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| 1 | Comparative effectiveness of i-SCAN^(TM) and high-definition white light characterizing small colonic polyps显示文摘AIM:To evaluate accuracy of in vivo diagnosis of adenomatous vs non-adenomatous polyps using i-SCAN digital chromoendoscopy compared with high-definition white light.METHODS:This is a single-center comparative effectiveness pilot study.Polyps(n = 103) from 75 averagerisk adult outpatients undergoing screening or surveillance colonoscopy between December 1,2010 and April 1,2011 were evaluated by two participating endoscopists in an academic outpatient endoscopy center.Polyps were evaluated both with high-definition white light and with i-SCAN to make an in vivo prediction of adenomatous vs non-adenomatous pathology.We determined diagnostic characteristics of i-SCAN and highdefinition white light,including sensitivity,specificity,and accuracy,with regards to identifying adenomatous vs non-adenomatous polyps.Histopathologic diagnosis was the gold standard comparison.RESULTS:One hundred and three small polyps,detected from forty-three patients,were included in the analysis.The average size of the polyps evaluated in the analysis was 3.7 mm(SD 1.3 mm,range 2 mm to 8 mm).Formal histopathology revealed that 54/103(52.4%) were adenomas,26/103(25.2%) were hyperplastic,and 23/103(22.3%) were other diagnoses include 'lymphoid aggregates','non-specific colitis,' and 'no pathologic diagnosis.' Overall,the combined accuracy of endoscopists for predicting adenomas was identical between i-SCAN(71.8%,95%CI:62.1%-80.3%) and high-definition white light(71.8%,95%CI:62.1%-80.3%).However,the accuracy of each endoscopist differed substantially,where endoscopist A demonstrated 63.0% overall accuracy(95%CI:50.9%-74.0%) as compared with endoscopist B demonstrating 93.3% overall accuracy(95%CI:77.9%-99.2%),irrespective of imaging modality.Neither endoscopist demonstrated a significant learning effect with i-SCAN during the study.Though endoscopist A increased accuracy using i-SCAN from 59%(95%CI:42.1%-74.4%) in the first half to 67.6%(95%CI:49.5%-82.6%) in the second half,and endoscopist B decreased accuracy using i-SCAN from 100%(95%CI:80.5%-100.0%) in the first half to 84.6%(95%CI:54.6%-98.1%) in the second half,neither of these differences were statistically significant.CONCLUSION:i-SCAN and high-definition white light had similar efficacy predicting polyp histology.Endoscopist training likely plays a critical role in diagnostic test characteristics and deserves further study. | Johanna L Chan Li Lin Michael Feiler Andrew I Wolf Diana M Cardona Ziad F Gellad | 2012 | World Journal of Gastroenterology2012，18，41： | 3 |
| 2 | Health services for children in western Europe 显示文摘 | Wolfe I Thompson M Gill P | 2013 | Lancet2013，381，9873： | 1 |
| 3 | Genome of the extremely radiation-resistant bacterium Deinococcus radiodurans viewed from the perspective of comparative genomics显示文摘 | Makarova K S Aravind L Wolf Y I Tatusov R L Minton K W Koonin E V Daly M J | 2001 | Microbiology and Molecular Biology Reviews2001，65，1： | 1 |
| 4 | Dissociation of cognitive and emotional empathy in Adults with Asperger syndrome: Using the Multifaceted Empathy Test (MET)显示文摘 | Dziobek I Rogers K Fleck S Bahnemann M Heekeren H Wolf O Convit A | 2008 | Journal of Autism and Developmental Disorders2008，38，： | 1 |
| 5 | Rates of nucleotide substitution vary greatly among plant mitochondrial,chloroplast,and nuclear DNAs显示文摘 | WOLFE K H L I W H SHARP P M | 1989 | Proc Natl Acad Sci1989，29，： | 1 |
