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| 1 | Regulatory T cells: immune suppression and beyond显示文摘Foxp3-expressing regulatory T cells(Tregs)were originally identified as critical in maintaining self-tolerance and immune homeostasis.The immunosuppressive functions of Tregs are widely acknowledged and have been extensively studied.Recent studies have revealed many diverse roles of Tregs in shaping the immune system and the inflammatory response.This review will discuss our efforts as well as the efforts of others towards understanding the multifaceted function of Tregs in immune regulation. | Yisong Y Wan | 2010 | Cellular & Molecular Immunology2010，7，3： | 14 |
| 2 | An essential role for TAK1 in the contact hypersensitivity response显示文摘Contact hypersensitivity(CHS)is a delayed-type hypersensitivity that can be induced by haptens,such as 2,4-dinitrofluorobenzene(DNFB).Innate and adaptive immunities are both important for the development of CHS.To treat CHS-related diseases,such as allergic contact dermatitis,a disease prevalent in industrialized countries,ways of interfering with improper immune function during CHS responses need to be identified.Transforming growth factor-b-activated kinase-1(TAK1),a member of mitogen-activated protein kinase kinase kinase family,is important for both innate and adaptive immunities.We thus hypothesized that the CHS response could be inhibited by interfering with TAK1 activity.Using a mouse model in which TAK1 deletion can be locally induced,we observed that TAK deficiency led to an impaired CHS response and was associated with defective T-cell expansion,activation and interferon(IFN)-c production.In addition,we investigated the effect of deleting TAK1 specifically in dendritic cells(DC)on the CHS response.We found that when TAK1 is deficient in DC,the CHS response was abolished and hapten-elicited T-cell responses were defective.Collectively,this study demonstrates an essential role of TAK1 in the induction of CHS and suggests that targeting TAK1 could be a viable approach to treat CHS. | Yan G Zhao Yunqi Wang Weidong Hao Yisong Y Wan | 2011 | Cellular & Molecular Immunology2011，8，4： | 4 |
| 3 | Genetic transformation of wheat mediated by Agrobacterium tumefaciens显示文摘 | Cheng M Fry J E Pang S Zhou H Hironaka C M Duncan D R Conner T W Wan Y | 1997 | Plant Physiol1997，，： | 2 |
| 4 | Influence of Eutrophication on the Distribution of Total Mercury and Methylmercury in Hydroelectric Reservoirs显示文摘 | Meng Bo Feng X B Chen C X Qiu G L Sommar J Guo Y N Liang P Wan Q | 2010 | EN2010，，5： | 2 |
| 5 | Microproteinuria for detecting calcineurin inhibitor-related nephrotoxicity after liver transplantation显示文摘AIM: To investigate whether microproteinuria could be used as an early and sensitive indicator to detect calcineurin inhibitor (CNI)-related nephrotoxicity after liver transplantation. METHODS: All liver transplant recipients with normal serum creatinine (SCr) and detectable microproteinuria at baseline were included in this study. The renal function was monitored by the blood clearance of 99mTc-diethylenetriaminepentaacetic acid every 6 mo. Microproteinuria, SCr and blood urea nitrogen (BUN) were measured at entry and at subsequent follow-up visits. The patients were divided into different groups according to the mean values of glomerular filtration rate (GFR) at the follow-up time points: Group 1, GFR decreased from baseline by 0%-10%; Group 2, GFR decreased from baseline by 11%-20%; Group 3, GFR decreased from baseline by 21%-40%; Group 4, GFR decreased from baseline by > 40% and/or SCr was increasing. RESULTS: A total of 143 patients were enrolled into this study (23 females and 120 males). The