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| 1 | One-Dimensional Numerical Model for Nonuniform Sediment Trans- port under Unsteady Flows in Channel Networks 显示文摘 | WU Weiming VIEIRA D A WANG S S Y | 2004 | Journal of Hydraulic Engineering2004，130，9： | 1 |
| 2 | Neoproterozoic subduction along the Ailaoshan zone, South China: Geochronological and geochemical evidence from amphibolite显示文摘 | Cai Yongfeng Wang Yuejun Cawood P A Fang Weiming Liu Huichuan Xing Xiaowan Zhang Yuzhi | 2014 | Precamb Res2014，245，： | 1 |
| 3 | Thermodynamics of the Cr-Ta-W system by combining the Ab initio and CALPHAD methods 显示文摘 | Larry Kaufman Turchi P E A Huang Weiming | 2001 | Calphad2001，25，3： | 1 |
| 4 | Lin28 regulates HER2 and promotes malignancy through multiple mechanisms显示文摘 | Chen Feng Veronique Neumeister WeiM a Yingqun Huang | 2012 | Cell Cycle2012，111，： | 1 |
| 5 | Processing recursive XQuery over XML streams: The Raindrop approach 显示文摘 | Weim M Z Rundensteiner E A Mani M | 2008 | Data & Knowledge Engineering2008，65，： | 1 |
| 6 | All-optical wavelength conversion based on sinusoidal cross-phase modulation in optical fibers显示文摘 | Weiming M Andrekson P A Toulouse J | 2005 | Photonics Technology Letters IEEE2005，17，2： | 1 |
| 7 | A stress-inducible pasma membrane protein 3(AcPMP3)in a monocotyledonous halophyte,Aneurolepidium chinense,regulates cellular Na+and K+accumulation under salt stress显示文摘 | Inada M Ueda A Weiming Shi | 2005 | Planta2005，220，： | 1 |
| 8 | Newly discovered gamet-barroisite schists from the Heilongjiang Complex in the Jiamusi Massif, northeastern China显示文摘 | Li Weiming Takasu A Liu Yongjiang | 2010 | Journal of Mineralogical and Petrological Sciences2010，105，2： | 1 |
| 9 | Chronic treatment with anesthetic propofol attenuates β-amyloid protein levels in brain tissues of aged mice显示文摘Alzheimer’s disease(AD)is the most common form of dementia.At the present time,however,AD still lacks effective treatments.Our recent studies showed that chronic treatment with anesthetic propofol attenuated brain caspase-3 activation and improved cognitive function in aged mice.Accumulation ofβ-amyloid protein(Aβ)is a major component of the neuropathogenesis of AD dementia and cognitive impairment.We therefore set out to determine the effects of chronic treatment with propofol on Aβlevels in brain tissues of aged mice.Propofol(50 mg/kg)was administrated to aged(18 month-old)wild-type mice once a week for 8 weeks.The brain tissues of mice were harvested one day after the final propofol treatment.The harvested brain tissues were then subjected to enzyme-linked immunosorbent assay(ELISA)and Western blot analysis.Here we report that the propofol treatment reduced Aβ(Aβ40 and Aβ42)levels in the brain tissues of the aged mice.Moreover,the propofol treatment decreased the levels ofβ-site amyloid precursor protein cleaving enzyme(the enzyme for Aβgeneration),and increased the levels of neprilysin(the enzyme for Aβdegradation)in the brain tissues of the aged mice.These results suggested that the chronic treatment with propofol might reduce brain Aβlevels potentially via decreasing brain levels ofβ-site amyloid precursor protein cleaving enzyme,thus decreasing Aβgeneration;and via increasing brain neprilysin levels,thus increasing Aβdegradation.These preliminary findings from our pilot studies have established a system and postulated a new hypothesis for future research. | Yiying Zhang Haijun Shao Yuanlin Dong Celeste A Swain Buwei Yu Weiming Xia Zhongcong Xie | 2014 | Translational Neurodegeneration2014，3，1： | 1 |
| 10 | One-dimensional numerical model for nonuniform sediment transport under unsteady flows in channel networks显示文摘 | Wu Weiming Dalmo A V Wang S S Y | 2004 | Journal of Hydraulic Engineering2004，130，9： | 1 |
| 11 | Fibromodulin reduces scar formation in adult cutaneouswounds by eliciting a fetal-like phenotype显示文摘Blocking transforming growth factor(TGF)β1 signal transduction has been a central strategy for scar reduction;however,this approach appears to be minimally effective.Here,we show that fibromodulin(FMOD),a 59-kD small leucine-rich proteoglycan critical for normal collagen fibrillogenesis,significantly reduces scar formation while simultaneously increasing scar strength in both adult rodent models and porcine wounds,which simulate human cutaneous scar repair.Mechanistically,FMOD uncouples promigration/contraction cellular signals from pro-fibrotic signaling by selectively enhancing SMAD3-mediated signal transduction,while reducing AP-1-mediated TGFβ1 auto-induction and fibrotic extracellular matrix accumulation.Consequently,FMOD accelerates TGFβ1-responsive adult fibroblast migration,myofibroblast conversion,and function.Furthermore,our findings strongly indicate that,by delicately orchestrating TGFβ1 activities rather than indiscriminately blocking TGFβ1,FMOD elicits fetal-like cellular and molecular phenotypes in adult dermal fibroblasts in vitro and adult cutaneous wounds in vivo,which is a unique response of living system undescribed previously.Taken together,this study illuminates the signal modulating activities of FMOD beyond its structural support functions,and highlights the potential for FMOD-based therapies to be used in cutaneous wound repair. | Zhong Zheng Aaron W James Chenshuang Li Wenlu Jiang Joyce Z Wang Grace X Chang Kevin S Lee Feng Chen Emily A Berthiaume Yao Chen Hsin Chuan Pan Eric C Chen Weiming Li Zhihe Zhao Xinli Zhang Kang Ting Chia Soo | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 0 |
| 12 | Dynamic photoelectrical regulation of ECM protein and cellular behaviors显示文摘Dynamic regulation of cell-extracellular matrix(ECM)-material interactions is crucial for various biomedical applications.In this study,a light-activated molecular switch for the modulation of cell attachment/detachment behaviors was established on monolayer graphene(Gr)/n-type Silicon substrates(Gr/Si).Initiated by light illumination at the Gr/Si interface,pre-adsorbed proteins(bovine serum albumin,ECM proteins collagen-1,and fibronectin)underwent protonation to achieve negative charge transfer to Gr films(n-doping)throughπ-πinteractions.This n-doping process stimulated the conformational switches of ECM proteins.The structural alterations in these ECM interactors significantly reduced the specificity of the cell surface receptor-ligand interaction(e.g.,integrin recognition),leading to dynamic regulation of cell adhesion and eventual cell detachment.RNA-sequencing results revealed that the detached bone marrow mesenchymal stromal cell sheets from the Gr/Si system manifested regulated immunoregulatory properties and enhanced osteogenic differentiation,implying their potential application in bone tissue regeneration.This work not only provides a fast and feasible method for controllable cells/cell sheets harvesting but also gives new insights into the understanding of cell-ECM-material communications. | Xiaozhao Wang Cai Yao Xudong Yao Junxin Lin Rui Li Kun Huang Weiming Lin Xiaojun Long Chao Dai Jiajun Dong Xuegong Yu a Wenwen Huang Wenjian Weng Qi Wang Hongwei Ouyang Kui Cheng | 2023 | Bioactive Materials2023，，4： | 0 |
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