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| 1 | Neuroimaging the brain-gut axis in patients with irritable bowel syndrome显示文摘AIM:To summarize and synthesize current literature on neuroimaging the brain-gut axis in patients with irritable bowel syndrome(IBS).METHODS:A database search for relevant literature was conducted using Pub Med,Scopus and Embase in February 2015.Date filters were applied from the year2009 and onward,and studies were limited to those written in the English language and those performed upon human subjects.The initial search yielded 797articles,out of which 38 were pulled for full text review and 27 were included for study analysis.Investigations were reviewed to determine study design,methodology and results,and data points were placed in tabular format to facilitate analysis of study findings across disparate investigations.RESULTS:Analysis of study data resulted in the abstraction of four key themes:Neurohormonal differences,anatomic measurements of brain structure and connectivity,differences in functional responsiveness of the brain during rectal distention,and confounding/correlating patient factors.Studies in this review noted alterations of glutamate in the left hippocampus(HIPP),commonalities across IBS subjects in terms of brain oscillation patterns,cortical thickness/gray matter volume differences,and neuroanatomical regions withincreased activation in patients with IBS:Anterio cingulate cortex,mid cingulate cortex,amygdala anterior insula,posterior insula and prefrontal cortex.A striking finding among interventions was the substantia influence that patient variables(e.g.,sex,psychologica and disease related factors)had upon the identification of neuroanatomical differences in structure and con nectivity.CONCLUSION:The field of neuroimaging can provide insight into underlying physiological differences that distinguish patients with IBS from a healthy population. | Kristen R Weaver Lee Anne B Sherwin Brian Walitt Gail D'Eramo Melkus Wendy A Henderson | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，2： | 8 |
| 2 | Altered vasoactive intestinal peptides expression in irritable bowel syndrome patients and rats with trinitrobenzene sulfonic acid-induced colitis显示文摘AIM: To investigate the vasoactive intestinal peptides(VIP) expression in irritable bowel syndrome(IBS) and trinitrobenzene sulfonic acid(TNBS) induced colitis.METHODS: The VIP gene expression and protein plasma levels were measured in adult participants(45.8% male) who met Rome Ⅲ criteria for IBS for longer than 6 mo and in a rat model of colitis as induced by TNBS.Plasma and colons were collected from naive and inflamed rats.Markers assessing inflammation(i.e.,weight changes and myeloperoxidase levels) were assessed on days 2,7,14 and 28 and compared to controls.Visceral hypersensitivity of the rats was assessed with colo-rectal distension and mechanical threshold testing on hind paws.IBS patients(n = 12) were age,gender,race,and BMI-matched with healthy controls(n = 12).Peripheral whole blood and plasma from fasting participants was collected and VIP plasma levels were assayed using a VIP peptide-enzyme immunoassay.Human gene expression of VIP was analyzed using a custom PCR array.RESULTS: TNBS induced colitis in the rats was confirmed with weight loss(13.7 ± 3.2 g) and increased myeloperoxidase activity.Visceral hypersensitivity tocolo-rectal distension was increased in TNBS treated rats up to 21 d and resolved by day 28.Somatic hypersensitivity was also increased up to 14 d post TNBS induction of colitis.The expression of an inflammatory marker myeloperoxidase was significantly elevated in the intracellular granules of neutrophils in rat models following TNBS treatment compared to naive rats.This confirmed the induction of inflammation in rats following TNBS treatment.VIP plasma concentration was significantly increased in rats following TNBS treatment as compared to naive animals(P < 0.05).Likewise,the VIP gene expression from peripheral whole blood was significantly upregulated by 2.91-fold in IBS patients when compared to controls(P < 0.00001; 95%CI).VIP plasma protein was not significantly different when compared with controls(P = 0.193).CONCLUSION: Alterations in VIP expression may play a role in IBS.Therefore,a better understanding of the physiology of VIP could lead to new therapeutics. | Arseima Y Del Valle-Pinero LeeAnne B Sherwin Ethan M Anderson Robert M Caudle Wendy A Henderson | 2015 | World Journal of Gastroenterology2015，21，1： | 7 |
