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| 1 | Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers显示文摘Gastric cancer and liver cancer are among the most common malignancies and the leading causes of death worldwide,due to late detection and high recurrence rates.Today,these cancers have a heavy socioeconomic burden,for which a full understanding of their pathophysiological features is warranted to search for promising biomarkers and therapeutic targets.Osteopontin (OPN) is overexpressed in most patients with gastric and liver cancers.Over the past decade,emerging evidence has revealed a correlation of OPN level and clinicopathological features and prognosis in gastric and liver cancers,indicating its potential as an independent prognostic indicator in such patients.Functional studies have verified the potential of OPN knockdown as a therapeutic approach in vitro and in vivo .Furthermore,OPN mediates multifaceted roles in the interaction between cancer cells and the tumor microenvironment,in which many details need further exploration.OPN signaling results in various functions,including prevention of apoptosis,modulation of angiogenesis,malfunction of tumor-associated macrophages,degradation of extracellular matrix,activation of phosphoinositide 3-kinase-Akt and nuclear factor-κB pathways,which lead to tumor formation and progression,particularly in gastric and liver cancers.This editorial aims to review recent findings on alteration in OPN expression and its clinicopathological associations with tumor progression,its potential as a therapeutic target,and putative mechanisms in gastric and liver cancers.Better understanding of the implications of OPN in tumorigenesis might facilitate development of therapeutic regimens to benefit patients with these deadly malignancies. | Dong-Xing Cao Zhi-Jie Li Xiao-Ou Jiang Yick Liang Lum Ester Khin Nikki P Lee Guo-Hao Wu John M Luk | 2012 | World Journal of Gastroenterology2012，18，30： | 29 |
| 2 | 代谢健康的肥胖和腹型肥胖与高血压风险增加相关显示文摘代谢健康型肥胖是指具有正常代谢特征的肥胖人群。研究者在中国农村地区队列研究(the rural Chinese cohort study)的成年人中,探究了代谢健康型肥胖与高血压风险的关系。这项前瞻性队列研究纳入中国成人9137名,在基线时(2007-2008年)无高血压、2型糖尿病或血脂异常,在2013-2014年进行随访。 | 周卫(译) 袁源(审校) Zhao Y Qin P Sun HH Liu Y Liu D Zhou Q Guo C Li Q Tian G Wu X Hu D Sun X Zhang M | 2020 | 中华高血压杂志2020，28，9： | 7 |
| 3 | 婚姻状况与心血管病风险的关系:系统评价和荟萃分析显示文摘虽然80%的未来心血管病风险可以从已知的心血管危险因素预测,如老年、男性、高血压、高血脂症、吸烟和糖尿病,但其余20%风险的决定因素仍不明确。婚姻对健康和死亡的益处已经在不同种族的两性中得到证实,并且与各种社会人口学特征无关。 | Wong CW Kwok CS Narain A Gulati M Mihalidou AS Wu P Alasnag M Myint PK Mamas MA 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 5 |
| 4 | p63免疫组化染色在腺样囊性癌和基底样鳞状细胞癌鉴别诊断中的价值显示文摘 | Emanuel P Wang B Wu M 黄文斌(摘译) 陈洁宇(摘译) 周晓军(审校) | 2005 | 临床与实验病理学杂志2005，21，5： | 5 |
| 5 | 油炸食品与心血管病风险和全因死亡率的关系:观察性研究的荟萃分析显示文摘研究者进行了一项荟萃分析,包括剂量反应分析,以定量确定油炸食品摄入与普通成年人群心血管病风险和全因死亡率之间的关系。方法:研究者在PubMed、EMBASE和Web of Science上检索2020年4月11日之前的所有文章。应用随机效应模型估计总的相对危险度(relative risks,RR)和95%CI。结果:与最低油炸食品摄入量相比,最高摄入量者主要心血管事件的总RR(95%CI)=1.28(1.15~1.43),n=17,I^(2)=82.0%,其中前瞻性研究:1.24(1.12~1.38),n=13,I^(2)=75.7%. | 刘青(译) 练桂丽(审校) Qin P Zhang M Han M Liu D Luo X Xu L Zeng Y Chen Q Wang T Chen X Zhou Q Li Q Qie R Wu X Li Y Zhang Y Wu Y Hu D Hu F | 2021 | 中华高血压杂志2021，29，2： | 3 |
| 6 | 有机小分子发光材料与聚合物发光材料在大气存放条件下的稳定性对比研究显示文摘分别采用紫外光电子能谱 (UPS)、X光电子能谱 (XPS)、原子力显微镜 (AFM )、以及光致发光光谱(PL)等方法对在大气存放条件下的 8 羟基喹啉铝 (Alq)薄膜和聚 ( 9,9 二辛烷基芴 ) (PFO)薄膜的电子结构、表面形貌以及发光特性进行了对比研究。研究结果表明 ,PFO的电子结构、表面形貌以及发光特性受外界气氛影响极小 ,是一种非常稳定的聚合物发光材料。这为聚合物发光器件的稳定性提供了有利的条件。 | 徐正 廖良生 李振声 李述汤 Inbase karan M Woo E P Wu W W | 2000 | 发光学报2000，21，3： | 3 |
