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| 1 | Inhibition and recovery of nitrification in treating real coal gasification wastewater with moving bed biofilm reactor显示文摘Moving bed biofilm reactor (MBBR) was used to treat real coal gasification wastewater. Nitrification of the MBBR was inhibited almost completely during start-up period. Sudden increase of influent total NH 3 concentration was the main factor inducing nitrification inhibition. Increasing DO concentration in the bulk liquid (from 2 to 3 mg/L) had little effect on nitrification recovery. Nitrification of the MBBR recovered partially by the addition of nitrifying sludge into the reactor and almost ceased within 5 days. Nitrification ratio of the MBBR achieved 65% within 12 days by increasing dilute ratio of the influent wastewater with tap water. The ratio of nitrification decreased to 25% when influent COD concentration increased from 650 to 1000 mg/L after nitrification recovery and recovered 70% for another 4 days. | Huiqiang Li Hongjun Han Maoan Du Wei Wang | 2011 | Journal of Environmental Sciences2011，23，4： | 34 |
| 2 | Enhanced anaerobic biodegradability of real coal gasification wastewater with methanol addition显示文摘Coal gasification effluent is a typical refractory industrial wastewater with a very poor anaerobic biodegradability due to its toxicity.Methanol was introduced to improve anaerobic biodegradability of real coal gasification wastewater,and the effect of methanol addition on the performance was investigated in a mesophilic upflow anaerobic sludge bed reactor with a hydraulic retention time of 24 hr.Experimental results indicated that anaerobic treatment of coal gasification wastewater was feasible with the addition of methanol.The corresponding maximum COD and phenol removal rates were 71% and 75%,respectively,with methanol concentration of 500 mg COD/L for a total organic loading rate of 3.5 kg COD/(m3 ·day) and a phenol loading rate of 0.6 kg/(m3 ·day).The phenol removal rate was not improved with a higher methanol concentration of 1000 mg COD/L.Substrate utilization rate (SUR) tests indicated that the SURs of phenol were 106,132,and 83 mg phenol/(g VSS·day) at methanol concentrations of 250,500,and 1000 mg COD/L,respectively,and only 45 mg phenol/(g VSS·day) in the control reactor.The presence of methanol could reduce the toxicity of coal gasification wastewater and increase the biodegradation of phenolic compounds. | Wei Wang,Hongjun Han,Min Yuan,Huiqiang Li State Key Laboratory of Urban Water Resource and Environment,Harbin Institute of Technology,Harbin 150090,China | 2010 | Journal of Environmental Sciences2010，22，12： | 25 |
| 3 | Flow Dynamics of a Spiral-groove Dry-gas Seal显示文摘The dry-gas seal has been widely used in different industries.With increased spin speed of the rotator shaft,turbulence occurs in the gas film between the stator and rotor seal faces.For the micro-scale flow in the gas film and grooves,turbulence can change the pressure distribution of the gas film.Hence,the seal performance is influenced.However,turbulence effects and methods for their evaluation are not considered in the existing industrial designs of dry-gas seal.The present paper numerically obtains the turbulent flow fields of a spiral-groove dry-gas seal to analyze turbulence effects on seal performance.The direct numerical simulation(DNS) and Reynolds-averaged Navier-Stokes(RANS) methods are utilized to predict the velocity field properties in the grooves and gas film.The key performance parameter,open force,is obtained by integrating the pressure distribution,and the obtained result is in good agreement with the experimental data of other researchers.Very large velocity gradients are found in the sealing gas film because of the geometrical effects of the grooves.Considering turbulence effects,the calculation results show that both the gas film pressure and open force decrease.The RANS method underestimates the performance,compared with the DNS.The solution of the conventional Reynolds lubrication equation without turbulence effects suffers from significant calculation errors and a small application scope.The present study helps elucidate the physical mechanism of the hydrodynamic effects of grooves for improving and optimizing the industrial design or seal face pattern of a dry-gas seal. | WANG Bing ZHANG Huiqiang CAO Hongjun | 2013 | Chinese Journal of Mechanical Engineering2013，26，1： | 18 |
| 4 | Kinematics and dynamics of a particle on a non-simple harmonic vibrating screen显示文摘 | Lijun Wang Zhenjun Ding Shuang Meng Huijun Zhao Huiqiang Song | 2017 | Particuology2017，15，3： | 14 |
