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| 1 | Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients显示文摘AIM: To investigate the effect of omega-3 fatty acid parenteral supplementation postoperatively on clinical outcomes and immunomodulation in colorectal cancer patients. METHODS: Forty-two patients undergoing radical colorectal cancer resection with an indication for total parenteral nutrition postoperatively were enrolled in this prospective, double-blind, randomized, controlled study. Patients received total parenteral nutrition supplemented with either soybean oil (LCT; Intralipid, Fresenius-Kabi, SO group, n = 21) or a combination of omega-3 fish oil and soybean oil (LCT:fish oil = 5:1, fish oil; Omegaven, Fresenius-Kabi, FO group, n = 21), up to a total of 1.2 g lipid/kg per day for 7 d postoperatively. A same volume calorie and nitrogen was administrated. Routine blood test, biochemistry, systemic levels of IL-6 and TNF-α, percentage of CD3+, CD4+, and CD8+ lymphocytes were evaluated preoperatively and on postoperative d 1 and 8. Patient outcome was evaluated considering mortality during the hospital stay, length of postoperative hospital stay, and occurrence of infectious complications. RESULTS: Both lipid regimens were well tolerated. No differences between the two groups were noticed in demographics, baseline blood test, biochemistry, serum levels of IL-6 and TNF-α, percentage of CD4+, CD8+ lymphocytes, and ratios of CD4+/CD8+. Compared with those on postoperative d 1, serum IL-6 levels onpostoperative d 8 were significantly depressed in the FO group than in the reference group (-44.43 ± 30.53 vs -8.39 ± 69.08, P = 0.039). Simultaneously, the ratios of CD4+/CD8+ were significantly increased in the FO group (0.92 ± 0.62 vs 0.25 ± 1.22, P = 0.035). In addition, depression of serum TNF-α levels (-0.82 ± 2.71 vs 0.27 ± 1.67, P = 0.125) and elevation of CD3+ and CD4+ lymphocyte percentage (12.85 ± 11.61 vs 3.84 ± 19.62, P = 0.081, 17.80 ± 10.86 vs 9.66 ± 17.55, P = 0.084, respectively) were higher in the FO group than in the reference group. Patients in the FO group trended to need a shorter postoperative hospital stay (17.45 ± 4.80 d vs 19.62 ± 5.59 d, P = 0.19). No statistically significant difference was found when stratified to mortality and occurrence of infectious complications. CONCLUSION: Postoperative supplementation of omega-3 fatty acids may have a favorable effect on the outcomes in colorectal cancer patients undergoing radical resection by lowering the magnitude of inflammatory responses and modulating the immune response. | Bin Liang, Shan Wang, Ying-Jiang Ye, Xiao-Dong Yang, You-Li Wang, Jun Qu, Qi-Wei Xie, Mu-Jun Yin, Division of Surgical Oncology and Division of Gastroenterological Surgery, Peking University People’s Hospital, Beijing 100044, China Author contributions: Liang B and Wang S contributed equally to this work Liang B and Wang S designed the research Liang B, Ye YJ, Yang XD, Wang YL, Qu J, Xie QW, Yin MJ performed the research and collected the data Wang S and Ye YJ supervised the research Liang B and Ye YJ analyzed the data Liang B wrote the paper and revised the manuscript. | 2008 | World Journal of Gastroenterology2008，14，15： | 31 |
| 2 | Isolation and characterization of bipotent liver progenitor cells from adult mouse显示文摘 | Li WL Su J Yao YC Tao XR Yan YB Yu HY Wang XM Li JX Yang YJ Lau JT HuYP | 2006 | 中国生物学文摘2006，20，5： | 26 |