| 7 | Preparation and hybridization analysis of DNA/RNA from E. coli on microfabricated bioelectronic chips显示文摘 | Cheng Jing Sheldon E L Wu Lei Uribe A Gerrue L O Carrino J Heller M J O'Connell J P | | 0，，： | 2 |
| 8 | MODIFIED MELT TEXTURING PROCESS FOR YBCO BASED ON THE POLYTHERMIC SECTION YO1.5-BA0.4CU0.6O IN THE Y-BA-CU-O PHASE DIAGRAM AT 0.21 BAR OXYGEN PRESSURE显示文摘 | Krabbes G Schatzle P Bieger W Wiesner U Stover G Wu M Strasser T Litzkendorf D Fischer K Gornert P | | 0，，： | 2 |
| 9 | Durable Asphalt Pavements Are Self Healing显示文摘The traffic volume and the number of heavy vehicles are growing continuously. Considering the continuous traffic flow and the limited time available for road maintenance,it is very important to design a durable pavement system. Asphalt pavements with a healing capability are believed to be very useful since they can extend the pavement service life thanks to rest periods and hot summers. In order to design durable asphalt pavements,research in understanding and upgrading the self-healing capability of bituminous materials in time is of major importance. The self healing capability of bituminous mastic was evaluated in this research with a direct tension healing test. In the test program,different healing times,crack status and modifications were applied. The results indicate that elastic recovery and flow capacity are important factors for the self healing capability of bituminous materials at different crack phases as simulated with the direct tension test. | QIU J VAN DE VEN M F C WU S P YU J Y MOLENAAR A A A | 2010 | 武汉理工大学学报2010，32，17： | 2 |
| 10 | 查看详情显示文摘 | Wu A Vilarinho P M Salvado I M M | | 0，，： | 2 |
| 11 | An image-guided mobile robotic welding system for SMAW repair processes 显示文摘 | Tung P C Wu M C Hwang Y R | 2004 | Internaotional Journal of Machine Tools & Manufacture2004，44，： | 1 |
| 12 | New directions in management accounting research 显示文摘 | Atkinson A A Balakrishnan P B Cote J M Grout T M Roberts H Ulan E Wu A | | Journal of Management Accounting Research0，997，： | 1 |
| 13 | On pre-straining and the evolution of material anisotropy in sheet metals显示文摘 | WU P D MACEWEN S R LLOYD D J JAIN M TUGCU P NEALE K W | 2005 | Int J Plasticity2005，21，： | 1 |
| 14 | , Efficient isolation of microspores and the production of mtcrospore-de-rlved embryos from Brawca napus显示文摘 | Swanson E B Coumans M P Wu S C | 1987 | Plant Cell Rep1987，6，： | 1 |
| 15 | Microcontact printing of catalytic nanoparticles for selective electroless deposition of metals on nonplanar polymeric substrates 显示文摘 | Ng W K Wu L Moran P M | 2002 | Appl Phys Lett2002，81，16： | 1 |
| 16 | P6 aeupoint injec- tion reduce postoperative nausea and vomiting显示文摘 | Shyr M H Hsu J C Wu Y W Hui Y L Tan P P | 1990 | Ma Tsui Hsueh Tsa Chi Anaesthesiol Sinica1990，28，6： | 1 |
| 17 | High resolution melting analysis of almond SNPs derived from ESTs显示文摘 | Wu S B Hunt P Sedgley M | 2008 | Theor Appl Genet2008，118，1： | 1 |
| 18 | Comparision ofnuclear accumulation of p53 protein with mutations inthe p53 gene of human breast cancer tissues显示文摘 | Fan P Wu Z Y Zha X M | 2001 | JNanjing Med Univ2001，15，2： | 1 |
| 19 | Energy Gradient Line For Drip Irrigation Laterals显示文摘 | Wu I P Gitlin H M | 1975 | Journal of The Irrigation and Drainage Division ASCE1975，101，4： | 1 |
| 20 | An S…S contact assembled tetranuclear copper( I ) complex with sulfer rich ligand, 4, 5-ethylenedithio-1,3-dithiole-2-thione 显示文摘 | DaiJ Munakata M Wu L P | 1997 | Inorg Chimica Acta1997，258，： | 1 |
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