| 5 | Recent Progress on Functional Genomics Research of Enterovirus 71显示文摘Enterovirus 71(EV71) is one of the main pathogens that causes hand-foot-and-mouth disease(HFMD). HFMD caused by EV71 infection is mostly self-limited; however, some infections can cause severe neurological diseases, such as aseptic meningitis, brain stem encephalitis, and even death. There are still no effective clinical drugs used for the prevention and treatment of HFMD. Studying EV71 protein function is essential for elucidating the EV71 replication process and developing anti-EV71 drugs and vaccines. In this review, we summarized the recent progress in the studies of EV71 noncoding regions(50 UTR and 30 UTR) and all structural and nonstructural proteins, especially the key motifs involving in viral infection, replication, and immune regulation. This review will promote our understanding of EV71 virus replication and pathogenesis, and will facilitate the development of novel drugs or vaccines to treat EV71. | Huiqiang Wang Yuhuan Li | 2019 | Virologica Sinica2019，34，1： | 14 |
| 6 | Numerical Analysis of a Spiral-groove Dry-gas Seal Considering Micro-scale Effects显示文摘A dry-gas seal system is a non-contact seal technology that is widely used in different industrial applications.Spiral-groove dry-gas seal utilizes fluid dynamic pressure effects to realize the seal and lubrication processes,while forming a high pressure gas film between two sealing faces due to the deceleration of the gas pumped in or out.There is little research into the effects and the influence on seal performance,if the grooves and the gas film are at the micro-scale.This paper investigates the micro-scale effects on spiral-groove dry-gas seal performance in a numerical solution of a corrected Reynolds equation.The Reynolds equation is discretized by means of the finite difference method with the second order scheme and solved by the successive-over-relaxation(SOR) iterative method.The Knudsen number of the flow in the sealing gas film is changed from 0.005 to 0.120 with a variation of film depth and sealing pressure.The numerical results show that the average pressure in the gas film and the sealed gas leakage increase due to micro-scale effects.The open force is enlarged,while the gas film stiffness is significantly decreased due to micro-scale effects.The friction torque and power consumption remain constant,even in low sealing pressure and spin speed conditions.In this paper,the seal performance at different rotor face spin speeds is also described.The proposed research clarifies the micro-scale effects in a spiral-groove dry-gas seal and their influence on seal performance,which is expected to be useful for the improvement of the design of dry-gas seal systems operating in the slip flow regime. | WANG Bing ZHANG Huiqiang | 2011 | Chinese Journal of Mechanical Engineering2011，24，1： | 12 |
| 7 | Liraglutide alleviates cardiac fibrosis through inhibiting P4hα-1 expression in STZ-induced diabetic cardiomyopathy显示文摘Diabetic cardiomyopathy is an important contributor to morbidity and mortality of diabetic patients by causing heart failure.Interstitial and perivascular fibrosis plays a crucial role in diabetic cardiomyopathy.However,there is a lack of effective specific treatments available for diabetic cardiomyopathy.In the present study,we aim to explore the effects of Liraglutide,a GLP-1 analogue,on diabetic cardiomyopathy in STZ-induced diabetic rats fed with high-fat diet.A total of 60 male Wistar rats were randomly assigned to three groups,i.e.normal group,model group,and Liraglutide group,with 20 rats in each group.Serum levels of TC,TG,LDL-C,NEFA,and hydroxyproline were measured using commercial kits.Cardiac function was evaluated by QRS waves,LVEDd,LVESd,and LVEF.Myocardial fibrosis was measured by immunohistochemistry.Our results demonstrated that chronic administration of Liraglutide decreased the level of blood glucose and significantly alleviated lipid metabolic disturbance compared with the model group.Furthermore,Liraglutide was found to improve the damaged cardiac function.In line with this,we also found that the alleviation of cardiac dysfunction was associated with the decreased fibrosis in diabetic myocardial tissues,which was reflected by the decreased expressions of P4hα-1,COL-1,COL-3,MMP-1,and MMP-9.Our results thus suggest that Liraglutide might have a myocardial protective effect by inhibiting P4hα-1-mediated myocardial fibrosis. | Tong Zhao Huiqiang Chen Fei Xu Juan Wang Yusheng Liu Xiaowei Xing Linlin Guo Mingxiang Zhang Qinghua Lu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 9 |
