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| 1 | Preparation of anion exchange membrane based on homogeneous quaternization of bromomethylated poly(arylene ether sulfone)显示文摘 | Chengji Zhao Wenjia Ma Wenmo Sun Hui Na | 2014 | J. Appl. Polym. Sci2014，，10： | 1 |
| 2 | 基于人工智能的影像组学在肝病中的应用现状显示文摘影像组学是指使用计算机从不同类型的影像图像中提取大量信息, 形成各种可定量的特征, 然后选取一些相关的特征通过人工智能方法构建模型, 用以预测一些临床问题(如诊断、治疗、预后)的结局。将影像组学应用于肝病研究将有助于肝病的早期诊断和早期治疗, 并改善患者生存和治愈率。影像组学的研究目前方兴未艾, 未来可能还会有巨大进展。因此, 我们总结了影像组学在肝病中的研究现状, 并指出相关不足及未来研究方向。 | Wenmo Hu Huayu Yang Haifeng Xu Yilei Mao | 2020 | Gastroenterology Report2020，8，2： | 1 |
| 3 | Experimental study on sliding shaft lining mechanical mechanisms under ground subsidence conditions显示文摘 | Yao Zhishu Yang Junjie Sun Wenmo | 2003 | Journal of Coal Science & Engineering2003，9，1： | 1 |
| 4 | Enhancing the antitumor activity of an engineered TRAIL-coated oncolytic adenovirus for treating acute myeloid leukemia显示文摘The use of oncolytic viruses has emerged as a promising therapeutic approach due to the features of these viruses,which selectively replicate and destroy tumor cells while sparing normal cells.Although numerous oncolytic viruses have been developed for testing in solid tumors,only a few have been reported to target acute myeloid leukemia(AML)and overall patient survival has remained low.We previously developed the oncolytic adenovirus rAd5pz-zTRAIL-RFP-SΔ24E1a(A4),which carries the viral capsid protein IX linked to tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)and results in increased infection of cancer cells and improved tumor targeting.To further improve the therapeutic potential of A4 by enhancing the engagement of virus and leukemia cells,we generated a new version of A4,zA4,by coating A4 with additional soluble TRAIL that is fused with a leucine zipper-like dimerization domain(zipper).ZA4 resulted in enhanced infectivity and significant inhibition of the proliferation of AML cells from cell lines and primary patient samples that expressed moderate levels of TRAIL-related receptors.ZA4 also elicited enhanced anti-AML activity in vivo compared with A4 and an unmodified oncolytic adenoviral vector.In addition,we found that the ginsenoside Rh2 upregulated the expression of TRAIL receptors and consequently enhanced the antitumor activity of zA4.Our results indicate that the oncolytic virus zA4 might be a promising new agent for treating hematopoietic malignancies such as AML. | Zixuan Wang Wenmo Liu Lizheng Wang Peng Gao Zhe Li Jiaxin Wu Haihong Zhang Hui Wu Wei Kong Bin Yu Xianghui Yu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
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