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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Metabolic profiling analysis of a D-galactosamine/lipopolysaccharide- induced mouse model of fulminant hepatic failure显示文摘 | Feng, B Wu, SM Lv, S Liu, F Chen, HS Yan, XZ Li, Y Dong, FT Wei, L | 2007 | 中国生物学文摘2007，21，11： | 23 |
| 3 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 4 | Voltammetric behavior and determination of rutin at a single-walled carbon nanotubes modified gold electrode 显示文摘 | ZENG B Z WEI S H XIAO F | 2006 | Sensors and Actuators B2006，115，： | 1 |
| 5 | The effects of Xylazine and fentanyl on various hormones and motabolites in karakul sheep and blesbok显示文摘 | Maraisal A L Greene S A Wei A B | 1991 | J S Afr Vet Assoc1991，62，1： | 1 |
| 6 | Biodegradation of polycyclic aromatic hydrocarbons by a mixed culture显示文摘 | Yuan S Y Wei S H Chang B V | 2000 | Chemosphere2000，41，： | 1 |
| 7 | Composting and compost application in China 显示文摘 | Wei Y S Fan Y B Wang M J | 2000 | Resources Conservation and Recycling2000，30，4： | 1 |
| 8 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 9 | (S)-Histidine-based dipeptides as organic catalysts for direct asymmetric Aldol reactions显示文摘 | Tsogoeva S B Wei S | 2005 | Tetrahedron: Asymmetry2005，16，11： | 1 |
| 10 | Angioembolization reduces operative intervention for blunt splenic injury显示文摘 | Wei B Hemmila MR Arbabi S | 2008 | J Trauma2008，64，8： | 1 |
| 11 | 显示文摘 | Wei Y Z Fang B Iwasa S Kumagai M | 2005 | Journal of Power Sources2005，141，2： | 1 |
| 12 | On g-inverse of a bordered matrix: revisited显示文摘 | Wei M S Gao W B | 2002 | Linear Algebra Appl2002，347，： | 1 |
| 13 | Fluorescence excitation- emission matrix spectroscopy with regional integration analysis for characterizing composition and transformation of dissolved organic matter in landfill leachates 显示文摘 | HE X S XI B D WEI Z M | 2011 | Journal of Hazardous Materials2011，190，123： | 1 |
| 14 | Chemical and Antioxidant Properties of Casein Peptide and Its Glucose Maillard Reaction Products in Fish Oil-in-Water Emulsions显示文摘 | Dong S Y Wei B B Chen B C | | 0，，24： | 1 |
| 15 | Diamondoid hydrocarbons as a molecular proxy for thermal maturity and oil cracking:Geochemical models from hydrous pyrolysis显示文摘 | Wei Z B Moldowan J M Zhang S C | 2007 | Organic Geochemistry2007，38，2： | 1 |
| 16 | Corrosion resistance improvement of magnesium alloy using nitrogen plasma ion implantation显示文摘 | WEI C B YANG S Q | 2005 | Surf Coat Technol2005，198，13： | 1 |
| 17 | Impact of dam construction on water quality and water self-purification capacity of the Lancang River, China显示文摘 | Wei G L Yang Z F Cui B S | 2009 | Water Resources Manage2009，23，： | 1 |
| 18 | Biodegradation of polycyclic aromatic hydrocarbons by a mixed culture 显示文摘 | YUAN S Y WEI S H CHANG B V | 2000 | Chemosphere2000，41，9： | 1 |
| 19 | Origin of p-type doping difficulty in ZnO:the impurity perspective 显示文摘 | Park C H Zhang S B Wei S H | 2002 | Physical Review B2002，66，7： | 1 |
| 20 | On the properties of reflexive g-inverses of a bordered matrix显示文摘 | Gou W B Wei M S | 2003 | Journal of East China Normal University2003，1，： | 1 |
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