| 8 | Analysis of combustion instability via constant volume combustion in a LOX/RP-1 bipropellant liquid rocket engine显示文摘Turbulent two-phase reacting flow in the chamber of LOX/RP-1 bipropellant liquid rocket engine is numerically investigated in this paper. The predicted pressure and mean axial velocity are qualitatively consistent with the experimental measurements. The self-excited pressure oscillations are obtained without any disturbance introduced through the initial and boundary conditions. It is found that amount of abrupt pressure peaks appear frequently and stochastically in the head regions of the chamber, which are the important sources to drive and strengthen combustion instability. Such abrupt pressures are induced by local constant volume combustion, because local combustible gas mixtures with high temperature are formed and burnt out suddenly due to some fuel droplets reaching their critical state in a rich oxygen surrounding. A third Damkhler number is defined as the ratio of the characteristic time of a chemical reaction to the characteristic time of a pressure wave expansion to measure the relative intensity of acoustic propagation and combustion process in thrusters. The analysis of the third Damkhler number distributions in the whole thrust chamber shows that local constant volume combustion happens in the head regions, while constant pressure combustion presents in the downstream regions. It is found that the combustion instability occurs in the head regions within about 30 mm from the thruster head. | ZHANG HuiQiang GA YongJing WANG Bing WANG XiLin | 2012 | Science China(Technological Sciences)2012，55，4： | 8 |
| 9 | Numerical evaluation of acoustic characteristics and their damping of a thrust chamber using a constant-volume bomb model显示文摘In order to numerically evaluate the acoustic characteristics of liquid rocket engine thrust chambers by means of a computational fluid dynamics method, a mathematical model of an artificial constant-volume bomb is proposed in this paper. A localized pressure pulse with a very high amplitude can be imposed on specified regions in a combustion chamber, the numerical procedure of which is described. Pressure oscillations actuated by the released constant-volume bomb can then be analyzed via Fast Fourier Transformation(FFT), and their modes can be identified according to the theoretical acoustic eigenfrequencies of the thrust chamber. The damping performances of the corresponding acoustic modes are evaluated by the half-power bandwidth method. The predicted acoustic characteristics and their damping for a special engine combustor agree well with the experimental data, validating the mathematical model and its numerical procedures. A small-thrust liquid rocket engine chamber is then analyzed by the present model. The First Longitudinal(1L) acoustic mode can be excited easily and is hard to be damped. The axial position of the central constantvolume bomb has little influence on the amplitude and damping capacity of the First Radial(1R) and 1L acoustic modes. Tangential acoustic modes can only be triggered by an off-centered constant-volume bomb, among which the First Tangential(1T) mode is the strongest and regarded as the most harmful one. The amplitude of the 1L acoustic mode is smaller, but its damping factor is larger, as a constant-volume bomb is imposed approaching the injector face. These results are contributed to evaluate the acoustic characteristics and their damping of the combustion chamber. | Jianxiu QIN Huiqiang ZHANG Bing WANG | 2018 | Chinese Journal of Aeronautics2018，31，3： | 7 |
| 10 | Ignition, flame propagation and extinction in the supersonic mixing layer flow显示文摘The supersonic mixing layer flow,consisting of a relatively cold,slow diluted hydrogen stream and a hot,faster air stream,is numerically simulated with detailed transport properties and chemical reaction mechanisms.The evolution of the combustion process in the supersonic reacting mixing layer is observed and unsteady phenomena of ignition,flame propagation and extinction are successfully captured.The ignition usually takes place at the air stream side of braid regions between two vortexes due to much higher temperature of premixed gases.After ignition,the flame propagates towards two vortexes respectively located on the upstream and downstream of the ignition position.The apparent flame speed is 1569.97 m/s,which is much higher than the laminar flame speed,resulting from the effects of expansion,turbulence,vortex stretching and consecutive ignition.After the flame arrives at the former vortex,the flame propagates along the outer region of the vortex in two branches.Then the upper flame branch close to fuel streamside distinguishes gradually due to too fuel-riched premixed mixtures in the front of the flame and the strong cooling effect of the adjacent cool fuel flow,while the lower flame branch continues to propagate in the vortex. | ZHANG YunLong WANG Bing ZHANG HuiQiang | 2014 | Science China(Technological Sciences)2014，57，11： | 7 |
