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| 1 | Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress显示文摘癌症房间以他们的能力著名给新陈代谢的小径换新电线在各种各样的压力条件下面支持幸存和增长。尽管在肝生产了,酉同类身体没在正常的成年的肝房间被消费。我们这里发现酉同类分解代谢或 ketolysis 在 hepatocellular 被重新激活在营养剥夺条件下面的癌(HCC ) 房间。机械学地, 3-oxoacid CoA-transferase 1 (OXCT1 ) ,其表情在正常的成年的肝纸巾被压制的限制率的 ketolytic 酶,被浆液重新导致被触发饥饿的 mTORC2-AKT-SP1 在 HCC 房间发信号。而且,我们观察到在 HCC 的那提高的 ketolysis 为 AMPK 激活的压抑是批评的并且保护 HCC 房间免受过多的 autophagy 的伤害,从而提高肿瘤生长。重要地,临床的 HCC 样品的分析表明那增加的 OXCT1 表情预言更高耐心的死亡。一起拿,我们这里揭开剥夺营养的 HCC 房间为精力由采用酉同类身体的新奇新陈代谢的改编供应和癌症前进。 | De Huang Tingting Li Lin Wang Long Zhang Ronghui Yan Kui Li Songge Xing Gongwei Wu Lan Hu Weidong Jia Sheng-Cai Lin Chi V Dang Libing Song Ping Gao Huafeng Zhang | 2016 | Cell Research2016，26，10： | 27 |
| 2 | STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer显示文摘Accumulated evidences have demonstrated that signal transducer and activator of transcription 3(STAT3)is a critical link between inflammation and cancer.Multiple studies have indicated that persistent activation of STAT3 in epithelial/tumor cells in inflammation-associated colorectal cancer(CRC)is associated with sphingosine-1-phosphate(S1P)receptor signaling.In inflammatory response whereby interleukin(IL)-6 production is abundant,STAT3-mediated pathways were found to promote the activation of sphingosine kinases(SphK1and SphK2)leading to the production of S1P.Reciprocally,S1P encourages the activation of STAT3 through a positive autocrine-loop signaling.The crosstalk between IL-6,STAT3 and sphingolipid regulated pathways may play an essential role in tumorigenesis and tumor progression in inflamed intestines.Therapeutics targeting both STAT3 and sphingolipid are therefore likely to contribute novel and more effective therapeutic strategies against inflammation-associated CRC. | Andrew V Nguyen Yuan-Yuan Wu Elaine Y Lin | 2014 | World Journal of Gastroenterology2014，20，30： | 7 |
| 3 | 深部俯冲板片三维构造重建及其几何学、运动学研究——以汤加—克马德克地区俯冲板片为例显示文摘西南太平洋板块与澳大利亚板块之间的汤加-克马德克俯冲带,是研究地球动力学最重要的区域之一.本文研究根据MIT~P08地震数据,结合板块构造边界、地震活动分布、海岸地形数据等,基于GOCAD软件平台建立三维地震层析成像,对西南太平洋板块的汤加-克马德克俯冲板片进行三维解释.地震层析成像显示汤加-斐济地区地幔至少存在三个“高速”异常体.早期汤加-克马德克俯冲板片穿过地幔转换带,并进入下地幔,最大深度达1600km.三维构造模型揭示了汤加克马德克板片在深度600~800km处存在断折形变,该俯冲板片去褶皱恢复后,测量其俯冲的最大位移达2600km.汤加-克马德克板片开始快速俯冲的时间至少在30Ma之前,平均移动速率约为68~104mrn/a.俯冲板片三维构造重建和恢复,可以有效揭示俯冲板片几何学、运动学,为研究深源地震成因、地球深部变化过程和动力学机制提供约束. | 鲁人齐 John Suppe 何登发 Jonny Wu Ravi V S Kanda 刘波 陈于高 | 2013 | 地球物理学报2013，56，11： | 3 |
| 4 | 全颗粒饲料对奶牛生产性能的影响显示文摘饲料中的中性洗涤纤维(NDF)含量和饲料颗粒直径是影响瘤胃功能的重要因素。试验评估了以颗粒饲料为主的奶牛瘤胃健康情况、NDF消化率和生产性能。选取8头荷斯坦母牛(336±30 d,体重346±35 kg),随机分配到交叉重复试验组中,奶牛安置于牛栏,自由采食。试验期为3周,前两周是适应期,最后一周为数据收集期。各组饲粮原料相同,但物理形式不同,分为全混合日粮(TMR)和颗粒料(直径=8 mm)。两组间物理有效NDF(pe NDF)不同,TMR组为39.8%,颗粒料组为11.8%。在试验过程中,干物质采食量(DMI)、饮水量、瘤胃反刍时间、瘤胃温度和pH情况均记录。3周后收集粪样,确定潜在的可消化NDF总消化率(pdNDF)。每阶段结束后计算平均日增重和饲料转化率。颗粒料组的DMI、DMI/体重和饮水量更高。而两组间平均日增重和饲料转化率无显著差异。颗粒料组的瘤胃反刍时间为241 min·d-1低于TMR组的507 min·d-1。饲料的不同物理外形对瘤胃温度、瘤胃pH无显著影响。TMR组的pdNDF总消化率为90.25%高于颗粒料组的86.82%。试验结果表明,动物易接受完整的颗粒饲料,DMI较高,且反刍时间减少,但瘤胃pH无显著变化。TMR组的pdNDF消化率显著增加。尽管两组奶牛在DMI和纤维消化方面表现不同,但总体表现相似,两组饲料的保存时间与其物理形式有关。在短期内,提供能满足NDF需求的完全颗粒饲料可改善瘤胃健康状况和动物生产性能,而较长时间的数据则需要进一步试验。 | Wang J Yang M Cao M Lin Y Che L Q Duraipandiyan V Al-Dhabi N A Fang Z F Xu S Y Feng B Liu G Wu D Bonfante E Palmonari A Mammi L Canestrari G Fustini M Formigoni A | 2016 | 饲料博览2016，0，12： | 2 |
| 5 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5h96o6pk0nfxvn6vqv.