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| 1 | Use of free vascularized fibular graft for congenital ulnar pseudarthrosis: surgical decision making in the growing child显示文摘 | Bae DS Waters PM Sampson CE | 2005 | J Pediatr Orthop2005，25，6： | 1 |
| 2 | Dangerousness: Assessing the risk of violent behavior显示文摘 | Shaffer CE Waters WF Adams SG | 1994 | Journal of Consulting and Clinical Psychology1994，62，： | 1 |
| 3 | Insufficient evidence of benefit:a systematic review of home telemonitoring for COPD显示文摘 | Bolton CE Waters CS Peirce S | 2011 | J Eval CIin Pract2011，17，6： | 1 |
| 4 | Oestrogen- induced apoptos isin colonocytes expressing oestrogen receptor beta显示文摘 | Qiu Y Waters CE Lewis AE | 2002 | J Endocrino2002，174，3： | 1 |
| 5 | Differential monocyte responses to TLR ligands in children with autism spectrum disorders显示文摘 | Enstrom AM Onore CE Van de Water JA | | 0，，01： | 1 |
| 6 | Difficuhy in brainstem death testing in the presence of high spinal cord injury 显示文摘 | Waters CE French G Burt M | 2004 | British Journal Anaesthesia2004，92，： | 1 |
| 7 | The stability of attachment security from infancy to adolescence and early adulthood: general introduction 显示文摘 | Waters E Hamilton CE Weinfield NS | 2000 | Child Dev2000，71，3： | 1 |
| 8 | Oestrogen-induced apoptosis in colonocytes expressing oestrogen receptor beta 显示文摘 | Qiu Y Waters CE Lewis AE | 2002 | J Endocrinol2002，174，3： | 1 |
| 9 | Consumption of gluten with gluten-degrading enzyme by celiac patients: A pilot-study显示文摘AIM:To assesses the safety and efficacy of Aspergillus niger prolyl endoprotease(AN-PEP)to mitigate the im-munogenic effects of gluten in celiac patients.METHODS:Patients with initial diagnosis of celiac disease as confirmed by positive serology with subtotal or total villous atrophy on duodenal biopsies who adhere to a strict gluten-free diet(GFD)resulting in normalised antibodies and mucosal healing classified as Marsh 0 orⅠwere included.In a randomised double-blind placebo-controlled pilot study,patients consumed toast(approximately 7 g/d gluten)with AN-PEP for 2 wk(safety phase).After a 2-wk washout period with adherence of the usual GFD,14 patients were randomised to gluten intake with either AN-PEP or placebo for 2 wk(efficacy phase).Measurements at baseline included complaints,quality-of-life,serum antibodies,immunophenotyping of T-cells and duodenal mucosa immunohistology.Furthermore,serum and quality of life questionnaires were collected during and after the safety,washout and efficacy phase.Duodenal biopsies were collected after the safety phase and after the efficacy phase.A change in histological evaluation according to the modified Marsh classification was the primary endpoint.RESULTS:In total,16 adults were enrolled in the study.No serious adverse events occurred during the trial and no patients withdrew during the trial.The mean score for the gastrointestinal subcategory of the celiac disease quality(CDQ)was relatively high throughout the study,indicating that AN-PEP was well tolerated.In the efficacy phase,the CDQ scores of patients consuming gluten with placebo or gluten with AN-PEP did not significantly deteriorate and moreover no differences between the groups were observed.During the efficacy phase,neither the placebo nor the AN-PEP group developed significant antibody titers.The IgA-EM concentrations remained negative in both groups.Two patients were excluded from entering the efficacy phase as their mucosa showed an increase oftwo Marsh steps after the safety phase,yet with undetectable serum antibodies,while 14 patients were considered histologically stable on gluten with AN-PEP.Also after the efficacy phase,no significant deterioration was observed regarding immunohistological and flow cytometric evaluation in the group consuming placebo compared to the group receiving AN-PEP.Furthermore,IgA-tTG deposit staining increased after 2 wk of gluten compared to baseline in four out of seven patients on placebo.In the seven patients receiving AN-PEP,one patient showed increased and one showed decreased IgA-tTG deposits.CONCLUSION:AN-PEP appears to be well tolerated.However,the primary endpoint was not met due to lack of clinical deterioration upon placebo,impeding an effect of AN-PEP. | Greetje J Tack Jolanda MW van de Water Maaike J Bruins Engelina MC Kooy-Winkelaar Jeroen van Bergen Petra Bonnet Anita CE Vreugdenhil Ilma Korponay-Szabo Luppo Edens B Mary E von Blomberg Marco WJ Schreurs Chris J Mulder Frits Koning | 2013 | World Journal of Gastroenterology2013，19，35： | 1 |
| 10 | Oestrogen-induced ap-optosis in colonocytes expressing oestrogen receptorβ显示文摘 | Qiu Y Waters CE Lewis AE | 2002 | Endocrinol2002，174，： | 1 |
| 11 | Periarticular heterotopic ossification in head-injured adults incidence and location 显示文摘 | Garland DE Blum CE Waters RL | 1980 | J Bone Joint Surg1980，62，7： | 1 |
| 12 | Periarticular heterotopic ossification in head-injured adults incidence and location显示文摘 | Garland DE Blum CE Waters RL | 1980 | J Bone Joint Surg(Am)1980，62，： | 1 |
| 13 | Dif{erenti al monocyte responses to TLR ligands in children with autism spectrum disorders显示文摘 | Enstrom AM Onore CE Van de Water JA | 2010 | Brain Behav Irnmun2010，24，1： | 1 |
| 14 | Periarticular heterotopic ossification in head-injured adults:Incidence and location显示文摘 | Garland DE Blum CE Waters RL | 1980 | JBJS1980，62，： | 1 |
| 15 | Differential monocyte responses to TLR ligands in children with autism spectrum disorders显示文摘 | Enstrom AM Onore CE Van de Water JA | 2010 | Brain Behav Immun2010，24，1： | 1 |
| 16 | The stability of at- tachment security from infancy to adolescence and early adulthood: General introduction 显示文摘 | WATERS E HAMILTON CE WEINFIELD NS | 2000 | Child Dev2000，71，3： | 1 |
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