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| 1 | Bile acid nuclear receptor FXR and digestive system diseases显示文摘Bile acids(BAs) are not only digestive surfactants but also important cell signaling molecules,which stimulate several signaling pathways to regulate some important biological processes. The bileacid-activated nuclear receptor, farnesoid X receptor(FXR), plays a pivotal role in regulating bile acid,lipid and glucose homeostasis as well as in regulating the inflammatory responses, barrier function and prevention of bacterial translocation in the intestinal tract. As expected, FXR is involved in the pathophysiology of a wide range of diseases of gastrointestinal tract, including inflammatory bowel disease, colorectal cancer and type 2 diabetes. In this review, we discuss current knowledge of the roles of FXR in physiology of the digestive system and the related diseases. Better understanding of the roles ofFXR in digestive system will accelerate the development of FXR ligands/modulators for the treatment of digestive system diseases. | Lili Ding Li Yang Zhengtao Wang Wendong Huang | 2015 | Acta Pharmaceutica Sinica B2015，5，2： | 47 |
| 2 | FXR: a metabolic regulator and cell protector显示文摘Farnesoid X 受体(FXR ) 是激活 ligand 的抄写因素的原子受体总科的一个成员。作为一个新陈代谢的管理者, FXR 戏在胆汁酸,胆固醇,类脂化合物,和葡萄糖新陈代谢给角色调音。因此, FXR 是为很多新陈代谢的混乱的一个潜在的药目标,特别那些与新陈代谢的症候群有关。更最近,我们的组和其它扩大了 FXR 的功能到非常新陈代谢的规定,它在肠,肝新生,和 hepatocarcinogenesis 包括抗菌剂生长。这些新调查结果比以前想建议 FXR 有宽广得多的角色,并且也为多重疾病作为一个药目标加亮 FXR。这评论总结 FXR 的基本信息,但是集中于它的新功能。 | Yan-Dong Wang Wei-Dong Chen David D Moore Wendong Huang | 2008 | Cell Research2008，18，11： | 33 |
| 3 | On Reliability-optimized Controller Placement for Software-Defined Networks显示文摘By decoupling control plane and data plane,Software-Defined Networking(SDN) approach simplifies network management and speeds up network innovations.These benefits have led not only to prototypes,but also real SDN deployments.For wide-area SDN deployments,multiple controllers are often required,and the placement of these controllers becomes a particularly important task in the SDN context.This paper studies the problem of placing controllers in SDNs,so as to maximize the reliability of SDN control networks.We present a novel metric,called expected percentage of control path loss,to characterize the reliability of SDN control networks.We formulate the reliability-aware control placement problem,prove its NP-hardness,and examine several placement algorithms that can solve this problem.Through extensive simulations using real topologies,we show how the number of controllers and their placement influence the reliability of SDN control networks.Besides,we also found that,through strategic controller placement,the reliability of SDN control networks can be significantly improved without introducing unacceptable switch-to-controller latencies. | HU Yannan WANG Wendong GONG Xiangyang QUE Xirong CHENG Shiduan | 2014 | China Communications2014，11，2： | 25 |
| 4 | A review on the South China Sea western boundary current显示文摘The advances in understanding the South China Sea (SCS) western boundary current (SCSwbc) have been reviewed since the works of Dale (1956) and Wyrtki (1961) in the middle of the 20th century. The features of the pattern of SCSwbc and the oceanic phenomena associated with it are focused on. The current is driven mainly by monsoon over the SCS and partially by winds over the tropical Pacific governed by the island rule. The SCSwbc exhibits strong seasonal variation in its direction and patterns. In winter, the current is strong and flows southwestward along the South China shelf and slope from the east of Dongsha Islands to the northern central Vietnamese coast, then turns to the south along the central and southern Vietnamese coast, and finally partially exits the SCS through the Karimata Strait. In summer and early fall, the SCSwbc can be divided into three segments based on their characteristics. The southern segment is stable, flowing northward from the Karimata Strait up to about 11 N, where it separates from the coast forming an eastward offshore current. The separation of the current from Vietnamese coast induces some striking features, such as upwelling and cold sea-surface temperature. The middle segment off the central Vietnamese coast may have a bimodal behavior: northward coastal current and meandering current in early summer (June-July), and cyclonic gyre in later summer and early fall (August-September). The northern segment is featured by the summer SCS Warm Current on the South China shelf and a southwestward subsurface current along the continental slope. | FANG Guohong WANG Gang FANG Yue FANG Wendong | 2012 | Acta Oceanologica Sinica2012，31，5： | 20 |
