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| 1 | Experimental cancer gene therapy by multiple anti-survivin hammerhead ribozymes显示文摘为癌症改进基因治疗的功效,我们设计了指向 survivin mRNA 的暴露的区域的四撞木鲛 ribozyme 侵入人体气管粘膜的病菌(到 R4 的 R1 ) 。除了在里面 vitro 描述,由教材扩展包括了劈开的顺序特性的一颗决心,为细胞增长并且为的试金在 vivo 肿瘤,生长被用来为 ribozyme 效率得分。survivin 表示的产生抑制经由 caspase-3-dependent 小径导致了有丝分裂的大祸和房间死亡。重要地, ribozyme 侵入人体气管粘膜的病菌的管理在一个 hepato 细胞的癌异种皮移植老鼠模型禁止了肿瘤生长。R1, R3 和 R4 ribozymes 的合作表示 synergistically 压制了 survivin 并且当这联合指向 survivin 抄本的所有主要形式,生产了大多数有势力反癌症效果。带在这份报告描述的多重撞木鲛 ribozymes 的侵入人体气管粘膜的病菌对癌症提供了柔韧的基因治疗策略。 | Qi Fei Hongyu Zhang Lili Fu Xinlan Dai Baomei Gao Min Ni Chao Ge Jinjun Li Xia Ding Yuwen Ke Xuebiao Yao Jingde Zhu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，6： | 10 |
| 2 | siRNA targeting stathmin inhibits invasion and enhances chemotherapy sensitivity of stem cells derived from glioma cell lines显示文摘Glioma 高度是大多数之一 angiogenic 肿瘤,和 glioma 干细胞(GSC ) 为到化疗和放射疗法的抵抗负责,以及在操作以后的复发。Stathmin 为有丝分裂是实质的并且在导出 glioma 的 endothelial 房间的增长和移植起一个重要作用。然而,在 stathmin 和 GSC 之间的关系不完全地被理解。这里,我们从 glioma 房间线 U87MG 和 U251 孤立 GSC,然后使用了为 silencing 指向 stathmin 的 siRNA。我们证明 stathmin 的 silencing 压制了增长,增加了 apoptosis 率,并且逮捕了在在 GSC 的 G2/M 阶段的房间周期。在 GSC 的 stathmin 的 Silencing 也导致了禁止了迁居 / 侵略以及 vasculogenic 的能力模仿。到 temozolomide 的 GSC 的危险性被 stathmin silencing 也提高。我们的调查结果为 glioma 处理在 GSC 作为一个潜在的目标建议 stathmin。 | Yuwen Song Luyan Mu Xuezhe Han Xiaoqian Liu Songbin Fu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 4 |
| 3 | Characterization and Proteomic Analysis of Novel Rice Lesion Mimic Mutant with Enhanced Disease Resistance显示文摘Lesion mmic mutants(LMMs)are plants that spontaneously form lesions without pathogeninfection or external stimulus and exhibit resistance to pathogens.Here,a rice LMM was created by ethylmethane sulfonate mutagenesis,named as hpil(hydrogen peroxide induced lesion).Diaminobenzidineand trypan blue staining showed that large amounts of H_(2)O_(2) were produced and cell death was occurredat and around the parts of lesion mimic in the rice leaves.The phenotype of hpil is controlled by a singlerecessive gene,localized at a 2 Mb interval on chromosome 2.The data suggested that hpil is a novelLMM with enhanced bacterial and fungal disease resistance,and multiple pathogenesis-related proteins(PRs)were up-regulated.The proteomes of leaves at three positions(different degrees of lesion mimicseverity)were characterized in hpil compared with its wild type plant.Differentially expressed proteinswere detected by two dimensional difference gel electrophoresis and 274 proteins were identified byMALDITOF/TOFTM.These proteins were related to metabolic process,cellular process and response tostimulus,with mostly down-regulated in hpil leaves.Many of these proteins were related to the Calvincycle,photosynthetic electron transport chain,glycolysis/gluconeogenesis and phosphonates pathways.Some resistance-related proteins including 14-3-3 proteins,OsPR10 and antioxidases such asperoxidase,superoxide dismutase and ascorbate peroxidase were up-regulated in leaves with lesionmimic.These results provide the foundation for cloning of the target gene and shed light on themechanism involved in autaimmunity of rice. | Yang Yong Lin Qiujun Chen Xinyu Liang Weifang Fu Yuwen Xu Zhengjin Wu Yuanhua Wang Xuming Zhou Jie Yu Chulang Yan Chengqi Mei Qiong Chen Jianping | 2021 | Rice science2021，28，5： | 2 |
