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| 1 | Liver biochemistry profile,significance and endoscopic management of biliary tract complications post orthotopic liver transplantation显示文摘AIM: To correlate the significance of liver biochemical tests in diagnosing post orthotopic liver transplantation (OLT) biliary complications and to study their profile before and after endoscopic therapy. METHODS: Patients who developed biliary complications were analysed in detail for the clinical information,laboratory tests,treatment offered,response to it,follow up and outcomes. The profile of liver enzymes was determined. The safety,efficacy and outcomes of endoscopic retrograde cholangiography (ERC) were also analysed. RESULTS: 40 patients required ERC for 70 biliary complications. GGT was found to be > 3 times (388.1 ± 70.9 U/mL vs 168.5 ± 34.2 U/L,P = 0.007) and SAP > 2 times (345.1 ± 59.1 U/L vs 152.7 ± 21.4 U/L,P = 0.003) the immediate post OLT values. Most frequent complication was isolated anastomotic strictures in 28 (40%). Sustained success was achieved in 26 (81%) patients. CONCLUSION: Biliary complications still remain an important problem post OLT. SAP and GGT can be used as early,non-invasive markers for diagnosis and also to assess the adequacy of therapy. Endoscopic management is usually effective in treating the majority of these biliary complications. | Yogesh M Shastri Nicolas M Hoepffner Bora Akoglu Christina Zapletal Wolf O Bechstein Wolfgang F Caspary Dominik Faust | 2007 | World Journal of Gastroenterology2007，13，20： | 6 |
| 2 | Comparative effectiveness of i-SCAN^(TM) and high-definition white light characterizing small colonic polyps显示文摘AIM:To evaluate accuracy of in vivo diagnosis of adenomatous vs non-adenomatous polyps using i-SCAN digital chromoendoscopy compared with high-definition white light.METHODS:This is a single-center comparative effectiveness pilot study.Polyps(n = 103) from 75 averagerisk adult outpatients undergoing screening or surveillance colonoscopy between December 1,2010 and April 1,2011 were evaluated by two participating endoscopists in an academic outpatient endoscopy center.Polyps were evaluated both with high-definition white light and with i-SCAN to make an in vivo prediction of adenomatous vs non-adenomatous pathology.We determined diagnostic characteristics of i-SCAN and highdefinition white light,including sensitivity,specificity,and accuracy,with regards to identifying adenomatous vs non-adenomatous polyps.Histopathologic diagnosis was the gold standard comparison.RESULTS:One hundred and three small polyps,detected from forty-three patients,were included in the analysis.The average size of the polyps evaluated in the analysis was 3.7 mm(SD 1.3 mm,range 2 mm to 8 mm).Formal histopathology revealed that 54/103(52.4%) were adenomas,26/103(25.2%) were hyperplastic,and 23/103(22.3%) were other diagnoses include 'lymphoid aggregates','non-specific colitis,' and 'no pathologic diagnosis.' Overall,the combined accuracy of endoscopists for predicting adenomas was identical between i-SCAN(71.8%,95%CI:62.1%-80.3%) and high-definition white light(71.8%,95%CI:62.1%-80.3%).However,the accuracy of each endoscopist differed substantially,where endoscopist A demonstrated 63.0% overall accuracy(95%CI:50.9%-74.0%) as compared with endoscopist B demonstrating 93.3% overall accuracy(95%CI:77.9%-99.2%),irrespective of imaging modality.Neither endoscopist demonstrated a significant learning effect with i-SCAN during the study.Though endoscopist A increased accuracy using i-SCAN from 59%(95%CI:42.1%-74.4%) in the first half to 67.6%(95%CI:49.5%-82.6%) in the second half,and endoscopist B decreased accuracy using i-SCAN from 100%(95%CI:80.5%-100.0%) in the first half to 84.6%(95%CI:54.6%-98.1%) in the second half,neither of these differences were statistically significant.CONCLUSION:i-SCAN and high-definition white light had similar efficacy predicting polyp histology.Endoscopist training likely plays a critical role in diagnostic test characteristics and deserves further study. | Johanna L Chan Li Lin Michael Feiler Andrew I Wolf Diana M Cardona Ziad F Gellad | 2012 | World Journal of Gastroenterology2012，18，41： | 3 |
