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| 1 | Comparative effectiveness of i-SCAN^(TM) and high-definition white light characterizing small colonic polyps显示文摘AIM:To evaluate accuracy of in vivo diagnosis of adenomatous vs non-adenomatous polyps using i-SCAN digital chromoendoscopy compared with high-definition white light.METHODS:This is a single-center comparative effectiveness pilot study.Polyps(n = 103) from 75 averagerisk adult outpatients undergoing screening or surveillance colonoscopy between December 1,2010 and April 1,2011 were evaluated by two participating endoscopists in an academic outpatient endoscopy center.Polyps were evaluated both with high-definition white light and with i-SCAN to make an in vivo prediction of adenomatous vs non-adenomatous pathology.We determined diagnostic characteristics of i-SCAN and highdefinition white light,including sensitivity,specificity,and accuracy,with regards to identifying adenomatous vs non-adenomatous polyps.Histopathologic diagnosis was the gold standard comparison.RESULTS:One hundred and three small polyps,detected from forty-three patients,were included in the analysis.The average size of the polyps evaluated in the analysis was 3.7 mm(SD 1.3 mm,range 2 mm to 8 mm).Formal histopathology revealed that 54/103(52.4%) were adenomas,26/103(25.2%) were hyperplastic,and 23/103(22.3%) were other diagnoses include 'lymphoid aggregates','non-specific colitis,' and 'no pathologic diagnosis.' Overall,the combined accuracy of endoscopists for predicting adenomas was identical between i-SCAN(71.8%,95%CI:62.1%-80.3%) and high-definition white light(71.8%,95%CI:62.1%-80.3%).However,the accuracy of each endoscopist differed substantially,where endoscopist A demonstrated 63.0% overall accuracy(95%CI:50.9%-74.0%) as compared with endoscopist B demonstrating 93.3% overall accuracy(95%CI:77.9%-99.2%),irrespective of imaging modality.Neither endoscopist demonstrated a significant learning effect with i-SCAN during the study.Though endoscopist A increased accuracy using i-SCAN from 59%(95%CI:42.1%-74.4%) in the first half to 67.6%(95%CI:49.5%-82.6%) in the second half,and endoscopist B decreased accuracy using i-SCAN from 100%(95%CI:80.5%-100.0%) in the first half to 84.6%(95%CI:54.6%-98.1%) in the second half,neither of these differences were statistically significant.CONCLUSION:i-SCAN and high-definition white light had similar efficacy predicting polyp histology.Endoscopist training likely plays a critical role in diagnostic test characteristics and deserves further study. | Johanna L Chan Li Lin Michael Feiler Andrew I Wolf Diana M Cardona Ziad F Gellad | 2012 | World Journal of Gastroenterology2012，18，41： | 3 |
| 2 | Effect of an angiotensin Ⅱ receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor-beta (TGF-beta) and alpha-actomyosin (alpha SMA), important mediators of radiation-induced pneumopathy and lung fibrosis显示文摘 | MOLTENI A WOLFE L F WARD W F | 2007 | Current Pharmaceutical Design2007，13，13： | 1 |
| 3 | Rheumatoid arthritis treatment and the risk of severe interstitial lung disease 显示文摘 | WOLFE F CAPLAN L MICHAUD K | 2007 | Scand J Rheumatol2007，36，3： | 1 |
| 4 | The effects of irrigation on out- comes in cases of perforated appendicitis in children显示文摘 | Hartwich J E Carter R F Wolfe L | 2013 | J Surg Res2013，180，2： | 1 |
