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| 1 | Intracellular signaling mechanisms regulating the activation of human eosinophils by the novel Th2 cytokine IL-33:implications for allergic inflammation显示文摘The novel interleukin(IL)-1 family cytokine IL-33 has been shown to activate T helper 2(Th2)lymphocytes,mast cells and basophils to produce an array of proinflammatory cytokines,as well as to mediate blood eosinophilia,IgE secretion and hypertrophy of airway epithelium in mice.In the present study,we characterized the activation of human eosinophils by IL-33,and investigated the underlying intracellular signaling mechanisms.IL-33 markedly enhanced eosinophil survival and upregulated cell surface expression of the adhesion molecule intercellular adhesion molecule(ICAM)-1 on eosinophils,but it suppressed that of ICAM-3 and L-selectin.In addition,IL-33 mediates significant release of the proinflammatory cytokine IL-6 and the chemokines CXCL8 and CCL2.We found that IL33-mediated enhancement of survival,induction of adhesion molecules,and release of cytokines and chemokines were differentially regulated by activation of the nuclear factor(NF)-KB,p38 mitogen-activated protein kinase(MAPK)and extracellular signal-regulated kinase(ERK)pathways.Furthermore,we compared the above IL-33 activities with two structurally and functionally related cytokines,IL-1 B and IL-18.IL-1β,but not IL-18,markedly upregulated cell surface expression of ICAM-1.IL-1βand IL-18 also significantly enhanced eosinophil survival,and induced the release of IL-6 and chemokines CXCL8 and CCL2 via the activation of the NF-κB,p38 MAPK and ERK pathways.Synergistic efects on the release of IL-6 were also observed in combined treatment withIL-1B,IL-18 and IL-33.Taken together,our findings provide insight into IL-33-mediated activation of eosinophils via differential intracellular signaling cascades in the immunopathogenesis of allergic inflammation. | Joyce YS Chow Chun K Wong Phyllis FY Cheung Christopher WK Lam | 2010 | Cellular & Molecular Immunology2010，7，1： | 22 |
| 2 | STIs and HIV among men having sex with men in china:a ticking time bomb显示文摘 | Wong FY Huang ZJ Wang W | 2009 | AIDS Educ Pre2009，21，： | 1 |
| 3 | Factors influencing the prenatal detection of structural congenital heart diseases显示文摘 | Wong SF Chan FY Cincotta RB | 2003 | Ultrasound Obste Gynecol2003，21，1： | 1 |
| 4 | STIs and HIV among men having sex with men in China: a ticking time bomb? 显示文摘 | Wong FY Huang ZJ Wang W | 2009 | AIDS Educ Prev2009，21，5： | 1 |
| 5 | Incidence of common re- spiratory viral infections related to climate factors in hospital- ized children in Hong Kong 显示文摘 | Tang JW Lai FY Wong F | 2010 | Epidemiol Infect2010，138，2： | 1 |
| 6 | STIs and HIV among men having sex with men in Chian: a ticking time bomb 显示文摘 | Wong FY Huang ZJ Wang W | 2009 | AIDS Educ Prey2009，12，5： | 1 |
| 7 | Incidence of common respiratory viral infections related to climate factors in hospitalized children in Hong Kong显示文摘 | Tang JW Lai FY Wong F | 2010 | Epidemiol Infect2010，138，2： | 1 |
| 8 | Preclinical antitumor activity of BMS-599626,a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling显示文摘 | Wong TW Lee FY Yu C | 2006 | Clin Cancer Res2006，12，20： | 1 |
| 9 | Incidence of common respiratory viral infections related to climate factors in hospitalized children in Hong- Kong 显示文摘 | Tang JW Lai FY Wong F | 2010 | Epidemiol Infect2010，138，2： | 1 |
| 10 | STIs and HIV amongmen having sex with men in China:a ticking time bomb显示文摘 | Wong FY Huang ZJ Wang W | 2009 | AIDS Educ Prev2009，12，5： | 1 |
| 11 | STIs and HIV among menhaving sex with men in China:a ticking time bomb?显示文摘 | Wong FY Huang ZJ Wang W | 2009 | AIDSEduc Prev2009，12，5： | 1 |
| 12 | Cerebral vascular regulation and brain injury in preterm infants 显示文摘 | BREW N WALKER D WONG FY | 2014 | Am J Physiol Regul Integr Comp Phvsiol2014，306，11： | 1 |
