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| 1 | WONCA研究论文摘要汇编——冠心病对阿尔茨海默病患者认知功能下降的影响:基层医疗中的前瞻性队列研究显示文摘背景动脉硬化性疾病增加痴呆的风险。由于二者有共同的病因和风险因素,冠心病(CHD)可以影响痴呆的病程。目的确定CHD是否加速了阿尔茨海默病的认知功能衰退,并讨论继发性心血管预防的潜在可能性,从而控制这种衰退。设计与场所基于德国6个城市的全科医生诊所开展前瞻性多中心队列研究。方法选取可能患有轻、中度阿尔茨海默病或混合型痴呆的患者〔n=118;年龄80~96岁,平均年龄(85.6±3.4)岁〕。根据家庭医师的诊断,评估CHD的存在。在以6个月为间隔的长达3年的家庭随访期间,采用简易精神状态检查量表(MMSE)和临床痴呆评定量表(CDR-So B)评估患者认知功能。并记录观察期内患者的死亡情况。结果 65例(55%)患者患CHD和/或心肌梗死后的心脏病。CHD的存在使得认知功能衰退加快约66%(由MMSE评分得出,P<0.05),认知功能能力下降约83%(由CDR-So B评分得出,P<0.05),但对存活率没有任何影响。结论研究表明,CHD对老年晚发性痴呆患者的认知功能衰退有显著影响。痴呆过程可能因此会受到心血管预防的积极影响,应该进一步证实该研究结论。 | BLECKWENN M KLEINEIDAM L WAGNER M 本刊编辑部 | 2017 | 中国全科医学2017，20，9： | 12 |
| 2 | Compared efficacy of preservation solutions on the outcome of liver transplantation:Meta-analysis显示文摘AIM To compare the effects of the four most commonly used preservation solutions on the outcome of liver transplantations.METHODS A systematic literature search was performed using MEDLINE, Scopus, EMBASE and the Cochrane Library databases up to January 31^(st), 2017. The inclusion criteria were comparative, randomized controlled trials(RCTs) for deceased donor liver(DDL) allografts with adult and pediatric donors using the gold standard University of Wisconsin(UW) solution or histidinetryptophan-ketoglutarate(HTK), Celsior(CS) and Institut Georges Lopez(IGL-1) solutions. Fifteen RCTs(1830 livers) were included; the primary outcomes were primary non-function(PNF) and one-year posttransplant graft survival(OGS-1). RESULTS All trials were homogenous with respect to donor and recipient characteristics. There was no statistical difference in the incidence of PNF with the use of UW, HTK, CS and IGL-1(RR = 0.02, 95%CI: 0.01-0.03, P = 0.356). Comparing OGS-1 also failed to reveal any difference between UW, HTK, CS and IGL-1(RR = 0.80, 95%CI: 0.80-0.80, P = 0.369). Two trials demonstrated higher PNF levels for UW in comparison with the HTK group, and individual studies described higher rates of biliary complications where HTK and CS were used compared to the UW and IGL-1 solutions. However, the meta-analysis of the data did not prove a statistically significant difference: the UW, CS, HTK and IGL-1 solutions were associated with nearly equivalent outcomes.CONCLUSION Alternative solutions for UW yield the same degree of safety and effectiveness for the preservation of DDLs, but further well-designed clinical trials are warranted. | Agnes Lilla Szilágyi Péter Mátrai Péter Hegyi Eszter Tuboly Daniella Pécz András Garami Margit Solymár Erika Pétervári Márta Balaskó Gábor Veres László Czopf Bastian Wobbe Dorottya Szabó Juliane Wagner Petra Hartmann | 2018 | World Journal of Gastroenterology2018，24，16： | 5 |
| 3 | The psychometric properties of the hospital survey on patient safety culture in Dutch hospitals显示文摘 | Smits M Christiaans-Dingelhoff l Wagner C | 2008 | BMC Health Serv Res2008，8，： | 1 |
| 4 | Microstructure development during extrusion in a wrought Mg-Zn-Zr alloy显示文摘 | SHAHZAD M WAGNER L | 2009 | Scripta Materialia2009，60，7： | 1 |
