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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Binding and neutralization of endotoxin by Limulus antilipopolysaccharide factor 显示文摘 | Warren H S Glennon M L Wainwright N | 1992 | Infect Immun1992，60，6： | 1 |
| 3 | Improved RT - PCR for diagnosis and epidemiological surveillance of rubella显示文摘 | Cooray S Warrener L Jin L | 2006 | J Clin Virol2006，35，1： | 1 |
| 4 | The right to privacy 显示文摘 | WARREN S D BRANDEIS L D | | Harvard Law Review0，1890，： | 1 |
| 5 | Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson’s disease: an open-label, phase I trial显示文摘 | William J Marks Jill L Ostrem Leonard Verhagen Philip A Starr Paul S Larson Roy AE Bakay Robin Taylor Deborah A Cahn-Weiner A Jon Stoessl C Warren Olanow Raymond T Bartus | 2008 | Lancet Neurology2008，，5： | 1 |
| 6 | The right to privacy 显示文摘 | BRANDEIS L WARREN S | | Harvard Law Review0，4，12： | 1 |
| 7 | Ecological niche modeling in Maxent: the importance of model complexity and the performance of model selection criteria 显示文摘 | Warren D L Seifert S N | 2011 | Ecological Applications2011，21，2： | 1 |
| 8 | Performance of turkey litter compost as slow-release fertilizer in containerized plant production显示文摘 | Kraust H T Warren S L | | 0，，01： | 1 |
| 9 | A test for linkage and association in general pedigrees:the pedigree disequilibrium test显示文摘 | Martin E R Monks S A Warren L L | 2000 | Am J Hum Genet2000，67，： | 1 |
| 10 | The right to privacy 显示文摘 | WARREN S BRANDEIS L | | Harvard law review0，1890，5： | 1 |
| 11 | Assembling millions of short DNA sequences using SSAKE显示文摘 | WARREN R L SUTTON G G JONES S J M | 2007 | Bioinformatics2007，23，4： | 1 |
| 12 | The acute metabolic effects of tumor necrosis factor administration in humans显示文摘 | WARREN R S STARNES H F Jr GABRILOVE J L | 1987 | Arch Surg1987，122，12： | 1 |
| 13 | Measuring quality of life of persons with spinal cord injury:external and structural validity显示文摘 | May L A Warren S | | 0，，07： | 1 |
| 14 | Whole-rock geochemical techniques for evaluating hydrothermal alteration, masschanges, and compositional gradients associated with epithermal Au-Ag mineralization显示文摘 | Warren I Simmons S F Mauk J L | 2007 | Econ Geol2007，102，5： | 1 |
| 15 | Characterizing het- erogeneous bacterial surface functional groups using discrete affinity spectra for proton binding显示文摘 | Cox J S Smith D S Warren L A | 1999 | Environmental Science& Technology1999，33，： | 1 |
| 16 | A transplantable insulinoma in the rat显示文摘 | CHICK W L WARREN S CHUTE R N | 1977 | Proc Natl Acad Sci1977，74，： | 1 |
| 17 | Penetration of lime- stone targets by ogive-nosed VAR 4340 steel projectiles at oblique angles: experiments and simulations 显示文摘 | Warren T L Hanchak S J Poormon Kevin L | 2004 | International Journal of Impact Engineering2004，30，： | 1 |
| 18 | Generalized Route to Metal Nanoparticles with Liquid Behavior显示文摘 | Warren S C Banholzer M J Slaughter L S | 2006 | J Am Chem Soc2006，128，12： | 1 |
| 19 | Small Steps are Easier Together:A Goal-Based Ecological Intervention to Increase Walking by Women in Rural Worksites显示文摘 | Warren B S Maley M Sugarwala L J | 2010 | Preventive M edicine2010，50，5： | 1 |
| 20 | Photoelectrochemical hydrogen evolution using Si microwire arrays显示文摘 | Boettcher S W Warren E L Putnam M C | 2011 | Journal of the American Chemical Society2011，133，5： | 1 |
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