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| 1 | Oral polymorphonuclear neutrophil characteristics in relation to oral health: a cross-sectional, observational clinical study显示文摘Polymorphonuclear neutrophils(PMNs) have a major role in the innate immune system. However, little is known about PMN contribution in relation to oral health. The objective of this study was to investigate the numbers and functional characteristics of oral PMNs(o PMNs) compared with circulatory PMNs(c PMNs). Oral rinse and venous blood samples were obtained from 268 systemically and orally healthy volunteers in a cross-sectional observational study. PMN counts, cell cycle analysis and cellular activation state were investigated. Also, reactive oxygen species(ROS) production was analyzed, with and without bacterial stimulation(Fusobacterium nucleatum). In males, 1.2 × 10~6± 1.0 × 10~6 oPMNs were collected, and showed a tendency to correlate with the levels of gingival bleeding(r = 0.215, P = 0.008). Comparable o PMNs counts were found among females(1.0 × 10~6± 0.7 × 10~6). More late-stage apoptotic/necrotic cells were found among the o PMNs(53.1%) compared with the c PMNs(8.5%; Po0.001). Without additional stimulation, o PMNs were more activated than c PMNs, as indicated by higher expression of CD11 b, CD63 and CD66 b, and higher constitutive ROS levels(Po0.001). Notably, in response to bacterial stimulation, o PMNs released comparable ROS levels as c PMNs(P = 0.042). In conclusion, this study provides data on viable o PMNs showing high levels of activation in orally and systemically healthy individuals, free of apparent caries lesions and periodontal disease. These data suggests that although the o PMNs are in a more mature stage of their life cycle compared with the c PMNs, o PMNs are still responsive to stimulation, which indicates their functional potential and possible contribution to a healthy oral ecosystem. | Patrick Rijkschroeff Ineke DC Jansen Fridus A van der Weijden Bart IF Keijser Bruno G Loos Elena A Nicu | 2016 | International Journal of Oral Science2016，8，3： | 2 |
| 2 | Chemical processes affecting the mobility of major,minor and trace elements during weathering of granitic rocks显示文摘 | Middelburg J J Van Der Weijden C H Woittiex J R W | 1988 | Chem Geol1988，68，： | 1 |
| 3 | Chemical processes affecting the mobility of major,minor and trace elements during weathering of granitic rocks显示文摘 | Middelburg J J Van der Weijden C H Woittiez J R W | 1988 | Chemical Geology1988，68，： | 1 |
| 4 | Sorption andsorption reversibility of cadmium on calcite in the presence of phosphate and sulfate显示文摘 | RD Van der Weijden J Meima RNJ Comans | 1997 | Mar Chem1997，57，12： | 1 |
| 5 | Titanium surface alterations following the use of different mechanical instruments: a systematic review显示文摘 | AnnaLouropoulou Dagmar E.Slot Fridus A.Van der Weijden | 2012 | Clinical Oral Implants Research2012，，6： | 1 |
| 6 | Alveolar bone dimensional changes of post-extraction sockets in humans: a systematic review 显示文摘 | Van der Weijden F Dell'Acqua F Slot DE | 2009 | J Clin Periodontol2009，36，12： | 1 |
| 7 | Oral hygiene in the prevention of periodontal diseases: The evidence显示文摘 | van der Weijden F Slot DE | 2011 | Periodontol20002011，55，1： | 1 |
| 8 | Lengthening clinicalcrowns:a solution for specific periodontal,restorative,and estheticproblems显示文摘 | Wolffe G N Van der Weijden F A Adam J | 1994 | Quintessence Int1994，25，2： | 1 |
| 9 | Chemical processes affecting the mobility of major, minor and trace elements during weathering of granitic rocks显示文摘 | Middelburg J J Weijden C H Woittiez J R | 1988 | Chemical Geology1988，68，： | 1 |
| 10 | Arsenic mobility in the ambient sulfidic environment:Sorption of arse- nic(V) and arsenic (III) onto disordered mackinawite显示文摘 | Wolthers M Charlet L van Der Weijden C H | 2005 | Geochimiea et Cosmochimica Aeta2005，69，14： | 1 |
| 11 | Copper recovery com- bined with electricity production in a microbial fuel cell 显示文摘 | Heijne A T Liu Fei van der Weijden R | 2010 | Envi- ronmental Science &Technology2010，44，11： | 1 |
| 12 | Low bone rain eral density is related to male gender and decreased functional ca pacity in early spondylarthropathies显示文摘 | Weijden MACVD Denderen JCV Lems WF | 2011 | Clinical Rheumatology2011，30，4： | 1 |
| 13 | Comparison of different approaches to assess bleeding on probing as indicators of gingivitis 显示文摘 | Van der Weijden GA Timmerman MF Nijbore A | 1994 | J Clin Periodontol1994，21，9： | 1 |
| 14 | Chemical processes affecting the mobility of major, minor and trace elements during weathering of granitic rocks 显示文摘 | Middelburg J J Van Der Weijden C H Woittiez J R W | 1988 | Chem Geol1988，68，： | 1 |
| 15 | Parturition in domestic animals:targets for future research显示文摘 | TAVERNE M A M Van der WEIJDEN G C | 2008 | Reprod Dom Anim2008，43，5： | 1 |
| 16 | High prevalence of low bone mineral density in patients within 10 years of onset of ankylosing spondylitis: a systematic review 显示文摘 | vander Weijden MA Claushuis TA Nazari T | 2012 | Clin Rheumatol2012，31，： | 1 |
| 17 | Chromium(Ⅲ)-chromium (Ⅵ) interconversions in seawater 显示文摘 | Van der Weijden C H Reith M | 1982 | Mar Chem1982，11，： | 1 |
| 18 | Evaluation of the long term efficacv and safety of locally applied minocycline in adult periodontitis patients显示文摘 | van der Weijden G van SteenbergenT | 1996 | J Clin Periodontol1996，23，： | 1 |
| 19 | Implant therapy in partially edentulous,periodontally compromised patients:a review显示文摘 | Van der Weijden GA van Bemmel KM Renvert S | | 0，，： | 1 |
| 20 | The impact of roads on the densities of four bird species in an open field habitat-evidence of a long-distance effect显示文摘 | VAN DER ZANDE A N TER KEURS W J VAN DER WEIJDEN W J | 1980 | Biological Conservation1980，8，： | 1 |
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