| 5 | Amplitude-Integrated Electroencephalography Predicts Outcome in Patients with Coma After Acute Brain Injury显示文摘Prognostication of coma patients after brain injury is important, yet challenging. In this study, we evaluated the predictive value of amplitude-integrated electroencephalography(a EEG) for neurological outcomes in coma patients. From January 2013 to January 2016, 128 coma patients after acute brain injury were prospectively enrolled and monitored with a EEG. The 6-month neurological outcome was evaluated using the Cerebral Performance Category Scale. a EEG monitoring commenced at a median of 7.5 days after coma onset. Continuous normal voltage predicted a good 6-month neurological outcome with a sensitivity of 93.6% and specificity of 85.2%. In contrast, continuous extremely low voltage, burst-suppression, or a flat tracing was correlated with poor 6-month neurological outcome with a sensitivity of 76.5% and specificity of 100%. In conclusion, a EEG is a promising predictor of 6-month neurological outcome for coma patients after acute brain injury. | Wendong You Qilin Tang Xiang Wu Junfeng Feng Qing Mao Guoyi Gao Jiyao Jiang | 2018 | Neuroscience Bulletin2018，34，4： | 15 |
| 6 | Observational study of the circulation in the southern South China Sea显示文摘CTD data from two oceanographic survey cruises, conducted by 'Shiyan No.3' R/V during two reversing monsoons, were employed to calculate and analyze the distributions of temperature, salinity and geopotential anomaly in the southern South China Sea (SSCS). Based on these distributions, the horizontal structures of the SSCS circulation are described systematically. Study results show that the SSCS circulation structure could be classified as a two-layer (the upper and the lower) pattern, and that the main circulation in the upper layer (0-400 m) is driven by the South China Sea monsoons and is opposite in direction to the reversal of the monsoons. The distributions of principal current systems and their features are presented. Two important local phenomena, local eddy and oceanic front, were observed. | Fang Wendong Guo Zhongxin Huang Yuting | 1998 | Chinese Science Bulletin1998，43，11： | 13 |
| 7 | Test Data Generation for Stateful Network Protocol Fuzzing Using a Rule-Based State Machine显示文摘To improve the efficiency and coverage of stateful network protocol fuzzing, this paper proposes a new method, using a rule-based state machine and a stateful rule tree to guide the generation of fuzz testing data. The method first builds a rule-based state machine model as a formal description of the states of a network protocol.This removes safety paths, to cut down the scale of the state space. Then it uses a stateful rule tree to describe the relationship between states and messages, and then remove useless items from it. According to the message sequence obtained by the analysis of paths using the stateful rule tree and the protocol specification, an abstract data model of test case generation is defined. The fuzz testing data is produced by various generation algorithms through filling data in the fields of the data model. Using the rule-based state machine and the stateful rule tree,the quantity of test data can be reduced. Experimental results indicate that our method can discover the same vulnerabilities as traditional approaches, using less test data, while optimizing test data generation and improving test efficiency. | Rui Ma Daguang Wang Changzhen Hu Wendong Ji Jingfeng Xue | 2016 | Tsinghua Science and Technology2016，21，3： | 13 |