| 3 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 4 | 美国重症肌无力基金会关于重症肌无力临床试验的建议显示文摘由美国重症肌无力基金会(MGFA)的医学科学建议委员会(MSAB)组成工作组,于2010年在美国和2011年在意大利召开专家共识会议讨论重症肌无力(MG)临床试验的问题,与会代表包括来自美国和欧洲的神经科医生、统计学家、企业界代表、MG患者以及MGFA和欧洲重症肌无力协会的平民代表。 | Benatar M Sanders DB Burns TM Cutter GR Guptill JT Baggi F Kaminski HJ Mantegazza R Meriggioli MN Quan J Wolfe GI 李海峰(摘译) 高翔(摘译) | 2013 | 中国神经免疫学和神经病学杂志2013，20，1： | 2 |
| 5 | Maturation of bovine oacytes in the presence of leptin improves development and reduces apoptosis of in vitro-produced blastocysts 显示文摘 | Boelhauve M Sinowatz F Wolf E | 2005 | Biol Reprod2005，73，4： | 1 |
| 6 | The repeatability of superovulatory response and embryo recovery in sheep显示文摘 | Bari F Khalid M Wolf B Haresigh W Murray A Merrell B | 2001 | Theriogenology2001，56，1： | 1 |
| 7 | An inventory model for deteriorating item显示文摘 | Raafat F Wolfe P M Eldin H K | 1991 | Computers and Industrial Engineering1991，20，1： | 1 |
| 8 | Platelets and cytokines in concert with endothelial activation in patients with peripheral arterial occlusive disease显示文摘 | Tsakiris DA Tschopl M Wolf F | 2000 | Blood coag Fibrinol2000，11，： | 1 |
| 9 | CO2 enhanced coalbed methane production in the Netherlands显示文摘 | Hamelinck C N Faaij A P C Turkenburg W C F van Bergen Pagnier H J M Barzandji O H M Wolf K -H A A Ruijg G J | 2002 | Energy2002，27，7： | 1 |
| 10 | Clinical pharma- cokinetics of erlotinib in patients with solid tumors and exposure-safety relationship in patients with non-small cell lung cancer 显示文摘 | LU J F EPPLER S M WOLF J | 2006 | Clin Pharmacol Ther2006，374，80： | 1 |
| 11 | Reversibility of PRKAG2 glycogen-storage cardiomyopathy and electrophysiological manifestations显示文摘 | Wolf CM Arad M Ahmad F | 2008 | Circulation2008，117，2： | 1 |
| 12 | Conservation of methylation reprogramming in mammalian development:aberrant reprogramming in cloned embryos显示文摘 | Dean W Santos F Stojkovic M Zakhartchenko V Walter J Wolf E Reik W | 2001 | Proceedings of the National Academy of Sciences2001，98，13： | 1 |
| 13 | Treatment of painful osteopo- rotic compression and burst fractures using kyphoplasty : a prospec- tive observational design 显示文摘 | Stoffel M Wolf I Ringel F | 2007 | J Neurosurg Spine2007，6，4： | 1 |
| 14 | Impedance sensor technology for cell-based assays in the framework of a high-content screening system显示文摘 | Schwarzenberger T Wolf P Brischwein M Kleinhans R Demmel F Lechner A | 2011 | Physiol Meas2011，32，7： | 1 |
| 15 | Achieving sub-pixel geolocation accuracy in support of MODIS land science显示文摘 | Wolfe R E Nishihama M Fleig A J Kuyper J A Roy D P Storey J C and Patt F S | | 0，，1： | 1 |
| 16 | Maturation of bovine oocytes in the presence of leptin improves development and reduces apoptesis of in vitro-produced blastocysts显示文摘 | Boelhauve M Sinowatz F Wolf E | 2005 | Biol Reprod2005，73，4： | 1 |
| 17 | Caspase - 3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor- 45/inhibitor of caspase - activated DNase inactivation显示文摘 | Wolf BB Schuler M Echeverri F | 1999 | J Biol Chem1999，274，30： | 1 |
| 18 | Epidermal growth factor, vascular endothelial growth factor and progesterone promote placental development in rat whole-embryo culture显示文摘 | Jojovic M Wolf F Marigold U | 1998 | Annt Embryol1998，198，2： | 1 |
| 19 | Spatio-temporal convoiutional sparse auto-encoder for sequence classification显示文摘 | Baccouche M Mamalet F Wolf C | | 0，，5： | 1 |
| 20 | The American College of Rheumatology 1990 criteria for the classification of fibromyalgia:report of the multicenter criteria committee显示文摘 | WOLFE F SMYTHE H YUNUS M | 1990 | Arthritis & Rheumatism1990，33，2： | 1 |
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