| 4 | Landscape Pattern of Ancient Terraces in Huangping County and Slopeto-Terrace Strategy显示文摘Formation and development of ancient terraces proves that slope-to-terrace project is a signifi cant measure for conserving water and soil in mountainous areas. UAV remote sensing technology was applied to obtain RS images with a resolution ratio of 0.1–0.5 m, Arc GIS was applied for data processing, and Fragstats3.3 was used to calculate characteristic indexes, to study landscape pattern of 4 ancient terraces in Huangping County, Guizhou Province. The results showed that terrace landscapes and woodland landscapes in the study area account for nearly 80% of the whole landscape(terrace 30%, woodland 50%); mean area of single fi eld is mainly concentrated between 100 m^2 and 200 m^2, and height between 0.7 m and 1.7 m, breadth 0.5 m and 0.6 m; most terraces have a gradient of 5–25°, accounting for 70% of the total number of fi eld. The water and soil conservation concept in the ancient terraces provides references for the slope-to-terrace project and the water and soil loss control of slope farmland. | LAN An'jun ZHAN Fengli FU Yuwen ZHONG Jiusheng LIU Fayong YOU Boyu | 2016 | Journal of Landscape Research2016，8，2： | 1 |
| 5 | Stress Analysis for the Field near Crack Tip of Bi-material Beam by Image Distinction of the Isodyne Pattern显示文摘 | Fu Yi Ji Xinhua Qin Yuwen | 2003 | SPIE2003，5286，： | 1 |
| 6 | Flexible rotation of transverse optical field for 2D self-accelerating beams with a designated trajectory显示文摘Self-accelerating beams have the unusual ability to remain diffraction-free while undergo the transverse shift during the free-space propagation.We theoretically identify that the transverse optical field distribution of 2D self-accelerating beam is determined by the selection of the transverse Cartesian coordinates,when the caustic method is utilized for its trajectory design.Based on the coordinate-rotation method,we experimentally demonstrate a scheme to flexibly manipulate the rotation of transverse optical field for 2D self-accelerating beams under the condition of a designated trajectory.With this scheme,the transverse optical field can be rotated within a range of 90 degrees,especially when the trajectory of 2D self-accelerating beams needs to be maintained for free-space photonic interconnection. | Lei Zhu Xuesong Zhao Chen Liu Songnian Fu Yuncai Wang Yuwen Qin | 2021 | Opto-Electronic Advances2021，4，3： | 1 |
| 7 | Nonlinear Fourier transform enabled eigenvalue spectrum investigation for fiber laser radiation显示文摘Fiber lasers are a paradigm of dissipative systems,which distinguish themselves from a Hamilton system where energy is conservative.Consequently,pulses generated in a fiber laser are always accompanied by the continuous wave(CW).Under certain hypothesis,pulses generated in a fiber laser can be considered as a soliton,a product of a Hamilton system.Therefore,all the descriptions of solitons of a fiber laser are approximate.Coexistence of solitons and the CW from a fiber laser prevents unveiling of real nonlinear dynamics in fiber lasers,such as soliton interactions.Pulse behavior in a fiber laser can be represented by the state of single pulse,the state of period doubling of single pulse,the states of two pulses either tightly bound or loosely distributed,the states of three pulses,and various combinations of the above-mentioned states.Recently,soliton distillation was proposed and numerically demonstrated based on the nonlinear Fourier transform(NFT)[J.Lightwave Technol.39,2542(2021)].Solitons can be separated from the coherent CW background.Therefore,it is feasible to isolate solitons from CW background in a fiber laser.Here,we applied the NFT to various pulses generated in a fiber laser,including single pulse,single pulse in period doubling,different double pulses,and multiple pulses.Furthermore,with the approach of soliton distillation,the corresponding pure solitons of those pulses are reconstructed.Simulation results suggest that the NFT can be used to identify soliton dynamics excluding CW influence in a fiber laser,which paves a new way for uncovering real soliton interaction in nonlinear systems. | YUTIAN WANG SONGNIAN FU JIAN KONG ANDREY KOMAROV MARIUSZ KLIMCZAK RYSZARD BUCZY'n SKI XIAHUI TANG MING TANG YUWEN QIN LUMING ZHAO | 2021 | Photonics Research2021，9，8： | 1 |
