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| 1 | One-step palliative treatment method for obstructive jaundice caused by unresectable malignancies by percutaneous transhepatic insertion of an expandable metallic stent显示文摘瞄准:为了描述包含可扩充的金属的经皮的 transhepatic 插入的一个简单一步舞方法,在妨碍的黄疸的治疗使用的斯滕特氏印模膏(他们) 由 unresectable 恶意引起了。方法:由于 unresectable 恶意与妨碍的黄疸诊断的十四个病人在学习被包括。在这些病人的恶意是很先进的癌或老年的结果。经皮的 transhepatic 胆管造影术在 ultrasonographic 指导下面被执行。在有一个内部金属性的指南的一根导管是先进的进十二指肠以后,一他们被放在胆总管,在一个点之间在到肝的核的 Vater 和入口的乳头状的小突起以外的 1 厘米。在用就一个单身者跨越距离是困难的情况中他们,另外的斯滕特氏印模膏被放。一根排水导管在地方被离开充当一把止血钳子。在胆汁郁积和斯滕特氏印模膏明显的分辨率被证实以后,导管被移开 2 或 3 d 过程以后。结果:EMS 的一步舞插入与 24.4 min 的一过程平均数时间在所有病人被完成。从要求了 2 他们的病人, 4 需要一过程时间超过 30 min。导管的移动的吝啬的时间过程以后是 2.3 d。所有病人与 7.8 瞬间的一吝啬的后续时间死于恶意。没有 stent 相关的复杂并发症或斯滕特氏印模膏阻塞被遇到。结论:他们的一步舞经皮的 transhepatic 插入是为决定胆汁的阻塞和罐头有效地改进病人生命的质量的一个简单过程。 | Hiroshi Yoshida Yasuhiro Mamada Nobuhiko Taniai Yoshiaki Mizuguchi Tetsuya Shimizu Shigeki Yokomuro Takayuki Aimoto Yoshiharu Nakamura Eiji Uchida Yasuo Arima Manabu Watanabe Eiichi Uchida Takashi Tajiri | 2006 | World Journal of Gastroenterology2006，12，15： | 28 |
| 2 | Novel serum tumor marker, RCASl, in pancreatic diseases显示文摘AIM: As tumor markers for pancreatic carcinoma,carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 have been used, but the sensitivity and specificity are not enough for the diagnosis of pancreatic carcinoma.METHODS: A novel serum tumor marker, RCAS1, was compared with two conventional serum tumor markers,CEA (highly specific for pancreatic cancer) and CA 19-9 (highly sensitive for pancreatic cancer), in 48 patients with pancreatic exocrine tumors.RESULTS: When the diagnosis of benign or malignant conditions was examined by one tumor marker, the sensitivity of RCAS1 alone (55%) was higher than that of CEA alone (27%) and the specificity of RCAS1 alone (92%) was greater than that of CA19-9 alone (78%). When examined by a combination of two markers, the sensitivity of a combination of RCAS1 and CA19-9 (95%) was superior to those of CA19-9 alone (78%), RCAS1 alone (55%, P = 0.002),CEA alone (27%) (P<0.001), RCAS1 and CEA (59%) and CA19-9 and CEA (82%).CONCLUSION: These results suggest that the combination of RCASL and CA19-9 is highly sensitive for pancreatic carcinoma. | Koji Yamaguchi Munechika Enjoji Manabu Nakashima Makoto Nakamuta Takashi Watanabe Masao Tanaka | 2005 | World Journal of Gastroenterology2005，11，33： | 12 |
| 3 | Efficacy of intra-arterial contrast-enhanced ultrasonography during transarterial chemoembolization with drug-eluting beads for hepatocellular carcinoma显示文摘AIM To assess the usefulness of intra-arterial contrastenhanced ultrasonography(IAUS) during transarterial chemoembolization(TACE) with drug-eluting beads(DEB) for hepatocellular carcinoma(HCC).METHODS Thirty two patients with 39 HCC underwent DEB-TACE guided with IAUS, and examined by contrast-enhanced ultrasonography(CEUS) or dynamic CT after DEB-TACE were enrolled in this study. CEUS findings before DEBTACE and IAUS findings were compared. Treatments judged to be complete and incomplete for lesions were appropriate and insufficient, respectively. Findings on CEUS and/or dynamic CT performed 1, 3 and 6 mo after DEB-TACE were evaluated using m RECIST(CR/PR/SD/PD).RESULTS The treatments were complete and incomplete in 26 and 13 lesions, respectively. On imaging evaluation using CEUS and/or dynamic CT one month after treatment, 25 and 1 lesions were judged to be CR and PR, respectively, and at 6 mo after treatment, the results were CR, PR, SD and PD for 24, 1, 0 and 1 of these lesions, respectively, in the 26 completely treated lesions. Of the 13 lesions in which treatment was incomplete, the results on imaging at one month after treatment were CR, PR, SD and PD for 0, 6, 4 and 3 lesions, respectively. The overall CR rate at 6 mo after treatment was 61.5%(24/39).CONCLUSION A combination of DEB-TACE with IAUS can improve the therapeutic effects in patients with HCC. | Kazue Shiozawa Manabu Watanabe Takashi Ikehara Shuhei Yamamoto Takashi Matsui Yoshinori Saigusa Yoshinori Igarashi Iruru Maetani | 2018 | World Journal of Hepatology2018，10，1： | 7 |
