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| 1 | TAOK1 negatively regulates IL-17-mediated signaling and inflammation显示文摘Interleukin 17(IL-17)is an important cytokine that can induce tissue inflammation and is involved in the pathogenesis of numerous autoimmune diseases.However,the regulation of its signaling transduction has not been well described.In this study,we report that thousand and one kinase 1(TAOK1)functions as a negative regulator of IL-17-mediated signal transduction and inflammation.TAOK1 knockdown promotes IL-17-induced cytokine and chemokine expression and the activation of mitogen-activated protein kinases and nuclear factor-κB.We further demonstrate that TAOK1 interacts with IL-17 receptor A(IL-17RA)independent of its kinase activity,and TAOK1 dose-dependently prevents the formation of the IL-17R-Act1(nuclear factor activator 1,also known as tumor necrosis factor receptor-associated factor 3 interacting protein 2)complex.Consistent with this,TAOK1 deficiency exacerbates colitis in the 2,4,6-trinitrobenzenesulfonic acid-induced experimental model of inflammatory bowel disease,likely by its promotion of the IL-17-mediated signaling pathway.TAOK1 expression is decreased in the colons of ulcerative colitis patients.In conclusion,these findings suggest that TAOK1 is involved in the development of IL-17-related autoimmune disorders. | Zhaoru Zhang Zhen Tang Xianwei Ma Kai Sun Liping Fan Jie Fang Jianping Pan Xiaojian Wang Huazhang An Jun Zhou | 2018 | Cellular & Molecular Immunology2018，15，8： | 10 |
| 2 | PROGRESS IN STUDIES OF ELECTROCATALYSTS AND DOPED CARBON ANODES IN ALUMINIUM ELECTROLYSIS CELLS显示文摘PROGRESSINSTUDIESOFELECTROCATALYSTSANDDOPEDCARBONANODESINALUMINIUMELECTROLYSISCELLSPROGRESSINSTUDIESOFELECTROCATALYSTSANDDOPE... | Liu,Yexiang Wang,Xiangmin Huang,YongzhongWang,Huazhang Yang,Jianhong(Department of Nonferrous Metallurgy, Central South University of Technology,Changsha 410083) | 1994 | 中国有色金属学会会刊:英文版1994，4，2： | 4 |
| 3 | Advanced treatment of coking wastewater by coagulation and zero-va- lent iron processes显示文摘 | Lai Peng Zhao Huazhang Wang Chao | 2007 | Journal of Hazardous Materials2007，147，： | 1 |
| 4 | Advanced Treatment of Coking Wastewater by Coagulation and Zero-Valent Iron Processes显示文摘 | Lai Peng Zhao Huazhang Wang Chao | 2007 | J Hazard Mater2007，147，1： | 1 |
| 5 | Advanced treatment of coking wastewater by coagulation and zero-valent iron processes 显示文摘 | Lai Peng Zhao Huazhang Wang Chao | 2007 | Journal of Hazardous Materials2007，147，12： | 1 |
| 6 | Advanced treatment of eoking wastewater by coagulation and zero-valent iron processes 显示文摘 | Lai Pang Zhao Huazhang Wang Chac | 2007 | Journal of Hazardous Materials2007，147，12： | 1 |
| 7 | The primers are referenced to Involvement of ERK,p38 and NF-KB singal transduction in regulation of TLR2,TLR4 and TLR9 gene expression induced by lipopolysaccharide in mouse dendritic cell显示文摘 | Huazhang AN Golen DT Wang JE | 2002 | Immunology2002，106，： | 1 |
| 8 | Advanced treatment of coking wastewater by coagulation and zero-valent iron processes 显示文摘 | Peng Lai Huazhang Zhao Chao Wang | 2007 | Journal of Hazardous Materials2007，147，： | 1 |
| 9 | Advanced treat ment of coking wastewater by coagulation and zero valent iron processes显示文摘 | Lai Peng Zhao Huazhang Wang Chao | 2007 | Journal of Hazardous Materials2007，147，1： | 1 |
