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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | 查看详情显示文摘 | Critchlow G W Webb P W Tremlett C J | | 0，，： | 1 |
| 3 | Differential ligand activation of estrogen receptors Eralpha and Erbeta at AP1 sites 显示文摘 | Peach K Webb P George G | 1997 | Science1997，277，： | 1 |
| 4 | A comparison of carvedilol and metoprolol antioxidant activities in vitro显示文摘 | Lysko P G Webb C L Gu J L | 2000 | Journal of Cardiovascu- lar Pharmacology2000，36，2： | 1 |
| 5 | Genes that regulate metastasis and angiogenesis显示文摘 | Webb C P Vande-Woude G F | 2000 | J Neurooncol2000，50，12： | 1 |
| 6 | Frequency and initiation of debris flows in Grand Canyon, Arizona 显示文摘 | Griffiths P G Webb R H Melis T S | 2004 | Journal of Geophysical Research2004，，109： | 1 |
| 7 | Isolation of a eDNA clone and localization of the human glutathione S - transferase 3 genes to chromosome bands llq13 and 12q13 -14显示文摘 | BOARD P G WEBB G C COGGAN M | 1989 | Ann Hum Genet1989，53，3： | 1 |
| 8 | Isolation of ac DNA clone and localization of the human glutathione S transferase 3 genes to chromosome bands 11q13 and 12q13 14显示文摘 | Borad P G Webb G C Coggan M | 1989 | Ann Hum Genet1989，33，3： | 1 |
| 9 | Differential ligand activation of estrogen receptors ER-a and ER-β at AP1 sites 显示文摘 | PAECH K WEBB P KUIPER G | 1997 | Secience1997，277，5331： | 1 |
| 10 | Isolation of a Cdna clone and localization of the human glutathione Stransferase 3 genes to chromosome bands llq13 and 12q 12-14显示文摘 | Board P G Webb G3 C Coggan M | 1989 | Aum Genet1989，53，： | 1 |
| 11 | Site-Specific Fertilizer Recommendations for Oil Palm Smallholders Using Information From Large Plantations显示文摘 | Webb M J Nelson P N Rogers L G | 2011 | Journal of Plant Nutrition and Soil Science2011，174，2： | 1 |
| 12 | A comparison of carvedilol andmetoprolol antioxidant activities in vitro显示文摘 | Webb C L Gu J L | 2000 | J Cardiovasc Pharmacol2000，36，2： | 1 |
| 13 | A comparison of carvedilol and metoprolol antioxidant activities in vitro显示文摘 | Lysko P G Webb C L Gu J L | 2000 | J Cardiovasc Pharmacol2000，36，2： | 1 |
| 14 | Recent developments in optical fibre sensing using fiber Bragg gratings 显示文摘 | Brady G P Kalli K Webb D J | 1994 | SPIE1994，2839，： | 1 |
| 15 | Effects of immunization with somatostatin on growth and arterio-venous differences of metabolites across muscle tissue of growing lambs 显示文摘 | Webb M M S McDowell G H Gooden J M Hoskinson R M Wynn P C | 1986 | Prod Nutr Soc Aust1986，11，： | 1 |
| 16 | Simultaneous Measurement of Strain and Temperature Using the First and Second Order Diffraction Wavelength of Bragg Gratings显示文摘 | Kalli K Webb D J | 1997 | IEEE Proc-Optoelectron1997，144，3： | 1 |
| 17 | Differential ligand activation of estrogen receptors ER-α and ER-β at AP1 sites显示文摘 | Paech K Webb P Kuiper G | 1997 | Science1997，277，： | 1 |
| 18 | A Model of Antibiotic Resistant Bacterial Epidemics in Hospitals显示文摘 | WEBB G F DAGATA E M MAGAL P | | 0，，： | 1 |
| 19 | Sediment yield and runoff frequency of small drainage basins in the Mojave Desert, USA 显示文摘 | GRIFFITHS P G HEREFORD R WEBB R H | 2006 | Geomorphology2006，74，1234： | 1 |
| 20 | Differential ligand activation of estrogen receptors ERα and ERβ at apl sites显示文摘 | Paech K Webb P Kuiper G G | 1997 | Science1997，277，： | 1 |
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