| 4 | Twenty-four hour intra-arterial infusion of 5-fluorouracil,cisplatin,and leucovorin is more effective than 6-hour infusion for advanced hepatocellular carcinoma显示文摘AIM: To evaluate the time dependence of intra-arterial 5-fluorouracil (5-FU) therapy for advanced hepatocellular carcinoma (aHCC). METHODS: Thirty-seven adult Japanese patients who had aHCC and liver cirrhosis were treated with combined intra-arterial 5-FU, cisplatin (CDDP), and leucovorin (LV). The Japan Integrated Staging score (JIS score) of each patient was 3 or more. The patients were divided into two groups, after which the 15 patients in group S were treated with 6-h infusion chemotherapy (LV at 12 mg/h, CDDP at 10 mg/h, and 5-FU at 250 mg/m2 per 4 h) and the 22 patients in group L were treated with 24-h infusion chemotherapy (LV at 12 mg/h, CDDP at 10 mg/h, and 5-FU at 250 mg/m2 per 22 h). Continuous infusion chemotherapy was performed via the proper hepatic artery every 5 d for 4 wk using an implanted drug reservoir. RESULTS: The percentages of patients with a partial response after 4 wk of chemotherapy were 6.7% in group S and 31.8% in group L. The survival of group L was significantly better than that of group S, with the median survival time being 496 d in group L and 226 d in group S (P < 0.05). CONCLUSION: Continuous 24-h intra-arterial infusion is more effective for aHCC and can markedly prolong survival time as compared to 6-h infusion. | Hidenari Nagai Masahiro Kanayama Katsuya Higami Kouichi Momiyama Akiko Ikoma Naoki Okano Katsuhiko Matsumaru Manabu Watanabe Koji Ishii Yasukiyo Sumino Kazumasa Miki | 2007 | World Journal of Gastroenterology2007，13，2： | 6 |
| 5 | Comparison of percutaneous radiofrequency ablation and CyberKnife®for initial solitary hepatocellular carcinoma:A pilot study显示文摘AIM To compare therapeutic outcomes and adverseevents in initial solitary hepatocellular carcinoma(HCC) treated with radiofrequency ablation (RFA) andCyberKnife?.METHODS: Seventy three consecutive patients withinitial solitary HCC treated with RFA (38 patients;RFA group) and CyberKnife (35 patients; CK group)were enrolled in this study. Background factorswere compared between the two groups. Local andintrahepatic distant recurrence control, and cumulativesurvival rates were compared between the two groups.These were determined using the Kaplan-Meier method,and the significance of differences was analyzed by log-rank test. The presence of more grade 3 on CTCAE ver.4.0 early and late adverse events was investigated.RESULTS: In background factors, age was significantlyhigher (P = 0.005) and the tumor diameter wassignificantly larger (P = 0.001) in the CK group. The1-year local recurrence control rates were 97.4%and 97.1% in the RFA and CK groups, respectively (P= 0.71); the 1-year intrahepatic distant recurrencecontrol rates were 85.6% and 86.1%, respectively (P= 0.91); and the 1-year cumulative survival rates were100% and 95.2%, respectively (P = 0.075), showingno significant difference in any rate between the twogroups. There were no late adverse event in the RFAgroup, but 11.4% in the CK group had late adverseevents. In the CK group, the Child-Pugh score at 12 moafter treatment was significantly higher than that in theRFA group (P = 0.003) and significantly higher than thescore before treatment (P = 0.034).CONCLUSION: The occurrence of adverse events is aconcern, but CyberKnife treatment is likely to becomean important option for local treatment of early HCC. | Kazue Shiozawa Manabu Watanabe Takashi Ikehara Yasushi Matsukiyo Michio Kogame Yui Kishimoto Yusuke Okubo Hiroyuki Makino Nobuhiro Tsukamoto Yoshinori Igarashi Yasukiyo Sumino | 2015 | World Journal of Gastroenterology2015，21，48： | 4 |