| 8 | Internal solitons in the northern South China Sea from insitu observations显示文摘In this paper, we demonstrate the characteris- tics of strong internal solitons at the southern edge of Dong- sha Islands in the northern South China Sea (SCS) during May―June 1998, using in situ time series data from the con- ductivity temperature depth (CTD), acoustic Doppler current profiler (ADCP) and thermistor chain. Our measurements indicated that the strongest internal solitons were larger than 90 m in wave amplitude, and propagated approximately westward in traveling direction, with the maximum current speed of about 2 m/s and the period of 10―20 min. The strongest internal solitons occurred noticeably during May 14―16, 1998, which is consistent with the occurrence period of the diurnal-dominated spring internal tides. | FANG Wendong SHI Ping LONG Xiaomin MAO Qingwen | 2005 | Chinese Science Bulletin2005，50，15： | 10 |
| 9 | Notoginsenoside Ft1 acts as a TGR5 agonist but FXR antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice显示文摘Obesity and its associated complications are highly related to a current public health crisis around the world.A growing body of evidence has indicated that G-protein coupled bile acid(BA) receptor TGR5(also known as Gpbar-1) is a potential drug target to treat obesity and associated metabolic disorders.We have identified notoginsenoside Ftl(Ftl) from Panax notoginseng as an agonist of TGR5 in vitro.However,the pharmacological effects of Ftl on diet-induced obese(DIO) mice and the underlying mechanisms are still elusive.Here we show that Ftl(100 mg/100 diet) increased adipose lipolysis,promoted fat browning in inguinal adipose tissue and induced glucagon-like peptide-1(GLP-1) secretion in the ileum of wild type but not Tgr5^(-/-) obese mice.In addition,Ftl elevated serum free and taurineconjugated bile acids(BAs) by antagonizing Fxr transcriptional activities in the ileum to activate Tgr5 in the adipose tissues.The metabolic benefits of Ftl were abolished in Cyp27 al^(-/-) mice which have much lower BA levels.These results identify Ftl as a single compound with opposite activities on two key BA receptors to alleviate high fat diet-induced obesity and insulin resistance in mice. | Lili Ding Qiaoling Yang Eryun Zhang Yangmeng Wang Siming Sun Yingbo Yang Tong Tian Zhengcai Ju Linshan Jiang Xunjiang Wang Zhengtao Wang Wendong Huang Li Yang | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 10 |
| 10 | Process Study and Exergy Analysis of a Novel Air Separation Process Cooled by LNG Cold Energy显示文摘In order to resolve the problems of the current air separation process such as the complex process, cumbersome operation and high operating costs, a novel air separation process cooled by LNG cold energy is proposed in this paper, which is based on high-efficiency heat exchanger network and chemical packing separation technology. The operating temperature range of LNG cold energy is widened from 133K-203K to 113K-283K by highefficiency heat exchanger network and air separation pressure is declined from 0.5MPa to about 0.35MPa due to packing separation technology, thereby greatly improve the energy efficiency. Both the traditional and novel air separation processes are simulated with air handling capacity of 20t·h 1. Comparing with the traditional process, the LNG consumption is reduced by 44.2%, power consumption decrease is 211.5 kWh per hour, which means the annual benefit will be up to 1.218 million CNY. And the exergy efficiency is also improved by 42.5%. | XU Wendong DUAN Jiao MAO Wenjun | 2014 | Journal of Thermal Science2014，23，1： | 10 |
| 11 | Risk assessment on the epidemics of human infection with a novel avian influenza A (H7N9) virus in Jiangsu Province, China显示文摘A novel avian influenza A (H7N9) virus was discovered in February 2013 in China and has resulted in more than 100 comfirmed human infections including 26 fatal cases as of May 2, 2013. The situation raises many urgent questions and global public health concerns. In this study, epidemiologic characteristics of infected human cases in Jiangsu province were analyzed and risk assessment was undertaken based on the information available. Briefly, it is highly unlikely that a pandemic of human infection with avian influenza A (H7N9) virus will happen in Jiangsu Province in the near future. In the end, some measures are recommended to prevent the situation from becoming worse. | Wendong Liu Yefei Zhu Xian Qi Ke Xu Aihua Ge Hong Ji Jing Ai Changjun Bao Fenyang Tang Minghao Zhou | 2013 | The Journal of Biomedical Research2013，27，3： | 9 |
