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| 1 | The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via Sirt1- and Pgc-1α-mediated regulation of Glut2显示文摘Zinc levels are high in pancreatic β-cells, and zinc is involved in the synthesis, processing and secretion of insulin in these cells. However, precisely how cellular zinc homeostasis is regulated in pancreatic β-cells is poorly understood. By screening the expression of 14 Slc39a metal importer family member genes, we found that the zinc transporter Slc39a5 is significantly downregulated in pancreatic β-cells in diabetic db/db mice, obese ob/ob mice and high-fat diet-fed mice. Moreover,β-cell-specific Slc39a5 knockout mice have impaired insulin secretion. In addition, Slc39a5-deficient pancreatic islets have reduced glucose tolerance accompanied by reduced expression of Pgc-1α and its downstream target gene Glut2. The down-regulation of Glut2 in Slc39a5-deficient islets was rescued using agonists of Sirt1, Pgc-1α and Ppar-γ. At the mechanistic level, we found that Slc39a5-mediated zinc influx induces Glut2 expression via Sirt1-mediated Pgc-1α activation. These findings suggest that Slc39a5 may serve as a possible therapeutic target for diabetes-related conditions. | Xinhui Wang Hong Gao Wenhui Wu Enjun Xie Yingying Yu Xuyan He Jin Li Wanru Zheng Xudong Wang Xizhi Cao Zhuoxian Meng Ligong Chen Junxia Min Fudi Wang | 2019 | Protein & Cell2019，10，6： | 6 |
| 2 | Triggering in-plane defect cluster on MoS_(2) for accelerated dinitrogen electroreduction to ammonia显示文摘Electrochemical nitrogen reduction reaction (eNRR) is an alternative promising manner for sustainable N2 fixation with low-emission. The major challenge for developing an efficient electrocatalyst is the cleaving of the stable Ntriple bondN triple bonds. Herein, we design a new MoS_(2) with in-plane defect cluster through a bottom-up approach for the first time, where the defect cluster is composed of three adjacent S vacancies. The well-defined in-plane defect clusters could contribute to the strong chemical adsorption and activation towards inert nitrogen, achieving an excellent eNRR performance with an ammonia yield rate of 43.4 ± 3 μg h^(−1) mgcat.^(−1) and a Faradaic efficiency of 16.8 ± 2% at −0.3 V (vs. RHE). The performance is much higher than that of MoS_(2) with the edge defect. Isotopic labeling confirms that N atoms of produced NH4+ originate from N2. Furthermore, the in-plane defect clusters realized the alternate hydrogenation of nitrogen in a side-on way to synthesize ammonia. This work provides a prospecting strategy for fine-tuning in-plane defects in a catalyst, and also promotes the progress of eNRR. | Wanru Liao Ke Xie Lijuan Liu Xiuyun Wang Yu Luo Shijing Liang Fujian Liu Lilong Jiang | 2021 | Journal of Energy Chemistry2021，30，11： | 3 |
| 3 | Nucleotide sequence of cDNA encoding the mitochondrial precursor protein of the ATPase inhibitor from the giant panda (Ailuropoda melanoleuca) 显示文摘 | Hou Wanru Du Yujie Chen Yu | 2007 | DNA Cell Biol2007，26，11： | 1 |
| 4 | Molecular cloning of ribosomal protein L26 (RPL26) cDNA from Ailuropoda melanoleuca and its potential value in phylogenetic study显示文摘 | Hou Wanru Sun Genlou Chen Yu | 2008 | Biochem Syst Ecol2008，36，3： | 1 |
| 5 | Two transition-metal-modified Nb/W mixed-addendum polyoxometalates for visible-light-mediated aerobic benzylic C–H oxidations显示文摘The visible-light-induced selective oxidation of ubiquitous C–H bonds into valuable C=O bonds under aerobic conditions is one of the most attractive approaches for the construction of carbonyl-containing molecules.In this work,two transition metal-containing Nb/W mixed-addendum POMs dimers with the formula of K_(2)Na_(2)H_(5)[(Fe(H_(2)O)_(4))_(3)(P_(2)W_(15)Nb_(3)O_(62))_(2)]·24H_(2)O(POM[Fe])and K_(2)Na_(3)H_(4)[(Cr(H_(2)O)_(4))_(3)(P_(2)W_(15)Nb_(3)O_(62))_(2)]·32H_(2)O(POM[Cr])have been synthesized and characterized by