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| 1 | Serum proinflammatory cytokines and nutritional status in pediatric chronic liver disease显示文摘AIM: To evaluate the nutritional status and its association with proinflammatory cytokines in children with chronic liver disease.METHODS: We performed a cross-sectional study with 43 children and adolescents, aged 0 to 17 years, diagnosed with chronic liver disease. All patients regularly attended the Pediatric Hepatology Unit and were under nutritional follow up. The exclusion criteria were fever from any etiology at the time of enrollment, inborn errors of the metabolism and any chronic illness. The severity of liver disease was assessed by Child-Pugh, Model for End-stage Liver Disease(MELD) and Pediatric End Stage Liver Disease(PELD) scores. Anthropometric parameters were height/age, body mass index/age and triceps skinfold/age according to World Health Organization standards. The cutoff points for nutritional status were risk of malnutrition(Z-score <-1.00) and malnutrition(Z-score <-2.00). Interleukin-1β(IL-1β), IL-6 and tumor necrosis factor-α levels were assessed by commercial ELISA kits. For multivariate analysis, linear regression was applied to assess the association between cytokine levels, disease severity and nutritional status. RESULTS: The median(25th-75 th centile) age of the study population was 60(17-116)-mo-old, and 53.5% were female. Biliary atresia was the main cause of chronic liver disease(72%). With respect to Child-Pugh score, cirrhotic patients were distributed as follows: 57.1% Child-Pugh A, a mild presentation of the disease, 34.3% Child-Pugh B, a moderate stage of cirrhosis and 8.6% Child-Pugh C, were considered severe cases. PELD and MELD scores were only above the cutoff point in 5 cases. IL-6 values were increased in patients at nutritional risk(34.9%) compared with those who were well-nourished [7.12(0.58-34.23) pg/m L vs 1.63(0.53-3.43) pg/m L; P = 0.02], correlating inversely with triceps skinfold-for-age z-score(rs =-0.61; P < 0.001). IL-6 levels were associated with liver disease severity assessed by Child-Pugh score(P = 0.001). This association remained significant after adjusting for nutritional status in a linear regression model. CONCLUSION: High IL-6 levels were found in children with chronic liver disease at nutritional risk. Inflammatory activity may be related to nutritional status deterioration in these patients. | Daniele Santetti Maria Inês de Albuquerque Wilasco Cristina Toscani Leal Dornelles Isabel Cristina Ribas Werlang Fernanda Urruth Fontella Carlos Oscar Kieling Jorge Luiz dos Santos Sandra Maria Goncalves Vieira Helena Ayako Sueno Goldani | 2015 | World Journal of Gastroenterology2015，21，29： | 2 |
| 2 | Quantum correlations in spin chains at finite temperatures and quantum phase transitions显示文摘 | Werlang T Riheiro G A P Gustavo Rigolin | 2010 | Phys Rev Lett2010，105，09： | 1 |
| 3 | Spotlighting quantum critical points via quantum correlations at finite temperatures 显示文摘 | Werlang T Ribeiro G A P Gustavo Rigolin | 2011 | Phys Rev A2011，83，62： | 1 |
| 4 | Molecular cloning and transgenic expression of a synthetic human erythropoietin gene in tobacco显示文摘 | SPERB F WERLANG I C MARGIS-PINHEIRO M | 2011 | Appl Biochem Biotechnol2011，165，2： | 1 |
| 5 | Robustness of quantum discord to sudden death显示文摘 | Werlang T Souza S Fanchinif F F | 2009 | Phys Rev A2009，80，02： | 1 |
| 6 | Effects of breeding at the second oestrus or after post-weaning hormonal treatment with altrenogest on subsequent reproductive performance of primiparous sows显示文摘 | Werlang R F Argenti L E Fries H C C | 2011 | Reproduction in Domestic Animals2011，46，5： | 1 |
| 7 | The Bayesian Foundations of Solution Concepts of Game显示文摘 | Tan T C Da Costa Werlang S R | 1988 | Journal of Economic Theory1988，45，2： | 1 |
| 8 | Effects of breedingat the second oestrus or after post-weaning hormonal treatmentwith altrenogest on subsequent reproductive performance of pri-miparous sows显示文摘 | Werlang R F Argenti L E Fries H C C | 2011 | ReprodDomAnim2011，46，5： | 1 |
| 9 | Thermal and Magnetic Quantum Discord in Heisenberg Models显示文摘 | WERLANG T RIGOLIN G | | 0，，： | 1 |
| 10 | Spotlighting quantum critical points via quantum correlations at finite temperatures显示文摘 | Werlang T Ribeiro G A P Rigolin G | 2011 | Phys Rev A2011，83，6： | 1 |
| 11 | Quantum Correlations in Spin Chains at Finite Temperatures and Quantum Phase Transitions显示文摘 | WERLANG T TRIPPE C RIBEIRO G A P | | 0，，： | 1 |
| 12 | Robustness of quantum discord to sudden death显示文摘 | Werlang T Souza S Fanchini F F | 2009 | Physical Review A2009，80，02： | 1 |
| 13 | Thermal and Magnetic Quantum Discord in Heisenberg models 显示文摘 | WERLANG T RIGOLIN G | 2010 | PhysRev A2010，81，04： | 1 |
| 14 | Non-Markovian Dynamics of Quantum Discord显示文摘 | FANCHINI F F WERLANG T BRASIL C A | 2010 | Phys Rev A2010，81，05： | 1 |
| 15 | Nash equilibrium under Knightian uncertainty: Breaking down backward induction显示文摘 | Dow J Werlang S | 1994 | Journal Economic Theory1994，64，： | 1 |
| 16 | Blends of polypropylene with solid silicone additive显示文摘 | PATRiCIA M WERLANG M | 2007 | J Appl Polym Sci2007，104，： | 1 |
| 17 | Blends of high-density polyethylene with solid silicone additive 显示文摘 | PATRICIA M WERLANG M | 2002 | Appl Polym Sci2002，83，： | 1 |
| 18 | The pass-through from de-preciation to inflation:a panel study显示文摘 | Goldfajn I Werlang D.C | | 0，，5： | 1 |
| 19 | Blends of polypropylene with solid silicone additive显示文摘 | Patricia M Werlang M | 2007 | Journal of Applied Polymer Science2007，104，： | 1 |
| 20 | Quantum Correlations in Spin Chains at Finite Temperatures and Quantum Phase Transitions显示文摘 | Werlang T Trippe C Ribeiro G A P | | 0，，09： | 1 |
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