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| 1 | 5-Lipoxygenase : regulation of expression and enzyme activity 显示文摘 | Radmark O Werz O Steinhilber D el al | 2007 | Trends Biochem Sci2007，32，7： | 1 |
| 2 | The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway 显示文摘 | Werz C Kohler K Hafen E | 2009 | PLoS Genet2009，5，10： | 1 |
| 3 | α‐Tocopherol long‐chain metabolite α‐13’‐COOH affects the inflammatory response of lipopolysaccharide‐activated murine RAW264.7 macrophages显示文摘 | Maria Wallert Lisa Schm?lz Andreas Koeberle Verena Krauth Michael Glei Francesco Galli Oliver Werz Marc Birringer Stefan Lorkowski | 2015 | Mol. Nutr. Food Res2015，，： | 1 |
| 4 | Midpalatal suture opening--A normative study显示文摘 | Werz R Dreskin M | 1977 | Am J Orthod1977，71，4： | 1 |
| 5 | Orthostatic limb shaking from carotid hypoperfusion显示文摘 | Zaidat OO Werz MA Landis D | 1999 | Neurology1999，53，2： | 1 |
| 6 | Orthostatic limb shaking from carotid hypoperfusion显示文摘 | Zaidat O O Werz M A Landis D M | 1999 | Neurology1999，53，3： | 1 |
| 7 | Orthostatic limb shaking from carotid hypoperfusion显示文摘 | Zaidat OO Werz MA Landis DM | 1999 | Neurology1999，53，： | 1 |
| 8 | Azebrafish homologue of the chemoking receptor CXCR4 is a germ-cell guidance receptor显示文摘 | Knaut H Werz C Geisler R | 2003 | Nature2003，421，： | 1 |
| 9 | Orthostatic limb shaking from carotid hypoperfusion显示文摘 | Zaidat O O Werz M A Landis D | 1999 | Neurology1999，53，3： | 1 |
| 10 | Extracellular signal regulated kinase-2 phosphorylates ROR 4 in vitro 显示文摘 | Lechtken A HOrnig M Werz O | 2007 | Biochemical and Biophysical Research Communications2007，358，3： | 1 |
| 11 | Fluorescent penta-and hexaene fatty acids by a Wittig-Horner/elimination strategy显示文摘 | Patalag L J Werz D B | 2012 | J Org Chem2012，77，： | 1 |
| 12 | Curcumin blocks prosta glandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1 显示文摘 | Koeberle A Northoff H Werz O | 2009 | Mol Cancer Ther2009，8，8： | 1 |
| 13 | From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution显示文摘Chronic inflammation results from excessive pro-inflammatory signaling and the failure to resolve the inflammatory reaction.Lipid mediators orchestrate both the initiation and resolution of inflammation.Switching from pro-inflammatory to pro-resolving lipid mediator biosynthesis is considered as efficient strategy to relieve chronic inflammation,though drug candidates exhibiting such features are unknown.Starting from a library of Vietnamese medical plant extracts,we identified isomers of the biflavanoid 8-methylsocotrin-4’-ol from Dracaena cambodiana,which limit inflammation by targeting 5-lipoxygenase and switching the lipid mediator profile from leukotrienes to specialized pro-resolving mediators(SPM).Elucidation of the absolute configurations of 8-methylsocotrin-4’-ol revealed the 2 S,γSisomer being most active,and molecular docking studies suggest that the compound binds to an allosteric site between the 5-lipoxygenase subdomains.We identified additional subordinate targets within lipid mediator biosynthesis,including microsomal prostaglandin E2 synthase-1.Leukotriene production is efficiently suppressed in activated human neutrophils,macrophages,and blood,while the induction of SPM biosynthesis is restricted to M2 macrophages.The shift from leukotrienes to SPM was also evident in mouse peritonitis in vivo and accompanied by a substantial decrease in immune cell infiltration.In summary,we disclose a promising drug candidate that combines potent 5-lipoxygenase inhibition with the favorable reprogramming of lipid mediator profiles. | Tran Thi Van Anh Alilou Mostafa Zhigang Rao Simona Pace Stefan Schwaiger Christian Kretzer Veronika Temml Carsten Giesel Paul M.Jordan Rossella Bilancia Christina Weinigel Silke Rummler Birgit Waltenberger Tran Hung Antonietta Rossi Hermann Stuppner Oliver Werz Andreas Koeberle | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 1 |
| 14 | ECM and cell surface proteolysis:Regulating cellular ecology显示文摘 | Werz Z | 1997 | Cell1997，91，4： | 1 |
| 15 | Therapeutic options for 5-1ipoxygenase inhibitors显示文摘 | Werz O Steinhilber D | 2006 | Pharmacol Therapeut2006，112，3： | 1 |
| 16 | Regulation of lifespan, metabolism, and stress responses by the drosophila SH2B protein 显示文摘 | Slack C Werz C Wieser D | 2010 | PLOS Genet2010，6，10： | 1 |
| 17 | Transverse myelitis associated with cinetobacter baumanii intrathecal pump catheter-related infection 显示文摘 | Ubogu E E Lindenberg J R Werz M A | 2003 | Reg Anesth Pain Med2003，28，5： | 1 |
| 18 | Reactive oxygen species released from granulocytes stimulate 5-lipoxygenase activity in a B-lymphocytic cell line显示文摘 | WERZ O SZELLAS D STEINHILBER D | 2000 | Eur J Biochem2000，267，5： | 1 |
| 19 | Souse Pollution control at iron ore sin- tering plants through waste gas recycling显示文摘 | Werz H Otto J Rengersem J | 1995 | Stahl und Eisen1995，115，： | 1 |
| 20 | Development of 5-1ipoxygenase inhibitors--lessons from cellular enzyme regulation 显示文摘 | Werz O Steinhilber D | 2005 | Biochem Pharmacol2005，70，3： | 1 |
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