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	题名	作者	年代	出处	被引量
1	Interleukin-6: a villain in the drama of pancreatic cancer development and progression显示文摘BACKGROUND: Pancreatic ductal adenocarcinoma(PDAC)is a devastating malignancy with a poor prognosis and little treatment options. The development and progression of the disease is fostered by inflammatory cells and cytokines. One of these cytokines is interleukin-6(IL-6), which plays an important role in a wide range of biologic activities.DATA SOURCES: A systematic search of PubMed was performed to identify relevant studies using key words such as interleukin-6,inflammatory cytokines, inflammation and pancreatic cancer or PDAC. Articles related to IL-6 and pancreatic cancer were systematically reviewed.RESULTS: IL-6 is elevated in the serum of pancreatic cancer patients and correlates with cachexia, advanced tumor stage and poor survival. Its expression is enhanced by hypoxia and proteins involved in pancreatic cancer development like Kras,mesothelin or ZIP4. IL-6 in turn contributes to the generation of a pro-tumorigenic microenvironment and is probably involved in angiogenesis and metastasis. In experimental mouse models of PDAC, IL-6 was important for the development and progression of precursor lesions.CONCLUSION: IL-6 emerges as a key player in pancreatic cancer development and progression, and hence should be considered as a new therapeutic target.	Reinhild Holmer Freya A Goumas Georg H Waetzig Stefan Rose-John Holger Kalthoff	2014	Hepatobiliary & Pancreatic Diseases International2014，13，4：	16
2	The JNK and p38 signal transduction following axotomy显示文摘	Herdegen T Waetzig V		0，，：	1
3	p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease显示文摘	Waetzig G H Seegert D Rosenstiel P	2002	J Immunol2002，168，10：	1
4	p38 mitogen-activa-ted protein kinase is activated and linked to TNF-alpha signaling ininflammatory bowel disease 显示文摘	Waetzig GH Seegert D Rosenstiel P	2002	J Immunol2002，168，10：	1
5	The IL-6/sIL-6R complex as a novel target for therapeutic approaches显示文摘	ROSE-JOHN S WAETZIG GH SCHELLER J	2007	Expert Opin Ther Targets2007，11，5：	1
6	MEKK1 controls neurite regrowth after experimental injury by balancing ERK1/2 and JNK2 signaling显示文摘	Waetzig V Herdegen T		0，，：	1
7	The IL-6/slL-6R com-plex as a novel target for therapeutic approaches显示文摘	Rose-John S Waetzig GH Scheller J	2007	Expert OpinTher Targets2007，11，5：	1
8	p38 mitogenactivated protein kinase is activated and linked to TNFalpha signaling in inflammatory bowel disease显示文摘	Waetzig GH Seegert D Rosenstiel P	2002	J Immunol2002，168，10：	1
9	AP-1 proteins in the adult brain:facts and fiction about effectors of neuroprotection and neurodegeneration显示文摘	Waetzig V	2001	Oncogene2001，20，19：	1
10	The bottleneck of JNK signaling:molecular and functional characteristics of MKK4 and MKK7显示文摘	Haeusgen W Herdegen T Waetzig V		0，，6：	1
11	Influence of the structure of MgO·nAl2O3 spinel lattices on transparent ceramics processing and properties 显示文摘	KRELL A WAETZIG K KLIMKE J	2012	J Eur Ceram Soc2012，32，28：	1
12	p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease显示文摘	Waetzig GH Seegert D Rosenstiel P	2002	J Immunol2002，168，10：	1
13	The IL-6/sIL- 6R complex as a novel target for therapeutic approaches 显示文摘	Rose John S Waetzig GH Schellcr J	2007	Expert Opin Ther Targets2007，11，5：	1
14	c-Jun N-terminal kinases trigger both degeneration and neurite outgrowth in primary hippocampal and cortical neurons显示文摘	Eminel S Roemer L Waetzig V	2008	J Neurochem2008，104，4：	1
15	Context-specific inhibition of JNKs: overcoming the dilemma of protection and damage 显示文摘	Waetzig V Herdegen T	2005	Trends Pharmacol Sci2005，26，9：	1
16	The bright side of JNKs- Multitalented mediators in neuronal sprouting,brain devel- opment and nerve fiber regeneration 显示文摘	Waetzig V Zhao Y Herdegen T	2006	Prog Neurobiol2006，80，2：	1
17	c-Jun N-terminal kinases mediate Fas-induced neurite regeneration in PC12 cells显示文摘	Waetzig V Loose K Haeusgen W	2008	Biochem Phamacol2008，76，11：	1
18	Changes in peptidyl-prolyl cis/trans isomerase activity and FK506 binding protein expression following neuroprotection by FK506 in the ischemic rat brain 显示文摘	Brecht S Schwarze K Waetzig V	2003	Neuroscience2003，120，4：	1
19	Concurrent protective and destructive signaling of JNK2 in neuroblastoma cells显示文摘	WAETZIG V WACKER U HAEUSGEN W	2009	Cell Signal2009，21，6：	1
20	AP- 1 proteins in the adult brain: Facts and fiction about effectors of neuroprotection and neurodegeneration 显示文摘	Herdegen T Waetzig V	2001	Oncogene2001，20，19：	1

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