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| 1 | Two RING-Finger Ubiquitin E3 Ligases Regulate the Degradation of SPX4, An Internal Phosphate Sensor, for Phosphate Homeostasis and Signaling in Rice显示文摘SPX-domain-containing proteins (SPXs) play an important role in inorganic phosphate (Pi) sensing,signaling,and transport in eukaryotes.In plants,SPXs are known to integrate cellular Pi status and negatively regulate the activity of Pi central regulators,the PHOSPATE STARVATION RESPONSE proteins (PHRs).The stability of SPXs,such as SPX4,is reduced under Pi-deficient conditions.However,the mechanisms by which SPXs are degraded remain unclear.In this study,using a yeast-twhybrid screen we iden.tified two RING-finger ubiquitin E3 ligases regulating SPX4 degradation,designated SDEL1 and SDEL2,which were post-transcriptionally induced by Pi starvation.We found that both SDELs were located in the nucleus and cytoplasm,had ubiquitin E3 ligase activity,and directly ubiquitinated the K^213 and K^299 lysine residues in SPX4 to regulate its stability.Furthermore,we found that PHR2,a Pi central regulator in rice,could compete with SDELs by interacting with SPX4 under Pi-sufficient conditions,which protected SPX4 from ubiquitination and degradation.Consistent with the biochemical function of SDEL1 and SDEL2,overexpression of SDEL1 or SDEL2 resulted in Pi overaccumulation and induced Pi-starvation signaling even under Pi-sufficient conditions.Conversely,their loss-of-function mutants displayed decreased Pi accumulation and reduced Pi-starvation signaling.Collectively,our study revealed that SDEL1 and SDEL2 facilitate the degradation of SPX4 to modulate PHR2 activity and regulate Pi homeostasis and Pi signaling in response to external Pi availability in rice. | Wenyuan Ruan Meina Guo Xueqing Wang Zhenhui Guo Zhuang Xu Lei Xu Hongyu Zhao Haiji Sun Chengqi Yan Keke Yi | 2019 | Molecular Plant2019，12，8： | 14 |
| 2 | Nat Microbiol:已结首次构建出小鼠肠道微生物组数据库显示文摘小鼠模型通常被广泛用于药理学和医学研究。我们都知道小鼠肠道中的微生物群落通常会对研究结果产生明显的影响,然而目前研究者们并没有获取到关于小鼠肠道中栖息细菌群落的详细信息。近日刊登在国际杂志Nature Microbiology上的一篇研究报告中。德国慕尼黑理工大学的研究者通过研究首次收集到了小鼠肠道中的多种细菌群落。同时研究者还对其进行了分裂、特性分析。最后得到了100种细菌,其中还包括15种迄今为止未知的细菌群落。 | Lu, Qiulun Yao, Yufeng Hu, Zhenkun Hu, Changqing Song, Qixue Ye, Jian Xu, Chengqi Wang, Annabel Z. Chen, Qiuyun Wang, Qing Kenneth | 2016 | 现代生物医学进展2016，16，32： | 13 |
| 3 | Signaling pathways and targeted therapy for myocardial infarction显示文摘Although the treatment of myocardial infarction(MI)has improved considerably,it is still a worldwide disease with high morbidity and high mortality.Whilst there is still a long way to go for discovering ideal treatments,therapeutic strategies committed to cardioprotection and cardiac repair following cardiac ischemia are emerging.Evidence of pathological characteristics in MI illustrates cell signaling pathways that participate in the survival,proliferation,apoptosis,autophagy of cardiomyocytes,endothelial cells,fibroblasts,monocytes,and stem cells.These signaling pathways include the key players in inflammation response,e.g.,NLRP3/caspase-1 and TLR4/MyD88/NF-κB;the crucial mediators in oxidative stress and apoptosis,for instance,Notch,Hippo/YAP,RhoA/ROCK,Nrf2/HO-1,and Sonic hedgehog;the controller of myocardial fibrosis such as TGF-β/SMADs and Wnt/β-catenin;and the main regulator of angiogenesis,PI3K/Akt,MAPK,JAK/STAT,Sonic hedgehog,etc.Since signaling pathways play an important role in administering the process of MI,aiming at targeting these aberrant signaling pathways and improving the pathological manifestations in MI is indispensable and promising.Hence,drug therapy,gene therapy,protein therapy,cell therapy,and exosome therapy have been emerging and are known as novel therapies.In this review,we summarize the therapeutic strategies for MI by regulating these associated pathways,which contribute to inhibiting cardiomyocytes death,attenuating inflammation,enhancing angiogenesis,etc.so as to repair and re-functionalize damaged hearts. | Qing Zhang Lu Wang Shiqi Wang Hongxin Cheng Lin Xu Gaiqin Pei Yang Wang Chenying Fu Yangfu Jiang Chengqi He Quan Wei | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 11 |