| 8 | Antioxidant procyanidin B2 protects oocytes against cryoinjuries via mitochondria regulated cortical tension显示文摘Background:Irreversible cryodamage caused by oocyte vitrification limited its wild application in female fertility preservation.Antioxidants were always used to antagonist the oxidative stress caused by vitrification.However,the comprehensive mechanism underlying the protective role of antioxidants has not been studied.Procyanidin B2(PCB2)is a potent natural antioxidant and its functions in response to vitrification are still unknown.In this study,the effects of PCB2 on vitrified-thawed oocytes and subsequent embryo development were explored,and the mechanisms underlying the protective role of PCB2 were systematically elucidated.Results:Vitrification induced a marked decline in oocyte quality,while PCB2 could improve oocyte viability and further development after parthenogenetic activation.A subsequent study indicated that PCB2 effectively attenuated vitrification-induced oxidative stress,rescued mitochondrial dysfunction,and improved cell viability.Moreover,PCB2 also acts as a cortical tension regulator apart from strong antioxidant properties.Increased cortical tension caused by PCB2 would maintain normal spindle morphology and promote migration,ensure correct meiosis progression and finally reduce the aneuploidy rate in vitrified oocytes.Further study reveals that ATP biosynthesis plays a crucial role in cortical tension regulation,and PCB2 effectively increased the cortical tension through the electron transfer chain pathway.Additionally,PCB2 would elevate the cortical tension in embryo cells at morula and blastocyst stages and further improve blastocyst quality.What's more,targeted metabolomics shows that PCB2 has a beneficial effect on blastocyst formation by mediating saccharides and amino acids metabolism.Conclusions:Antioxidant PCB2 exhibits multi-protective roles in response to vitrification stimuli through mitochondria-mediated cortical tension regulation. | Qingrui Zhuan Jun Li Xingzhu Du Luyao Zhang Lin Meng Yuwen Luo Dan Zhou Hongyu Liu Pengcheng Wan Yunpeng Hou Xiangwei Fu | 2023 | Journal of Animal Science and Biotechnology2023，14，1： | 0 |
| 9 | Climate Prediction and Diagnostic Analysis of Typhoon Precipitation in Midsummer of Yongzhou显示文摘By consulting the typhoon yearbook and restoring the historical weather chart,technical separation of typhoon precipitation in Yongzhou from July to September of 1981-2015 was conducted.On this basis,climatic characteristics of typhoon precipitation in midsummer of Yongzhou were analyzed,and climate prediction and diagnostic analysis were carried out.The research results showed that typhoon precipitation was an important component of midsummer precipitation in Yongzhou,but its contribution to total precipitation was not as much as precipitation of the westerly belt system.When the ridge line of the western Pacific subtropical high was northward,typhoon precipitation was more than westerly precipitation in midsummer of Yongzhou;when the subtropical high was southward,there were more patterns of westerly precipitation year;when the subtropical high was normally northward,typhoon precipitation and westerly