| 11 | SERK Receptor-like Kinases Control Division Patterns of Vascular Precursors and Ground Tissue Stem Cells during Embryo Development in Arabidopsis显示文摘During embryo development, the vascular precursors and ground tissue stem cells divide to renew them-selves and produce the vascular tissue, endodermal cells, and cortical cells. However, the molecular mech-anisms regulating division of these stem cells have remained largely elusive. In this study, we show that loss of function of SOMATIC EMBRYOGENESIS RECEPTOR-UKE KINASE (SERK) genes results in aberrant em-bryo development. Fewer cortical, endodermal, and vascular cells are generated in the embryos of serk1 serk2bak1 triple mutants. WUSCHEL-RELATED HOMBOBOX5 (WOXS) is ectopically expressed in vascular cells of serkl serk2 bak1 embryos. The first transverse division of vascular precursors in mid-globular em-bryos and second asymmetric division of ground tissue stem cells in early-heart embryos are abnormally altered to a longitudinal division. The embryo defects can be partially rescued by constitutively activated mitogen-activated protein kinase (MAPK) kinase kinase YODA (YDA) and MAPK kinase MKK5. Taken together, our results reveal that SERK-mediated signals regulate division patterns of vascular precursors and ground tissue stem cells, likely via the YDA-MKK4/5 cascade, during embryo development. | Huiqiang Li Zeping Cai Xiaojuan Wang Meizhen Li Yanwei Cui Nan Cui Fei Yang Mingsong Zhu Junxiang Zhao Wenbin Du Kai He Jing Yi Frans E.Tax Suiwen Hou Jia Li Xiaoping Gou | 2019 | Molecular Plant2019，12，7： | 7 |
| 12 | Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options显示文摘Acetaminophen,also known as N-acetyl-p-aminophenol(APAP),is commonly used as an antipyretic and analgesic agent.APAP overdose can induce hepatic toxicity,known as acetaminophen-induced liver injury(AILI).However,therapeutic doses of APAP can also induce AILI in patients with excessive alcohol intake or who are fasting.Hence,there is a need to understand the potential pathological mechanisms underlying AILI.In this review,we summarize three main mechanisms involved in the pathogenesis of AILI:hepatocyte necrosis,sterile inflammation,and hepatocyte regeneration.The relevant factors are elucidated and discussed.For instance,N-acetyl-p-benzoquinone imine(NAPQI)protein adducts trigger mitochondrial oxidative/nitrosative stress during hepatocyte necrosis,danger-associated molecular patterns(DAMPs)are released to elicit sterile inflammation,and certain growth factors contribute to liver regeneration.Finally,we describe the current potential treatment options for AILI patients and promising novel strategies available to researchers and pharmacists.This review provides a clearer understanding of AILI-related mechanisms to guide drug screening and selection for the clinical treatment of AILI patients in the future. | Xiaopeng CAI Huiqiang CAI Jing WANG Qin YANG Jun GUAN Jingwen DENG Zhi CHEN | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，4： | 7 |
| 13 | The chimeric Japanese encephalitis/Dengue 2 virus protects mice from challenge by both dengue virus and JEV virulent virus显示文摘 | Yang, Jian Yang, Huiqiang Li, Zhushi Lin, Hua Zhao, Yu Wang, Wei Tan, Shuai Zeng, Xianwu Li, Yuhua | 2017 | Protein & Cell2017，8，3： | 7 |
| 14 | Stability analysis of backflling in subsiding area and optimization of the stoping sequence显示文摘In underground mining by sublevel caving method, the deformation and damage of the surface induced by subsidence are the major challenging issues. The dynamic and soft backflling body increases the safety risks in the subsiding area. In this paper, taking Zhangfushan iron mine as an example, the ore body and the general layout are focused on the safety of backflling of mined-out area. Then, we use the ANSYS software to construct a three-dimensional(3D) model for the mining area in the Zhangfushan iron mine. According to the simulation results of the initial mining stages, the ore body is stoped step by step as suggested in the design. The stability of the backflling is back analyzed based on the monitored displacements, considering the stress distribution to optimize the stoping sequence. The simulations show that a reasonable stoping sequence can minimize the concentration of high compressive stress and ensure the safety of stoping of the ore body. | Ping Wang Huiqiang Li Yan Li Bo Cheng | 2013 | Journal of Rock Mechanics and Geotechnical Engineering2013，5，6： | 6 |