| 4 | Reworking effects in the Holocene Zhuye Lake sediments:A case study by pollen concentrates AMS ^(14)C dating显示文摘Transported by wind and water,the relatively old sediments can deposit in the terminal lake of an inland drainage basin.The reworking effect can affect the lake sediments 14 C dating and explanations for proxies.The Zhuye Lake is the terminal lake of the Shiyang River Basin.Previous studies indicated that sediments in different locations of the lake basin showed different climatic change patterns.And then,some radiocarbon dates were inverted for some Late Pleistocene sections.Whether this phenomenon is related with the reworking effect? The pollen concentrates 14 C dating can avoid the reservoir effect,which is an ideal method for studying the reworking effect.In this study,we used the pollen concentrates as dating materials and dated five Holocene sections in the Zhuye Lake Basin.Based on the 14 C dates comparison between the pollen concentrates,organic matter,and shells,the pollen concentrates dates are relatively older than other dating materials.Based on the result,the reworking effect worked in the Zhuye Lake Basin during the Holocene;however,in different locations of the lake basin the reworking effects were in different levels.Furthermore,the Holocene lacustrine deposits were formed mostly during the early and middle Holocene.This study provided clues for reworking effect studies of other lakes in arid China. | LIYu WANG NaiAng LI ZhuoLun ZHANG ChengQi ZHOU XueHua | 2012 | Science China Earth Sciences2012，55，10： | 7 |
| 5 | Effects of Target and Distractor Saturations on the Cognitive Performance of an Integrated Display Interface显示文摘Color coding is often used to enhance decision quality in complex man-machine interfaces of integrated display systems. However, people are easily distracted by irrelevant colors and by the numerous data points and complex structures in the interface. Although an increasing number of studies are seriously focusing on the problem of achieving efficient color coding, few are able to determine the effects of target and distractor saturations on cognitive performance. To study the performances of target colors among distractors, a systematic experiment is conducted to assess the influence of high and low saturated targets on cognitive performance, and the affecting extent of different saturated distractors of homogeneous colors on targets. According to the analysis of the reaction time through the non-parametric statistical method, a calculation method of the cognitive performance of each color is proposed. Based on the calculation of the color differences and the accumulation of the reaction times, it is shown that with the different saturated distractors of homogeneous colors, the high saturated yellow targets perform better than the low saturated ones, and the green and blue targets have moderate performances. When searching for a singleton target placed on a black background, the color difference between the target and the distractor should be more than 20ΔE*ab units in the yellow saturation coding, whereas the color difference should be more than 40ΔE*ab units in the blue and green saturation coding. In addition, as regards saturation coding, the influence of the color difference between the target and the background on cognitive performance is greater than that of the color difference between the target and the distractor. Seemingly, the hue attribute determines whether the saturation difference between the target and the distractor affects the cognitive performance. Based on the experimental results, the simulation design of the instrument dials in a flight situation awareness interface is completed and tested. Simulation results show the feasibility of the method of choosing the target and distractor colors, and the proposed research provides the instruction for the color saturation design of the interface. | XUE Chengqi LI Jing WANG Haiyan NIU Yafeng | 2015 | Chinese Journal of Mechanical Engineering2015，28，1： | 7 |
