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| 1 | Calcium channel α2δ1 subunit as a novel biomarker for diagnosis of hepatocellular carcinoma显示文摘Objective:Hepatocellular carcinoma(HCC)is the fifth most common malignancy worldwide.The identification of new simple,inexpensive and highly accurate markers for HCC diagnosis and screening is needed.This case-control study evaluates the role of annexin A2 and voltage-gated calcium channelsα2δ1 subunit as serum biomarkers for HCC diagnosis.Methods:The study comprised three groups:group 1,50 patients with an initial diagnosis of HCC associated with chronic hepatitis C virus infection;group 2,25 patients diagnosed with chronic hepatitis C virus infection and cirrhosis without any evidence of HCC;and group 3,15 healthy controls.All participants were subjected to clinical and laboratory investigations,and radiological scanning.The serum levels of alpha-fetoprotein(AFP),annexin A2,and theα2δ1 subunit were evaluated by using ELISA technique.Results:The serum levels of annexin A2 significantly increased in patients with HCC(10.4±2.5 ng/m L;P<0.001)or with cirrhosis(9.31±1.8 ng/m L;P<0.001)comparing to that of healthy controls(0.296±0.09 ng/m L).However,there was no significant difference in serum annexin A2 levels in patients with HCC comparing to those with cirrhosis.Serumα2δ1 subunit significantly increased in patients with HCC(20.12±3.7 ng/m L)comparing to that in patients with cirrhosis(10.41±3.4 ng/m L,P<0.001)and healthy controls(10.2±2.9 ng/m L,P<0.001).Conclusions:The serumα2δ1 subunit may function as a new biomarker for HCC diagnosis.Conversely,serum annexin A2 has low diagnostic value as an HCC marker,especially in patients with underlying cirrhosis. | Sana Amhimmid Badr Maryan Waheeb Fahmi Manal Mahmoud Nomir Mamdouh Mohammad El-Shishtawy | 2018 | Cancer Biology & Medicine2018，15，1： | 2 |
| 2 | Streptococcal necrotizing fasciitis with toxic shock syndrome fol owing cervical adenitis显示文摘 | Waheeb S Salim M Yosef M | | 0，，09： | 1 |
| 3 | Bile duct injuries following laparoscopic cholecysteetomy: a clinical study 显示文摘 | WAHEEB R KUBATI A L | 2010 | Saudi J Gastroenterol2010，16，2： | 1 |
| 4 | Streptococcal necrotizing fasciitis with toxic shock syndrome following cervical adenitis显示文摘 | Waheeb S Salim M Yosef M | 2004 | Int J of Pediatr Otorhinolaryngol2004，68，： | 1 |
| 5 | Retinopathy in chronic hepatitis C patients during interferon treament with ribavirin显示文摘 | Lam WC Waheeb S Thai Q Heathcote J | 2001 | Br J Ophthalmol2001，85，10： | 1 |
| 6 | Retinopathy in chronic hepatitisC patients during interferon treatment with ribavirin显示文摘 | Jain K Lam WC Waheeb S | 2001 | Br JOphthalmol2001，85，10： | 1 |
| 7 | Adenosquamous cacrcinoma of the pancreas with an acantholytic pattern together with osteoclast-like and pleomorphic gaint cells显示文摘 | Waheeb S Chetty R | 2005 | J Clin Pathol2005，58，： | 1 |
| 8 | Clinical and histopathological spectrum of IgA nephropathy in Kuwait显示文摘 | Ghani AA Al Waheeb S Al Homoud E | 2011 | Ann Saudi Med2011，31，2： | 1 |
| 9 | Retinopathy in chronic hepatitis C patiens during interferon treatment with ribavirin显示文摘 | Jain K Lam WC Waheeb S | 2001 | Br J Ophthalmol2001，85，10： | 1 |
| 10 | Renal biopsy in patients with type 2 diabetes mellitus: indications and nature of the lesions显示文摘 | Ghani A A1 Waheeb S Sahow A | 2009 | Ann Saudi Med2009，29，6： | 1 |
| 11 | Streptococcal neerotizing fasci- iris with toxic shock syndrome followilrg cervical adenitis显示文摘 | Waheeb S Salim M Yosef M | 2004 | Int J of Pediatr Otorhinolaryngol2004，68，： | 1 |
| 12 | Topical anesthesia in phacoemulsification显示文摘 | Waheeb S | 2010 | 0-man J Ophthalmol2010，3，3： | 1 |
| 13 | Streptococcal necrotizing fasciitis with toxic shock syndrome followiIrg cervical adenitis显示文摘 | Waheeb S Salim M Yosef M | | 0，，： | 1 |
| 14 | Clinical and kis- topathological spectrum of IgA nephropathy in Kuwait显示文摘 | Ghani AA A1 Waheeb S AI Homoud E | 2011 | Ann Sa- udi Med2011，31，2： | 1 |
| 15 | Human spermatogonial stem cells:a possible origin for spermatocytic seminoma显示文摘 | Waheeb R Hofmann M C | 2011 | J Androl2011，34，42： | 1 |
| 16 | Clinical and histopathological spectrum of IgA nephropathy in Kuwait 显示文摘 | Ghani AA A1 Waheeb S A1 Homoud E | 2011 | Ann Sa- udi Med2011，31，2： | 1 |
| 17 | Streptococcal necro tizing fasciitis with toxic shock syndrome following cervi cal adenitis显示文摘 | Waheeb S Salim M Yosef M | 2004 | Int J Pediatr Otorhinolaryngol2004，68，9： | 1 |
| 18 | Molecular cytogenetic analysis of Brassica rapa-Brassica oleracea var. alboglabra monosomic addition lines显示文摘 | Robert Hasterok Elzbieta Wolny Sylwia Kulak Aleksandra Zdziechiewicz Jolanta Maluszynska Waheeb K. Heneen | 2005 | Theoretical and Applied Genetics2005，，2： | 1 |
| 19 | Streptococcal necrotizing fasciitis with toxic shock syndrome following cervical adenitis显示文摘 | Waheeb S Salim M Yosef M | 2004 | Int J Pediatr Otorhinolaryngol2004，68，9： | 1 |
| 20 | Clinical and histopathological spectrum of IgA nephropathy in Kuwait 显示文摘 | Ghani AA AI Waheeb S A1 Homoud E ct al | 2011 | Ann Saudi Med2011，31，2： | 1 |
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