| 3 | Meeting report:a hard look at the state of enamel research显示文摘The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines(ENAMEL) Development workshop was held on 23 June 2017 at the Bethesda headquarters of the National Institute of Dental and Craniofacial Research(NIDCR). Discussion topics included model organisms, stem cells/cell lines, and tissues/3 D cell culture/organoids. Scientists from a number of disciplines,representing institutions from across the United States, gathered to discuss advances in our understanding of enamel, as well as future directions for the field. | ophir d klein olivier duverger wendy shaw rodrigo s lacruz derk joester janet moradian-oldak megan k pugach j timothy wright sarah e millar ashok b kulkarni john d bartlett thomas gh diekwisch pamela den besten james p simmer | 2017 | International Journal of Oral Science2017，9，4： | 3 |
| 4 | Holliday junction processing activity of the BLM-Topo Ⅲα-BLAF75 complex显示文摘 | WENDY B STEVEN R VALERIA B | 2007 | J Bioll Chem2007，282，31： | 1 |
| 5 | An application-specific protocol architecture for wireless microsensor networks显示文摘 | Wendi H Anatha C Hari B | 2002 | IEEE Transactions on wireless communication2002，1，4： | 1 |
| 6 | Understanding and Managing the Service Supply Chain 显示文摘 | LISA M ELLRAM WENDY L T COREY B | 2004 | Journal of Supply Chain Management2004，40，4： | 1 |
| 7 | Magnetic manipulation of copper-tin nanowires capped with nickel ends显示文摘 | ANNE K B JEREMY S T ARTHUR B E WENDY C C | 2004 | Nano Letters2004，4，3： | 1 |
| 8 | The global re-cycling of persistent organic pollutants s strongly retarded by soils 显示文摘 | Wendy A O Knut B Sandra N M | 2003 | Environ Pollution2003，121，： | 1 |
| 9 | A generalized skeletal hyperostosis in two siblings caused by a novel mutation in the SOST gene 显示文摘 | Wendy B Erna C Ulrike S | 2005 | Bone2005，36，： | 1 |
| 10 | An application-specific protocol architecture for wireless microsensor networks显示文摘 | Wendi B Heinzelman Anantha P Chandrakasan Hari Balakrishnan | 2002 | IEEE Transactions on Wireless Communications2002，4，1： | 1 |
| 11 | QoS-aware routing based on bandwidth estimation for mobile Ad Hoc networks显示文摘 | Chen L Heinzelman Wendi B | 2005 | IEEE Journal on Selected Areas in Communications2005，23，2： | 1 |
| 12 | Prehabilitation Before Total Knee Arthroplasty Increases Strength and Function in Older Adults With Severe Osteo- arthritis 显示文摘 | Ann M Swank Joseph B Kachelman Wendy Bibeau Peter M Quesada John Nyland Arthur Malkani Robert V Topp | 2011 | Journal of Strength and Conditioning Re- search2011，2，2： | 1 |
| 13 | An application--specific protocol architecture for wireless microsen or networks 显示文摘 | Wendi B Heinzelman | 2002 | IEEE Transaction on Wireless Communications2002，1，4： | 1 |
| 14 | Understanding and managing the service supply chain显示文摘 | Lisa M Ellram Wendy L T Comy B | 2004 | Journal of Supply Chain Management2004，，： | 1 |
| 15 | Interventions to break and create con-sumerhabits显示文摘 | Verplanken B and Wendy W | 2006 | Journal of Public Policy & Marketing2006，，25： | 1 |
| 16 | Understanding and managing the services supply chain显示文摘 | LISA M E WENDY L T COREY B | 2004 | Journal of Supply Chain Management2004，40，4： | 1 |
| 17 | An application-specific protocol architecture for wireless microsensor networks显示文摘 | Anantha P Chandrakasan Hari Balakrishnan | 2002 | IEEE Trans on Wireless Comm2002，1，4： | 1 |
| 18 | Determination of M elamine residues in catfish tissue by triple quadrupole LC - MS - MS with HILIC chromatog - raphy 显示文摘 | Wendy C A Sherri B T Christine M K | 2007 | Laboratory Information Bulletin2007，23，： | 1 |
| 19 | The carboxyl-terminal region of staphylococcal enterotoxin type A is required for a fully active molecule 显示文摘 | WENDY O H MARY T T MARSHA J B | 1991 | Infection and Immunity1991，59，6： | 1 |
| 20 | Energy-efficient real-time mul- ticast muting in mobile Ad Hoc networks显示文摘 | Bulent Tavli Wendi B Heinzelman | 2011 | IEEE Transactions on Computer2011，60，6： | 1 |
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