| 3 | Recent developments and future prospects of Vitreoscilla hemoglobin application in metabolic engineering显示文摘 | Zhang, L Li, YJ Wang, ZN Xia, Y Chen, WS Tang, KX | 2007 | 中国生物学文摘2007，21，10： | 25 |
| 4 | Effect of extracorporeal bioartificial liver support system on fulminant hepatic failure rabbits显示文摘AIM To evaluate the possibility of usingcultured human hepatocytes as a bridge betweenbioartificial liver and liver transplantation.METHODS In this experiment,the efficacy ofextracorporeal bioartificial liver support system(EBLSS)consisting of spheriodal human livercells and cultured hepatocytes supernatant wasassessed in vivo using galactosamine inducedrabbit model of fulminant hepatic failure.RESULTS There was no difference of survivalbetween the two groups of rabbits,but in thesupported rabbits serum alanineaminotransferase,total bilirubin and creatininewere significantly lower and hepatocyte necrosiswas markedly milder than those in controlanimals.In addition,a good viability of humanliver cells was noted after the experiment.CONCLUSION EBLSS plays a biologic role inmaintaining and compensating the function ofthe liver. | Wang YJ Li MD Wang YM Chen GZ Lu GD Tan ZX | 2000 | World Journal of Gastroenterology2000，6，2： | 17 |
| 5 | Peroxynitrite induces Alzheimer-like tau modifications and accumulation in rat brain and its underlying mechanisms.显示文摘 | Zhang YJ Xu YF Liu YIH Yin J Li HL Wang Q Wang JZ. | 2006 | 中国生物学文摘2006，20，9： | 10 |
| 6 | Intrahepatic transplantation of hepatic oval cells for fulminant hepatic failure in rats显示文摘AIM:To evaluate the effect of intrahepatic transplantation of hepatic oval cells(HOC)on fulminant hepatic failure(FHF)in rats.METHODS:HOC obtained from rats were labeled with green fluocescent protein(GFP)or 5,6carboxyfluorescein diacetate succinmidyl ester(CFDASE).Cell fluorescence was observed under fluorescent microscope at 6,24,48 and 72 h after labeling.CFDASE labeled HOC(5×10 6 cells each rat)were injected into livers of rats with FHF induced by D-galactosamine.Serum albumin(ALB),alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bilirubin(TBil)levels were measured at different time points.Liver function of rats was examined on days 3,7,14 and 21 after HOC transplantation.RESULTS:The positive rate of GFP and CFDA-SE labeled HOC was 10%and 90%,respectively,with no significant change in cell viabilities.The survival rate was higher in HOC transplantation group than in control group,especially 48(9/15 vs 6/15)and 72 h(9/15 vs 4/15)after HOC transplantation.The serum ALT,AST and TBil levels were decreased while the serum Alb level was increased after HOC transplantation.Fluorescence became faded and diffused in liver tissues,suggesting that proliferation and differentiation occur in transplanted HOC.CONCLUSION:CFDA-SE is superior to GFP in labeling HOC,although fluorescence intensity is decreased progressively with cell division.HOC transplantation can improve the liver function and increase the survival rate of recipients. | Chen-Xuan Wu,Qi Zou,Zheng-Yan Zhu,Ying-Tang Gao,Yi-Jun Wang,Department of Hepatobiliary,The Third Center of Affiliated Hospital of Tianjin Medical University Key Laboratory of Artificial Cells of Tianjin,Tianjin 300170,China Author contributions:Wang YJ,Wu CH and Zou Q designed the research Zou Q,Zhu ZY,Gao YT performed the research Zou Q analyzed the data Wang YJ and Wu CX wrote the paper.Supported by Tianjin Science Committee,Grant No.05SYSYJC02600 and Tianjin Health Bureau,Grant No.05KYR01 | 2009 | World Journal of Gastroenterology2009，15，12： | 7 |