| 15 | Large Eddy Simulation of a dilute particleladen turbulent flow over a backwardfacing step显示文摘Dilute gas-particle turbulent flows over a backward-facing step are numerically simulated by Large Eddy Simulation (LES) for the continuous phase and Lagran- gian particle trajectory method for the particle phase. Predicted results of mean velocities and fluctuating velocities of both phases agree well with the experimental data, and demonstrate that the main characteristics of the flow are accurately captured by the simulations. Characteristics of separation and reattachments as well as essential features of the coherent structure are obtained, in which the processes of vortex roll up, growth, pairing and breaking up are shown in details. Particle dispersions are then investigated through particles’ instantaneous distri- butions in coherent structure as well as the mean and fluctuating properties of particle number density (PND). The predicted mean PND agree well with experiment results. For small particles, the instantaneous distributions show much preferential concentration, while their mean PND shows more uniform distribution in down- stream region. On the contrary, for large particles, their instantaneous distributions are much uniform (without clear preferential concentration) due to less effect of large eddy coherent, while their mean PND across the section is not uniform for more particles are distributed in the main flow region. The preferential concentra- tion of particles by the large-scale eddies can lead to a high fluctuating PND. | ZHANG HuiQiang WANG Bing CHAN CheongKi WANG XiLin | 2008 | Science China(Technological Sciences)2008，51，11： | 5 |
| 16 | Growth model of a hydrothermal low-temperature Si-rich chimney:Example from the CDE hydrothermal field,Lau Basin显示文摘The CDE hydrothermal field was first discovered during a Chinese cruise to the East Lau Basin Spreading Centre in 2007.Apart from significant amounts of loose Fe-Si-Mn(oxyhydr) oxide(referred to as oxide below) precipitates,a small Si-rich oxide chimney was also recovered on this cruise.In this study,we report on the mineralogical and geochemical analyses of this chimney and a model for its growth that has been developed.Based on the mineralogy and O isotope results,the chimney walls can be divided into four growth generations(layers) from the inner to the outer layers:amorphous opal and barite layer(precipitation temperature 68.5°C based on oxygen isotope determinations),a rod-like amorphous layer(precipitation temperature 39.6°C),a filamentous Fe-Si oxide layer,and an outer Fe-Mn oxide layer.Investigations based on SEM and EDS showed that neutrophilic Fe-oxidizing bacteria play an important role in the formation of this chimney,particularly in the outer two generations.In the first stage,the metabolic activity of the microbes results in the pervasive precipitation of the filamentous Fe-rich oxides inside a ring formed by some amorphous opal and barite;therefore,a loose porous layer forms.In the second stage,amorphous opal then precipitates inside this wall as a result of conductive cooling and gradually controls the mixing between the hydrothermal fluids and ambient seawaters.In the third stage,barite and some amorphous opal form from the higher temperature fluids at the summit of the chimney growth history.In the last stage,the chimney wall becomes thicker and denser and the exchange of hydrothermal fluids and seawater ceases.As a result,a Fe-Mn oxide layer precipitates onto the outer surface of the chimney wall as neutrophilic Fe-oxidizing bacteria reoccupy the surface of the chimney.This mineral sequence and the resultant growth generations are confirmed by the chemical characteristics of the chimney wall.Sr isotopes extracted from the Fe oxides of the four-generation wall generally show a decreasing trend of the 87 Sr/86 Sr ratios from the second layer to the inner layer(from 0.707008 to 0.705877) except for the outer layer(0.706502).The Sr isotope and chondrite normalized REE patterns of the corresponding bulk samples from the chimney wall also display a similar trend.Our study shows that the biogenic filament network plays a key role in the formation of the chimney in contrast to previous growth models of higher temperature chimneys,which often ignore the influence of biogenic factors. | SUN ZhiLei ZHOU HuaiYang YANG QunHui YIN XiJie WANG Hu YAO HuiQiang DONG CongFang | 2012 | Science China Earth Sciences2012，55，10： | 4 |
