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| 1 | Object-oriented protocol hierarchies for distributed workflow systems显示文摘 | Lockemann P C Walter H D | 1995 | Theory and Practice of Object Systems1995，1，4： | 2 |
| 2 | CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients显示文摘AIM To characterize peripheral blood natural killer(NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus(HIV)/hepatitis C virus(HCV) coinfected patients.METHODS Peripheral mononuclear cells from 24 HIV/HCV(HBVnegative) coinfected and 5 HIV/HCV/HBV seronegative individuals were evaluated. HIV/HCV coinfected patients were divided in to groups: G1, patients with METAVIR F0-F2 and G2, patients with METAVIR F3-F4. NK surface cell staining was performed with: AntiCD3(APC/Cy7), anti-CD56(PE/Cy5), anti-CD57(APC), anti-CD25(PE), anti-CD69(FITC), anti-NKp30(PE), antiNKp46(PE/Cy7), anti-NKG2D(APC), anti-DNAM(FITC); anti-CD62L(PE/Cy7), anti-CCR7(PE), anti-TRAIL(PE), anti-Fas L(PE), anti CD94(FITC). Flow cytometry data acquisition was performed on BD FACSCanto, analyzed using Flow Jo software. Frequency of fluorescence was analyzed for all single markers. Clinical records were reviewed, and epidemiological and clinical data were obtained.RESULTS Samples from 11 patients were included in G1 and from 13 in G2. All patients were on ARV, with undetectable HIV viral load. Liver fibrosis was evaluated by transient elastography in 90% of the patients and with biopsy in 10% of the patients. Mean HCV viral load was(6.18 ± 0.7 log10). Even though, no major significant differences were observed between G1 and G2 regarding NK surface markers, it was found that patients with higher liver fibrosis presented statistically lower percentage of NK cells than individual with low to mild fibrosis and healthy controls(G2: 5.4% ± 2.3%, G1: 12.6% ± 8.2%, P = 0.002 and healthy controls 12.2% ± 2.7%, P = 0.008). It was also found that individuals with higher liver fibrosis presented lower CD4 LT count than those from G1(G2: 521 ± 312 cells/μL, G1: 770 ± 205 cells/μL; P = 0.035).CONCLUSION Higher levels of liver fibrosis were associated with lower percentage of NK cells and LTCD4+ count; and they may serve as noninvasive biomarkers of liver damage. | Natalia Laufer Diego Ojeda María Laura Polo Ana Martinez Héctor Pérez Gabriela Turk Pedro Cahn Norberto Walter Zwirner Jorge Quarleri | 2017 | World Journal of Hepatology2017，9，25： | 2 |
| 3 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 4 | Combination of bacterial vaginosis and leukorrhea as a predictor of cervical chlamydial or gonococcal infection 显示文摘 | Lauren S Jeffrey F P Walter H | 2002 | Obstet Gynecol2002，99，4： | 1 |
| 5 | Approximate Expressions for the Elastic Con- stants of Cord Rubber Laminates 显示文摘 | Walter J D Patel H P | 1979 | Rubber Chemistry Technolo- gy1979，52，4： | 1 |
| 6 | Chronic performance of steroid-eluting epicardial leads in a growing pediatric population:a 10-yearcomparison显示文摘 | HORENSTEIN M S WALTERS H 3rd KARPAWICH P P | 2003 | Pace2003，26，71： | 1 |
| 7 | Characterization of natural and artificial low-angle boundaries in YBCO TSMG samples 显示文摘 | Delamare M P Walter H Bringmann B | 2000 | hysica C2000，329，： | 1 |
| 8 | Determination of horizontal anisotropy with three wells显示文摘 | Neuman S P G R Walter H W Bentley | | 0，，： | 1 |
| 9 | Neural mechanisms of a genome-wide supported psychosis variant 显示文摘 | Esslinger C Walter H Kirsch P | 2009 | Science2009，324，： | 1 |
| 10 | Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma显示文摘 | Thorleifsson G Magnusson KP Sulem P Walters GB Gudbjartsson DF Stefansson H | | 0，，5843： | 1 |
| 11 | Biosynthesis of 6-methylsalicylic acid 显示文摘 | Dimroth P Walter H Lynen F | 1970 | EurJ Biochem1970，13，1： | 1 |
| 12 | Physical mapping of the major histocompatibility complex class II and class III regions of the rat显示文摘 | Walter L Hurt P Himmelbauer H | 2002 | Immunogenetics2002，54，4： | 1 |
| 13 | Maceration activity of an endopolygalacturonase from Candida macedoniensis 显示文摘 | CALL H P WALTER J EMEIS C C | 1985 | Journal of Food Biochemistry1985，9，4： | 1 |
| 14 | Phosphorylated ITIMs enable ubiquitylation of an inhibitory cell surface receptor显示文摘 | Walter RB Husermann P Raden BW | 2008 | Traffic2008，9，2： | 1 |
| 15 | Identification and population dynamics of yeasts in sourdough fermentation processes by PCR-denaturing gradient显示文摘 | Christiane B M Walter P H Christian H | 2003 | Applied and Environmental Microbiology2003，，12： | 1 |
| 16 | Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity显示文摘 | Thorleifsson G Walters G B Gudbjartsson D F Steinthorsdottir V Sulem P Helgadottir A Styrkarsdottir U Gretarsdottir S Thorlacius S Jonsdottir I Jonsdottir T Olafsdottir E J Olafsdottir G H Jonsson T Jonsson F Borch-Johnsen K Hansen T Andersen G Jorgensen | | 0，，01： | 1 |
| 17 | Resolution Evalua- tion of Ultrasonic Diagnosis Tools for Electrical Insulation Devices and the Detection of Electrical Trees显示文摘 | Uenol H Walter P Cornelissen C | 2007 | IEEE Transactions on Dielectrics and Electrical Insulation2007，14，： | 1 |
| 18 | MnDPDP enhanced imaging of the liver: Correlation with surgical findings 显示文摘 | Ayton V Walters H | 1997 | Acta Radiol1997，38，： | 1 |
| 19 | Hair transplanting: An important but often forgotten treatment for female pattern hair loss显示文摘 | Walter P Unger MD Robin H | 2003 | J Am Acad Dermatol2003，49，： | 1 |
| 20 | Genetic studies of pangwales, transhumant and settled gaddis 显示文摘 | Bhasin M K Singh I P Walter H | 1986 | Ant hropol Anz1986，44，1： | 1 |
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