维普期刊资源整合服务平台（V6.5）

维普中文期刊产品整合服务

8篇 您的检索式：作者名="Wee LE"

选中清除导出查看参考文献查看引证文献引用追踪共1页首页上一页第1页下一页末页 /1 跳转

		题名	作者	年代	出处	被引量
	1	The pedagogical value of a student-run community-based experiential learning project:The Yong Loo Lin School of Medicine Public Health Screening显示文摘	Wee LE Yeo WX Tay CM	2010	Ann Acad Med Singapore2010，39，9：	1
	2	CRF ( 1 ) receptor antagonists attenuate escalated cocaine self-administration in rats 显示文摘	Specio SE Wee S O' Dell LE	2008	Psychopharmacology2008，196，3：	1
	3	Hypertension management andlifestyle changes following screening for hypertension in an Asianlow socioeconomic status community : a prospective study 显示文摘	Wee LE Wong J Chin RT	2013	Ann Acad Med Singapore2013，42，9：	1
	4	CRF1 receptor antagonists attenuate escalated cocaine self-administration in rats显示文摘	Specio SE Wee S O'Dell LE	2008	Psychopharmacology2008，196，：	1
	5	A peritoneal dial- ysis regimen low in glucose and glucose degradation products results in increased cancer antigen 125 and peritoneal activa- tion 显示文摘	le Poole CY Welten AG Wee PM	2012	Petit Dial Int2012，32，3：	1
	6	The pedagogical value of a student-run community-based experiential learning project:The Yong Loo Lin School of Medicine Public Health Screening显示文摘	Wee LE Yeo WX Tay CM	2010	Annals of the Academy of Medicine Singapore2010，39，9：	1
	7	The pedagogical value of a student -run community -based experiential learning project: The Yong Loo Lin School of Medicine Public Health Screening 显示文摘	Wee LE Yeo WX Tay CM	2010	Ann Acad Med Singapore2010，39，9：	1
	8	Engineering immunosuppressive drug-resistant armored(IDRA)SARS-CoV-2 T cells for cell therapy显示文摘Solid organ transplant(SOT)recipients receive immunosuppressive drugs(ISDs)and are susceptible to developing severe COVID-19.Here,we analyze the Spike-specific T-cell response after 3 doses of mRNA vaccine in a group of SOT patients(n=136)treated with different ISDs.We demonstrate that a combination of a calcineurin inhibitor(CNI),mycophenolate mofetil(MMF),and prednisone(Pred)treatment regimen strongly suppressed the mRNA vaccine-induced Spike-specific cellular response.Such defects have clinical consequences because the magnitude of vaccine-induced Spike-specific T cells was directly proportional to the ability of SOT patients to rapidly clear SARS-CoV-2 after breakthrough infection.To then compensate for the T-cell defects induced by immunosuppressive treatment and to develop an alternative therapeutic strategy for SOT patients,we describe production of 6 distinct SARS-CoV-2 epitope-specific ISD-resistant T-cell receptor(TCR)-T cells engineered using the mRNA electroporation method with reactivity minimally affected by mutations occurring in Beta,Delta,Gamma,and Omicron variants.This strategy with transient expression characteristics marks an improvement in the immunotherapeutic field and provides an attractive and novel therapeutic possibility for immunosuppressed COVID-19 patients.	Qi Chen Adeline Chia Shou Kit Hang Amy Lim Wee Kun Koh Yanchun Peng Fei Gao Jili Chen Zack Ho Lu-En Wai Kamini Kunasegaran Anthony Tanoto Tan Nina Le Bert Chiew Yee Loh Yun Shan Goh Laurent Renia Tao Dong Anantharaman Vathsala Antonio Bertoletti	2023	Cellular & Molecular Immunology2023，20，11：	0

返回顶部每页显示：

共1页首页上一页第1页下一页末页 /1 跳转

goolge学术搜索-维普

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费