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| 1 | Design Principles of the Non-smooth Surface of Bionic Plow Moldboard显示文摘The diverse non-smooth body surfaces to reduce soil adhesion are the evolutional results for the soil animals to fit the adhesive and wet environment and can be used as a biological basis for the design of bionic plow moldboard. The model surfaces for bionic simulation should be taken from soil animal digging organs, on which the soil motion is similar to what is on the surface of moldboard. By analyzing the distribution of non-smooth units on the body surface of the ground beetle jaw and the soil moving stresses, the design principles of the bionic moldboard for the local and the whole moldboard were presented respectively. As well, the effect of soil moving speed on reducing adhesion, the dimensions relationship between soil particles and non-smooth convexes, the relationship between the enveloping surface of non-smooth convexes and the initial smooth surface of the plow body, and the convex types of the sphere coronal and the pangolin scales,etc.were discussed. | Luquan Ren, Shiqiao Deng, Jingchun Wang, Zhiwu Han Key Laboratory of Terrain-Machine Bionics Engineering (Ministry of Education,China), Jilin University at Nanling Campus, Changchun 130022,P.R. China | 2004 | Journal of Bionic Engineering2004，1，1： | 28 |
| 2 | Antihepatoma effect of alpha-fetoprotein antisense phosphorothioate oligodeoxyribonucleotides in vitro and in mice显示文摘AIM To evaluate antihepatoma effect ofantisense phosphorothioate oligodeo-xyribonucleotides (S-ODNs) targeted to alpha-fetoprotein (AFP) genes in vitro and in nudemice.METHODS AFP gene expression was examinedby immunocytochemical method or enzyme-linked immunosorbent assay. Effect of S-ODNson SMMC-7721 human hepatoma cell growth invitro was determined using microculturetetrazolium assay. In vivo antitumor activitiesof S-ODNs were monitored by measuring tumorweight differences in treated and control micebearing SMMC-7721 xenografts. Induction of cellapoptosis was evaluated by fluorescence-activated cell sorter (FACS) analysis.RESULTS Antisense S-ODN treatment led toreduced AFP gene expression. Specificantisense S-ODNs, but not control S-ODNs,inhibited the growth of heaptoma cells in vitro.In vivo. only antisense S-ODNs exhibitedobvious antitumor activities. FACS analysisrevealed that the growth inhibition by antisenseS. ODNs was associated with their cell apoptosisinduction.CONCLUSION Antisense S-ODNs targeted toAFP genes inhibit the growth of human hepatomacells and solid hepatoma, which is related totheir cell apoptosis induction. | Xing Wang Wang~1 Jin Hui Yuan~1 Ru Gang Zhang~1 Li Xia Guo~1 Yong Xie~2 Hong Xie~1 ~1Department of Biotherapy,Shanghai Institute of Cell Biology,Chinese Academy of Sciences,Shanghai 200031,China ~2Department of Biology,Hong Kong University of Science and Technology,ChinaDr.Xing Wang Wang earned Ph.D.from Shanghai Institute of Materia Medical,Chinese Academy of Sciences in 1997.Now a professor at Shanghai Institute of Cell Biology,Chinese Academy of Sciences. | 2001 | World Journal of Gastroenterology2001，7，3： | 21 |
| 3 | Effects of aminoguanidine on nitric oxide production induced by inflammatory cytokines and endotoxin in cultured rat hepatocytes显示文摘AIM To study the effects of aminoguanidine(AG) and two L-arginine analogues Nω-nitro-L-arginine methyl ester (L-NAME) and Nω-nitro-L-arginine (L-NNA) on nitric oxide (NO) productioninduced by cytokines (TNF-α, IL-11β, and IFN-γ)and bacterial lipopolysaccharide (LPS) mixture(CM) in the cultured rat hepatocytes, andexamine their mechanisms action.METHODS Rat hepatocytes were incubatedwith AG, L-NAME, L-NNA, Actinomycin D (ActD)and dexamethasene in a medium containing CM(LPS plus TNF-α, IL-1β, and IFN-γ) for 24 h. NOproduction in the cultured supernatant wasmeasured with the Griese reaction. IntracellularcGMP level was detected with radioimmunoasey.RESULTS NO production was markedlyblocked by AG and L-NAME in a dose-dependentmanner under inflammatory stimuli conditiontriggered by CM in vitro. The rate of themaximum inhibitory effects of L-NAME (38.9%)was less potent than that obtained with AG(53.7%, P<0.05). There was no significantdifference between the inhibitory effects of AGand two L-arginine analogues on intracellularcGMP accumulation in rat cultured hepatocytes.Non-specific NOS expression inhibitordexamethasone ( DEX ) and iNOS mRNAtranscriptional inhibitor ActD also significantlyinhibited CM-induced NO production. AG(0.1mmol.L-1) and ActD (0.2ng@Lt) wereequipotent in decreasing NO production inducedby inflammatory stimuli in vitro, and botheffects were more potent than that induced bynon-selectivity NOS activity inhibitor L-NAME(0. 