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| 1 | Herbal Traditional Chinese Medicine and suspected liver injury: A prospective study显示文摘AIM To analyze liver tests before and following treatment with herbal Traditional Chinese Medicine(TCM) in order to evaluate the frequency of newly detected liver injury.METHODS Patients with normal values of alanine aminotransferase(ALT) as a diagnostic marker for ruling out pre-existing liver disease were enrolled in a prospective study of a safety program carried out at the First German Hospital of TCM from 1994 to 2015. All patients received herbal products, and their ALT values were reassessed 1-3 d prior to discharge. To verify or exclude causality for suspected TCM herbs, the Roussel Uclaf Causality Assessment Method(RUCAM) was used.RESULTS This report presents for the first time liver injury data derived from a prospective, hospital-based and largescale study of 21470 patients who had no liver disease prior to treatment with herbal TCM. Among these, ALT ranged from 1 × to < 5 × upper limit normal(ULN) in 844 patients(3.93%) and suggested mild or moderate liver adaptive abnormalities. However, 26 patients(0.12%) experienced higher ALT values of ≥ 5 × ULN(300.0 ± 172.9 U/L, mean ± SD). Causality for TCM herbs was RUCAM-based probable in 8/26 patients, possible in 16/26, and excluded in 2/26 cases. Bupleuri radix and Scutellariae radix were the two TCM herbs most commonly implicated. CONCLUSION In 26(0.12%) of 21470 patients treated with herbal TCM, liver injury with ALT values of ≥ 5 × ULN was found, which normalized shortly following treatment cessation, also substantiating causality. | Dieter Melchart Stefan Hager Sabine Albrecht Jingzhang Dai Wolfgang Weidenhammer Rolf Teschke | 2017 | World Journal of Hepatology2017，9，29： | 11 |
| 2 | Prospective investigation of adverse effects of acu- puncture in 97 733 patients显示文摘 | Melqhart D Weidenhammer W Streng A | 2004 | Arch Intern Med2004，164，1： | 1 |
| 3 | Acupuncture for patients with migraine: a randomized controlled trial显示文摘 | Hammes MG Weidenhammer W Willich SN | 2005 | J AMA2005，293，17： | 1 |
| 4 | Acu-puncture for osteoarthritic pain:an observational-study in routine care显示文摘 | Linde K Weidenhammer W Streng A | 2006 | Rheumatology(Oxford)2006，45，2： | 1 |
| 5 | The correlation between physical and intellectual performance in old age显示文摘 | Fischer B Weidenhammer W Lehrl S | 1986 | Geriatr Pregeriatr Rehab1986，2，3： | 1 |
| 6 | Acupuncture in patients with tension-type headache: randomised controlled trial显示文摘 | Melchart D Streng A Hoppe A Brinkhaus B Witt C Wagenpfeil S Pfaffenrath V Hammes M Hummelsberger J Irnich D Weidenhammer W Willich SN Linde K | 2005 | BMJ2005，331，7513： | 1 |
| 7 | Liver enzyme ele- vation in patients treated with traditional Chinese medicine显示文摘 | Melchart D Linde K Weidenhammer W | 1999 | JAMA1999，282，： | 1 |
| 8 | Acupuncture for patients with migraine:a randomized controlled trial显示文摘 | Linde K Streng A Jurgens S Hoppe A Brinkhaus B Witt C Wagenpfeil S Pfaffenrath V Hammes MG Weidenhammer W Willich SN Melchart D | 2005 | JAMA2005，293，： | 1 |
| 9 | Acupuncture for Chronic Low Back Pain in Routine Care A Multicenter Observational Study显示文摘 | Weidenhammer W Linde K Streng A | 2007 | Clin J Pain2007，23，2： | 1 |
| 10 | Prospective investigation of adverse effects of acupuncture in 97 733patients显示文摘 | Melchart D Weidenhammer W Streng A | 2004 | Arch Intern Med2004，164，1： | 1 |
| 11 | Distinguishing resource competition and chemical interference: orercoming the methodological impasse 显示文摘 | Weidenhammer JD | 1996 | Agronomy Journal1996，88，： | 1 |
| 12 | The inotropic peptide β ARKct improves β AR responsiveness in normal and failing cardiomyocytes through G(βγ)-mediated L-type calcium current disinhibition显示文摘 | V(o)lkers M Weidenhammer C Herzog N | 2011 | Circ Res2011，108，1： | 1 |
| 13 | S100A1 in cardiovas- cular health and disease: closing the gap between basic science and clinical therapy显示文摘 | Kraus C Rohde D Weidenhammer C | 2009 | J Mol Cell Cardiol2009，47，4： | 1 |
| 14 | Prospective investigation of adverse effects of acupuncture in 97 733 patients显示文摘 | Weidenhammer W Streng A | 2004 | Arch Intern Med2004，164，1： | 1 |
| 15 | Acupuncture for chronic pain within the research program of 10 German Health Insurance Funds-basic results from an observational study显示文摘 | Weidenhammer W Streng A Linde K | 2007 | Complement Ther Med2007，15，4： | 1 |
| 16 | Pro-spective investigation of adverse effects of acupunc-ture in 97 733patients显示文摘 | Melchart D Weidenhammer W Streng A | 2004 | Arch Intern Med2004，164，1： | 1 |
| 17 | Acupuncture for chronic pain within the research program of 10 German Health Insurance Funds-basic results from an observational study 显示文摘 | Weidenhammer W Streng A Linde K | 2007 | Complement Ther Med2007，15，4： | 1 |
| 18 | Liver enzyme elevation in patients treated with traditional Chinese medicine显示文摘 | Melchart D Linde K Weidenhammer W | 1999 | JAMA1999，282，： | 1 |
| 19 | Prospeetive investigation of adverse effects of acupuncture in 97 733 patients显示文摘 | Melehart D Weidenhammer W Streng A | 2004 | Arch InternMed2004，164，1： | 1 |
| 20 | The role of m Per2 clock gene in glucocorticoid and feeding rhythms显示文摘 | Yang S Liu A Weidenhammer A | 2009 | Endocrinology2009，150，5： | 1 |
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