precipitation were less,with more dry years.In summer,abnormal cold sea surface temperature(SST)in tidal zone and warm pool zone of western Pacific and abnormal warm SST in NinoZ zone(strong El Nino event)were favorable for that the ridge line of the western Pacific subtropical high was southward,and there were more patterns of westerly precipitation year in midsummer of Yongzhou.On the contrary,when subtropical high was northward or normally northerly,there was less westerly precipitation.In non La Nina years when the subtropical high was northward,most of them were typhoon precipitation years.In La Nina years when the subtropical high was northward,most of them were dry years. | Zhiyu LONG Wei FU Shen LIU Yuwen ZHOU | 2020 | Meteorological and Environmental Research2020，11，5： | 0 |
| 10 | Self-templating synthesis of biomass-based porous carbon nanotubes for energy storage and catalytic degradation applications显示文摘Dwindling energy sources and a worsening environment are huge global problems,and biomass wastes are an under-exploited source of material for both energy and material generation.Herein,self-template decoction dregs of Ganoderma lucidum-derived porous carbon nanotubes(ST-DDLGCs)were synthesized via a facile and scalable strategy in response to these challenges.ST-DDLGCs exhibited a large surface area(1731.51 m^(2)g^(-1))and high pore volume(0.76 cm^(3)g^(-1)),due to the interlacing tubular structures of precursors and extra-hierarchical porous structures on tube walls.In the ST-DDLGC/PMS system,the degradation efficiency of capecitabine(CAP)reached~97.3%within 120 min.Moreover,ST-DDLGCs displayed high catalytic activity over a wide pH range of 3–9,and strong anti-interference to these typical and ubiquitous anions in wastewater and natural water bodies(i.e.,H_(2)PO_(4)^(-),NO_(3)^(-),Cl^(-) and HCO_(3)^(-)),in which a ^(1)O_(2)-dominated oxidation was identified and non-radical mechanisms were deduced.Additionally,ST-DDLGC-based coin-type symmetrical supercapacitors exhibited outstanding electrochemical performance,with specific capacitances of up to 328.1 F g^(-1)at 0.5 A g^(-1),and cycling stability of up to 98.6%after 10,000 cycles at a current density of 2 A g^(-1).The superior properties of ST-DDLGCs could be attributed to the unique porous tubular structure,which facilitated mass transfer and presented numerous active sites.The results highlight ST-DDLGCs as a potential candidate for constructing inexpensive and advanced environmentally functional materials and energy storage devices. | Manman Xu Shiqi Fu Yukai Wen Wei Li Qiongfang Zhuo Haida Zhu Zhikeng Zheng Yuwen Chen Anqi Wang Kai Yan | 2024 | Green Energy & Environment2024，9，3： | 0 |
| 11 | Negative refraction mediated by bound states in the continuum显示文摘Negative refraction might occur at the interface between a two-dimensional photonic crystal(Ph C)slab and a homogeneous medium,where the guiding of the electromagnetic wave along the third dimension is governed by total internal reflection.Herein,we report on the observation of negative refraction in the Ph C slab where the vertical guiding is enabled by a bound state in the continuum and essentially beyond the light cone.Such abnormal refraction and guiding mechanism are based on the synchronous crafting of spatial dispersion and the radiative lifetime of Bloch modes within the radiative continuum.Microwave experiments are provided to further validate the numerical proposal in an all-dielectric Ph C platform.It is envisioned that the negative refraction observed beyond the light cone might facilitate the development of optical devices in integrated optics,such as couplers,multiplexers,and demultiplexers. | ZHANYUAN ZHANG FEIFEI QIN YI XU SONGNIAN FU YUNCAI WANG YUWEN QIN | 2021 | Photonics Research2021，9，8： | 0 |
