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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Skin care of the pediatric patient显示文摘 | Pallija G Mondozzi M Webb AA | 1999 | J Pediatr Nurs1999，14，2： | 1 |
| 3 | Antiviral activity and hepatoprotection by heme oxygenase-1 in hepatitis B virus infection显示文摘 | Protzer U Seyfried S Quasdorff M Sass G Svorcova M Webb D | | Gastroenterology0，，： | 1 |
| 4 | Pulmonary valve replacement late after repair of tetralogy of FallOT显示文摘 | EMETS I M WILLIAMS W G WEBB G D | 1997 | Ann Thorac Surg1997，64，2： | 1 |
| 5 | Applications and processing of SiGe and SiGe:C for high-speed HBT devices显示文摘 | WEBB D A WARD M G | 2001 | Materials Science in Semiconductor Processing2001，4，： | 1 |
| 6 | Percutaneous aortic valve implantation retrograde from the femoral artery显示文摘 | Webb J G Chandavimol M Thompson C R Ricci D R Carere R G Munt B I | 2006 | Circulation2006，113，： | 1 |
| 7 | Phylodiversitydependent seedling mortality,size structure,and disease in a Bornean rain forest显示文摘 | Webb C O Gilbert G S Donoghue M J | 2006 | Ecology2006，87，： | 1 |
| 8 | Long - term re- sults of aortic valve - sparing operations for aortic root aneurysm 显示文摘 | DAVID T E FEINDEL C M WEBB G D | 2006 | J Thorac Cardiovasc Surg2006，132，2： | 1 |
| 9 | Isolation of a eDNA clone and localization of the human glutathione S - transferase 3 genes to chromosome bands llq13 and 12q13 -14显示文摘 | BOARD P G WEBB G C COGGAN M | 1989 | Ann Hum Genet1989，53，3： | 1 |
| 10 | Isolation of ac DNA clone and localization of the human glutathione S transferase 3 genes to chromosome bands 11q13 and 12q13 14显示文摘 | Borad P G Webb G C Coggan M | 1989 | Ann Hum Genet1989，33，3： | 1 |
| 11 | Discrete particle motion on sieves-a numerical study using the DEM simulation显示文摘 | Li J Webb C Pandiella S S Campbell G M | 2003 | Powder Technology2003，133，： | 1 |
| 12 | Isolation of a Cdna clone and localization of the human glutathione Stransferase 3 genes to chromosome bands llq13 and 12q 12-14显示文摘 | Board P G Webb G3 C Coggan M | 1989 | Aum Genet1989，53，： | 1 |
| 13 | Ureteral endometriosis diagnosed atureteroscopy显示文摘 | Zanetta G Webb M J Segura J W | 1998 | Ohater Gynecol1998，91，： | 1 |
| 14 | Site-Specific Fertilizer Recommendations for Oil Palm Smallholders Using Information From Large Plantations显示文摘 | Webb M J Nelson P N Rogers L G | 2011 | Journal of Plant Nutrition and Soil Science2011，174，2： | 1 |
| 15 | Competition of hospital-acquired and community-acquired methicillin-resistant Staphylococcus aureus strains in hospitals显示文摘 | Webb G F Horn M A D'Agata E M | | 0，，01： | 1 |
| 16 | Mannitol in cardioplegia as an oxygen free radical scanvenger measured by malondialdehyde 显示文摘 | Larsen M Webb G Kennington S | 2002 | Perfusion2002，17，1： | 1 |
| 17 | Percutaneous aortic valve implantation retrograde from the femoral artery显示文摘 | WEBB J G CHANDVIRNOL M THOMPSON C R | 2006 | Circulation2006，113，： | 1 |
| 18 | Ureteral endometriosis diagnosed at uretroscopy显示文摘 | Zanetta G Webb M J Segura JW | 1998 | Obstet Gynecol1998，91，52： | 1 |
| 19 | A protocol of urokinase infusion and warfarin for the management of the thrombosed haemodialysis catheter显示文摘 | WEBB A ABDALLA M RUSSELL G I | 2001 | Nephrol Dial Transplant2001，16，10： | 1 |
| 20 | Atrial septal defects in the adult:recent progress and overview显示文摘 | Webb G Gatzoulis M A | 2006 | Circulation2006，114，15： | 1 |
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