| 6 | Improvement in grain refinement efficiency of Mg-Zr master alloy for magnesium alloy by friction stir processing显示文摘Previous studies have proved that the zirconium(Zr)alloying and grain refining performance of a Mg-Zr master alloy on Mg alloy is closely related to the distribution of Zr particle size,and a Mg-Zr master alloy with more Zr particles in size range of 1-5μm exhibits a better refining efficiency.In this paper,friction stir processing(FSP)was used to modify the Zr particles size distribution of a commercially available Mg-30 wt.%Zr master alloy,and the subsequent grain refinement ability was studied by trials on a typical Mg-3Nd-0.2Zn-0.6Zr(wt.%,NZ30K)alloy.It is found that plenty of large Zr particles in the as-received Mg-30%Zr master alloy are broken by FSP.Grain refinement tests reveal that the refining efficiency of Mg-30%Zr alloy is significantly improved by FSP,which is attributed to the better distribution of Zr particles.The refinement effect by adding 0.6%FSP-ed Mg-30%Zr is approximately equivalent to that by adding 1.0%as-received Mg-30%Zr.Due to the easy and convenient operation of FSP,this study provides a new method to develop a more efficient Mg-Zr refiner. | Chengqi Wang Ming Sun Feiyan Zheng Liming Peng Wenjiang Ding | 2014 | Journal of Magnesium and Alloys2014，2，3： | 7 |
| 7 | Early Holocene environment at a key location of the northwest boundary of the Asian summer monsoon: a synthesis on chronologies of Zhuye Lake, Northwest China显示文摘The intensified monsoon increases summer rainfall and creates wet conditions in the Asian summer monsoon region during the early Holocene. Along with millennial-scale changes of the monsoon intensity, it is still unclear whether the boundary of the monsoon region changes according to monsoon variability. Investigations into the early Holocene environment in monsoon marginal zones are crucial for understanding the monsoon boundary changes. Zhuye Lake is located at the northwest edge of the Asian summer monsoon, the northern Qilian Mountains, which are less affected by modern summer monsoon water vapor. Previous studies have reached different conclusions regarding the early Holocene climatic and environmental changes based on different dating methods(14C and OSL(optically stimulated luminescence)) and materials(shells, carbonate, pollen concentrates and bulk organic carbon). In this study, we synthesized 102 14C dates and 35 OSL dates from ten Holocene sedimentary sections and ten paleo-shorelines in the lake basin. A comparison between ages from different dating methods and materials generally shows that carbon reservoir effects are relatively slight in Zhuye Lake while the disordered chronologies are mainly related to the erosion processes and reworking effects. In addition, proxy data, including lithology, pollen, total organic carbon and carbonate, were collected from different sites of Zhuye Lake. According to the new synthesis, the early Holocene environment was relatively humid, associated with high runoff and lake water levels. The result indicates that the monsoon boundary moves to the north during the period of the intensified monsoon. A typical arid-area lake was formed during the mid-Holocene when carbonate accumulation and high organic matter contents were the main features of this period. The lake retreated strongly during the late Holocene, showing a drought trend. Overall, the lake evolution is generally consistent with the Holocene Asian summer monsoon change, showing the monsoon influence to monsoon marginal zones. | Yu LI NaiAng WANG ChengQi ZHANG Yue WANG | 2014 | Journal of Arid Land2014，6，5： | 6 |
| 8 | Laser textured dimple-patterns to govern the surface wettability of superhydrophobic aluminum plates显示文摘A laser texturing technique herein can endow bare aluminum alloy surface with regular dimple-pattern array and thus generates a case hardening.After STA treatment,these laser-textured samples become superhydrophobic.The surface wettability of the laser-textured samples can be regulated by controlling the dimple-pattern dimensions during the laser processing.It is noteworthy that a fluorescence method is utilized to record the zones on the superhydrophobic surface penetrated by small enough water molecules.Compared with a general method of the Cassie-Baxter theoretical calculation,this fluorescence method intuitively exhibits the air trapping ability of the superhydrophobic surface.Furthermore,the laser-textured superhydrophobic samples have a notable hysteresis phenomenon at the initial period of UMT friction because the air cushion trapped within superhydrophobic samples have strong repellency against water droplets on the hydrophilic steel ball.Additionally,such samples display strong mechanical stability in comparison with bare aluminum alloy because of the presence of case hardening on the surface of the laser patterns.The research results above provide a valuable reference for designing a surface with different wettability,which may inspire practical applications in the fields of fluid transport,droplet manipulation,water harvesting and microfluidic devices. | Wei Tong Lingling Cui Rongxian Qiu Chengqi Yan Yuntong Liu Nan Wang Dangsheng Xiong | 2021 | Journal of Materials Science & Technology2021，，30： | 3 |