| 12 | Energy-efficient adaptive sensor scheduling for target tracking in wireless sensor networks显示文摘Sensor scheduling is essential to collaborative target tracking in wireless sensor networks(WSNs).In the existing works for target tracking in WSNs,such as the information-driven sensor query(IDSQ),the tasking sensors are scheduled to maximize the information gain while minimizing the resource cost based on the uniform sampling intervals,ignoring the changing of the target dynamics and the specific desirable tracking goals.This paper proposes a novel energyefficient adaptive sensor scheduling approach that jointly selects tasking sensors and determines their associated sampling intervals according to the predicted tracking accuracy and tracking energy cost.At each time step,the sensors are scheduled in alternative tracking mode,namely,the fast tracking mode with smallest sampling interval or the tracking maintenance mode with larger sampling interval,according to a specified tracking error threshold.The approach employs an extended Kalman filter(EKF)-based estimation technique to predict the tracking accuracy and adopts an energy consumption model to predict the energy cost.Simulation results demonstrate that,compared to a non-adaptive sensor scheduling approach,the proposed approach can save energy cost significantly without degrading the tracking accuracy. | Wendong XIAO Sen ZHANG Jianyong LIN Chen Khong THAM | 2010 | 控制理论与应用(英文版)2010，8，1： | 9 |
| 13 | Water Soluble C_(60)-Liposome and the Biological Effect of C_(60) to Human Cervix Cancer Cells显示文摘A preparative technique to obtain water soluble C_(60)-liposome by means of molecular package of C_(60) with lecithin has been established.The concentration of C_(60) presented in liposome is 1.09 x 10-4mol/dm3.The molecular system of C_(60)-liposome with human cervix cancer cells is irradiated with laser(570nm,800mW),there is obvious biological effect of C_(60) to huma cervix cancer cells. | LI Wenzhu QIAN Kaixian HUANG Wendong ZHANG Xinxin CHEN Wanxi | 1994 | Chinese Physics Letters1994，11，4： | 9 |
| 14 | Internal tide characteristics over northern South China Sea continental slope显示文摘21-day in-situ ADCP current and CTD data from an anchored observational station by R/V Shiyan 3 are used to investigate the characteristics of internal tide in the northern South China Sea continental slope. The results show that tide and internal tide are both mixed type in the observed region and dominated by diurnals; the maximum internal tidal major axes of K1, O1 were largest and reached 11 cm/s, 10 cm/s, respectively, and their current vectors rotate anticlockwise. The 300 m-deep internal tide presents obvious quasi-diurnal oscillation and its average amplitude reaches 50 m. Furthermore, internal tide carried high energy; in the upper layers above 140 m, the kinetic energy of internal tides accounts for 15%-37% of overall kinetic energy, most of internal tide energy concentrates around the thermocline. | GUO Pu FANG Wendong GAN Zijun CHEN Rongyu LONG Xiaomin | 2006 | Chinese Science Bulletin2006，51，B12： | 8 |
| 15 | Preparation of a SiC/Cristobalite-AlPO_4 Multi-layer Protective Coating on Carbon/Carbon Composites and Resultant Oxidation Kinetics and Mechanism显示文摘In order to improve the oxidation resistance of carbon/carbon (C/C) composites,a SiC/C-AlPO4 multi-layer coating was fabricated on the C/C composites by a simple and low-cost method.The internal SiC bonding layer was prepared by a two-step pack cementation process and the external C-AlPO4 coating was deposited by hydrothermal electrophoretic deposition process.Phase compositions and microstructures of the as-prepared multi-layer coating were characterized by X-ray diffraction (XRD),scaning electron microspocy (SEM) and energy dispersive spectrometer (EDS).Anti-oxidation properties,oxidation behavior and the failure behavior of the coated composites were investigated.The