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| 1 | Blunted nitric oxide regulation in Tibetans under high-altitude hypoxia显示文摘Nitric oxide(NO) is an important molecule for vasomotor tone, and elevated NO signaling was previously hypothesized as a unique and adaptive physiological change in highland Tibetans. However, there has been lack of NO data from Tibetans living at low altitude and lowlander immigrants living at high altitude, which is crucial to test this hypothesis. Here, through cross-altitude(1990–5018 m) and cross-population(Tibetans and Han Chinese) analyses of serum NO metabolites(NOx) of 2086 individuals, we demonstrate that although Tibetans have a higher serum NOx level compared to lowlanders, Han Chinese immigrants living at high altitude show an even higher level than Tibetans. Consequently, our data contradict the previous proposal of increased NO signaling as the unique adaptive strategy in Tibetans.Instead, Tibetans have a relatively lower circulating NOx level at high altitude. This observation is further supported by data from the hypoxic experiments using human umbilical vein endothelial cells and gene knockout mice. No difference is detected between Tibetans and Han Chinese for endothelial nitric oxide synthase(e NOS), the key enzyme for circulating NO synthesis, suggesting that e NOS itself is unlikely to be the cause. We show that other NO synthesis-related genes(e.g. GCH1) carry Tibetan-enriched mutations significantly associated with the level of circulating NOx in Tibetans. Furthermore, gene network analysis revealed that the downregulation and upregulation of NOx is possibly achieved through distinct pathways.Collectively, our findings provide novel insights into the physiological and genetic mechanisms of the evolutionary adaptation of Tibetans to high-altitude hypoxia. | Yaoxi He Xuebin Qi Ouzhuluobu Shiming Liu Jun Li Hui Zhang Baimakangzhuo Caijuan Bai Wangshan Zheng Yongbo Guo Duojizhuoma Baimayangji Dejiquzong Bianba Gonggalanzi Yongyue Pan Qula Kangmin Cirenyangji Wei Guo Yangla Yi Peng Xiaoming Zhang Kun Xiang Zhaohui Yang Liangbang Wang Gengdeng Yanfeng Zhang Tianyi Wu Bing Su Chaoying Cui | 2018 | National Science Review2018，5，4： | 7 |
| 2 | ASYMPTOTIC BEHAVIOR OF THE POSITIVE SOLUTION OF A NONAUTONOMOUS FOOD-CHAIN MODEL WITH DIFFUSION显示文摘A nonautonomous food-chain system with diffusion is investigated in this paper, whose coefficients asymptotically approach periodic functions. Under some sufficient conditions all positive solutions of the system asymptotically approach the periodic solution of the corresponding periodic system, by using comparison theorem and constructing Lyapunov-type functions. | Wang Aili Yan Enrang Wei Chaoying | 2005 | Annals of Differential Equations2005，21，3： | 2 |
| 3 | Comparison of Mastoscopic and Conventional Axillary Lymph Node Dissection in Breast Cancer: Long-term Results From a Randomized, Multicenter Trial显示文摘 | Chengyu Luo Wenbin Guo Jie Yang Qiuru Sun Wei Wei Suhua Wu Shubing Fang Qingliang Zeng Zhensheng Zhao Fanjie Meng Xuandong Huang Xianlan Zhang Ruihua Li Xiufeng Ma Chaoying Luo Yun Yang | 2012 | Mayo Clinic Proceedings2012，，12： | 1 |
| 4 | Interactive Relationship between KIBS and Knowledge Environment显示文摘 | Zhou Jizhong Tang Chaoying Xiong Wei | 2005 | InternationalJournal of Technology Management2005，32，34： | 1 |