| 13 | Endoscopic submucosal dissection vs laparoscopic colorectal resection for early colorectal epithelial neoplasia显示文摘AIM: To compare the short term outcome of endoscopic submucosal dissection(ESD) with that of laparoscopic colorectal resection(LC) for the treatment of early colorectal epithelial neoplasms that are not amenable to conventional endoscopic removal. METHODS: This was a retrospective cohort study. The clinical data of all consecutive patients who underwent ESD for endoscopically assessed benign lesions that were larger than 2 cm in diameter from 2009 to 2013 were collected. These patients were compared with a cohort of controls who underwent LC from 2005 to 2013. Lesions that were proven to be malignant by initial endoscopic biopsies were excluded. Mid and lower rectal lesions were not included because total mesorectal excision, which bears a more complicated postoperative course, is not indicated for lesions without histological proof of malignancy. Both ESD and LC were performed by the same surgical unit with a standardized technique. The patients were managed according to a standard protocol, and they were closely monitored for complications after the procedures. All hospital records were reviewed, and the following data were compared between the ESD and LC groups: patient demographics, size and location of the lesions, procedure time, shortterm clinical outcomes and pathology results. RESULTS: From 2005 to 2013, 65 patients who underwent ESD and 55 patients who underwent LC were included in this study. The two groups were similar in terms of sex(P = 0.41) and American Society of Anesthesiologist class(P = 0.58), although patients in the ESD group were slightly older(68.6 ± 9.4 vs 64.6 ± 9.9, P = 0.03). ESD could be accomplished with a shorter procedure time(113 ± 66 min vs 153 ± 43 min, P < 0.01) for lesions of comparable size(3.0 ± 1.2 cm vs 3.4 ± 1.4 cm, P = 0.22) and location(colon/rectum:59/6 vs colon/rectum: 52/3, P = 0.43). ESD appeared to be associated with a lower short-term complication rate, but the difference did not reach statistical significance(10.8% vs 23.6%, P = 0.06). In the LC arm, a total of 22 complications occurred in 13 patients. A total of 7 complications occurred in the ESD arm, including 5 perforations and 2 episodes of bleeding. All perforations were observed during the procedure and were successfully managed by endoscopic clipping without emergency surgical intervention. Patients in the ESD arm had a faster recovery than patients in the LC arm, which included shorter time to resume normal diet(2 d vs 4 d, P = 0.01) and a shorter hospital stay(3 d vs 6 d, P < 0.01). CONCLUSION: ESD showed better short-term clinical outcomes in this study. Further prospective randomized studies will be required to evaluate the efficacy and superiority of colorectal ESD over LC. | Sophie SF Hon Simon SM Ng Tiffany CL Wong Philip WY Chiu Tony WC Mak WW Leung Janet FY Lee | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，17： | 1 |
| 14 | Use of umbilical artery Doppler velocimetry in the monitoring of pregnancy in women with pre-existing diabetes显示文摘 | Wong SF Chan FY Cincotta RB | 2003 | Aust N Z J Ob- stet Gynecol2003，43，4： | 1 |
| 15 | HIV seroprevalence, risk behaviors,and cognitive factors amongAsian and Pacific Islander Amenrican men who have sex with men: a summaru and critique of cepirical studies and methodological issues显示文摘 | Nemoto T Wong FY Ching A | 1998 | AIDS Education and Prevention1998，10，3： | 1 |
| 16 | An improved fast algorithm for the restora- tion of image based on chain codes description显示文摘 | Shih FY Wong WT | 1994 | Graphical Models and Image Processing1994，5614，： | 1 |
| 17 | Disparities and risks of sexually transmissible infections among men who have sex with men in China:a meta-analysis and data synthesis显示文摘 | Chow EP Tucker JD Wong FY | 2014 | PLoS One2014，9，89： | 1 |
| 18 | STIs and HIV among men having sex with men in China:a ticking time bomb显示文摘 | Wong FY Huang Z J Wang W | | 0，，05： | 1 |
| 19 | STIs and H1V among men who having sex with men in China: a ticking time bomb 显示文摘 | Wong FY Huang ZJ Wang W | 2009 | AIDS Educ Prev2009，12，5： | 1 |
| 20 | Cardiac function in fetuses of poorly-controlled pre-gestational diabetic pregnancies-a pilot study显示文摘 | Wong SF Chan FY Cincotta RB | 2003 | Gynecol Obstet Invest2003，56，2： | 1 |
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