results indicate that the multi-layer coating exhibits obviously two-layer structure.The inner layer is composed of β-SiC,α-SiC phase with a scale of silicon phase.The outer layer is composed of cristobalite aluminum phosphate (C-AlPO4) crystallites.The SEM observation shows the good bonding between the inner and outer layers.The multi-layer coating displays an excellent oxidation resistance in air in the temperature range from 1573 to 1773 K,and the corresponding oxidation activation energy of the coated C/C composites is calculated to be 117.2 kJ/mol.The oxidation process is predominantly controlled by the diffusion of O2 through the C-AlPO 4 coating.The failure of the multi-layer coating results from the generation of the microholes that may be left by the escape of the oxidation gases. | Jianfeng Huang Wendong Yang Liyun Cao | 2010 | Journal of Materials Science & Technology2010，26，11： | 7 |
| 16 | Effects of closing and reopening live poultry markets on the epidemic of human infection with avian influenza A virus显示文摘Live poultry markets(LPMs) are crucial places for human infection of influenza A(H7N9 virus).In Yangtze River Delta,LPMs were closed after the outbreak of human infection with avian influenza A(H7N9) virus,and then reopened when no case was found.Our purpose was to quantify the effect of LPMs' operations in this region on the transmission of influenza A(H7N9) virus.We obtained information about dates of symptom onset and locations for all human influenza A(H7N9) cases reported from Shanghai,Jiangsu and Zhejiang provinces by May 31,2014,and acquired dates of closures and reopening of LPMs from official media.A two-phase Bayesian model was fitted by Markov Chain Monte Carlo methods to process the spatial and temporal influence of human cases.A total of 235 cases of influenza A(H7N9) were confirmed in Shanghai,Jiangsu and Zhejiang by May 31,2014.Using these data,our analysis showed that,after LPM closures,the influenza A(H7N9) outbreak disappeared within two weeks in Shanghai,one week in Jiangsu,and one week in Zhejiang,respectively.Local authorities reopened LPMs when there was no outbreak of influenza A(H7N9),which did not lead to reemergence of human influenza A(H7N9).LPM closures were effective in controlling the H7N9 outbreak.Reopening of LPM in summer did not increase the risk of human infection with H7N9.Our findings showed that LPMs should be closed immediately in areas where the H7N9 virus is confirmed in LPM.When there is no outbreak of H7N9 virus,LPMs can be reopened to satisfy the Chinese traditional culture of buying live poultry.In the long term,local authorities should take a cautious attitude in permanent LPM closure. | Jian Lu Wendong Liu Rui Xia Qigang Dai Changjun Bao Fenyang Tang Yefei Zhu Qiao Wang | 2016 | The Journal of Biomedical Research2016，30，2： | 7 |
| 17 | Enhancing production of ergosterol in Pichia pastoris GS115 by over-expression of 3-hydroxy-3-methylglutaryl CoA reductase from Glycyrrhiza uralensis显示文摘The rate-limiting enzyme in the mevalonic acid(MVA)pathway which can lead to triterpenoid saponin glycyrrhizic acid(GA)is 3-hydroxy-3-methylglutaryl-CoA reductase(HMGR).In order to reveal the effect of copy number variation in the HMGR gene on the MVA pathway,the HMGR gene from Glycyrrhiza uralensis Fisch.(GuHMGR)was cloned and over-expressed in Pichia pastoris GS115.Six recombinant P.pastoris strains containing different copy numbers of the GuHMGR gene were obtained and the content of ergosterol was analyzed by HPLC.The results showed that all the recombinant P.pastoris strains contained more ergosterol than the negative control and the strains with 8 and 44 copies contained significantly more ergosterol than the other strains.However,as the copy number increased,the content of ergosterol showed an increasing–decreasing–increasing pattern.This study provides a rationale for increasing the content of GA through over-expressing the GuHMGR gene in cultivars of G.uralensis. | Ying Liu Xiaoqing Zhu Wendong Li Hao Wen Ya Gao Yong Liu Chunsheng Liu | 2014 | Acta Pharmaceutica Sinica B2014，4，2： | 7 |