| 17 | Chinese herbal medicine compound Yi-Zhi-Hao pellet inhibits replication of influenza virus infection through activation of heme oxygenase-1显示文摘As a leading cause of respiratory disease, influenza A virus(IAV) presents a pandemic threat in annual seasonal outbreaks. Given the limitation of existing anti-influenza therapies, there remains to be a requirement for new drugs. Compound Yi-Zhi-Hao pellet(CYZH) is a famous traditional Chinese medicine(TCM) used in the clinic, whose formula has been recorded in Complication of National Standard for Traditional Chinese Medicine to treat common cold. In this study, we found that CYZH exhibited a broad-spectrum anti-influenza activity and inhibited the expression of viral RNA and proteins in vitro. Mechanistically, CYZH had no inhibitory activities against viral protein hemagglutinin and IAV RNA-dependent RNA polymerase. Instead, it induced activation of erythroid 2-related factor 2(Nrf2) and nuclear factor kappa B(NF-κB), which subsequently upregulated heme oxygenase-1(HO-1) expression.Also, CYZH protected cells from oxidative damage induced by reactive oxygen series. In conclusions,CYZH inhibits IAV replication in vitro, at least partly by activating expression of the Nrf2/HO-1 pathway. | Jinqiu Yin Linlin Ma Huiqiang Wang Haiyan Yan Jin Hu Wen Jiang Yuhuan Li | 2017 | Acta Pharmaceutica Sinica B2017，7，6： | 4 |
| 18 | Treatment of spinal tuberculosis with ultrashort-course chemotherapy in conjunction with partial excision of pathologic vertebrae显示文摘 | Zili Wang Zhaohui Ge Weidong Jin Yongdong Qiao Huiqiang Ding Haoning Zhao Zhikai Lin Jun Chen Weiyu Yang | 2007 | The Spine Journal2007，，6： | 3 |
| 19 | The molecular determinants governing the immunogenicity of Japanese encephalitis live attenuated vaccines显示文摘In the course of isolating the attenuated Japanese encephalitis vaccine SA14-14-2,two attenuated strains SA14-9-7 and SA14-5-3 were also obtained that elicited low antibody responses in humans(o10%and 62%,respectively)and exerted much weaker immune protection in animal challenge experiments.However,the reason for these differences remains unknown.In order to understand why SA14-14-2 is superior to SA14-9-7 and SA14-5-3,we employed a reverse genetics method to identify the key mutations in the virus genome that determine the immunogenicity of live attenuated Japanese encephalitis viruses.We first sequenced the full genomic sequences of SA14-9-7 and SA14-5-3 and found mutations that changed four amino-acid base pairs when compared to the envelope gene of SA14-14-2.We mutated the genome of SA14-14-2 to generate these mutations both singly(E-177,E-264,E-279 and E-315)and in combination(E-177/264,E-279/315 and E-177/264/279/315)and tested these mutants along with parental strains SA14-14-2,SA14-9-7 and SA14-5-3 for their immunogenicity in vivo.When mice were immunized with SA14-9-7 and SA14-5-3,lower levels of neutralizing antibodies were generated compared with the immune response to SA14-14-2.Furthermore,SA14-5-3 was more immunogenic than SA14-9-7,which replicated the results previously seen in humans.Point mutations E-177,E-264,E-279 and E-315 diminished the immunogenicity of SA14-14-2 with E-264 and E-315,contributing the most to this phenotype.The mutant rJEV(E-177/E-264/E-279/E-315)containing all four point mutations exhibited the lowest immunogenicity with a seroconversion rate of 0 at an inoculation dose of 103 PFU(plaque-forming unit).We have identified the key amino acids in the envelope protein that account for the superior immunogenicity of SA14-14-2. | Yuhua Li Yin Fu Xinyu Liu Huiqiang Yang Yongxin Yu Lili Jia Xuguang Li Aaron Farnsworth Junzhi Wang | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 3 |
| 20 | Epidemiological Investigation of an Inhalational Anthrax Patient Traveling for Medical Treatment in Beijing Municipality,China,August 2021显示文摘Summary What is already known about this topic?Inhalational anthrax,also known as pulmonary anthrax,is an infectious disease caused by Bacillus anthracis.The patients are usually infected by inhaling aerosolized B.anthracis spores from dead animals or animal products.Compared to cutaneous anthrax,inhalational anthrax is rare and deadly and few cases in China were reported.What is added by this report?This report covers all information of clinical features,laboratory testing,and epidemiological characteristics as well as exposure history of a recent primary inhalational anthrax patient who was seeking medical treatment in Beijing Municipality in August 2021.New laboratory techniques,including second-generation sequencing,polymerase chain reaction,and rapid test for serum antibody,played an important role in the process.What are the implications for public health practice?The information provided in this report,including the correct sample type,epidemiological investigation details,and application of the new diagnostic criteria of anthrax,could assist public health professionals in dealing with anthrax epidemics. | Changying Lin Xiangfeng Dou Daitao Zhang Yinqi Sun Huiqiang Han Chunzhi Chen Xiaojun Zhang Shuang Li Yanwei Chen Hongbin Zhang Bin Wang Zhichao Liang Xin Zhang Feng Wei Jiangli Wang Feng Liu Quanyi Wang Jian Shi Peng Yang | 2022 | China CDC weekly2022，4，1： | 3 |
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