mean follow-up was 32 mo (range 16-36 mo). Downward trends in renal function over time were observed in the study groups. SCr and BUN increased significantly only in Group 4 patients (P < 0.001). β2-microglobulin (β2m) and α1-microglobulin (α1m) significantly increased with the subtle change of renal function in recipients who were exposed to CNI-based immunosuppression regimens. The reductions in GFR were closely correlated with elevated α1m (r2 = -0.728, P < 0.001) and β2m (r2 = -0.787, P < 0.001). CONCLUSION: β2m and α1m could be useful as early and sensitive indicators of CNI-induced nephrotoxicity. | Jing Li Bin Liu Lu-Nan Yan Lan-Lan Wang Wan Y Lau Bo Li Wen-Tao Wang Ming-Qing Xu Jia-Yin Yang Fu-Gui Li | 2009 | World Journal of Gastroenterology2009，15，23： | 2 |
| 6 | On the geometrieity of Lattices generated by orbits of subspaces under finite classical groups显示文摘 | Huo Y Wan Z | 2001 | Journal of Algebra2001，243，： | 1 |
| 7 | Mechanical property characterization of mouse zona pellucida显示文摘 | Sun Y Wan K T Roberts K P | 2003 | IEEE Transactions on Nanobioscience2003，2，4： | 1 |
| 8 | The Comparison of PCA and Discrete Rough Set for Feature Extraction of Remote Sensing Image Classification-A Case Study on Rice Classification 显示文摘 | Lei T C Wan S Chou T Y | 2007 | Computational Geosciences2007，12，1： | 1 |
| 9 | Synthesis and characterization of hydroxyapatite-bacterial cellulose nanocomposites显示文摘 | Wan Y Z Hong L | 2005 | Composites Science and Technology2005，66，1112： | 1 |
| 10 | Au@Y203: Eu3+ rare earth oxide hollow sub-microspheres with encapsulated gold nanoparticles and their optical properties 显示文摘 | Min YL Wan Y Yu SH | 2009 | Solid State Sci2009，11，： | 1 |
| 11 | Preparation and characterization of gelatin gel with a gradient structure 显示文摘 | Wang Y L Cheng G X Yao K D | 2000 | Polymer Int2000，49，12： | 1 |
| 12 | Electronic structure of FCC phase in Fe-Mn-Si based shape memory alloys and its stability显示文摘 | Chen S P Xu Z Y | 2001 | Science in China (E)2001，44，5： | 1 |
| 13 | The antiviral agents,MAP30 and GAP31,are not toxic to human spermatozoa and maybe useful in preventing the sexual transmission of human immunodeficiency virus type 1显示文摘 | Schreiber CA Wan L Sun Y | 1999 | Fertil Steril1999，72，4： | 1 |
| 14 | The preventive effect of adjuvant-free administration of TNF-PADRE autovaccine on collagen-Ⅱ-induced rheumatoid arthritis in mice显示文摘 | Wan Y Yuan S Xue X | 2009 | Cell Immunol2009，258，1： | 1 |
| 15 | Influence of the Reynolds number on chaotic mixing in a spatially periodic micromixer and its characterization using dynamical system techniques 显示文摘 | XIA H M SHU C WAN Y M | 2006 | Journal of Micromechanics and Microengineering2006，16，1： | 1 |
| 16 | Genetic analysis of a novel dominant rice dwarf mutant 986083D显示文摘 | Qin R Z Qiu Y Cheng Z J Shan X Y Guo X P Zhai H Q Wan J M | 2008 | Euphytica2008，160，： | 1 |
| 17 | Tissue distribution and maternal transfer of poly-and perfluorinated compounds in Chinese sturgeon (Acipenser sinensis) : implications for reproductive risk 显示文摘 | Peng H Wei Q W Wan Y | 2010 | Environ Sci Technol2010，44，5： | 1 |
| 18 | Renewable energy development in China: Resource assessment, technology status, and greenhouse gas mitigation potential 显示文摘 | Li J Wan Y Ohi J | 1997 | Applied Energy1997，56，： | 1 |
| 19 | Acclimatization of soil respiration to warming in a tall grass prairie显示文摘 | Luo Y Wan S H ui D | 2001 | Nature2001，413，： | 1 |
| 20 | Low-complexity estimator for four-dimensional parameters under a reparameterized distributed source model显示文摘 | Wan Q Peng Y N | 2001 | IEE Proceedings-Radar Sonar Navigation2001，148，6： | 1 |
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