1 mmol@ L- 1) under similar stimuli conditions(P | Guo Liang Zhang Ye Hong Wang Hui Ling Teng Zhi Bin Lin Department of Pharmacology,School of Basic Medical Sciences,Beijing University,Beijiog 100083,ChinaDr.Guo Liang Zhang graduated from Xinxiang Medical College in 1982,got Ph.D.at Nagoya City University Medical School,Japan in 1994,finished postdoctoral research at Beijing Medical Univcrsity in 1996,now an associate professor of pharmacology,specialized in hepatic pharmacology,having 15 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 20 |
| 4 | Immunization with chlamydial plasmid protein pORF5 DNA vaccine induces protective immunity against genital chlamydial infection in mice显示文摘To validate the immune protective efficacy of pORF5 DNA vaccine and to analyze potential mechanisms related to this protection. In this study, pORF5 DNA vaccine was constructed and evaluated for its protective immunity in a mouse model of genital chlamydial infection. Groups of BALB/c mice were immunized intranasally with pORF5 DNA vaccine. Humoral and cell mediated immune responses were evaluated. The clearance ability of chlamydial challenge from the genital tract and the chlamy- dia-induced upper genital tract gross pathology and histopathological characterization were also de- tected. The results showed that the total and the IgG2a anti-pORF5 antibody levels in serum were sig- nificantly elevated after pcDNA3.1-pORF5 vaccination, as were the total antibody and IgA levels in vaginal fluids. pcDNA3.1-pORF5 induced a significantly high level of Th1 response as measured by robust gamma interferon (IFN-γ). Minimal IL-4 was produced by immune T cells in response to the re-stimulation with pORF5 protein or the inactive elementary body in vitro. pcDNA3.1-pORF5-vacci- nated mice displayed significantly reduced bacterial shedding upon a chlamydial challenge and an accelerated resolution of infection. 100% of pcDNA3.1-pORF5 vaccinated mice successfully resolved the infection by day 24. pcDNA3.1-pORF5-immunized mice also exhibited protection against patho- logical consequences of chlamydial infection. The stimulated index was significantly higher than that of mice immunized with pcDNA3.1 and PBS (P<0.05). Together, these results demonstrated that immu- nization with pORF5 DNA vaccine is a promising approach for eliciting a protective immunity against a genital chlamydial challenge. | LI ZhongYu1,2, WANG ShiPing1, Wu YiMou2, ZHONG GuangMing3 & CHEN Ding3 1 Xiangya School of Medicine, Central South University, Changsha 410078, China 2 Department of Microbiology and Immunology, University of South China, Hengyang 421001, China 3 University of Texas Health Science Center at San Antonio, TX 78229, USA | 2008 | Science China(Life Sciences)2008，51，11： | 16 |
| 5 | Influence of whole peptidoglycan of bifidobacterium on cytotoxic effectors produced by mouse peritoneal macrophages显示文摘INTRODUCTIONBifidobacteria are physiologically beneficial bacteria which are perdominant in human intestine ,and possess the most important functions .They play an important role in maintaining microbial balance of the intestine .Furthermore , their presence is thought to be an important indication of health of the body [1-4].Whole peptidoglycan ( WPG) is the major component in the cell wall of bifidobacterium ,which is also a biological responsemodifier with nontoxic side dffcets. | Li Sheng Wang~1 Hui Ming Zhu~1 Dian Yuan Zhou~2 Yu Lin Wang~1 Wan Dai Zhang~2 ~1Departrnent of Gastroenterology,Shenzhen Municipal People’s Hospital,Jinan University of Medical Sciences,Shenzhen 518020,Guangdong Province,China ~2Chinese PLA Institute of Digestion,the First Military Medical University,Guangzhou 510515,Guangdong Province,ChinaLi Sheng Wang graduated and obtained Ph.D,from the First Military Medical University in 1998,now working at Department of Gastroenterology,Shenzhen Municipal People’s Hospital.Jinan University of Medical Sciences.having 35 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 15 |
