| 2 | Non-cell-autonomous manner of AAV administration to attenuate cardiomyocyte hypertrophy by targeting paracrine signaling on ECM to reduce viral dosage显示文摘Dear Editor,Adeno-associated virus(AAV)is one of the most powerful vectors for exogenous gene delivery.1 However,the risks associated with the high dosages of AAV administration that are required to achieve meaningful effects limit the applicability of this method.Generally,AAV only presents cell autonomous manner in infected cells.Besides,mosaic genetic editing or gene therapy would trigger global biological function restore by above 30–40%infective ratio in heart diseases. | Lei Liu Peng Yue Yue Zhang Yimin Hua Wenwei Bi Hualin Yan Hongyu Liao Jiawen Li Kaiyu Zhou Yifei Li | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 0 |
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