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| 1 | Differences in atheroma between Caucasian and Asian subjects with anterior stroke:A vessel wall MRI study显示文摘Background and purpose While extracranial carotid artery stenosis is more common among Caucasians and intracranial artery stenosis is more common among Asians,the differences in atherosclerotic plaque characteristics have not yet been extensively examined.We sought to investigate plaque location and characteristics within extracranial carotid and intracranial arteries in symptomatic Caucasians and Chinese using vessel wall MRI.Methods Subjects with recent anterior circulation ischaemic stroke were recruited and imaged at two sites in the USA and China using similar protocols.Both extracranial carotid and intracranial arteries were reviewed to determine plaque location and characteristics.Results The prevalence of extracranial carotid plaque in Caucasians and Chinese was 73.1%and 49.1%,respectively(p=0.055).Prevalence of intracranial plaque was 38.5%and 69.1%in Caucasians and Chinese,respectively(p=0.02).Furthermore,42% of Caucasians and 16%of Chinese had high-risk plaque(HRP)features(intraplaque haemorrhage,luminal surface disruption)in the extracranial carotid artery(p=0.03).The prevalence of HRP features in intracranial arteries was not significantly different between the two cohorts(4%vs 11%;p=0.42).Conclusions Differences in the location and characteristics of cerebrovascular atherosclerosis were identified by vessel wall MRI in US Caucasian and Chinese subjects with recent anterior circulation ischaemic stroke.Extracranial carotid plaques with HRP features were more common in Caucasians.Intracranial plaques were more common in Chinese subjects,but no significant difference between the two cohorts in intracranial HRP prevalence was found.Larger studies using vessel wall imaging to investigate racial differences in cerebrovascular disease may inform underlying mechanisms of HRP development and may ultimately help guide appropriate therapy. | Hiroko Watase Mi Shen Binbin Sui Peiyi Gao Dong Zhang Jie Sun Niranjan Balu Daniel S Hippe Gail P Jarvik Xihai Zhao Rui Li Shuo Chen Chun Yuan Thomas S Hatsukami | 2021 | Stroke & Vascular Neurology2021，6，1： | 4 |
| 2 | The complete nucleotide sequence and multipartite organization of the tobacco mitochondrial genome: comparative analysis of mitochondrial genomes in higher plants 显示文摘 | Sugiyama Y Watase Y Nagase M | 2005 | Mol Genet Genomics2005，272，6： | 1 |
| 3 | Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT1显示文摘 | Anaka K Watase K Manabe T | 1997 | Science1997，276，： | 1 |
| 4 | Comparison of carotid atherosclerotic plaques between subjects in Northern and Southern China: a Chinese atherosclerosis risk evaluation study显示文摘Background and purpose To investigate differences in the characteristics of carotid atherosclerotic plaques of symptomatic subjects in northern and southern China using MRI.Methods Sixty-three subjects in northern China(mean age:59.1±8.6 years,45 men)and 56 subjects in southern China(mean age:60.4±8.6 years,38 men)were included.All subjects underwent carotid artery multicontrast vessel wall MRI.Plaque morphology,calcification,lipid-rich necrotic core,intraplaque haemorrhage,luminal surface disruption and high-risk plaque were measured and identified.All plaque characteristics were compared between subjects in northern and southern China using Mann-Whitney U test or χ^(2) test.results Compared with subjects in southern China,those in northern China had significantly greater areas for lumen(57.7±14.9 mm^(2) vs 50.4±18.3 mm^(2),p=0.009),wall(38.4±13.1 mm^(2) vs 31.9±11.7 mm^(2),p<0.001)and total vessel(96.1±20.2 mm^(2) vs 82.4±22.7 mm^(2),p=0.001)and mean wall thickness(1.25±0.43 mm vs 1.13±0.40 mm,p=0.019).χ^(2) analysis showed that subjects in northern China tended to have a higher prevalence of intraplaque haemorrhage(14.3%vs 5.4%,p=0.106)and high-risk plaque(20.6%vs 10.7%,p=0.140)than those in southern China,although these differences were not statistically significant(all p>0.05).Conclusion Subjects in northern China have significantly larger vessel size and may have a higher prevalence of vulnerable plaques than those in southern China.Our findings provide additional perspective to optimise the management of cerebrovascular disease in individuals in different regions in China. | Dandan Yang Yang Ji Dan Wang Hiroko Watase Daniel S Hippe Xihai Zhao Chun Yuan | 2020 | Stroke & Vascular Neurology2020，5，2： | 1 |
| 5 | Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT - 1 显示文摘 | Tanaka K Watase K Manabe T l | 1997 | Science1997，276，5319： | 1 |
| 6 | Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1显示文摘 | Tanaka K Watase K Manabe T | 1997 | Science1997，276，5319： | 1 |
| 7 | Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1显示文摘 | Tanaka K Watase K Manabe T | 1997 | Science1997，276，5319： | 1 |
| 8 | Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1显示文摘 | Tanaka K Watase K Manabe T | 1997 | Science1997，276，5319： | 1 |
| 9 | Structure of kainic acid and its isomer, allokainicacid 显示文摘 | Nitta l Watase H Tomiie Y | 1958 | Nature1958，181，： | 1 |
| 10 | Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1 显示文摘 | Tanaka K Watase K Manabe T | 1996 | Science1996，276，： | 1 |
| 11 | Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1 显示文摘 | Tanaka K Watase K Manabe T | 1997 | Science1997，276，5319： | 1 |
| 12 | Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT1 显示文摘 | Tanaka K Watase K Manabe T | 1997 | Science1997，276，5319： | 1 |
| 13 | Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1显示文摘 | Tanaka K Watase K Manabe T | | 0，，5319： | 1 |
| 14 | Effects of grapefruit juice on the pharmacokinetics of the calcium channel blockers nifedipine and nisoldipine显示文摘 | AZUMA J YAMAMOTO I WATASE T | 1998 | Current Ther Res1998，59，9： | 1 |
| 15 | DSC, rheology, Xray and NMR of very concentrated agarose gels显示文摘 | Watase M Nishinari K Clark A H | 1989 | Macromolecules1989，22，： | 1 |
| 16 | Rheological properties of agarosegelatin gels显示文摘 | Watase M Nishinari K | 1980 | Rheologica Acta1980，19，： | 1 |
| 17 | Rheological and thermal properties of carrageenen gels 显示文摘 | Watase M and Nishinari K | 1987 | Makromol Chem1987，188，： | 1 |
| 18 | Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1 显示文摘 | Tanaka K Watase K Manabe T | 1997 | Science1997，276，5319： | 1 |
| 19 | Low-temperature electrodeposition of roomtemperature ultraviolet-light-emitting zinc oxide 显示文摘 | Izaki M Watase S Takahashi H | 2003 | Advanced Materials2003，15，23： | 1 |
| 20 | 显示文摘 | WATASE S NAKAMOTO M KITAMURA T | 2000 | Dalton Trans2000，，： | 1 |
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