| 6 | Syntheses of amphiphilic biodegradable copolymers of poly(ethyl ethylene phosphate) and poly(3-hydroxybutyrate) for drug delivery显示文摘Biodegradable and amphiphilic triblock copolymers poly(ethyl ethylene phosphate)-poly(3-hydroxybutyrate)-poly(ethyl ethylene phosphate) (PEEP-b-PHB-b-PEEP) have been successfully synthesized through ring-opening polymerization. The structures are confirmed by gel permeation chromatography and NMR analyses. Crystallization investigated by X-ray diffraction reveals that the block copolymer with higher content of poly(ethyl ethylene phosphate) (PEEP) is more amorphous, showing decreased crystallizability. The obtained copolymers self-assemble into biodegradable nanoparticles with a coreshell micellar structure in aqueous solution, verified by the probe-based fluorescence measurements and transmission electronic microscopy (TEM) observation. The hydrophobic poly(3-hydroxybutyrate) (PHB) block serves as the core of the micelles and the micelles are stabilized by the hydrophilic PEEP block. The size and size distribution are related to the compositions of the copolymers. Paclitaxel (PTX) has been encapsulated into the micelles as a model drug and a sustained drug release from the micelles is observed. MTT assay also demonstrates that the block copolymers are biocompatible, rendering these copolymers attractive for drug delivery. | CHENG Jing1 & WANG Jun2 1 Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, China 2 Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China | 2009 | Science China Chemistry2009，52，7： | 10 |
| 7 | Genome size and sequence composition of moso bamboo: A comparative study显示文摘Moso bamboo (Phyllostachys pubescens) is one of the world's most important bamboo species. It has the largest area of all planted bamboo―over two-thirds of the total bamboo forest area―and the highest economic value in China. Moso bamboo is a tetraploid (4x=48) and a special member of the grasses family. Although several genomes have been sequenced or are being sequenced in the grasses family, we know little about the genome of the bambusoids (bamboos). In this study, the moso bamboo genome size was estimated to be about 2034 Mb by flow cytometry (FCM), using maize (cv. B73) and rice (cv. Nipponbare) as internal references. The rice genome has been sequenced and the maize genome is being sequenced. We found that the size of the moso bamboo genome was similar to that of maize but significantly larger than that of rice. To determine whether the bamboo genome had a high proportion of repeat elements, similar to that of the maize genome, approximately 1000 genome survey sequences (GSS) were generated. Sequence analysis showed that the proportion of repeat elements was 23.3% for the bamboo genome, which is significantly lower than that of the maize ge-nome (65.7%). The bamboo repeat elements were mainly Gypsy/DIRS1 and Ty1/Copia LTR retrotrans-posons (14.7%), with a few DNA transposons. However, more genomic sequences are needed to con-firm the above results due to several factors, such as the limitation of our GSS data. This study is the first to investigate sequence composition of the bamboo genome. Our results are valuable for future genome research of moso and other bamboos. | GUI YiJie1, WANG Sheng1, QUAN LiYan1, ZHOU ChangPing2, LONG ShiBao2, ZHENG HuaJun3, JIN Liang1, ZHANG XianYin 1, MA NaiXun 4 & FAN LongJiang1 1 Institute of Crop Science/Institute of Bioinformatics, Zhejiang University, Hangzhou 310029, China 2 Zhejiang Anji Bamboo Exposition Garden, Anji 313300, China 3 Chinese National Human Genome Center at Shanghai, Shanghai 201203, China 4 The Research Institute of Subtropical Forestry, Chinese Academy of Forestry, Fuyang 311400, China | 2007 | Science China(Life Sciences)2007，50，5： | 10 |
