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您的检索式：作者名="Wanfang Yang"
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| 1 | Up-regulation of iNOS by hypoxic postconditioning inhibits H9c2 cardiomyocyte apoptosis induced by hypoxia/re-oxygenation显示文摘Apoptosis 是局部缺血和灌注导致的房间死亡的一个关键模式,并且 ischemic postconditioning (PostC ) 被报导了禁止房间 apoptosis。可诱导的氮的氧化物 synthase (iNOS ) 被证实了在被触发并且调停起一个重要作用对局部缺血 / 组织缺氧的迟了的 cardio 保护。在这研究,我们发现那 hypoxic PostC 显著地起来调整 iNOS 和减少的 cardiomyocyte apoptosis 的表示。有 1400w (iNOS 的一个高度选择的禁止者) 或 iNOS siRNA 的预告的处理削弱了 hypoxic PostC 的 anti-apoptotic 效果。这些调查结果建议 iNOS 可以是为由 hypoxic PostC 的 apoptosis 的抑制负责的关键分子的机制之一。 | Huanxin Zhao Rong Yang Yujuan Shi Wanfang Yang Qun Zeng Guoyi Zhao Xiaoliang Wang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，7： | 4 |
| 2 | A Priori Error Estimates of Finite Element Methods for Linear Parabolic Integro-Differential Optimal Control Problems显示文摘In this paper,we study the mathematical formulation for an optimal control problem governed by a linear parabolic integro-differential equation and present the optimality conditions.We then set up its weak formulation and the finite element approximation scheme.Based on these we derive the a priori error estimates for its finite element approximation both in H1 and L^(2)norms.Furthermore some numerical tests are presented to verify the theoretical results. | Wanfang Shen Liang Ge Danping Yang Wenbin Liu | 2014 | Advances in Applied Mathematics and Mechanics2014，6，5： | 0 |
| 3 | Integrated mass spectrometry imaging reveals spatial-metabolic alteration in diabetic cardiomyopathy and the intervention effects of ferulic acid显示文摘Diabetic cardiomyopathy(DCM)is a metabolic disease and a leading cause of heart failure among people with diabetes.Mass spectrometry imaging(MSI)is a versatile technique capable of combining the molecular specificity of mass spectrometry(MS)with the spatial information of imaging.In this study,we used MSI to visualize metabolites in the rat heart with high spatial resolution and sensitivity.We optimized the air flow-assisted desorption electrospray ionization(AFADESI)-MSI platform to detect a wide range of metabolites,and then used matrix-assisted laser desorption ionization(MALDI)-MSI for increasing metabolic coverage and improving localization resolution.AFADESI-MSI detected 214 and 149 metabolites in positive and negative analyses of rat heart sections,respectively,while MALDI-MSI detected 61 metabolites in negative analysis.Our study revealed the heterogenous metabolic profile of the heart in a DCM model,with over 105 region-specific changes in the levels of a wide range of metabolite classes,including carbohydrates,amino acids,nucleotides,and their derivatives,fatty acids,glycerol phospholipids,carnitines,and metal ions.The repeated oral administration of ferulic acid during 20 weeks significantly improved most of the metabolic disorders in the DCM model.Our findings provide novel insights into the molecular mechanisms underlying DCM and the potential of ferulic acid as a therapeutic agent for treating this condition. | Yanhua Liu Xin Zhang Shu Yang Zhi Zhou Lu Tian Wanfang Li Jinfeng Wei Zeper Abliz Zhonghua Wang | 2023 | Journal of Pharmaceutical Analysis2023，13，12： | 0 |
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