| 6 | Acute pancreatitis secondary to intramural duodenal hematoma:Case report and literature review显示文摘Nontraumatic intramural duodenal hematoma(IDH) is rare disease and it is generally related to coagulation abnormalities.Reports of nontraumatic IDH associated with pancreatic disease are relatively rare,and various conditions including acute or chronic pancreatitis are thought to be associated with nontraumatic IDH.However,the association between IDH and acute pancreatitis remains unknown.We report the case of a 45-year-old man who presented with vomiting and right hypochondrial pain.He had no medical history,but was a heavy drinker.The diagnosis of IDH was established by computed tomography,ultrasonography and endoscopy,and it was complicated by acute pancreatitis.The lesions resolved with conservative management.We discuss this case in the context of previously reported cases of IDH concomitant with acute pancreatitis.In our patient,acute pancreatitis occurred concurrently with hematoma,probably due to obstruction of the duodenal papilla,or compression of the pancreas caused by the hematoma.The present analysis of the published cases of IDH with acute pancreatitis provides some information on the pathogenesis of IDH and its relationship with acute pancreatitis. | Kazue Shiozawa Manabu Watanabe Yoshinori Igarashi Yasushi Matsukiyo Teppei Matsui Yasukiyo Sumino | 2010 | World Journal of Radiology2010，2，7： | 3 |
| 7 | The significance of circulating vascular endothelial growth factor (VEGF) protein in gastric cancer显示文摘 | Manabu Ohta Hiroyuki Konno Tatsuo Tanaka Megumi Baba Kinji Kamiya Tuyoshi Syouji Kenji Kondoh Masaya Watanabe Hirofumi Terada Satoshi Nakamura | 2002 | Cancer Letters2002，，2： | 2 |
| 8 | Upregulation of TRPC1 in the development of cardiac hypertrophy显示文摘 | Takayoshi Ohba Hiroyuki Watanabe Manabu Murakami Yoichiro Takahashi Kenji Iino Sadao Kuromitsu Yasuo Mori Kyoichi Ono Toshihiko Iijima Hiroshi Ito | 2006 | Journal of Molecular and Cellular Cardiology2006，，3： | 2 |
| 9 | Association of Plasma Homocysteine Concentration With Atherosclerotic Carotid Plaques and Lacunar Infarction显示文摘 | Tsutomu Sasaki Manabu Watanabe Yoji Nagai Taku Hoshi Masashi Takasawa Masaru Nukata Akihiko Taguchi Kazuo Kitagawa Naokazu Kinoshita Masayasu Matsumoto | 2002 | Stroke: Journal of the American Heart Association2002，，6： | 2 |
| 10 | JNK contributes to temozolomide resistance of stem-like glioblastomacells via regulation of MGMT expression显示文摘 | Masashi Okada Atsushi Sato Keita Shibuya Eriko Watanabe Shizuka Seino Shuhei Suzuki Manabu Seino Yoshitaka Narita Soichiro Shibui Takamasa Kayama Chifumi Kitanaka | 2014 | International Journal of Oncology2014，，2： | 2 |
| 11 | Effect of Left Colonic Artery Preservation on Anastomotic Leakage in Laparoscopic Anterior Resection for Middle and Low Rectal Cancer显示文摘 | Takao Hinoi Masazumi Okajima Manabu Shimomura Hiroyuki Egi Hideki Ohdan Fumio Konishi Kenichi Sugihara Masahiko Watanabe | 2013 | World Journal of Surgery2013，，12： | 2 |
| 12 | Analysis of temperature distributions in Kamaboko during microwave heating 显示文摘 | Mao Weijie Manabu Watanabe Noboru Sakai | 2005 | Journal of Food Engineering2005，71，： | 1 |
| 13 | Regulatory role of neuron-restrictive silencing factor in expression of TRPC1显示文摘 | Takayoshi Ohba Hiroyuki Watanabe Yoichiro Takahashi Takashi Suzuki Ichiro Miyoshi Shinnsuke Nakayama Eisaku Satoh Kenji Iino Hironobu Sasano Yasuo Mori Sadao Kuromitsu Keiichi Imagawa Yoshihiko Saito Toshihiko Iijima Hiroshi Ito Manabu Murakami | 2006 | Biochemical and Biophysical Research Communications2006，，3： | 1 |
| 14 | Analysis of temperature distributions in Kamaboko during microwave heating 显示文摘 | Mao Weijie Manabu Watanabe Noboru Sakai | 2005 | Journal of Food Engineering2005，71，： | 1 |
| 15 | In-flighttparticle measurement of alkali-free glass raw materials in 12-phase AC arc plasma显示文摘 | Yaping Liu Manabu Tanaka Sooseok Choi Takayuki Watanabe | | 0，，05： | 1 |
| 16 | Evaluation of sorafenib for hepatocellular carcinoma by contrast-enhanced ultrasonography:A pilot study显示文摘AIM:To determine the usefulness of arrival time parametric imaging(AtPI) using contrast-enhanced ultrasonography(CEUS) with Sonazoid in evaluating early response to sorafenib for hepatocellular carcinoma(HCC).METHODS:Fourteen advanced HCC patients who received sorafenib 400/800 mg/d for at least 4 wk and were followed up by CEUS were enrolled in this study.CEUS was performed before treatment and 2 and 4 wk after treatment,and images of the target lesion in the arterial phase were recorded for each patient.The images were analyzed by AtPI.Color mapping(CM) images obtained by AtPI were compared before and after the treatment.In these CM images,the mean arrival time of the contrast agent in the region