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 6 | International experts consensus guidelines on robotic liver resection in 2023显示文摘The robotic liver resection(RLR)has been increasingly applied in recent years and its benefits shown in some aspects owing to the technical advancement of robotic surgical system,however,controversies still exist.Based on the foundation of the previous consensus statement,this new consensus document aimed to update clinical recommendations and provide guidance to improve the outcomes of RLR clinical practice.The guideline steering group and guideline expert group were formed by 29 international experts of liver surgery and evidence-based medicine(EBM).Relevant literature was reviewed and analyzed by the evidence evaluation group.According to the WHO Handbook for Guideline Development,the Guidance Principles of Development and Amendment of the Guidelines for Clinical Diagnosis and Treatment in China 2022,a total of 14 recommendations were generated.Among them were 8 recommendations formulated by the GRADE method,and the remaining 6 recommendations were formulated based on literature review and experts’opinion due to insufficient EBM results.This international experts consensus guideline offered guidance for the safe and effective clinical practice and the research direction of RLR in future. | Rong Liu Mohammed Abu Hilal Go Wakabayashi Ho-Seong Han Chinnusamy Palanivelu Ugo Boggi Thilo Hackert Hong-Jin Kim Xiao-Ying Wang Ming-Gen Hu Gi Hong Choi Fabrizio Panaro Jin He Mikhail Efanov Xiao-Yu Yin Roland S Croner Yu-Man Fong Ji-Ye Zhu Zheng Wu Chuan-Dong Sun Jae Hoon Lee Marco V Marino Iyer Shridhar Ganpati Peng Zhu Zi-Zheng Wang Ke-Hu Yang Jia Fan Xiao-Ping Chen Wan Yee Lau | 2023 | World Journal of Gastroenterology2023，29，32： | 2 |
| 7 | Tensile strain-hardening behavior of PVA-ECC 显示文摘 | Li V C Wang Shuxin Wu C | 2001 | Materials Journal2001，98，6： | 1 |
| 8 | Thermal processing enhances the nutritional value of tomatoes by increasing total antioxidant activity 显示文摘 | Dewanto V Wu X Adom K K | 2002 | J Agric Food Chem2002，50，10： | 1 |
| 9 | Growth,feed conversion,protein utilization,and sensory evaluation of nile tilapia fed diets containing corn gluten meal,full-fat soy,and synthetic amino acids显示文摘 | Wu Y V Rosati R Warner K | 2000 | J Aquat Food Prod Technol2000，9，： | 1 |
| 10 | A simple method for cryopreservation of Ginkgo biloba callus显示文摘 | Elena V P Lee E J Wu C H | 2009 | Plant Cell Tissue and Organ Culture2009，97，3： | 1 |
| 11 | Combining bioinformatics and phylogenetics to identify large sets of single-copy orthologous genes (COSⅡ) for comparative, evolutionary and systematic studies: a test case in the euasterid plant clade显示文摘 | Wu F N Mueller L A Crouzillat D Petiard V Tanksley S D | 2006 | Genetics2006，174，： | 1 |
| 12 | Role of the N terminus in RNase a homologues:differences in catalytic activity,ribonuclease inhibitor interaction and cytotoxieity显示文摘 | Boix E Wu Y N Vasandani V M | 1996 | J Mol Biol1996，257，： | 1 |
| 13 | Robustness measures and robust scheduling for job shops 显示文摘 | V J Leon S D Wu H Storer | 1993 | IIE Transactions1993，26，5： | 1 |
| 14 | Computer modelling and tooling design for near net shaped components using hot isostatic pressing 显示文摘 | YUAN W X MEI J SAMAROV V SELIVERSTOV D WU X | 2007 | Journal of Materials Processing Technology2007，182，123： | 1 |
| 15 | Generalization of the phase-screen approximation for the scattering of acoustic waves显示文摘 | DE HOOP M V LE ROUSSEAU J H WU R S | 2000 | Wave Motion2000，，31： | 1 |
| 16 | Bilater- al aldosterone-producing adenomas= differentiation from bilateral adrenal hyperplasia显示文摘 | WU V C CHUEH S C CHANG H W | 2008 | Q J M2008，101，： | 1 |
| 17 | Microstructure and hydrogenation behavior of ball-milled and melt-spun Mg-10Ni-2Mm alloys 显示文摘 | WU Y HAN W ZttOU S X LOTOTSKY M V SOLBERG J K YARTYS V A | 2008 | J Alloys Compd2008，466，12： | 1 |
| 18 | Methylation of Naphthalene on MTW-Type Zeolites: Influence of Template Origin and Substitution of Al by Ga 显示文摘 | Wu Wei Wu Weiguo Kikhtyanin O V | 2010 | Appl Catal A2010，375，2： | 1 |
| 19 | The Application of Ecological Principles to Urban and Urbanizing Landscapes显示文摘 | Zipperer W C Wu J Pouyat R V | | 0，，03： | 1 |
| 20 | Risk factors for nasal carriage of methicillin - resistant Staphylococcus anreus among pa- tients with end - stage renal disease in Taiwan 显示文摘 | WANG C Y WU V C WANG W J | 2012 | J Formos Med Assoc2012，111，1： | 1 |
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