| 8 | Experimental investigation of time-dependent cavitation in an oscillatory squeeze film显示文摘The occurrence of time-dependent cavitation and tensile stress in an oscillatory oil squeeze film were investigated experimentally. The test apparatus was a simple thrust bearing consisting of two parallel circular plates separated by a thin viscous oil film. During the test, one plate was at rest while the other (transparent) oscillated in a direction normal to its surface. This test configuration was chosen to avoid the rotational motion and complicated geometry of a squeeze film journal bearing. The frequency of oscillation was in the range of 5 to 50 Hz and was controlled by an electro-magnetic exciter. The process of cavity formation and its subsequent development was recorded by a high-speed video camera. Concomitant pressure in the oil film was measured both within and without the cavitation region. It was found that both tensile stress and cavities existed in a squeeze film under certain working conditions. | CHEN Xiaoyang, SUN Meili, WANG Wen, D. C. SUN, ZHANG Zhiming & WANG XiaojingResearch Institute of Bearings, Shanghai University, Shanghai 200072, China Department of Mechanical Engineering, State University of New York at Binghamton, NY 13902-6000, USA | 2004 | Science China(Physics,Mechanics & Astronomy)2004，47，z1： | 10 |
| 9 | Non-linear buffeting response analysis of long-span suspension bridges with central buckle显示文摘The rigid central buckle employed in the Runyang Suspension Bridge (RSB) was the first time it was used in a suspension bridge in China. By using a spectral representation method and FFT technique combined with measured data,a 3D fluctuating wind field considering the tower wind effect is simulated. A novel FE model for buffeting analysis is then presented,in which a specific user-defined Matrix27 element in ANSYS is employed to simulate the aeroelastic forces and its stiffness or damping matrices are parameterized by wind velocity and vibration frequency. A nonlinear time history analysis is carried out to study the influence of the rigid central buckle on the wind-induced buffeting response of a long-span suspension bridge. The results can be used as a reference for wind resistance design of long-span suspension bridges with a rigid central buckle in the future. | Wang Hao1,2,Li Aiqun1,Zhao Gengwen1 and Li Jian2 1.College of Civil Engineering,Southeast University,Nanjing 210096,China 2.Civil and Environmental Engineering,University of Illinois at Urbana-Champaign,Urbana,IL 61801,USA | 2010 | Earthquake Engineering and Engineering Vibration2010，9，2： | 7 |
| 10 | Microwave-assisted Polymerization of D,L-Lactide with Stannous Octanoate as Catalyst显示文摘Poly (lactic acid) (PLA) was synthesized by microwave-assisted ring-opening poly- merization of D, L-lactide with stannous octanoate (SnOct2) as catalyst. Its weight-average molar mass (Mw) ranged from 39000 to 67000 and the polydispersity index from 1.3 to 1.7. The polymerization rate was much faster than that of the conventional thermal polymerization. A degradation of newly formed PLA in reaction mixture by microwave irradiation was observed. | Li Jian LIU* Chao ZHANG, Li Qiong LIAO, Xu Li WANG, Ren Xi ZHUO Department of Polymer Science, College of Chemistry and Molecular Science, Wuhan University The Research Laboratory of SEDC of Biomedical Polymer Materials at Wuhan University, Wuhan 430072 | 2001 | Chinese Chemical Letters2001，12，8： | 7 |
| 11 | Development and application of genotyping technologies显示文摘With the completion of Human Genome Project,International HapMap Project and the publication of copy number variation in human genome,a great number of accurate,rapid,and cost-effective technologies for SNP analysis have been developed,promoting the research of the complex diseases.This article presents a review of widely used genotyping techniques,and the progress and prospect in the study of complex diseases in terms of the projects and achievements of Chinese National Human Genome Center at Shanghai(CHGCs). | SHI JinXiu,WANG Ying & HUANG Wei Shanghai-MOST Key Laboratory of Health and Disease Genomics,Chinese National Human Genome Center at Shanghai,Shanghai 201203,China | 2009 | Science China(Life Sciences)2009，52，1： | 6 |