| 12 | Investigation of transfer ionization processes in the collision of partially stripped carbon ions on Argon显示文摘The ratios of the cross section of the transfer-ionization to the single-electron-capture of Argon induced by Cq+ (q=1,2,3) ions are measured by means of position sensitive and time-of-flight techniques. Our experimental results are compared with the data of Heq+ (q=1,2)-Ar of DuBois. A qualitative interpretation is presented based on the Classical-Over-Barrier Model of Bohr. | WANG Jun CHEN XiMeng DING BaoWei FU HongBin CUI Ying SHAO JianXiong LU YanXia GAO ZhiMin LIU YuWen Du Juan SUN GuangZhi CHEN Lin | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，7： | 0 |
| 13 | Double-branch fusion network with a parallel attention selection mechanism for camouflaged object detection显示文摘To meet the challenge of camouflaged object detection(COD),which has a high degree of intrinsic similarity between the object and background,this paper proposes a double-branch fusion network(DBFN)with a parallel attention selection mechanism(PASM).In detail,a schismatic receptive field block(SRF)combined with an attention mechanism for low-level information is performed to learn texture features in one branch,and an integration of the SRF,a hybrid attention mechanism(HAM),and a depth feature polymerization module(DFPM)is employed for high-level information to extract detection features in the other branch.Then,both texture features and detection features are input into the PASM to acquire selective expression matrices.Eventually,the final result is obtained after further selective matrix optimization with atrous spatial pyramid pooling(ASPP)and a residual channel attention block(RCAB)being applied serially.Experimental results on three public datasets verify that our method outperforms the state-of-the-art methods in terms of four evaluation metrics,i.e.,mean absolute error(MAE),weighted Fβmeasure(Fβω),structural measure(S_(α)),and E-measure(E_(φ)) | Junjiang XIANG Qing PAN Zhengrong ZHANG Songnian FU Yuwen QIN | 2023 | Science China(Information Sciences)2023，66，6： | 0 |
| 14 | 10 Gb/s classical secure key distribution based on temporal steganography and private chaotic phase scrambling显示文摘Secure distribution of high-speed digital encryption/decryption keys over a classical fiber channel is strongly pursued for realizing perfect secrecy communication systems.However,it is still challenging to achieve a secret key rate in the order of tens of gigabits per second to be comparable with the bit rate of commercial fiber-optic systems.In this paper,we propose and experimentally demonstrate a novel solution for high-speed secure key distribution based on temporal steganography and private chaotic phase scrambling in the classical physical layer.The encryption key is temporally concealed into the background noise in the time domain and randomly phase scrambled bit-by-bit by a private chaotic signal,which provides two layers of enhanced security to guarantee the privacy of key distribution while providing a high secret key rate.We experimentally achieved a record classical secret key rate of 10 Gb/s with a bit error rate lower than the hard-decision forward error correction(HD-FEC)over a 40 km standard single mode fiber.The proposed solution holds great promise for achieving high-speed key distribution in the classical fiber channel by combining steganographic transmission and chaotic scrambling. | ZHENSEN GAO ZHITAO DENG LIHONG ZHANG XULIN GAO YUEHUA AN ANBANG WANG SONGNIAN FU ZHAOHUI LI YUNCAI WANG YUWEN QIN | 2024 | Photonics Research2024，12，2： | 0 |