| 10 | Ad- vanced treatment of coking wastewater by coagulation and zero-valent iron processes 显示文摘 | Lai Peng Zhao Huazhang Wang Chao | 2007 | J Hazard Mater2007，147，12： | 1 |
| 11 | Tile primers are referenced to involvement of ERK, p38and NF-κB singal transduction in regulation of TLR2,TLR4 and TLR9 gene expression induced by lipopolysaceharide in mouse dendritic cell显示文摘 | Huazhang A N Golen D T Wang J E | 2002 | Immunology2002，106，1： | 1 |
| 12 | Advanced treatment of coking wastewater by coagulation and zero-valent iron processes显示文摘 | Lai Peng Zhao Huazhang Wang Chao | 2007 | Journal of Hazardous Materials2007，147，12： | 1 |
| 13 | The behavior and improvement of SnO2-based inert anodes in aluminium electrolysis显示文摘 | Yang jianhong Liu Yexiang Wang Huazhang | 1993 | Light Metals1993，，： | 1 |
| 14 | The cathodic processes for electrocodeposition of TiB2 in molten fluoride 显示文摘 | Wang Huazhang Tang Xiao | 1997 | The Chinese Journal of Nonferrous Metals1997，7，2： | 1 |
| 15 | Ad- vanced treatment of coking wastewater by coagulation and zero-valent iron processes 显示文摘 | Lai Peng Zhao Huazhang Wang Chao | 2007 | J Hazard Mater2007，147，： | 1 |
| 16 | Advanced treatment of coking wastewater by coagulation and zero-valent iron processes 显示文摘 | Lai Peng Zhao Huazhang Wang Chao | 2007 | Journal of Hazardous Materials2007，147，12： | 1 |
| 17 | Advanced treatment of coking wastewater by coagulation and zero-valent iron processes显示文摘 | Lai Peng Zhao Huazhang Wang Chao | 2007 | Journal of Hazardous Materials2007，147，1： | 1 |
| 18 | Advanced treatment of coking wastewater by coagulation and zero- valent iron processes 显示文摘 | Lai Peng Zhao Huazhang Wang Chao | 2007 | Journal of Hazardous Materials2007，147，12： | 1 |
| 19 | General Design and Thermodynamic Analysis of a Supercritical Carbon Dioxide Cannon显示文摘This paper presents a new supercritical carbon dioxide(SCO_(2))cannon based on the carbon dioxide(CO_(2))’s thermodynamic cycle under constant volume.First,Virial equation and NIST database are applied to formulate SCO_(2)’s property and analyze the thermodynamic cycle,which is aimed to get the optimization equation using the cannon’s exit velocity as objective function.Then the cannon’s structural parameters,such as diaphragm thickness and barrel length,and CO_(2)’s filling mass,are optimized.Finally,the flow field and velocity’s change during the launch process is performed with FLUENT.In field test,the ultra-high pressure sensor and ultra-high speed camera are used to measure the pressure distribution along the barrel’s axial direction and the projectile’s exit velocity under different conditions.The results show that all the performance indexes meet the design requirement.The innovative SCO_(2)cannon in this paper has obvious advantages such as high safety,low cost and fast loading,which can be applied in many situations such as disaster relief,peacekeeping and anti-terrorism.Moreover,the unique energy storage method and thermodynamic design ensure its subsequent development. | ZHANG Fan LIU Hongrui WU You LI Jiaqi YU Huazhang WANG Xiaoliang GUO Baoting YUAN Yixiang | 2021 | Journal of Thermal Science2021，30，1： | 1 |
| 20 | Advanced treatment of coking wastewater by coagulation and zero-valent iron processes 显示文摘 | Lai Peng Zhao Huazhang Wang Chao | 2007 | Journal of Hazardous Materials2007，147，1： | 1 |
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