| 12 | VEGF-specific siRNAs modified with 2′-deoxy effectively suppress VEGF expression and inhibit growth of nasopharyngeal carcinoma xenograft in a mouse model显示文摘Vascular endothelial growth factor (VEGF) is up-regulated in the vast majority of human tumors. The up-regulation of VEGF not only plays important roles in tumor angiogenesis, but also provides a target for tumor treatment with small interfering RNA (siRNA) that targets VEGF; however, it is unclear whether a quite high up-regulation of VEGF will affect the efficiency of RNA interference strategies targeting VEGF. A high level expression of VEGF was found in CNE cells from a nasopharyngeal carcinoma cell line. In this study, we investigate whether VEGF-specific siRNAs can effectively suppress VEGF expression in CNE cells, and study the methods for the use of VEGF-specific siRNAs as potential therapeutic agents. CNE cells with high VEGF expression induced by hypoxia were transfected with VEGF-specific siRNAs. The expression of VEGF was effectively suppressed by VEGF-specific siRNAs, measured by ELISA, Western blot analysis and RT-PCR. Furthermore, experiments in nude mice bearing nasopharyngeal carcinoma xenograft were initiated 5 d after injection of CNE cells. VEGF-specific siRNAs were modified with 2′-deoxy, then injected into the tumors, and a liposome-mediated siRNA transfection system and ultrasound exposure were used to help delivery of the siRNAs. Tumor growth was reduced significantly after 3 weeks' treatment. These studies suggest that VEGF-specific siRNAs still can effectively suppress VEGF expression even in tumor cell lines with a relatively high level of VEGF expression, such as CNE, and VEGF-specific siRNAs modified with 2′-deoxy can be used as potential agents for tumor therapy. | CHEN ShanYi1, GAO GuoFeng1, CHEN Wei1, Lü Qing2, TANG Shen2, HUA Zhong2, YE WenBin2, GU DaYong2, WANG ShaYan1 & ZHANG YaOu2 1 Shenzhen People’s Hospital, Clinical Medical College of Jinan University, Shenzhen 518020, China 2 Life Science Division, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China | 2008 | Science China(Life Sciences)2008，51，2： | 6 |
| 13 | High Expression of NKG2A/CD94 and Low Expression of Granzyme B Are Associated with Reduced Cord Blood NK Cell Activity显示文摘Human umbilical cord blood (CB) has recently been used as a source of stem cells in transplantation. NK cells derived from CB are the key effector cells involved in graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL). It was reported that the activity of CB NK cells was lower than that of adult peripheral blood (PB) NK cells. In this study,we analyzed the expression of some NK cell receptors and cytotoxicity-related molecules in CB and PB NK cells. The expressions of activating NK receptors,CD16,NKG2D and NKp46,did not show significant difference between CB and PB NK cells. But the expression of inhibitory receptor NKG2A/CD94 was significantly higher on CB NK cells. As to the effector function molecules,granzyme B was expressed significantly lower in CB NK cells,but the expressions of intracellular perforin,IFN-γ,TNF-α and cell surface FasL and TRAIL did not show difference between CB and PB NK cells. The results indicated that the high expression of NKG2A/CD94 and low expression of granzyme B may be related with the reduced activity of CB NK cells. | Yanyan Wang1,2,Han Xu1,2,Xiaodong Zheng1,Haiming Wei1,Rui Sun1 and Zhigang Tian1,31Institute of Immunology,Hefei National Laboratory for Physical Materials at Microscale and School of Life Sciences,University of Science and Technology of China,Hefei 230027,China 2Yanyan Wang and Han Xu equally contributed to the present study | 2007 | Cellular & Molecular Immunology2007，4，5： | 5 |
| 14 | Adsorption of Acetanilide Herbicides on Soil and Its Components: Ⅳ. Sorption of Acetanilide Herbicides on Soils and its Correlation with Soil Properties显示文摘Sorption of acetanilide herbicides, metolachlor, acetochlor, pretilachlor and butachlor on eight soils with various physical and chemical properties was studied. The adsorption isotherms could fit Freundich equation well (r 2 ≥0.91) and the adsorption extents increased in the order: metolachlor < acetochlor < pratilachlor < butachlor. The product of Freundlich adsorption constants, Kf (1/n), showed to have a good correlation with organic matter content (OM) of soils for each of these herbicides, suggesting that OM is the primary factor dominating in the adsorption process of these asetanilide herbicides. Multivariant correlation regression between Kf (1/n) and two factors, water solubility (S.) of herbicides and OM, was also performed. Kf(1/n) correlated with 1/S. and OM/S. well, showing that high S. corresponds to a weak tendency to adsorb on soils. Infrared (IR) spectra and electron spin resonance (ESR) parameters confirmed that multifunctional H-bonds and charge-transfer bonds were the main adsorption mechanisms of these acetanilide herbicides. The abilities of herbicides to form these adsorption bonds with HA increased in the same order as the extent of adsorption. | LIU WEIPING WANG QIQUAN YANG WEICHUN and WANG XIAORONG State Key Laboratory of Pollution Control and Resource Reuse Research, Nanjing University, Nanjing 210093 (China) Institute of Environmental Science, Zhejiang University at Yuquan, Hangzhou 510027 | 2001 | Pedosphere2001，11，3： | 5 |