| 7 | Effects of radical cholecystectomy on nutritional and immune status in patients with gallbladder carcinoma显示文摘INTRODUCTION Carcinoma of the gallbladder is the most commonneoplasm in biliary tract,and its incidence has beenrising in recent years.The rate of correct diagnosisin early gallbladder carcinoma has been raised afterthe wide use of CT,ultrasound scans and frozensection examination.Now radical cholecystectomyis advocated as the best management for patientswith early gallbladder carcinoma.In the | Jiao XY Shi JS Wang JS Yang YJ He P | 2000 | World Journal of Gastroenterology2000，6，3： | 6 |
| 8 | Induction of mucosal and systemic immune response by single-dose oral immunization with biodegradable microparticles containing DNA encoding HBsAg显示文摘 | He XW Wang F Jiang L Li J Liu SK Xiao ZY Jin XQ Zhang YN He Y Li K Guo YJ Sun SH | 2005 | 第二军医大学学报2005，26，10： | 5 |
| 9 | DNA damage-induced cell death: lessons from the central nervous system显示文摘脱氧核糖核酸损坏不能,但是总是,导致房间死亡。当连接脱氧核糖核酸的几条小径损坏信号到线粒体依赖者,独立死亡机械被阐明了时,这些小径的连接由多重其它服从于规定不好的因素理解。我们建议了二个概念的模型解释推迟并且对脱氧核糖核酸的可变房间死亡反应损坏:综合监视对自治小径。在这评论,我们讨论这二个模型怎么可以解释在死亡反应被辐射剂量,房间周期地位和 neuronal 开发调整的地方,离子辐射(红外) 在发展中的中枢神经系统导致的房间死亡的体内规定。 | Helena Lobo Borges Rafael Linden Jean YJ Wang | 2008 | Cell Research2008，18，1： | 4 |
| 10 | Antioxidant activity of polyphenols from seeds of Vitis amurvitro in vitro显示文摘 | Wang JN Chen YJ Hano Y | 2000 | Acta Pharmacol Sin2000，21，： | 2 |
| 11 | Spinosin, a C-glycoside flavonoid from semen Zizhiphi Spinozae, potentiated pentobarbital-induced sleep via the serotonergic system 显示文摘 | Wang LE Bai YJ Shi XR | 2008 | Pharmacol Biochem Be2008，90，3： | 1 |
| 12 | Proliferation of neural stem cells correlates with Wnt-3 protein in hypoxlcischemic neonate rats after hyperbaric oxygen therapy 显示文摘 | Wang XL Yang YJ Xie M | 2007 | Neuroreport2007，18，16： | 1 |
| 13 | Improved injectability and in vitro degradation of a calcium phosphate cement containing poly (lactide-co-glycolide) microspheres显示文摘 | Qi XP Ye JD Wang YJ | 2008 | Acta Biomater2008，4，6： | 1 |
| 14 | Stenting of Symptomatic M1 Stenosis of Middle Cerebral Artery : An Initial Experience of 40 Patients 显示文摘 | Jiang WJ Wang YJ Du B | 2004 | Stroke2004，35，： | 1 |
| 15 | Role of PKC in the novel synergistic action of urotensin Ⅱ and angiotensin Ⅱ and in urotensin Ⅱ-induced vasoconstriction显示文摘 | Ding YJ Zhu YZ Shi Y Yao T Zhu YC | 2007 | Am J Physiol Heart Circ Physiol2007，292，1： | 1 |
| 16 | Stenting of symptomatic M1 stenosis of middle cerebral artery:an initial experience of 40 patients显示文摘 | Jiang WJ Wang YJ Du B | 2004 | Stroke2004，35，： | 1 |
| 17 | An association study of 13 SNPs from seven candidate genes with pediatrie asthma and a preliminary study for genetic testing by multiple varants in Taiwanese population 显示文摘 | Wang JY Liou YH Wu YJ | 2009 | J Clin Immunol2009，29，2： | 1 |
| 18 | Elevated expressions of MMP7,TROP2,and survivin are associated with survival,disease recurrence,and liver metastasis of colon cancer显示文摘 | Fang YJ Lu ZH Wang GQ | 2009 | Int J Colorectal Dis2009，24，8： | 1 |
| 19 | Amino acids modulate the hypotensive effect of angiotensin-(1-7) at the caudal ventrolateral medulla in rats显示文摘 | Wang J Peng YJ Zhu DN | 2005 | Regul Pept2005，129，： | 1 |
| 20 | Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling显示文摘 | Tang DZ Hou W Zhou Q Zhang M Holz J Sheu TJ Li TF Cheng SD Shi Q Harris SE Chen D Wang YJ | 2010 | J Bone Miner Res2010，25，6： | 1 |
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