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| 1 | IL23R single nucleotide polymorphisms could be either beneficial or harmful in ulcerative colitis显示文摘AIM To investigate the association of seven single nucleotide polymorphisms(SNPs) of the IL23 R gene with the clinical picture of ulcerative colitis(UC). METHODS Genomic DNA samples of 131 patients (66 males, 65 females, mean age 55.4 ± 15.8 years) with Caucasian origin, diagnosed with UC were investigated. The diagnosis of UC was based on the established clinical, endoscopic, radiological, and histopathological guidelines. DNA was extracted from peripheral blood leukocytes by routine salting out method. Polymerase chain reaction and restriction fragment length polymorphism were used to identify the alleles of seven SNPs of IL23 R gene(rs11209026, rs10889677, rs1004819, rs2201841, rs7517847, rs10489629, rs7530511).RESULTS Four out of seven analyzed SNPs had statistically significant influence on the clinical picture of UC. Two SNPs were associated with greater colonic extension(rs2201841 P = 0.0084; rs10489629 P = 0.0405). For two of the SNPs, there was more frequently need for operations (rs2201841 P = 0.0348, OR = 8.0; rs10889677 P = 0.0347, OR = 8.0). The rs2201841 showed to be a risk factor for the development of iron deficiency (P = 0.0388, OR = 6.1837). For patients with the rs10889677, a therapy with azathioprine was more frequently necessary(P = 0.0116, OR = 6.1707). Patients with rs10489629 SNP had a lower risk for weight loss(P = 0.0169, OR = 0.3394). Carriers of the heterozygous variant had a higher risk for an extended disease (P = 0.0284). The rs7517847 showed a protective character leading to mild bowel movements. Three SNPs demonstrated no statistically significant influence on any examined clinical features of UC.CONCLUSION We demonstrated susceptible or protective character of the investigated IL23 R SNPs on the phenotype of UC, confirming the genetic association. | Sarah Fischer Erzsébet Kovesdi Lili Magyari Veronika Csongei Kinga Hadzsiev Béla Melegh Péter Hegyi Patrícia Sarlós | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 2 | Collocation, filtering and nonparametricregression, part 1 显示文摘 | Fischer B and Hegland M | 1999 | ZfV1999，2，： | 2 |
| 3 | Gastric Bypass Leads to Improvement of Diabetic Neuropathy Independent of Glucose Normalization—Results of a Prospective Cohort Study (DiaSurg 1 Study)显示文摘 | Beat P. Müller-Stich Lars Fischer Hannes G. Kenngott Matthias Gondan Jonas Senft Gabriella Clemens Felix Nickel Thomas Fleming Peter P. Nawroth Markus W. Büchler | 2013 | Annals of Surgery2013，，5： | 2 |
| 4 | Collocation filtering and nonparametric regression 显示文摘 | Fischer B HeglaodM | 1999 | ZFV1999，，1： | 2 |
| 5 | Identification of potent, selective P2Y - purinoceptor agonists: structure - activity relationships for 2 - thioether derivatives of adenosine 5 '- triphosphate显示文摘 | Fischer B Boyer JL Hoyle CH | 1993 | J Med Chem1993，36，： | 1 |
| 6 | Neural regulation of airway smooth muscle tone显示文摘 | Canning B J Fischer A | 2001 | Respir Physiol2001，125，12： | 1 |
| 7 | Reducing the peak-to-average power ratio of multicarrier modulation by selected mapping 显示文摘 | R W Bauml R F H Fischer J B Huber | 1996 | Electronics Letters1996，32，22： | 1 |
| 8 | Performed tobacco-specific nitrosamines in tobacco role nitrate and influence of tobacco type显示文摘 | Fischer S Spiegelhalder B Preussmann R | 1984 | Carcin ogenesis1984，10，8： | 1 |
| 9 | Policy, plan and pro- gramme environmental assessment in England, the Netherlands and Germany: practice and prospects显示文摘 | Fischer T B Wood C Jones C | 2002 | Environment and Planning B: Planning and Design2002，29，2： | 1 |
| 10 | Cross-linking of interfacial layers affects the salt and temperature stability of multilayered emulsions consisting of fish gelatin and sugar beet pectin显示文摘 | Zeeb B Fischer L Weiss J | 2011 | J Agr Food Chem2011，59，10： | 1 |
| 11 | Can nucleotides prevent Cu - induced oxidative damage? 显示文摘 | Baruch - Suchodolsky R Fischer B | 2008 | J Inorg Biochem2008，102，4： | 1 |
| 12 | Budget Balance Booklet 显示文摘 | Thomas B Fischer | 2008 | (3) :15 - 162008，19，： | 1 |
| 13 | Three-dimensional Helical CT of the Tracheobronchial Tree:Evaluation of Imaging Protocols and Assessment of Suspected Stenoses with Bronchoscopic Correlation显示文摘 | Kauczor HU Wolcke B Fischer B | 1996 | AJR1996，167，2： | 1 |
| 14 | Increased efficacy of micro-opioid agonist-induced antinociception by metabotropic glutamate re-ceptor antagonists in C57BL/6 mice:comparison with(-)-6-phosphon-omethyl-deca-Hydroisoquinoline-3-carboxylic acid(LY235959)显示文摘 | Fischer B D Miller L L Henry F E | 2008 | Psychopharmacology(Berl)2008，198，2： | 1 |
| 15 | Quinazolinones as gamma-secretase modulators 显示文摘 | FISCHER C SHAH S HUGHES B L | 2011 | Bioorg Med Chem Lett2011，21，2： | 1 |
| 16 | Strategic Environmental Assessment in Post-modernTimes 显示文摘 | Fischer T B | 2003 | Environmental Impact Assessment Review2003，23，： | 1 |
| 17 | Using EEG spectral com- ponents to assess algorithms for detecting fatigue 显示文摘 | B T Jap S Lal P Fischer E Bekiaris | 2009 | Expert Sys- tems with Applications2009，2009，： | 1 |
| 18 | Crosslinking of interfacial layers in multilayered oil-in-water emulsions using laccase:Characterization and p H-stability显示文摘 | Zeeb B Gibis M Fischer L | 2012 | Food Hydrocolloid2012，27，1： | 1 |
| 19 | Noncovalent interm olecular forces in p o lycrystallin e and amorphous saccharides in thefar in frared显示文摘 | W alther M Fischer B M Jepsen P U | 2003 | Ch em ical P h y sics2003，288，2： | 1 |
| 20 | Platelets stimulate prolifera- tion of bone cells: involvement of platelet-derived growth factor, mi- croparticles and membranes 显示文摘 | Gruber R Varga F Fischer M B | 2002 | Clinical Oral Implants Research2002，13，5： | 1 |
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