| 6 | Finite group elements where no irreducible character vanishes显示文摘 | Isaacs I M Navarro G Wolf T R | 1999 | J Algebra1999，222，： | 1 |
| 7 | Heterogeneity of DM1 kinase repeat expansion in different fetal tissues and further expansion during cell proliferation in vitro:evidence for a casual involvement of methyl-directed DNA mismatch repair in triplet repeat stability显示文摘 | Kennerkencht I Wolf M | 1995 | Hum Mol Genet1995，4，： | 1 |
| 8 | Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha,macrophage inflammatory protein-1 beta,and SLC that are expressed in human breast cancer显示文摘 | Wolf M Clark-Lewis I Buri C | 2003 | Am J Pathol2003，162，： | 1 |
| 9 | Treatment of painful osteopo- rotic compression and burst fractures using kyphoplasty : a prospec- tive observational design 显示文摘 | Stoffel M Wolf I Ringel F | 2007 | J Neurosurg Spine2007，6，4： | 1 |
| 10 | Microchip-based purification of DNA from biological samples显示文摘 | Breadmore M C Wolfe K A Arcibal I G | 2003 | Analyt ical Chemistry2003，75，： | 1 |
| 11 | Microchip based purification of DNA from biological samples显示文摘 | Breadmore M C Wolfe K A Arcibal I G | 2003 | Analytical Chemistry2003，75，： | 1 |
| 12 | Specifically cleaves the chemokines macrophage inftammatory protein-1 alpha,macrophage inflammatory protein-1 beta,and SLC that are expressed in human breast cancer显示文摘 | Wolf M Clark-lewis I Buri C | 2003 | Am J Pathol2003，162，4： | 1 |
| 13 | Functional imaging of neurocognitive dysfunction in attention deficit hyperactivity disonder显示文摘 | WOLF I TOST H RUF M | 2005 | Radiologe2005，45，2： | 1 |
| 14 | Intrahospital transport of critical- ly ill ventilated patients: a risk factor for ventilator-associated pneu- monia-a matched cohort study 显示文摘 | Bercault N Wolf M Runge I | 2005 | Crit Care Med2005，33，11： | 1 |
| 15 | An untypeable Shigella flexneri strain associated with an outbreak in Califormia显示文摘 | TREVEJO R T ABBOIT S L WOLFE M I | 1999 | J Clin Microbiol1999，37，： | 1 |
| 16 | Comparison and evaluation of methods for liver segmentation from CT datasets显示文摘 | Heimann T van Ginneken B Styner MA Arzhaeva Y Aurich V Bauer C Beck A Becket C Beichel R Bekes G Bello F Binnig G Bischof H Bornik A Cashman PM Chi Y Cordova A Dawant BM Fidrich M Furst JD Furukawa D Grenacher L Hornegger J Kainmuller D Kitney RI Kobatake H Lamecker H Lange T Lee J Lennon B Li R Li S Meinzer HP Nemeth G Raicu DS Rau AM van Rikxoort EM Rousson M Rusko L Saddi KA Schmidt G Seghers D Shimizu A Slagmolen P Sorantin E Soza G Susomboon R Waite JM Wimmer A Wolf I | 2009 | IEEE Transactions on Medical Imaging2009，28，8： | 1 |
| 17 | A disinte- grin and metalloprotease 10 is a novel mediator of vascular endothelial growth factor-induced endothelial cell function in angiogenesis and is associated with atherosclerosis 显示文摘 | Donners M M Wolfs I M Olieslagers S | 2010 | Arterioscler Thromb Vasc Biol2010，30，11： | 1 |
| 18 | Epithelioid sarcoma with angiomatoid features: report of an unusual case arising in an elderly patient within a burn scar 显示文摘 | Kaddu S Wolf I Horn M | 2008 | Cutan Pathol2008，35，3： | 1 |
| 19 | Microchip-based purification of DNA from biological samples显示文摘 | WOLFE K A ARCIBAL I G | 2003 | Anal Chem2003，75，： | 1 |
| 20 | Soft tissue navigation for laparoscopic prostatectomy:E-valuation of camera pose estimation for enhanced visualization in Medical Imaging显示文摘 | Baumhauer M Simpfendoerfer T Wolf I | 2011 | Journal of Endocrinology2011，，12： | 1 |
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