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| 1 | Commissioning progress of the FAST显示文摘The Five-hundred-meter Aperture Spherical radio Telescope(FAST) was completed with its main structure installed on September 25, 2016, after which it entered the commissioning phase. This paper aims to introduce the commissioning progress of the FAST over the past two years. To improve its operational reliability and ensure effective observation time, FAST has been equipped with a real-time information system for the active reflector system and hierarchical commissioning scheme for the feed support system, which ultimately achieves safe operation of the two systems. For meeting the high-performance indices, a highprecision measurement system was set up based on the effective control methods that were implemented for the active reflector system and feed support system. Since the commissioning of the FAST, a low-frequency ultra-wideband receiver and 19-beam1.05-1.45 GHz receiver have been mainly used. Telescope efficiency, pointing accuracy, and system noise temperature were completely tested and ultimately achieved the acceptance indices of the telescope. The FAST has been in the process of national acceptance preparations and has begun to search for pulsars. In the future, it will still strive to improve its capabilities and expand its application prospects. | Peng Jiang YouLing Yue HengQian Gan Rui Yao Hui Li GaoFeng Pan JingHai Sun DongJun Yu HongFei Liu NingYu Tang Lei Qian JiGuang Lu Jun Yan Bo Peng ShuXin Zhang QiMing Wang Qi Li Di Li | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，5： | 11 |
| 2 | The first pulsar discovered by FAST显示文摘To assist with the commissioning [1] of the Five-hundredmeter Aperture Spherical radio Telescope (FAST), we performed a pulsar search, with the primary goal of developing and testing the pulsar data acquisition and processing pipelines. We tested and used three pipelines, two (Pl and P2 hereafter) searched for the periodic signature of pulsars whereas the other one was used to search for bright single pulses (P3 hereafter). | Lei Qian ZhiChen Pan Di Li George Hobbs WeiWei Zhu Pei Wang ZhiJie Liu YouLing Yue Yan Zhu HongFei Liu DongJun Yu JingHai Sun Peng Jiang GaoFeng Pan Hui Li HengQian Gan Rui Yao XiaoYao Xie Fernando Camilo Andrew Cameron Lei Zhang Shen Wang FAST Collaboration | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，5： | 3 |
| 3 | Bcl-x L Retrotranslocates Bax from the Mitochondria into the Cytosol显示文摘 | Frank Edlich Soojay Banerjee Motoshi Suzuki Megan M. Cleland Damien Arnoult Chunxin Wang Albert Neutzner Nico Tjandra Richard J. Youle | 2011 | Cell2011，，1： | 2 |
| 4 | Inhibition of Proliferation of Prostate Cancer Cell Line DU-145 in vitro and in vivo Using Salvia miltiorrhiza Bunge显示文摘Objective:To investigate the antiproliferative activity of Salvia miltiorrhiza Bunge.(SM)on the castration-resistant prostate cancer(CRPC)cell line DU-145 in vitro and in vivo.Methods:Prostate cancer cell line(DU-145)and normal prostate cell line(RWPE-1)were treated with SM at different concentrations(3.125,12.5,25 and 50μg/mL)to investigate the antiproliferative effects.DNA laddering analysis was performed to investigate the apoptosis of DU-145 cells.Molecular mechanism was investigated by Western blot analysis of p53,Bcl-2,prostate specific antigen(PSA),and androgen receptor(AR).Six-week-old male BALB/c nude mice were randomly divided into normal control group(n=101)and treated group(n=101)which administered 500 mg/kg SM for 2 weeks.Tumor volumes were measured.Results:Treatment with SM resulted in a dose-dependent decrease in cell number of DU-145 cells in comparison with RWPE-1.DNA laddering analysis indicated the apoptosis of DU-145 cells.Treatment with SM increased the expression of p53 and reduced the expression of Bcl-2 proteins.The levels of PSA were considerably reduced in SM-treated group compared to the controls,and a decrease in AR expression was observed when cells were treated with SM in the same pattern as a reduction in PSA.In the tumour xenograft study,SM given once a day for 2 weeks significantly inhibited tumour growth.Conclusion:SM might contribute to the anticancer actions such as induction of apoptosis and inhibition of proliferation of prostate cancer cells. | Woong Jin Bae Jin Bong Choi Kang Sup Kim U Syn Ha Sung Hoo Hong Ji Youl Lee Tae-Kon Hwang Sung Yeoun Hwang WANG Zhi-ping Sae Woong Kim | 2020 | Chinese Journal of Integrative Medicine2020，26，7： | 1 |