| 5 | Highly selective propene epoxidation with hydrogen/oxygen mixtures over titaniasupported silver catalysts显示文摘 | Wolf A Schuth F | 2001 | Catalysis Letters2001，73，： | 1 |
| 6 | 显示文摘 | DAMJANORIC A YEH L S R WOLF J F | 1980 | J Electrochem Soc1980，127，： | 1 |
| 7 | Comparison and evaluation of methods for liver segmentation from CT datasets显示文摘 | Heimann T van Ginneken B Styner MA Arzhaeva Y Aurich V Bauer C Beck A Becket C Beichel R Bekes G Bello F Binnig G Bischof H Bornik A Cashman PM Chi Y Cordova A Dawant BM Fidrich M Furst JD Furukawa D Grenacher L Hornegger J Kainmuller D Kitney RI Kobatake H Lamecker H Lange T Lee J Lennon B Li R Li S Meinzer HP Nemeth G Raicu DS Rau AM van Rikxoort EM Rousson M Rusko L Saddi KA Schmidt G Seghers D Shimizu A Slagmolen P Sorantin E Soza G Susomboon R Waite JM Wimmer A Wolf I | 2009 | IEEE Transactions on Medical Imaging2009，28，8： | 1 |
| 8 | Dielectric properties forevaluating apple maturity显示文摘 | Wolf D F Zacha riah G L | 1973 | Transactions of the ASAE1973，16，5： | 1 |
| 9 | Rates of degradation of malathion by bacteria isolated from aquatic system显示文摘 | Doris F Paris David L Lewis Wolfe N Lee | 1979 | Environmentalscience & Technology1979，9，2： | 1 |
| 10 | Factorial design applied to concentrate bioactive component of Cymbopogon citratus essential oil using short path distillation 显示文摘 | TOVAR L P WOLF MACIEL M R PINO G M F | 2010 | Chemical Engineering Research and Design2010，88，23： | 1 |
| 11 | Rheumatoid arthritis 显示文摘 | Scott D L Wolfe F Huizinga T W | 2010 | Lancet2010，376，9746： | 1 |
| 12 | 50Hz extremely low frequency electromagnetic fields enhance cell proliferation and DNA damage:possible involvement of a redox mechanism显示文摘 | TORSELLO A TEDESCO B | 2005 | BBA-Molecular CellRes2005，1743，： | 1 |
| 13 | Relationships Among Typha Biomass,Pore Water Methane,and Reflectance in a Delaware(USA)Brackish Marsh显示文摘 | Gross M F Hardisky M A Wolf P L | 1993 | Journal of Coastal Research1993，9，2： | 1 |
| 14 | Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements显示文摘 | Schoffer A A Aravind L Madden T L Shavirin S Spouge J L Wolf Y I Koonin E V Altschul S F | 2001 | Nucleic Acids Res2001，29，： | 1 |
| 15 | Rheumatoid ar- thritis 显示文摘 | SCOOT D L WOLFE F HUIZINGA T W | 2010 | Lancet2010，376，9746： | 1 |
| 16 | Treatment for rheumatoid arthritis and the risk of hospitalization for pneumonia:associations with prednisone,disease-modifying antirheumatic drugs,and anti-tumor necrosis factor therapy显示文摘 | Wolfe F Caplan L Michaud K | | 0，，02： | 1 |
| 17 | Synthesis and anticonvulsant activity of some new 2-substituted 3-ary-4(3H) quinazolinone显示文摘 | WOLF J F RATHMAN T L SLEEVI M C | 1990 | J Med Chem1990，33，： | 1 |
| 18 | Computer-assisted and conventional total knee replacement:A comparative,prospective,randomized study with radiological and CT evaluation显示文摘 | Lützner J Krummenauer F Wolf C | 2008 | J Bone Joint Surg Br2008，90，8： | 1 |
| 19 | Treatment for rheumatoid arthritis and the risk of hospitalization for pneumonia: associations with prednisone, disease modifying antirheumatic drugs,and anti-tumor necrosis factor therapy显示文摘 | Wolfe F Caplan L Michaud K | 2006 | Arthritis Rheum2006，54，： | 1 |
| 20 | Dielectric properties for evaluating apple maturity显示文摘 | Wolf D F Zachariah G L | 1973 | Transactions of the ASAE1973，16，5： | 1 |
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