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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Surveillance of nosocomial infections in a neurology intensive care unit显示文摘 | Markus Dettenkofer Winfried Ebner Thomas Els Regina Babikir Carl Lücking Klaus Pelz Henning Rüden Franz Daschner | 2001 | Journal of Neurology2001，，11： | 1 |
| 3 | Familial hypercholesterolemia: developments in diagnosis and treatment 显示文摘 | Gerald K Ulrich L Winfried M | 2014 | Dtsch Arztebl Int2014，111，3132： | 1 |
| 4 | Neurokinin-1 Receptor Antagonists Protect Mice from CD95-and Tumor Necrosis Factor-α-Mediated Apoptotic Liver Damage显示文摘 | RENATE B MARKUS B WINFRIED L | 2004 | Journal of Pharmacology And Experimental Therapeutics2004，308，： | 1 |
| 5 | Makecular and functional characteristics of dendritic cells generated from highly purified CD+14peripheral blood monocytes显示文摘 | Winfried F Pick L Otto M | 1996 | Immunology1996，1257，： | 1 |
| 6 | Identification of Novel Genes Coding for Small Expressed RNAs显示文摘 | Mariana L Q Reinhard R Winfried L | 2001 | Science2001，294，5543： | 1 |
| 7 | Duplexes of 21-nucleotide RNAs mediate RNA interference in all cultured mammalian cells显示文摘 | Jens H Winfried L | 2001 | Nature2001，411，： | 1 |
| 8 | Regional and seasonal differences in light absorption by yellow substance in the Southern Bight of the North Sea显示文摘 | RODERICK E W WINFRIED W C SANDOR V L | 1999 | Journal of Sea Research1999，42，： | 1 |
| 9 | Characterization of the first nonmammalian T2 cytokine gene cluster: the cluster contains functional single-copy genes for IL-3, IL-4, IL-13, and GM-CSF,a gene for IL-5 that appears to be a pseudogene, and a gene encoding another cytokinelike transcript, KK34 显示文摘 | Avery S Rothwell L Winfried D J | 2004 | Interferon cytokine Res2004，24，： | 1 |
| 10 | T cell responses to hepatitis B surface antigen are detectable in non-vaccinated individuals显示文摘AIM: To evaluate, whether humoral hepatitis-B-vaccine non-responders also fail to mount a T cell response and to compare these results to normal vaccinees. METHODS: Fourty-seven health care employees were enrolled in this study including all available non- responders (n = 13) with an anti-HBsAg titer < 10 kU/L and all available low-responders (n = 12) with an anti- HBsAg titer < 100 kU/L. Also, 12 consecutive anti-HBsAg negative pre-vaccination subjects were enrolled as well as 10 subjects (+7 from the vaccinated group) with titers > 1000 kU/L as controls. PBMC from all subjects were analyzed by IFN-γ and IL-4 ELISPOT assays for the presence of hepatitis B surface antigen (HBsAg) reactive T cells. RESULTS: Non-responders and low-responders had no or only very limited T cell responses, respectively. Indi- viduals responding to vaccination with the induction of a high anti-HBsAg titer showed a strong T cell response after the third vaccination. Surprisingly, these individuals showed response even before the first vaccination. T cell response to control antigens and mitogens was similar in all groups. CONCLUSION: Our data suggest that there is no gen- eral immune deficiency in non-/low-responders. Thus, we hypothesize that the induction of anti-HBsAg re- sponses by vaccination is significantly dependent on the pre-existing T cell repertoire against the specific antigen rather than the presence of a general T cell defect. | Martin R Weihrauch Michael von Bergwelt-Baildon Milos Kandic Martin Weskott Winfried Klamp Joachim Rsler Joachim L Schultze | 2008 | World Journal of Gastroenterology2008，14，16： | 1 |
| 11 | Neutrophil granulocyte--committed cells can be driven to acquire dendritic cell characteristics显示文摘 | Oehler L Majdic O Winfried FP | 1998 | J Exp Med1998，187，7： | 1 |
| 12 | Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammaliancells显示文摘 | Sayda M E Jens H Winfried L | 2001 | Nature2001，411，： | 1 |
| 13 | Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells显示文摘 | Sayda ME Jens H Winfried L | 2001 | Nature2001，411，： | 1 |
| 14 | Change and customization in complex engineering domains显示文摘 | CLAUDIA E CLARKSON L WINFRIED Z | 2004 | Research in Engineering Design2004，15，1： | 1 |
| 15 | Structure and fractal dimensions of root systems of four co-occurring fruit tree species from Botswana显示文摘 | Armin L O Winfried K Helge D | 2000 | Annals of Forest Science2000，57，： | 1 |
| 16 | Regional and seasonal differences in light absorption by yellow sub-stance in Southern Bright of North Sea显示文摘 | Boderick E W Winfried W C Sandor V L | 1999 | Journal of Sea Research1999，142，： | 1 |
| 17 | Maternal control of resting - egg production in Daphnia显示文摘 | Victor A Winfried L | 2001 | Nature2001，414，： | 1 |
| 18 | Expression Analysis and Potential Functional Role of the CXCR4 Chemokine Receptor in Bladder Cancer显示文摘 | Andreas Eisenhardt Ulrich Frey Monika Tack Dieter Rosskopf Gerd Lümmen Herbert Rübben Winfried Siffert | 2004 | European Urology2004，，1： | 1 |
| 19 | Topology, scaling relations and Leonardos rule in root systems from African tree species显示文摘 | Armin L O Winfried K Douglas L G | 2001 | Tree Physiology2001，21，： | 1 |
| 20 | Duplexes of 21± nucleotide RNAs mediate RNA interference in cultured mammalian cells显示文摘 | Sayda M E Jens H Winfried L el at | 2001 | Nature2001，411，： | 1 |
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