of interest from the starting point [mean time(MT)] was calculated.In each patient,differences between MT before and MT 2 and 4 wk after the treatment were compared with responses evaluated 4-8 wk after the treatment by dynamic computed tomography(CT),and statistical analysis was performed.Modified response evaluation criteria in solid tumors was used for the response evaluation.RESULTS:In CM images both 2 and 4 wk after the treatment,delays in the arrival time of the contrast agent were noted in 8 of the 14 patients.In the other 6 patients,no color changes were observed in the tumor,or red and/or yellow increase,suggesting a decrease in blood flow velocity between images 2 and 4 wk after the treatment and those before the treatment.Dynamic CT could be performed 4-8 wk after the treatment in 13 of the 14 patients.Median differences in the MT were 1.13 s and 1.015 s,2 and 4 wk after the treatment,respectively,in the 8 patients who showed stable disease(SD)/partial response(PR) on dynamic CT.Median differences in the MT were-0.39 s and-0.95 s,2 and 4 wk after the treatment,respectively,in the 5 patients who showed progressive disease(PD).Differences in the median MT between SD/PR and PD groups were significant 2 and 4 wk after the treatment with P = 0.019 and P = 0.028,respectively.CONCLUSION:AtPI by CEUS using Sonazoid is suggested to be useful for evaluating early responses to sorafenib. | Kazue Shiozawa Manabu Watanabe Yoshinori Kikuchi Takahide Kudo Kenichi Maruyama Yasukiyo Sumino | 2012 | World Journal of Gastroenterology2012，18，40： | 1 |
| 17 | Fundamental characteristics of a synthesized light source for optical coherence tomography显示文摘 | Sato Manabu Wakaki Ichiro Watanabe Yuuki | 2005 | Applied optics2005，44，13： | 1 |
| 18 | Cirp protects against tumor necrosis factor-α-induced apoptosis via activation of extracellular signal-regulated kinase显示文摘 | Toshiharu Sakurai Katsuhiko Itoh Hiroaki Higashitsuji Kohsuke Nonoguchi Yu Liu Hirohiko Watanabe Tadasu Nakano Manabu Fukumoto Tsutomu Chiba Jun Fujita | 2006 | BBA - Molecular Cell Research2006，，3： | 1 |
| 19 | Perforated appendiceal diverticulitis associated with appendiceal neurofibroma in neurofibromatosis type 1显示文摘An appendiceal neurofibroma(ANF) is a rare neoplasm associated with neurofibromatosis type 1(NF-1),an inheritable neurocutaneous disorder that involves multiple systems including the intraabdominal organs.Appendiceal diverticulitis occasionally ruptures in the absence of intense abdominal pain,which can lead to serious consequences.Recent reports highlight the association between appendiceal diverticulum and appendiceal neoplasms; however,there is still little information on the association between appendiceal diverticulitis and ANF in NF-1.A 51-year-old Japanese male with NF-1 was referred to the division of surgery for mild right lower quadrant pain.It was suspected he had perforated acute appendicitis with periappendiceal abscess based on clinical manifestations and findings of computed tomography.An emergency appendectomy was conducted.The pathological examination revealed diffusely proliferated tumor cells of a neurofibroma,coexistent with multiple appendiceal diverticulums,leading to the diagnosis ofperforated appendiceal diverticulitis associated with ANF.Although he developed a remnant abscess,he recovered with the conservative treatments of antibiotics and drainage.This case suggests that appendiceal diverticulitis might be a complication of appendiceal involvement of NF-1,and that it occasionally ruptures in the absence of intense abdominal pain.Clinicians should recognize that NF-1 can cause various abdominal manifestations. | Akihiko Ozaki Manabu Tsukada Kazuo Watanabe Masaharu Tsubokura Shigeaki Kato Tetsuya Tanimoto Masahiro Kami Hiromichi Ohira Yukio Kanazawa | 2015 | World Journal of Gastroenterology2015，21，33： | 1 |
| 20 | High expression of skp2 correlates with poor prognosis in endometrial endometrioid adenocarcinoma显示文摘 | Yuko Kamata Jun Watanabe Yukari Nishimura Tsutomu Arai Miwa Kawaguchi Manabu Hattori Akane Obokata Hiroyuki Kuramoto | 2005 | Journal of Cancer Research and Clinical Oncology2005，，9： | 1 |
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