| 15 | Sequencing,annotation and comparative analysis of nine BACs of the giant panda(Ailuropoda melanoleuca)显示文摘A 10-fold BAC library for the giant panda was constructed and nine BACs were selected to generate finish sequences.These BACs could be used as a validation resource for the de novo assembly accuracy of the whole genome shotgun sequencing reads of the giant panda newly generated by Illumina GA sequencing technology.Complete Sanger sequencing,assembly,annotation and comparative analysis were carried out on the selected BACs of a joint length 878 kb.Homologue search and de novo prediction methods were used to annotate genes and repeats.Twelve protein coding genes were predicted,seven of which could be functionally annotated.The seven genes have an average gene size of about 41 kb,an average coding size of about 1.2 kb and an average exon number of 6 per gene.Besides,seven tRNA genes were found.About 27 percent of the BAC sequence is composed of repeats.A phylogenetic tree was constructed using a neighbor-join algorithm across five species,including the giant panda,human,dog,cat and mouse,which reconfirms dog as the most closely related species to the giant panda.Our results provide detailed sequence and structure information for new genes and repeats of the giant panda,which will be helpful for further studies about the giant panda. | ZHENG Yang1,2,3,CAI Jing4,LI JianWen3,6,LI Bo3,LIN RunMao3,TIAN Feng3,WANG XiaoLing3 & WANG Jun3,5 1Beijing Institute of Genomics,Chinese Academy of Sciences(CAS),Beijing 100029,China 2College of Life Science,Graduate University of Chinese Academy of Sciences,Beijing 100049,China 3Beijing Genomics Institute at Shenzhen,Shenzhen 518083,China 4CAS-Max Planck Junior Research Group on Evolutionary Genomics,State Key Laboratory of Genetic Resources and Evolution,Kunming Institute of Zoology,Chinese Academy of Sciences(CAS),Kunming 650223,China 5Department of Biology,University of Copenhagen,Copenhagen DK-2200,Denmark 6School of Biological Science and Engineering,South China University of Technology,Guangzhou 510006,China | 2010 | Science China(Life Sciences)2010，53，1： | 5 |
| 16 | 2D/3D-QSAR comparative study on mutagenicity of nitroaromatics显示文摘Nitroaromatics are typical toxic organic pollutants and are ubiquitous in environment with diverse structures. They are widely used in many industries and formed during many natural and anthropogenic processes. Most of these pollutants are potentially carcinogenic and the as-sessment and prediction of the mutagenicity of nitroaromatics are of great interest. In this paper the structure-mutagenicity relationships of 219 nitroaromatics are investigated by molecular or-bital theory based classic structure-activity relationships and comparative molecular field analysis (CoMFA). A comparison is undertaken in respect of the interpretation of mechanism and predic-tive ability for these two categories of QSAR approaches and highly predictive QSAR models have been developed. | WANG Xiaodong1, LIN Zhifen2, YIN Daqiang1, LIU Shushen1 & WANG Liansheng1 1. State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment at Nanjing University, Nanjing 210093, China 2. Key Laboratory of Tropical Marine Environmental Dynamics, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301,China | 2005 | Science China Chemistry2005，48，3： | 4 |