| 5 | Electrophoretic, solubility, and functional properties of commercial soy protein isolartes 显示文摘 | Arrese E L Sorgentini D A Wagner J R Anon M C | 1991 | Journal of Agricultural and Food Chemistry1991，39，： | 1 |
| 6 | Liver surgery in the era of tissue-preserving resections:early and late outcome in patients with primary and secondary hepatic tumors显示文摘 | Redaelli C A Wagner M Krahenbuhi L | 2002 | World J Surg2002，26，9： | 1 |
| 7 | 显示文摘 | Nelson J A Brant E L Wagner M J | 2003 | Chem Mater2003，15，： | 1 |
| 8 | Placental site trophoblastic tumor: human placental lactogen and preg- nancy-associated major basic protein as immunohistologic markers 显示文摘 | Rhoton-Vlasak A Wagner J M Rutgers J L | 1998 | numPalhol1998，29，3： | 1 |
| 9 | Phylogeny of dissimilatory sulfite reduetases supports an early origin of sulfate respiration 显示文摘 | Wagner M Roger A J Flax J L | 1998 | Journal of Bacteriology1998，180，11： | 1 |
| 10 | Empirical atomic sensitivity factors for quantitative analysis by electron spectroscopy for chemical analysis显示文摘 | Wagner C D Davis L E Zeller M V | 1981 | Surf Int Anal1981，3，5： | 1 |
| 11 | Myostatin mutation associated with gross muscle hypertrophy in a child显示文摘 | Schuelke M Wagner K R Stolz L E | 2004 | N Engl J Med2004，350，26： | 1 |
| 12 | Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcHlO ubiquitin conjugase in human carcinomas of diverse anatomic origin 显示文摘 | WAGNER K W SAPINOSO L M EL RIFAI W | 2004 | Oncogene2004，23，39： | 1 |
| 13 | Corrosion fatigue behavior of the high-strength magnesium alloy AZ80显示文摘 | HILPERT M WAGNER L | 2000 | Materials Engineering and Performance2000，9，4： | 1 |
| 14 | Colorado high altitude corona tests, part scope, tests, and instrumentation显示文摘 | Robertson L M Wagner C F Bliss T J | 1957 | AIEE Trans on PAS1957，96，6： | 1 |
| 15 | Persistence and Efficacy of Termiticides Used in Preconstruction Treatments to Soil in Mississippi显示文摘 | MULROONEY J E DAVIS M K WAGNER T L | 2006 | J Econ Entom2006，99，2： | 1 |
| 16 | Myostin mutation associated with gross muscle hypertrophy in a child显示文摘 | Schuelke M Wagner K Stolz L | 2004 | New Engl J Med2004，350，26： | 1 |
| 17 | Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma显示文摘 | Matthias L?hr Anne Hoffmeyer Jens-Christian Kr?ger Mathias Freund Johannes Hain Albrecht Holle Peter Karle Wolfram T Kn?fel Stefan Liebe Petra Müller Horst Nizze Matthias Renner Robert M Saller Thomas Wagner Karlheinz Hauenstein Walter H Günzburg Brian Sa | 2001 | The Lancet2001，，9268： | 1 |
| 18 | Comparison of the efficacy of inactivated combination and modified-live virus vaccines against challenge infection with neuropathogenic equine herpesvirus type 1(EHV-1)显示文摘 | Goodman L B Wagner B Flaminio M J | 2006 | Vaccine2006，24，17： | 1 |
| 19 | Myostatin mutation associated with gross muscle hypertrophy in a child 显示文摘 | Schuelke M Wagner K R Stolz L E | 2004 | Engl Med2004，350，： | 1 |
| 20 | High-glucose-triggered apoptosis in cultured endothelial cell显示文摘 | Parzer SM Wagner L Pettermann M | 1995 | Diabetes1995，44，： | 1 |
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