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| 1 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 2 | 热应激和低营养摄入对猪肠道完整性和功能的影响显示文摘热应激会损害肠道完整性,并诱发肠渗漏。因此,本试验研究了直接或间接热应激(通过减少采食量)对生长猪肠道通透性的影响。选用体重(43±4)kg的杂交后备母猪(n=48),分别安置在以下控制环境中:热中性(TN)环境(20℃,湿度35%~50%,自由采食)、热应激(HS)环境(35℃,湿度20%~35%,自由采食)、热中性环境配对饲喂(PFTN,以消除不同采食量的交互影响)。第1、3、7天使猪只安乐死,采集的空肠样品被安装到尤式灌流室,测定跨膜电阻抗值(TER)和异硫氰基荧光标记的脂多糖(LPS)渗透性(APP,表示为表观渗透系数)。此外,评估肠道完整性以及应激基因和蛋白标志物。结果表明,不考虑热应激天数,HS组与TN组猪相比,血浆内毒素水平增加45%(P〈0.05),空肠TER降低30%(P〈0.05),LPS渗透率增加2倍(P〈0.01)。此外,与PFTN组相比,HS组第7天的猪LPS渗透性有增加的趋势(P=0.06)。整个试验阶段HS组溶菌酶和碱性磷酸酶活性下降,分别下降46%和59%(P〈0.05);然而,3 d和7 d空肠免疫细胞标记物——髓过氧化物酶活性增加(P〈0.05)。由此可见,热应激和减少采食量都会降低肠道完整性,并增加内毒素渗透性。推测这可能会导致炎症加重,在炎热的夏季可能是导致猪生长性能降低的原因。 | Pearce S C Mani V Weber T E Rhoads R P Patience J F Baumgard L H Gabler N K | 2016 | 中国饲料2016，，3： | 3 |
| 3 | 24h动态中心动脉收缩压和左心室质量的关系:一项前瞻性多中心研究显示文摘研究者在7个欧洲中心中调查左心室质量与肱动脉诊室血压以及肱动脉压和中心动脉动态收缩压之间的关系。使用校准的示波装置测量,经平均压/舒张压校准和转换函数计算中心动脉收缩压。由不知道血压值的单个操作者通过M型超声心动图测定左心室质量。研究者调查了未使用抗高血压药物的受试者289人(女性137人,平均年龄50.8岁)。 | 黄洁 叶鹏 Weber T Wassertheurer S Schmidt-Trucks?ss A Rodilla E Ablasser C Jankowski P Lorenza Muiesan M Giannattasio C Mang C Wilkinson I Kellermair J Hametner B Pascual JM Zweiker R Czarnecka D Paini A Salvetti M Maloberti A McEniery C | 2017 | 中华高血压杂志2017，25，11： | 2 |
| 4 | Categorization of Scope 3 Emissions for Streamlined Enterprise Carbon Footprinting 显示文摘 | Huang Y A Weber C L Matthews H S | 2009 | Environmental Science & Technology2009，43，22： | 1 |
| 5 | Myocardial fibrosis: functional significance and regulatory factors 显示文摘 | Weber K T Brilla C G Janicki J S | 1993 | Cardiovas Res1993，27，： | 1 |
| 6 | Embodied environment emissions in U S international trade: 1997-2004 显示文摘 | Weber C L Matthews H S | 2007 | Environmental Science and Technology2007，41，14： | 1 |
| 7 | Legislative mandates for use of active surveillance cultures to screen for methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci:position statement from the Joint SHEA and APIC Task Force显示文摘 | Weber SG Huang SS Oriola S W.Huskins C Noskin GA Harriman K | | American Journal of Infection Control0，，： | 1 |
| 8 | Embodied environmental emissions in US international trade, 1997-2004 显示文摘 | Weber C L Matthews H S | 2007 | Environmental Science & Technology2007，41，14： | 1 |
| 9 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 10 | Testing and demonstration results of the 350 m long HTS cable system installed in albany, NY 显示文摘 | WEBER C S LEE R RINGO S | 2007 | IEEE Trans Appl Supercond2007，17，2： | 1 |
| 11 | The Importance of Carbon Footprint Estimation Boundaries 显示文摘 | Matthews H S Hendrickson C T Weber C L | 2008 | Environmental Science & Technology2008，42，16： | 1 |
| 12 | Mutation of Short Tandem Repeats显示文摘 | WEBER S J L C WONG | 1993 | Hum Mol Genet1993，2，： | 1 |
| 13 | Collagen network of the myocardium function,structural remodeling and regulatory mechanisms显示文摘 | Weber K T Sun Y Tyagi S C | 1994 | J Mol Cell Cardiol1994，26，3： | 1 |
| 14 | Differential effects of lipopolysaccharide and tumor necrosis factor on monocytic IκB kinase signalsome activation and IκB proteolysis显示文摘 | Fischer C Page S Weber M | | 0，，： | 1 |
| 15 | Embodied Environmental Emissions in US International Trade 1997 - 2004 显示文摘 | Weber C L Matthews H S | 2007 | Environmental Science and Technology2007，41，： | 1 |
| 16 | Bilateral stimulation of globus pallidus internus for treatment of cervical dystonia 显示文摘 | JK Krauss T Pohle S Weber C Ozdoba JM Burgun- der | 1999 | Lancet1999，354，： | 1 |
| 17 | A new approach to building identification from very-high-spatial-resolution images显示文摘 | Lhomme S He D Weber C | 2009 | Inter- national Journal of Remote Sensing2009，30，56： | 1 |
| 18 | Horizontal transmission of hepatitis B virus 显示文摘 | Davis L C Weber D J Lemon S M | 1989 | Lancet1989，1，8643： | 1 |
| 19 | The importance of carbon footprint estimation boundaries 显示文摘 | Matthews H S Hendrickson C T Weber C L | 2008 | Environmental Science & Technology2008，42，16： | 1 |
| 20 | The importance of carbon footprint estimation boundaries显示文摘 | Matthews H S Hendrickson C Weber C | 2008 | Environmental Science &Technology2008，42，： | 1 |
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