| 5 | Extraction and characterization of polyphenol oxidase in pawpaw (Asimina triloba) fruit 显示文摘 | Caodi Fang Changzheng Wang Youling Xiong | 2007 | Journal of Food Biochemistry2007，31，： | 1 |
| 6 | The role of mitochondria in apoptosis * 显示文摘 | Wang C Youle R J | 2009 | Ann Rev Genet2009，43，： | 1 |
| 7 | The clinical feasibility and effect of online cone beam computer tomography-guided intensity-modulated radiotherapy for nasopharyngeal cancer显示文摘 | Jin Wang Sen Bai Nianyong Chen Feng Xu Xiaoqin Jiang Yan Li Qingfeng Xu Yali Shen Hong Zhang Youling Gong Renming Zhong Qingfeng Jiang | 2008 | Radiotherapy and Oncology2008，，： | 1 |
| 8 | Evolution in physiochemical and cloud condensation nuclei activation properties of crop residue burning particles during photochemical aging显示文摘As a main form of biomass burning in agricultural countries, crop residue burning is a significant source of atmospheric fine particles. In this study, the aging of particles emitted from the burning of four major crop residues in China was investigated in a smog chamber.The particle size distribution, chemical composition and cloud condensation nuclei(CCN)activity were simultaneously measured. The properties of crop residue burning particles varied substantially among different fuel types. During aging, the particle size and mass concentration increased substantially, suggesting condensational growth by formation of secondary aerosols. The particle composition was dominated by organics. Aging resulted in considerable enhancement of organics and inorganics, with enhancement ratios of 1.24–1.44 and 1.33–1.76 respectively, as well as a continuous increase in the oxidation level of organics. Elevated CCN activity was observed during aging, with the hygroscopicity parameter κ varying from 0.16 to 0.34 for fresh particles and 0.19 to 0.40 for aged particles.Based on the volume mixing rule, the hygroscopicity parameter of organic components(κorg) was derived. κorgexhibited an increasing tendency with aging, which was generally consistent with the tendency of the O:C ratio, indicating that the oxidation level was related to the hygroscopicity and CCN activity of organic aerosols from crop residue burning. Our results indicated that photochemical aging could significantly impact the CCN activation of crop burning aerosols, not only by the production of secondary aerosols, but also by enhancing the hygroscopicity of organic components, thereby contributing to the aerosol indirect climate forcing. | Yan Ma Chao Chen Junfeng Wang Youling Jiang Zewen Zheng Hui Chen Jun Zheng | 2019 | Journal of Environmental Sciences2019，31，3： | 1 |
| 9 | The role of mitochondria in apoptosis显示文摘 | Wang C Youle R J | 2009 | Annual Review of Genetics2009，43，： | 1 |
| 10 | Protein extraction from chicken myofibdls irrigated with various polyphosphatc显示文摘 | XIONG Youling L LOU Xin WANG Chong | 2000 | Food Chem- istry and Toxicology2000，65，1： | 1 |
| 11 | Protein Extraction from chicken Mofibrils Irrigated with Various Polyphosphate 显示文摘 | Xiong Youling Lou X Wang C | 2000 | Food Chemistry and Toxicology2000，65，1： | 1 |
| 12 | The role of mitochondria in apoptosis显示文摘 | Wang C Youle RJ | 2009 | Annu Rev Genet2009，43，4： | 1 |
| 13 | The role of mitochondria in apoptosis 显示文摘 | WANG C YOULE R J | 2009 | Annu Rev Genet2009，43，： | 1 |
| 14 | Inhibition of lipid oxidation in cooked beef patties by hydrolyzed potato protein is related to its reducing and radical scavenging ability显示文摘 | WANG L L XIONG Youling | 2005 | J Agric Food Chem2005，53，23： | 1 |
| 15 | The role of mitochondria in apoptosis显示文摘 | Wang C X Youle R J | 2009 | Annu Rev Genetics2009，43，： | 1 |
| 16 | Protein extraction fromchicken myofibrils irrigated with various polyphosphate and NaClsolutions 显示文摘 | XIONG Youling L? LOU X WANG C | 2000 | Journal of Food Science2000，65，1： | 1 |
| 17 | The role of mitochondria in apoptosis显示文摘 | Wang C Youle RJ | 2009 | Annu Rev Genet2009，43，： | 1 |
| 18 | The role of mitochondria in apoptosis显示文摘 | Wang C Youle R J | 2009 | Annu Rev Genet2009，43，： | 1 |
| 19 | The role of mitochondria in apoptosis显示文摘 | Wang C Youle RJ | | 0，，： | 1 |
| 20 | The role of mito- chondria in apoptosis显示文摘 | Chunxin Wang Richard J Youle | 2009 | Annual Review of Genetics2009，43，： | 1 |
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