| 18 | Estimation of Ecological Water Requirements Based on Habitat Response to Water Level in Huanghe River Delta,China显示文摘In recent years,wetland ecological water requirements (EWRs) have been estimated by using hydrological and functional approaches,but those approaches have not yet been integrated for a whole ecosystem.This paper presents a new method for calculating wetland EWRs,which is based on the response of habitats to water level,and determines water level threshold through the functional integrity of habitats.Results show that in the Huanghe (Yellow) River Delta water levels between 5.0 m and 5.5 m are required to maintain the functional integrity of the wetland at a value higher than 0.7.One of the dominant plants in the delta,Phragmites australis,tolerates water level fluctuation of about ± 0.25 m without the change in wetland functional integrity.The minimum,optimum and maximum EWRs for the Huanghe River Delta are 9.42×106 m3,15.56×106 m3 and 24.12×106 m3 with water levels of 5.0 m,5.2 m and 5.5 m,corresponding to functional integrity indices of 0.70,0.84 and 0.72,respectively.A wetland restoration program has been performed,which aims to meet these EWRs in attempt to recover from losses of up to 98% in the delta's former wetland area. | CUI Baoshan HUA Yanyan WANG Chongfang LIAO Xiaolin TAN Xuejie TAO Wendong | 2010 | Chinese Geographical Science2010，20，4： | 7 |
| 19 | Effects of advanced oxidation pretreatment on residual aluminum control in high humic acid water purification显示文摘Due to the formation of disinfection by-products and high concentrations of Al residue in drinking water purification, humic substances are a major component of organic matter in natural waters and have therefore received a great deal of attention in recent years. We investigated the effects of advanced oxidation pretreatment methods usually applied for removing dissolved organic matters on residual Al control. Results showed that the presence of humic acid increased residual Al concentration notably. With 15 mg/L of humic acid in raw water, the concentrations of soluble aluminum and total aluminum in the treated water were close to the quantity of Al addition. After increasing coagulant dosage from 12 to 120 mg/L, the total-Al in the treated water was controlled to below 0.2 mg/L. Purification systems with ozonation, chlorination, or potassium permanganate oxidation pretreatment units had little effects on residual Al control; while UV radiation decreased Al concentration notably. Combined with ozonation, the effects of UV radiation were enhanced. Optimal dosages were 0.5 mg O 3 /mg C and 3 hr for raw water with 15 mg/L of humic acid. Under UV light radiation, the combined forces or bonds that existed among humic acid molecules were destroyed; adsorption sites increased positively with radiation time, which promoted adsorption of humic acid onto polymeric aluminum and Al(OH) 3 (s). This work provides a new solution for humic acid coagulation and residual Al control for raw water with humic acid purification. | Wendong Wang Hua Li Zhenzhen Ding Xiaochang Wang | 2011 | Journal of Environmental Sciences2011，23，7： | 6 |
| 20 | Double perovskite oxides Sr_2Mg_(1-x)Fe_xMoO(6-δ) for catalytic oxidation of methane显示文摘The double perovskite oxides Sr2Mg1-xF exMoO6-δ were investigated as catalysts for the methane oxidation.The structural properties of catalysts were characterized in detail by X-ray diffraction,X-ray photoelectron spectroscopy and X-ray absorption spectroscopy.The catalytic property was strongly influenced by the Fe substitution.The relation between catalytic performance and the degree of Fe substitution was examined with regard to the structure and surface characteristics of the mixed oxides.The Fe-containing catalysts exhibited higher activity attributable to the possible(Fe2+,Mo6+) and (Fe3+,Mo5+)valency pairs,and the highest activity was observed for Sr2Mg0.2Fe0.8MoO6-δ.The enhancement of the catalytic activity may be correlated with the Fe-relating surface lattice oxygen species and was discussed in view of the presence of oxygen vacancies. | Chen Li Wendong W ang Congying Xu Yuanxu Liu BO He Chusheng Chen | 2011 | Journal of Natural Gas Chemistry2011，20，4： | 6 |
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