| 15 | Multimodel ensemble projection of photovoltaic power potential in China by the 2060s显示文摘为了实现能源转型的目标,中国对太阳能的需求一直在极速增长.然而,太阳能发电潜力受到天气条件的影响并预期在气候变暖背景下发生改变.本文中,作者利用第六次国际耦合模式比较计划(CMIP6)24个气候模式的气象变量以及4个不同形式的光伏模型,预估了在2060年代低排放或高排放情况下中国的光伏发电潜力.多模式集合平均光伏功率在2004-2014年为277.2KWhm-2yr-1,并呈现出从西到东的下降趋势.到2054-2064年,在低排放情景下,全国平均光伏发电潜力将增加2.29%,而在高排放情景下则减少0.43%.低排放情景的排放控制大大增强了地表太阳辐射,促进了东部的光伏发电.相反,在高排放情景下,强烈的变暖对光伏发电产生了抑制作用.极端暖事件使光伏发电潜力在低排放情景下降低0.28%,而高排放情景下降低0.44%,分别相当于当代损失量的两倍和三倍.预估表明排放控制带来的清洁空气和适度变暖对中国未来的太阳能利用是有益的. | Xu Zhao Xu Yue Chenguang Tian Hao Zhou Bin Wang Yuwen Chen Yuan Zhao Weijie Fu Yihan Hu | 2023 | Atmospheric and Oceanic Science Letters2023，16，5： | 0 |
| 16 | Echo State Network Based on Improved Knowledge Distillation for Edge Intelligence显示文摘Echo state network(ESN)as a novel artificial neural network has drawn much attention from time series prediction in edge intelligence.ESN is slightly insufficient in long-term memory,thereby impacting the prediction performance.It suffers from a higher computational overhead when deploying on edge devices.We firstly introduce the knowledge distillation into the reservoir structure optimization,and then propose the echo state network based on improved knowledge distillation(ESN-IKD)for edge intelligence to improve the prediction performance and reduce the computational overhead.The model of ESN-IKD is constructed with the classic ESN as a student network,the long and short-term memory network as a teacher network,and the ESN with double loop reservoir structure as an assistant network.The student network learns the long-term memory capability of the teacher network with the help of the assistant network.The training algorithm of ESN-IKD is proposed to correct the learning direction through the assistant network and eliminate the redundant knowledge through the iterative pruning.It can solve the problems of error learning and redundant learning in the traditional knowledge distillation process.Extensive experimental simulation shows that ESN-IKD has a good time series prediction performance in both long-term and short-term memory,and achieves a lower computational overhead. | Jian ZHOU Yuwen JIANG Lijie XU Lu ZHAO Fu XIAO | 2024 | Chinese Journal of Electronics2024，33，1： | 0 |
| 17 | 大规模无创产前检测的基因组分析揭示了多个性状的遗传关联、病毒的感染模式以及中国人群的遗传历史显示文摘文章简介本研究分析了参与无创产前基因检测(NIPT)的141,431名中国女性的全基因组低深度测序数据。研究团队使用这些数据描绘了中国人的群体遗传特征,并探索了遗传因素与母婴健康等性状的相互关联情况。 | Siyang Liu Shujia Huang Fang Chen Lijian Zhao Yuying Yuan Stephen Starko Francis Lin Fang Zilong Li Long Lin Rong Liu Yong Zhang Huixin Xu Shengkang Li Yuwen Zhou Robert W.Davies Qiang Liu Robin G.Walters Kuang Lin Jia Ju Thorfinn Korneliussen Melinda A.Yang Qiaomei Fu Jun Wang Lijun Zhou Anders Krogh Hongyun Zhang Wei Wang Zhengming Chen Zhiming Cai Ye Yin Huanming Yang Mao Mao Jay Shendure 汪建 Anders Albrechtsen 金鑫 Rasmus Nielsen 徐讯 | 2019 | 科学新闻2019，0，2： | 0 |
| 18 | Linear shallow neural network to accelerate transmitter dispersion eye closure quaternary(TDECQ)assessment显示文摘To support the ever-emerging capacity requirement of datacenter interconnection(DCI)applications,transmitter dispersion eye closure quaternary(TDECQ)has been proposed by IEEE802.3 standard[1],which is specifically employed for the four-level pulse amplitude modulation(PAM-4)signals.However,the traditional scheme of TDECQ assessment needs several iterative operations。 | Junjiang XIANG Zejun CHEN Yijun CHENG Hailin YANG Xuancheng HUO Meng XIANG Gai ZHOU Yuwen QIN Songnian FU | 2024 | Science China(Information Sciences)2024，67，4： | 0 |
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