| 9 | AFF3-DNA methylation interplay in maintaining the mono-allelic expression pattern of XIST in terminally differentiated cells显示文摘X chromosome inactivation and genomic imprinting are two classic epigenetic regulatory processes that cause mono-allelic gene expression.In female mammals,mono-allelic expression of the long non-coding RNA gene X-inactive specific transcript(XIST)is essential for initiation of X chromosome inactivation upon differentiation.We have previously demonstrated that the central factor of super elongation complex-like 3(SEC-L3),AFF3,is enriched at gamete differentially methylated regions(DMRs)of the imprinted loci and regulates the imprinted gene expression.Here,we found that AFF3 can also bind to the DMR downstream of the XIST promoter.Knockdown of AFF3 leads to de-repression of the inactive allele of X IST in terminally differentiated cells.In addition,the binding of AFF3 to the XIST DMR relies on DNA methylation and also regulates DNA methylation level at DMR region.However,the KAP1-H3K9 methylation machineries,which regulate the imprinted loci,might not play major roles in maintaining the mono-aUelic expression pattern of XIST in these cells.Thus,our results suggest that the differential mechanisms involved in the X IST DMR and gDMR regulation,which both require AFF3 and DNA methylation. | Yue Zhang Chao Wang Xiaoxu Liu Qian Yang Hongliang Ji Mengjun Yang Manman Xu Yunyan Zhou Wei Xie Zhuojuan Luo Chengqi Lin | 2019 | Journal of Molecular Cell Biology2019，11，9： | 3 |
| 10 | Climatic and environmental change in Yanchi Lake, Northwest China since the Late Glacial: A comprehensive analysis of lake sediments显示文摘现代气候研究证明了亚洲夏天季风水蒸汽运输限于 Qilian 山的东方部分。在 Holocene 上千年规模,夏天季风的西北边界是否根据气候变化变化,是一个关键科学问题。扬奇·莱克位于北 Qilian 山和 Hexi 走廊的中间,在现代气候是亚洲夏天季风影响的更少的地方。它是为检验亚洲夏天季风的长期的变化的一个关键研究区域。Paleoclimatic 数据,包括花粉的 AMS 14C 日期专注并且器官的碳,岩性学,谷物尺寸,矿物质作文和 geochemical 代理的体积从扬奇·莱克的沉积被获得。按年代先后的结果证明湖的节的更低的部分主要在晚冰川、早的 Holocene 时期被形成,当时代理数据显示湖扩大与矿物质盐的高内容被联系。这节的中间的部分在早、中间的 Holocene 的过渡时期期间被形成。由重做的效果影响了,花粉从节的中间的部分集中 AMS 14C 日期通常是比从更低的部分的那些旧的。自从 mid-Holocene,扬奇·莱克显著地撤退了,免职率显然落下。扬奇·莱克记录与一致晚冰川并且 Holocene 湖在典型季风领域在 Qinghai 西藏高原和气候的记录记录,它在晚冰川、早的 Holocene 期间显示湖扩大和强壮的亚洲夏天季风。长期的 monsoonal 模式与在 Holocene 上的中亚的湖进化不同千年规模。这研究在夏天季风的西北的边缘上证明季风影响,并且也证明夏天季风的北边界根据千年规模的气候变化移动的事实。 | LI Yu WANG Nai'ang LI Zhuolun ZHOU Xuehua ZHANG Chengqi | 2013 | Journal of Geographical Sciences2013，23，5： | 3 |
| 11 | The role of internationalization in explaining innovation performance显示文摘 | Mario I. Kafouros Peter J. Buckley John A. Sharp Chengqi Wang | 2007 | Technovation2007，，1： | 2 |
| 12 | What drives outward FDI of Chinese firms? Testing the explanatory power of three theoretical frameworks显示文摘 | Chengqi Wang Junjie Hong Mario Kafouros Agyenim Boateng | 2011 | International Business Review2011，，3： | 2 |
| 13 | Characterization and Proteomic Analysis of Novel Rice Lesion Mimic Mutant with Enhanced Disease Resistance显示文摘Lesion mmic mutants(LMMs)are plants that spontaneously form lesions without pathogeninfection or external stimulus and exhibit resistance to pathogens.Here,a rice LMM was created by ethylmethane sulfonate mutagenesis,named as hpil(hydrogen peroxide induced lesion).Diaminobenzidineand trypan blue staining showed that large amounts of H_(2)O_(2) were produced and cell death was occurredat and around the parts of lesion mimic in the rice leaves.The phenotype of hpil is controlled by a singlerecessive gene,localized at a 2 Mb interval on chromosome 2.The data suggested that hpil is a novelLMM with enhanced bacterial and fungal disease resistance,and multiple pathogenesis-related proteins(PRs)were up-regulated.The proteomes of leaves at three positions(different degrees of lesion mimicseverity)were characterized in hpil compared with its wild type plant.Differentially expressed proteinswere detected