| 4 | The nutritive effect and toxicity of copper and zinc in mice显示文摘The objective of this study was to determine whether the marginal deficient and excessive copper(Cu) and zinc(Zn) would affect the biological indices and cellular structure.Two hundreds mice were divided randomly into 5 groups.Mice were fed with normal diet in control;and supplemented with Cu at 15.9,31.9,63.7 or 127mg·kg^-1 in group Ⅱ,at 2.36mg·kg^-1 in group Ⅳ;Zn at 126,252,505 and 1010mg·kg^-1 in group Ⅲ,at 9.32mg·kg^-1 in group Ⅴ.Ten mice were sampled from each group and sacrificed on day 30,60,80 and 95,and the activities of alkaline phosphatase(AKP),superoxidation dismutase (SOD) and ceruloplasmin(CPL) in plasma were determined,the histopathology of organs were observed.The results showed that marginal excessive Cu and Zn in diet had an evidently nutritive effect on growth (P>0.05),increased the Cu and Zn accumulation in liver(P<0.05),also improved the activities of AKP(P<0.01),SOD(P<0.01),CPL(P>0.05).With the increase of Zn or Cu in diet,the activities of enzymes came to a lower-level(P<0.05).Mouse growth was suppressed.Also,the low-level Cu or Zn in diet reduced the mouse growth,decreased the activities of plasma AKP,CPL and SOD.The marginal deficient or excessive Cu and Zn had serious damages in histology of organs,such as cloudy swelling,necrosis,cytoplasm crack,pyknosis or karyolysis,coagulation necrosis. | WangXZ YangZQ | 2002 | 中国药理学与毒理学杂志2002，16，6： | 0 |
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