various analytical and spectral techniques.POM[Fe]was proved to be an efficient photocatalyst for benzylic C–H oxidation under visible light and using oxygen as an oxidant to produce the corresponding carbonyl complex in good yields.A plausible mechanism involving superoxide radical was proposed for the catalytic reaction.POM[Fe]showed good reusability in the recycling experiments.IR spectroscopy and XRD analysis indicate that POM[Fe]can retain its integrity after catalysis. | Yubin Ma Fan Gao Wanru Xiao Na Li Shujun Li Bing Yu Xuenian Chen | 2022 | Chinese Chemical Letters2022，33，9： | 1 |
| 6 | Delamination of Birnessite MnO_(2) into Nanosheets as Anode Materials for Lithium Ion Batteries显示文摘The delamination of birnessite MnO_(2) into nanosheets by freezing and thawing method was reported here.The proton⁃type birnessite manganese oxide(H⁃birnessite)was added to tetramethylammonium hydroxide(TMAOH)solution in a polypropylene tube which was then sealed.Fifty cycles consisting of fast freezing(in liquid nitrogen for 30 s)and thawing(in 70℃ water for 30 min)were operated.The as⁃prepared slurry was characterized by X⁃ray diffraction(XRD)and transmission electron microscope(TEM).The XRD result showed the layered structural H⁃birnessite was delaminated.The TEM result revealed the product had a nanosheet⁃like morphology.Employed as an anode material for lithium⁃ion batteries,MnO_(2) nanosheets as⁃prepared delivered a specific charging capacity of 1040.6 mAh/g after 100 cycles at 100 mA/g. | Ao Xia Jue Yi Wanru Yu Xin Yang Chenpeng Zhao | 2021 | Journal of Harbin Institute of Technology(New Series)2021，28，4： | 0 |
| 7 | Advances in Research on Hypoglycemic Functions of Polysaccharides from Medicinal and Edible Plants显示文摘Plant polysaccharides have an excellent hypoglycemic effect through various ways such as promoting insulin secretion,improving insulin resistance,regulating related enzyme activities,improving sugar,protein and fat metabolism,promoting hepatic glycogen synthesis,inhibiting gluconeogenesis,and improving immune system function and resistance.At present,more than 200 polysaccharides derived from traditional Chinese medicines have been reported,and most of them are isolated and purified from plants.With the deepening of research on plant polysaccharides,more and more attention has been paid to the development of safe and economical natural hypoglycemic products.This paper first introduced the hypoglycemic effects of Folium Mori polysaccharides,Cucurbita moschata polysaccharides,Momordica charantia polysaccharides,Dioscoreae Rhizoma polysaccharides and Camellia sinensis O.Kuntze polysaccharides.Besides,it discussed the utilization ways of hypoglycemic plant polysaccharides,and the prospects of applying polysaccharide hypoglycemic effect to diabetes treatment,so as to provide reference for the research and utilization of plant polysaccharide hypoglycemic effects and the development of natural hypoglycemic foods. | Xiaohan ZHANG Chenghui ZHANG Wenrui YU Wanru XUE Tong TONG Jialin SUN Xuqiao FENG | 2018 | Medicinal Plant2018，9，6： | 0 |
| 8 | The Diagnosis and Differential Diagnosis of Ureteral Fibroepithelial Polyps显示文摘OBJECTIVE To study the clinical pathologic characteristics and differential diagnosis of ureteral fibroepithelial polyps. METHODS One case of ureteral fibroepithelial polyps was studied by clinical data analysis and light microscopy. RESULTS The tumor was located in the lower ureter. Histologically, the polyp was composed of expanded blood vessels and fibrous connective tissue under normal or proliferous transitional epithelium. CONCLUSION Benign ureteral fibroepithelial polyps are extremely rare, recognition of it's precise histological features can facilitate its correct diagnosis. | Wanru Geng Ning Li Qi Yu Huiqin Zhou Hongmin Xu | 2006 | Chinese Journal of Clinical Oncology2006，3，5： | 0 |
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