by two dimensional difference gel electrophoresis and 274 proteins were identified byMALDITOF/TOFTM.These proteins were related to metabolic process,cellular process and response tostimulus,with mostly down-regulated in hpil leaves.Many of these proteins were related to the Calvincycle,photosynthetic electron transport chain,glycolysis/gluconeogenesis and phosphonates pathways.Some resistance-related proteins including 14-3-3 proteins,OsPR10 and antioxidases such asperoxidase,superoxide dismutase and ascorbate peroxidase were up-regulated in leaves with lesionmimic.These results provide the foundation for cloning of the target gene and shed light on themechanism involved in autaimmunity of rice. | Yang Yong Lin Qiujun Chen Xinyu Liang Weifang Fu Yuwen Xu Zhengjin Wu Yuanhua Wang Xuming Zhou Jie Yu Chulang Yan Chengqi Mei Qiong Chen Jianping | 2021 | Rice science2021，28，5： | 2 |
| 14 | Carbonate formation and water level changes in a paleo-lake and its implication for carbon cycle and climate change, arid China显示文摘碳酸盐免职是在湖的一个主要的无机的碳水池,它变化取决于气候变化和内部湖动力学。关于在湖碳酸盐和气候之间的关系的研究将帮助在湖的系统理解碳周期的机制。这研究的途径是明确地在 paleo 湖(宰埃·莱克) 与 Holocene 长期的气候变化和湖进化连接碳酸盐形成,它是在干旱中国的典型内陆排水盆的一个终端湖。这篇论文从宰埃·莱克的不同地点在谷物尺寸,碳酸盐内容和沉积样品的矿物学的作文上论述分析。方解石和霰石是为湖碳酸盐的二个主要部件的结果表演,和碳酸盐丰富与湖扩大被联系在期间对中间的 Holocene 晚冰川、早。在中国的干旱区域的 Holocene 湖扩大通常与能在终端湖加强盆宽的表面碳酸盐累积的高盆宽的降水被连接。为这个原因,宰埃·莱克在 Holocene 的湿时期期间起碳水池的一个作用。 | Yu LI Nai'ang WANG Zhuolun LI Xuehua ZHOU Chengqi ZHANG Yue WANG | 2013 | Frontiers of Earth Science2013，7，4： | 2 |
| 15 | Sequence Signatures of Nucleosome Positioning in Caenorhabditis elegans显示文摘Our recent investigation in the protist Trichomonas vaginalis suggested a DNA sequence periodicity with a unit length of 120.9 nt, which represents a sequence signature for nucleosome positioning. We now extended our observation in higher eukaryotes and identified a similar periodicity of 175 nt in length in Caenorhabditis elegans. In the process of defining the sequence compositional characteristics, we found that the 10.5-nt periodicity, the sequence signature of DNA double helix, may not be sufficient for cross-nucleosome positioning but provides essential guiding rails to facilitate positioning. We further dissected nucleosome-protected sequences and identified a strong positive purine (AG) gradient from the 5′-end to the 3′-end, and also learnt that the nucleosome-enriched regions are GC-rich as compared to the nucleosome-free sequences as purine content is positively correlated with GC content. Sequence characterization allowed us to develop a hidden Markov model (HMM) algorithm for decoding nucleosome positioning computationally, and based on a set of training data from the fifth chromosome of C. elegans, our algorithm predicted 60%-70% of the well-positioned nucleosomes, which is 15%-20% higher than random positioning. We concluded that nucleosomes are not randomly positioned on DNA sequences and yet bind to different genome regions with variable stability, well-positioned nucleosomes leave sequence signatures on DNA, and statistical positioning of nucleosomes across genome can be decoded computationally based on these sequence signatures. | Kaifu Chen Lei Wang Meng Yang Jiucheng Liu Chengqi Xin Songnian Hu Jun Yu | 2010 | Genomics, Proteomics & Bioinformatics2010，8，2： | 2 |
| 16 | The Impact of Inward FDI on the Performance of Chinese Manufacturing Firms显示文摘 | PETER J BUCKLEY JEREMY CLEGG CHENGQI WANG | 2002 | Journal of Intema-tional Business Studies2002，33，4： | 1 |
| 17 | Country-of-Origin Effects of Foreign Direct Investment显示文摘 | Associate Prof. and Reader Chengqi Wang Prof. Jeremy Clegg Lecturer Mario Kafouros | 2009 | Management International Review2009，，2： | 1 |
| 18 | The Impact of Foreign Direct Investment on Chinese export performance显示文摘 | Chengqi Wang Peter J Buckley and Jeremy Clegg | 2002 | 28th Annual Conference of European International Business Academy2002，810，： | 1 |
| 19 | The role of internationalization in explaining innovation performance显示文摘 | Mario I. Kafouros Peter J. Buckley John A. Sharp Chengqi Wang | 2007 | Technovation2007，，1： | 1 |
| 20 | Exploring the Role of Government Involvement in Outward FDI from Emerging Economies 显示文摘 | Chengqi Wang JunjieHong | 2012 | Journal of International Business Studies2012，，43： | 1 |
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