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| 1 | Outcome of patients with acute, necrotizing pancreatitis requiring drainage-does drainage size matter?显示文摘AIM:To assess the outcome of patients with acute necrotizing pancreatitis treated by percutaneous drainage with special focus on the influence of drainage size and number. METHODS:We performed a retrospective analysis of 80 patients with acute pancreatitis requiring percutaneous drainage therapy for infected necroses. Endpoints were mortality and length of hospital stay. The influence of drainage characteristics such as the median drainage size, the largest drainage size per patient and the total drainage plane per patient on patient outcome was evaluated. RESULTS:Total hospital survival was 66%. Thirty-four patients out of all 80 patients (43%) survived acute necrotizing pancreatitis with percutaneous drainage therapy only. Eighteen patients out of all 80 patients needed additional percutaneous necrosectomy (23%). Ten out of these patients required surgical necrosectomy in addition, 6 patients received open necrosectomy without prior percutaneous necrosectomy. Elective surgery was performed in 3 patients receiving cholecystectomy and one patient receiving resection of the parathyroid gland. The number of drainages ranged from one to fourteen per patient. The drainage diameter ranged from 8 French catheters to 24 French catheters. The median drainage size as well as the largest drainage size used per patient and the total drainage area used per patient did not show statistically significant influence on mortality. CONCLUSION:Percutaneous drainage therapy is an effective tool for treatment of necrotizing pancreatitis.Large bore drainages did not prove to be more effective in controlling the septic focus. | T Bruennler J Langgartner S Lang CE Wrede F Klebl S Zierhut S Siebig F Mandraka F Rockmann B Salzberger S Feuerbach J Schoelmerich OW Hamer | 2008 | World Journal of Gastroenterology2008，14，5： | 23 |
| 2 | 健康老年妇女近段股骨骨密度和结构的定量CT研究显示文摘目的采用定量CT(QCT)和双能X线吸收测量(DXA)仪对健康老年妇女近段股骨骨密度(BMD)和骨结构进行研究,并对2种测量方法的结果进行比较。方法对66名65岁以上健康妇女左侧髋关节进行DXA测量,计算出股骨颈和粗隆区BMD;对其双侧近段股骨进行QCT测量,计算出股骨颈、粗隆区和整体股骨ROI的皮质骨、松质骨和总体骨的BMD和体积;并将QCT三维图像模拟DXA的平面投影计算出模拟DXA股骨颈BMD和模拟DXA股骨粗隆区BMD。对所获数据进行配对t检验或非参数秩和检验,并用Pearson法分析DXA和QCT相对应ROI的相关性。结果用QCT可以对股骨近段不同ROI(股骨颈、粗隆区和整体股骨区)及不同骨成分(皮质骨、松质骨和总体骨)的BMD及体积等参数进行精确的定量分析。除右侧股骨颈皮质骨BMD[(0.52±0.04)g/cm^3]、股骨粗隆区皮质骨BMD[(0.49±0.03)g/cm^3]、股骨粗隆区综合骨BMD[(0.22±0.04)g/cm^3]大于左侧相应参数[分别为[(0.51±0.04)、(0.48±0.03)、(0.21±0.04)g/cm^3],差异均有统计学意义(P值均〈0.05),但差别均〈3.3%;而模拟DXA股骨颈BMD、模拟DXA股骨粗隆区BMD、股骨颈皮质骨体积、股骨颈松质骨BMD、股骨颈松质骨体积、股骨颈综合骨BMD、股骨颈综合骨体积、股骨粗隆区皮质骨体积、股骨粗隆区松质骨BMD、股骨粗隆区松质骨体积、股骨粗隆区综合骨体积左侧参数分别为(0.52±0.10)g/cm^2、(0.78±0.13)g/cm^2、5.80cm^3、(0.06±0.03)g/cm^3、(5.19±1.40)cm^3、(0.25±0.04)g/cm^3、15.66cm^3、(21.74±3.43)cm^3、(0.08±0.03)g/cm^3、(34.27±6.09)cm^3、(76.12±11.11)cm^3,右侧分别为(0.52±0.10)g/cm^2、(0.78±0.13)g/cm^2、6.01cm^3、(0.06±0.02)g/cm^3、(5.17±1.27)cm^3、(0.25±0.04)g/cm^3、15.62cm^3、(22.12±3.60)cm^3、(0.09±0.03)g/cm^3、(34.17±5.94)cm^3、(76.53±10.71)cm^3,差异均无统计学意义(P值均〉0.05)。左右两侧近段股骨QcT各相对应参数之间的r值范围在0.656~0.955,均具有相关性(P〈0.05)。QcT模拟DXA股骨颈和粗隆区BMD与真正DXA测量的相应值之间r值分别为0.685和0.855,具有相关性(P〈0.05)。结论利用QCT技术可以对老年妇女近段股骨不同区域和不同成分的BMD和结构进行精确定量分析,QCT是骨质疏松研究中非常有用的测量技术。 | 程晓光 Li Jing 刘霞 王予生 李谨 屈辉 H Genant T Lang | 2009 | 中华放射学杂志2009，43，2： | 8 |
| 3 | Optimizing hepatitis C virus treatment through pharmacist interventions: Identification and management of drug-drug interactions显示文摘AIM To quantify drug-drug-interactions(DDIs) encountered in patients prescribed hepatitis C virus(HCV) treatment, the interventions made, and the time spent in this process.METHODS As standard of care, a clinical pharmacist screened for DDIs in patients prescribed direct acting antiviral(DAA) HCV treatment between November 2013 and July 2015 at the University of Colorado Hepatology Clinic. HCV regimens prescribed included ledipasvir/sofosbuvir(LDV/SOF), paritaprevir/ritonavir/ombitasvir/dasabuvir(OBV/PTV/r + DSV), simeprevir/sofosbuvir (SIM/SOF), and sofosbuvir/ribavirin (SOF/RBV). This retrospective analysis reviewed the work completed by the clinical pharmacist in order to measure the aims identified for the study. The number and type of DDIs identified were summarized with descriptive statistics.RESULTS Six hundred and sixty four patients(83.4% Caucasian, 57% male, average 56.7 years old) were identified; 369 for LDV/SOF, 48 for OBV/PTV/r + DSV, 114 for SIM/SOF, and 133 for SOF/RBV. Fifty-one point five per cent of patients were cirrhotic. Overall, 5217 medications were reviewed (7.86 medications per patient) and 781 interactions identified (1.18 interactions per patient). The number of interactions were fewest for SOF/RBV (0.17 interactions per patient) and highest for OBV/PTV/r + DSV (2.48 interactions per patient). LDV/SOF and SIM/SOF had similar number of interactions (1.28 and 1.48 interactions per patient, respectively). Gastric acid modifiers and vitamin/herbal supplements commonly caused interactions with LDV/SOF. Hypertensive agents, analgesics, and psychiatric medications frequently caused interactions with OBV/PTV/r + DSV and SIM/SOF. To manage these interactions, the pharmacists most often recommended discontinuing the medication (28.9%), increasing monitoring for toxicities (24.1%), or separating administration times (18.2%). The pharmacist chart review for each patient usually took approximately 30 min, with additional time for more complex patients. CONCLUSION DDIs are common with HCV medications and management can require medication adjustments and increased monitoring. An interdisciplinary team including a clinical pharmacist can optimize patient care. | Jacob A Langness Matthew Nguyen Amanda Wieland Gregory T Everson Jennifer J Kiser | 2017 | World Journal of Gastroenterology2017，23，9： | 5 |
| 4 | Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial显示文摘 | Gunnar Folprecht Thomas Gruenberger Wolf O Bechstein Hans-Rudolf Raab Florian Lordick J?rg T Hartmann Hauke Lang Andrea Frilling Jan Stoehlmacher Jürgen Weitz Ralf Konopke Christian Stroszczynski Torsten Liersch Detlev Ockert Thomas Herrmann Eray Goekkurt | 2010 | Lancet Oncology2010，，1： | 3 |
| 5 | CD133,a novel marker for human prostatic epithelial stem cells显示文摘 | Richardson G D Robson C N Lang S H Neal D E Maitland N J Collins A T | 2004 | J Cell Sci2004，117，16： | 1 |
| 6 | Efficient optimization of support vector machine learning parameters for unbalanced datasets 显示文摘 | Eitrich T Lang B | 2006 | Journal of computational and applied mathematics2006，196，2： | 1 |
| 7 | gibberellin biosynthesis and the regulation of plant development显示文摘 | Pimenta Lange M J Lange T | 2006 | Plant Biology2006，，3： | 1 |
| 8 | High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide2C (OATP2C , SLCO1B1) 显示文摘 | Niemi M Schaeffeler E Lang T | 2004 | Pharmacogenetics2004，14，7： | 1 |
| 9 | De novo alveolar bone formation adjacent to endosseous implants 显示文摘 | Berglundh T Abrahamsson I Lang NP | 2003 | Clin Oral Implants Res2003，14，3： | 1 |
| 10 | The effectiveness and patient comfort of the novel streamlined pharynx airway liner (SLIPA) compared with the conventional laryngeal mask airway in ophthalmic surgery显示文摘 | Lange M Smul T Zimmermann P | 2007 | Anesth Analg2007，104，2： | 1 |
| 11 | Rules for robot draughtsmen显示文摘 | Lang T | 1969 | The Geographical Magazine1969，42，1： | 1 |
| 12 | Virtual reality in surgical training显示文摘 | Lange T Indelicato DJ Rosen JM | 2000 | Surg Oncol Clin N Am2000，9，1： | 1 |
| 13 | Separation of Eperythrozoon ovis from erythrocytes显示文摘 | Lang F M Ferrier G R Nicholls T J | 1986 | Vet Rec1986，119，： | 1 |
| 14 | Senescence induced by altered telomere state, not telomere loss显示文摘 | Karlseder J Smogorzewska A de Lange T | 2002 | Science2002，259，： | 1 |
| 15 | Multitarget tracking using probability hypothesis density smoothing 显示文摘 | Nadarajah N Kirubarajan T Lang T | 2011 | IEEE Transactions on Aerospace and Electronic Systems2011，47，4： | 1 |
| 16 | Current practice of insulin pump therapy in children and adolescents - the Han- hover recipe显示文摘 | Danne T yon Schutz W Lange K | 2006 | Pediatr Diabetes2006，7，4： | 1 |
| 17 | Orange fruit colour in Capsicum due to deletion of capsanthin-capsombin synthesis gene显示文摘 | Lang Y Q Yanagawa S Sasanuma T et ol | 2004 | Breeding Science2004，54，： | 1 |
| 18 | De novo alveolar bone formation adjacent to endosseous implants 显示文摘 | Berglundh T Abrahamsson I Lang NP | 2003 | Clin Oral Implants Res2003，14，3： | 1 |
| 19 | Gibberellin biosynthesis in developing pumpkin seedings显示文摘 | Lange T Kappler J Fischer A | | 0，，： | 1 |
| 20 | Assessment of lung development using hyperpolarized helium- 3 diffusion MR imaging显示文摘 | Altes T Mata J Lange EE | 2006 | J Magn Reson Imaging2006，24，6： | 1 |
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