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1篇 您的检索式：作者名="Wailun Man"

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		题名	作者	年代	出处	被引量
	1	(Salen)osmium (Ⅵ) nitrides catalyzed glutathione depletion in chemotherapy显示文摘Glutathione depletion provides a promising strategy for the design of non-platinum anticancer drugs.Here we report a series of electrophilic (salen)osmium(Ⅵ) nitrides that react with glutathione to generate (salen)osmium(Ⅲ) ammine compounds.In vitro studies indicate that these osmium(VI) nitrides show comparable cytotoxicity to cisplatin against various carcinoma.Mechanistic studies with the representative compound[OsⅥ(N)(LH)(OH_(2))](PF6)(1,LH=N,N’-bis(salicylidene)-o-cyclohexyldiamine dianion) suggest that 1 induces glutathione depletion,reactive oxygen species generation,endoplasmic reticulum stress,and in turn triggers death receptor-mediated apoptosis and autophagy in lung cancer cells.In vivo evaluations show that 1 can inhibit tumor xenograft growth effectively with no body weight drop.	Wanqiong Huang Chen Pan Yongliang Huang Tao Huang Xiaonan Dong Yunzhou Chen Huatian Shi Taichu Lau Wailun Man Wenxiu Ni	2023	Chinese Chemical Letters2023，34，10：	0

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