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| 1 | 用RFLP方法研究陕西省主要小麦品种遗传多样性及其演变显示文摘研究用RFLP方法,对我国主要小麦产区,陕西省40年代以来广为种植的小麦品种的遗传多样性进行了研究,结果表明,占总带数26.2%的HINDII酶的RFLP带具有遗传多态性。24个小麦品种平均遗传相似系数为0.948。53.8%的探针显示了多态性。平均多态性信息含量指数为0.252。陕西省小麦品种遗传多样性以70年代为最高,之后开始降低。 | 朱列层 唐国顺 HAZEN S P KIM H S WARD R W | 1999 | 西北植物学报1999，19，2： | 11 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | Paternal smoking, genetic polyrnorphisms in CYP1A1 and childhood leukemia risk 显示文摘 | Lee K M Ward M H Han S | 2009 | Leukemia Res2009，33，2： | 1 |
| 4 | Micro T-mixer as a rapid mixing micromixer 显示文摘 | WONG S H WARD M C L WHARTON C W | 2004 | Sensors and Actuators B-Chemical2004，100，3： | 1 |
| 5 | Electromagnetic fields about a loop source of current显示文摘 | Ryu J Morrison F H Ward S H | 1970 | Geophysics1970，35，： | 1 |
| 6 | Mineral discrimination and removal of inductive coupling with multrfrequency IP 显示文摘 | Pelton W H Ward S H Hallof P G | 1978 | Geophysics1978，43，3： | 1 |
| 7 | Three dimensional resistivity inversion using alpha centers 显示文摘 | Petriek W R Jr Sill W R Ward S H | 1981 | Geophysics1981，46，8： | 1 |
| 8 | Micro Tmixer as a rapid mixing micromixer显示文摘 | WONG S H WARD M C L WHARTON C W | 2004 | Sensors and Actuators B:Chemical2004，100，3： | 1 |
| 9 | Mineral Discrimination and Removal of Inductive Coupling with Multifrequency IP显示文摘 | Pelton W H Ward S H | 1978 | Geophysics1978，43，3： | 1 |
| 10 | Rapid Radiation Events in the Family Ursidae Indicated by Likihood Phylogenetic Estimationfrom Multiple Fragments of mtDNA 显示文摘 | Waits L P O'Brien S J Ward R H | 1999 | Mol Phylogenet Evol1999，13，1： | 1 |
| 11 | A central role of salicylic acid in plant disease resistance显示文摘 | DELANEY T P UKNES S VERNOOIJ B FRIEDRICH L WER- MANN K NEGROTYO D GAFFNEY T GUT-RELLA M KESS- MANN H WARD E RYALS J | 1994 | Science1994，266，5188： | 1 |
| 12 | DNA barcoding Australias fish species显示文摘 | WARD R D ZEMLAK T S INNES B H | 2005 | Philosophical Transactions of the Royal Society B: Biological Sciences2005，360，1462： | 1 |
| 13 | Purification and identification of the STAT5 protease in myeloid cells显示文摘 | Schuster B Hendry L Byers H Lynham SF Ward MA John S | 2007 | Biochem J2007，404，： | 1 |
| 14 | The influence of mini-BAL cultures on patient out- comes implications for the antibiotic management of ventil- atorassociated pneumonia显示文摘 | Koffel M H Ward S | 1998 | Chest1998，，113： | 1 |
| 15 | Determination of the natural periods of building 显示文摘 | Crawford R Ward H S | 1964 | Bulletin of the Seismological Society of America1964，54，6： | 1 |
| 16 | Three - dimensional resistivity inversion using alpha centers显示文摘 | Sill W R Ward S H | 1981 | Geophysics1981，46，： | 1 |
| 17 | A comparative analysis of patients with early-onset vs late-onset nosocomial pneumonia in the ICU setting显示文摘 | IBRAHIM E H WARD S SHERMAN G | 2000 | Chest2000，117，5： | 1 |
| 18 | DNA barcoding Australia's fish species显示文摘 | Ward R D Zemlak T S Innes B H | 2005 | Phil Trans R Soc B2005，360，： | 1 |
| 19 | A new class of contrast agents for MRI based on proton chemical ex- change dependent saturation transfer (CEST)显示文摘 | Ward K M Aletras A H Balaban R S | 2000 | J Magn Reson2000，143，： | 1 |
| 20 | Two-Dimensional Cross- Borehole Resistivity Model Fitting显示文摘 | LaBrecque D J Ward S H | 1990 | Geotechnical and Environmental Geophysics1990，1，： | 1 |
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