| 5 | A loss-of-function mutant allele of a glycosyl hydrolase gene has been co-opted for seed weight control during soybean domestication显示文摘The resultant DNA from loss-of-function mutation can be recruited in biological evolution and development.Here,we present such a rare and potential case of“to gain by loss”as a neomorphic mutation during soybean domestication for increasing seed weight.Using a population derived from a chromosome segment substitution line of Glycine max(SN14)and Glycine soja(ZYD06),a quantitative trait locus(QTL)of 100-seed weight(q HSW)was mapped on chromosome 11,corresponding to a truncatedβ-1,3-glucosidase(βGlu)gene.The novel gene hsw results from a 14-bp deletion,causing a frameshift mutation and a premature stop codon in theβGlu.In contrast to HSW,the hsw completely lostβGlu activity and function but acquired a novel function to promote cell expansion,thus increasing seed weight.Overexpressing hsw instead of HSW produced large soybean seeds,and surprisingly,truncating hsw via gene editing further increased the seed size.We further found that the core 21-aa peptide of hsw and its variants acted as a promoter of seed size.Transcriptomic variation in these transgenic soybean lines substantiated the integration hsw into cell and seed size control.Moreover,the hsw allele underwent selection and expansion during soybean domestication and improvement.Our work cloned a likely domesticated QTL controlling soybean seed weight,revealed a novel genetic variation and mechanism in soybean domestication,and provided new insight into crop domestication and breeding,and plant evolution. | Siming Wei Bin Yong Hongwei Jiang Zhenghong An Yan Wang Bingbing Li Ce Yang Weiwei Zhu Qingshan Chen Chaoying He | 2023 | Journal of Integrative Plant Biology2023，65，11： | 1 |
| 6 | 胃癌肝囊性转移2例报告分析(英文)显示文摘Cystic liver metastasis,which lacks specific clinical manifestations and standardized treatment,rarely occurs after radical gastrectomy.This study presented two gastric cancer cases with cystic liver metastasis treated in Wuxi People's Hospital from September 2008 to November 2012.The two female patients were 66 and 65 years old,respectively.Poorly differentiated ulcerated adenocarcinoma classified as stage III B [Tumor,Node,and Metastasis Classification(T4aN2M0)] and clinical manifestations of abdominal distension and ascites were detected in both patients.Cyst fluids were subjected to cytological analysis.Results confirmed the presence of liver metastasis of gastric cancer.The two patients benefited from local intracavitary chemotherapy or systemic intravenous chemotherapy. | Wei Huang Fang Huang Junying Xu Chaoying Liu | 2014 | The Chinese-German Journal of Clinical Oncology2014，13，3： | 0 |
| 7 | Management and operation of extra-large Fangcang hospitals:experience and lessons from containing the highly contagious SARS-CoV-2 Omicron in Shanghai,China显示文摘Introduction Omicron is more contagious and stealthier than the previous strains.The basic reproduction number of Omicron is around 8–12,whereas that of the previous mainstream strain Delta is only 5–8[1].Omicron’s symptoms are relatively mild[2]compared with Delta’s symptoms;however,Omicron’s transmission ability is very strong,and its risk to children and the elderly remains high[3].In addition,the vaccine’s preventive effect on Omicron has weakened.Therefore,Omicron can easily cause a rapid outbreak in a city.The population density of megacities and the limited public health resources further exacerbate the difficulty of Omicron prevention and control. | Yun Xian Chenhao Yu Minjie Chen Lin Zhang Xinyi Zheng Shijian Li Erzhen Chen Zhongwan Chen Weihua Chen Chaoying Wang Qingrong Xu Tao Han Weidong Ye Wenyi Xu Xu Zhuang Yu Zheng Min Chen Jun Qin Yu Feng Shun Wei Yiling Fan Zhiruo Zhang Junhua Zheng | 2023 | Frontiers of Medicine2023，17，1： | 0 |
| 8 | REDISCOVERING THE FORBIDDEN CITY显示文摘Beijing is a city with four distinct seasons,and boasts striking views throughout the year.Of all astonishing attractions,t is the magnificent Forbidden City that truly reflects the authentic views of Beijing's four seasons. | Wang Wei(Translated) Wu Chaoying(Photos) Xu Hewei(Photos) Zhou Shijie(Photos) Zuo Ailing(Photos) | 2021 | Beijing2021，，7： | 0 |
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