| 17 | Global existence of smooth solutions to two-dimensional compressible isentropic Euler equations for Chaplygin gases显示文摘In this paper we investigate the two-dimensional compressible isentropic Euler equations for Chaplygin gases. Under the assumption that the initial data is close to a constant state and the vorticity of the initial velocity vanishes, we prove the global existence of the smooth solution to the Cauchy problem for twodimensional flow of Chaplygin gases. | KONG DeXing 1 , LIU KeFeng 2 & WANG YuZhu 3, 1 Department of Mathematics, Zhejiang University, Hangzhou 310027, China 2 Department of Mathematics, University of California at Los Angeles, CA 90095, USA 3 Department of Mathematics, Shanghai Jiao Tong University, Shanghai 200248, China | 2010 | Science China Mathematics2010，53，3： | 4 |
| 18 | On the Struggle for International Power of Discourse on Climate Change显示文摘With climate change developing into one of the global focal issues,the struggle for the international power of discourse on climate change tends to be intensified,The struggle is in essence the contest for national interest revolving around economic and development interest,The weight of international power of discourse acquired by each country is determined by its national strength and its relevant policies as well. | Wang Weinan is PhD at the Institute of Asia and Pacific Studies,Shanghai Academy of Social Sciences | 2010 | China International Studies2010，30，4： | 3 |
| 19 | Oligomeric Procyanidins Induce Generation of Reactive Oxygen Species and Collapse of Mitochchondrial Membrane Potential in Glioblastoma Cell Lines显示文摘Objective The aim of the present study was to clarify the mechanism underlying glioma cell death upon oligomeric procyanidins (F2) exposure. Methods The cytotoxicity of F2 on U87 (human malignant glioblastoma cell line) and C6 (rat glioma cell line) cancer cells was evaluated, and changes of mitochondrial membrane potential (MMP) and production of reactive oxygen species (ROS) in drug-treated cells were monitored. Moreover, morphological changes associated with F2-induced cells death were examined. Results F2 induced a concentration-dependent increase in ROS production and decrease in MMP. Furthermore, pre-incubation with N-acetylcysteine (NAC) and rotenone (Rt), resulted in partial inhibition of F2-induced ROS generation and marked attenuation of cell death and the cytoplasmic vacuolization induced by F2. In addition, pretreatment with Rt markedly attenuated the MMP loss in F2-treated cells. However, pretreatment with NAC only markedly attenuated the MMP loss in F2-treated C6 cells. Conclusion The increase in ROS level is at least one of mechanisms associated with F2-induced glioma cell death as well as the cytoplasmic vacuolization formation that contribute to the cytotoxicity of F2 in glioma cells. | ZHANG Feng-jiao1, YANG Jing-yu1, MOU Yan-hua1, SUN Bao-shan2, WANG Ji-ming3, WANG Fang1, WU Chun-fu1 1. Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China 2. Estaco Vitivinícola Nacional, Instituto National de Investigaco Agrária, Dois Portos 2565-191, Portugal 3. Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick Maryland 21702, USA | 2009 | Chinese Herbal Medicines2009，1，1： | 3 |
| 20 | The Sequence Architecture of Volcanic Basin Fillings-An Example From Xujiaweizi Faulted Depression In Songliao Basin显示文摘The basin filling geometric pattern of volcanic eruptive rocks depends on both of the eruptive locations in a basin and structural styles of fault terraces. It is divided into three types by eruptive locations and occurrences of eruptive rocks, including the pattern of eruption along fault and occurrence (PEAFO), the pattern of eruption on footwall of a fault and occurrence (PEOFO) and the pattern of eruption on hangingwall of fault and occurrence (PEOHO) in Xujiaweizi fault depression of Songliao basin, Northeast of China. Those basin filling patterns of volcanic eruptive rocks are of specific geometric characteristics controlling or affecting sedimentation, geometry of sedimentary body and sequence architecture during a sequence evolution. The study shows that the volcanic rocks developed at different stages of lowstand, transgressive and highstand can give different controls or affects on the sequence architecture. | CHENG Rihui, LIU Wanzhu, SHAN Xuanlong, WANG Pujun (Faculty of Earth Sciences at Jilin University, Changchun, 130061, P.R.China) CHEN Shumin and QU Yongbao (Daqing Petroleum Bureau Prospecting and Exploration Institute, Daqing, 163712, P.R.China) | 2001 | Global Geology2001，6，2： | 3 |
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