinical benefits in TAVR over SAVR in low-risk patients. | Aaqib H Malik Syed Zaid Hasan Ahmad Joshua Goldberg Tanya Dutta Cenap Undemir Martin Cohen Wilbert S Aronow Steven L Lansman | 2020 | Journal of Geriatric Cardiology2020，17，1： | 0 |
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